National Toxicology Program

National Toxicology Program

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(CAS NO. 57465-28-8) AND 2,2N,4,4N,5,5N-HEXACHLOROBIPHENYL (PCB 153) (CAS NO. 35065-27-1) IN FEMALE HARLAN SPRAGUE-DAWLEY RATS (GAVAGE ... STUDIES OF A BINARY MIXTURE OF 3,3N,4,4N,5-PENTACHLOROBIPHENYL (PCB 126) (CAS NO. 57465-28-8) AND 2,2N,4,4N,5,5N-HEXACHLOROBIPHENYL (PCB 153) (CAS NO. 35065-27-1) IN FEMALE HARLAN SPRAGUE-DAWLEY RATS ... in Female Rats in the 2-Year Gavage Study of a Binary Mixture of PCB 126 and PCB 153: Groups 1, 2, 3, 5, 7 . . . . . . . . . . . . . . . . ...
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2,3´,4,4´,5-PENTACHLOROBIPHENYL (PCB 118) (CAS NO. 31508-00-6) IN FEMALE HARLAN SPRAGUE-DAWLEY RATS (GAVAGE STUDIES) ... TOXICOLOGY AND CARCINOGENESIS STUDIES OF 2,3´,4,4´,5-PENTACHLOROBIPHENYL (PCB 118) (CAS NO. 31508-00-6) IN FEMALE HARLAN ... APPENDIX A Summary of Lesions in Female Rats in the 2-Year Gavage Study of PCB 118 . . . . . . . . . 91 APPENDIX B Organ ... . . . . . . . . . . . . . . . . . . . . . . . . . . . 173 4 PCB 118, NTP TR 559 SUMMARY Background 2,3´,4,4´,5-Pentachloro...
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(CAS NO. 57465-28-8) AND 2,3N,4,4N,5-PENTACHLOROBIPHENYL (PCB 118) (CAS NO. 31508-00-6) IN FEMALE HARLAN SPRAGUE-DAWLEY RATS (GAVAGE STUDIES) ... STUDIES OF A BINARY MIXTURE OF 3,3N,4,4N,5-PENTACHLOROBIPHENYL (PCB 126) (CAS NO. 57465-28-8) AND 2,3N,4,4N,5-PENTACHLOROBIPHENYL (PCB 118) (CAS NO. 31508-00-6) IN FEMALE HARLAN SPRAGUE-DAWLEY RATS (GAVAGE ... in Female Rats in the 2-Year Gavage Study of a Binary Mixture of PCB 126 and PCB 118 . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
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3,3N,4,4N,5-PENTACHLOROBIPHENYL (PCB 126) (CAS NO. 57465-28-8) IN FEMALE HARLAN SPRAGUE-DAWLEY RATS (GAVAGE STUDIES) NATIONAL ... CARCINOGENESIS STUDIES OF 3,3N,4,4N,5-PENTACHLOROBIPHENYL (PCB 126) (CAS NO. 57465-28-8) IN FEMALE HARLAN SPRAGUE-DAWLEY ... of Lesions in Female Rats in the 2-Year Gavage Study of PCB 126 . . . . . . . . 89 APPENDIX B Organ Weights and ... . . . . . . . . . . . . . . . . . . . . . . . . . . . 245 4 PCB 126, NTP TR 520 SUMMARY Background 3,3N4,4N5-Pentachlorobiph...
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2,2N,4,4N,5,5N-HEXACHLOROBIPHENYL (PCB 153) (CAS NO. 35065-27-1) IN FEMALE HARLAN SPRAGUE-DAWLEY RATS (GAVAGE STUDIES) ... CARCINOGENESIS STUDIES OF 2,2N,4,4N,5,5N-HEXACHLOROBIPHENYL (PCB 153) (CAS NO. 35065-27-1) IN FEMALE HARLAN SPRAGUE-DAWLEY ... Service U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES 2 PCB 153, NTP TR 529 CONTRIBUTORS National Toxicology Program ... of Lesions in Female Rats in the 2-Year Gavage Study of PCB 153 . . . . . . . . 61 APPENDIX B Organ Weights and ...
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30 - Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) http://ntp.niehs.nih.gov/go/16325 Abstract for TR-530 - Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CAS No. 57465-28-8) and ...
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1 - Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) (CASRN 31508-00-6) http://ntp.niehs.nih.gov/go/16331 Abstract for TR-531 - Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) (CASRN 31508-00-6) Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CAS No. 57465-28-8) and 2,3',4,4',5-Pentachlorob...
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TEF transgenics (PCB 126 / PECDF mixture) M020020 Link to Data Search (Data is not available for all studies.) Overviews of NTP Protocols http://ntp.niehs.nih.gov/go/ts-m020020 TEF transgenics (PCB 126 / PECDF mixture) - M020020 CASRN: TEFTGMIXTURE Synonyms/Common Names: PCB 126/PECDF MIXTURE (TEF TRANSGENICS) TEF TRANSGENICS (3,3',4,4',5-PENTACHLOROBIPHENYL/2,3,4,7,8-PENTACHLORODIBENZOFURAN MIXTURE) Secondary: 57465-28-8 - 3,3,4,4,5-Pentachlorobiphenyl (PCB 126) 57117-31-4 - ...
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29 - 2,2',4,4',5,5',-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) http://ntp.niehs.nih.gov/go/20264 Abstract for TR-529 - 2,2',4,4',5,5',-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) Toxicology and Carcinogenesis Studies of 2,2',4,4',5,5',-Hexachlorobiphenyl (PCB 153) (CAS No. 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies) ... the chronic toxicity and carcinogenicity of DLCs and structurally related polychlorinated biphenyls (PCBs) and mixtures of these compounds. ...
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Study Results & Research Projects » Reports & Publications » All Long-Term Reports » Abstract for TR-520 - 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) http://ntp.niehs.nih.gov/go/9301 Abstract for TR-520 - 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) Toxicology and Carcinogenesis Studies of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CAS No. ... carcinogenicity of DLCs and structurally-related polychlorinated biphenyls (PCBs) and mixtures of these compounds. ***** 3,3',4,4',5-Pentachlorobiphenyl (PCB ...
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TEF transgenics (PCB 126) M020018 Link to Data Search (Data is not available for all studies.) Chemical Properties Toxicity Effects (HSDB) Overviews of NTP Protocols http://ntp.niehs.nih.gov/go/ts-m020018 TEF transgenics (PCB 126) - M020018 CASRN: 57465-28-8 Formula: C12-H5-Cl5 Synonyms/Common Names: PCB 126 (TEF TRANSGENICS) TEF TRANSGENICS (3,3',4,4',5 PENTACHLOROBIPHENYL) Known Uses: Special evaluation of relative potency factors for papilloma induction by dioxin-like compounds in ...
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9 - 2,3',4,4',5-Pentachlorobiphenyl (PCB 118)(CASRN 31508-00-6) http://ntp.niehs.nih.gov/go/33539 Abstract for TR-559 - 2,3',4,4',5-Pentachlorobiphenyl (PCB 118)(CASRN 31508-00-6) TR-559 Toxicology and Carcinogenesis Studies of 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) (CAS No. 31508-00-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies) Link ... evaluate the chronic toxicity and carcinogenicity of DLCs and structurally related polychlorinated biphenyls (PCBs) and mixtures of these compounds. ...
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TEF Evaluation (PCB Mixture; PCB 126/PCB 118) M970041 Link to Data Search (Data is not available for all studies.) Overviews of NTP Protocols http://ntp.niehs.nih.gov/go/ts-m970041 TEF Evaluation (PCB Mixture; PCB 126/PCB 118) - M970041 CASRN: TEFPCBMIX Synonyms/Common Names: PCB MIXTURE (TOXIC EQUIVALENCY FACTOR EVALUATION) TOXIC EQUIVALENCY FACTOR EVALUATION (PCB MIXTURE (PCB 126/PCB 118)) Secondary: 31508-00-6 - 2,3',4,4',5-Pentachlorobiphenyl 57465-28-8 - 3,3,4,4,5-Pentachlorobiphenyl (PCB ...
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(CAS NO. 57117-31-4), AND 3,3N,4,4N,5-PENTACHLOROBIPHENYL (PCB 126) (CAS NO. 57465-28-8) IN FEMALE HARLAN SPRAGUE-DAWLEY ... (CAS NO. 57117-31-4), AND 3,3N,4,4N,5-PENTACHLOROBIPHENYL (PCB 126) (CAS NO. 57465-28-8) IN FEMALE HARLAN SPRAGUE-DAWLEY ... . . . 179 4 A Mixture of TCDD, PeCDF, and PCB 126, NTP TR 526 SUMMARY Background 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), and 3,3N,4,4N,5- pentachlorobiphenyl (PCB 126) are members of a class of chemicals ...
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First listed in the Second Annual Report on Carcinogens (1981) Also known as PCBs or chlorodiphenyls (Cl) x (Cl) y Polychlorinated biphenyls (number of chlorine atoms [x + y] = 1-10) Carcinogenicity Polychlorinated biphenyls (PCBs) are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals. Not all PCB mixtures caused tumors in experimental animals. Cancer Studies in Experimental Animals Oral exposure to PCBs caused liver ...
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(CASRN 57117-31-4), and 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) http://ntp.niehs.nih.gov/go/9307 ...PCB 126) (CASRN 57465-28-8) Toxicology and Carcinogenesis Studies of a Mixture of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) (CAS No. 1746-01-6), 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CAS No. 57117-31-4), and 3,3',4,4',5-Pentachlorobiphenyl (PCB ... Chemical Formula: TCDD: C12H4Cl4O2 PeCDF: C12H3Cl5O PCB 126: C12H5Cl5 DIOXIN TOXIC EQUIVALENCY FACTOR EVALUATION OVERVIEW ...
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...PCB 126) M950120 Link to Data Search (Data is not available for all studies.) Chemical Properties Toxicity Effects (HSDB) Overviews of NTP Protocols http://ntp.niehs.nih.gov/go/ts-m950120 3,3,4,4,5-Pentachlorobiphenyl (PCB 126) - M950120 CASRN: ... Synonyms/Common Names: 1,1'-BIPHENYL, 3,3',4,4',5-PENTACHLORO- (9CI) PCB 126 Known Uses: Dielectric medium in transformers ... Single Gavage Administration Toxicokinetic Study of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) in Female Harlan Sprague-Dawley ...
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TEF evaluation (PCB 118) M030022 Link to Data Search (Data is not available for all studies.) Chemical Properties Toxicity Effects (HSDB) Overviews of NTP Protocols http://ntp.niehs.nih.gov/go/ts-m030022 TEF evaluation (PCB 118) - M030022 CASRN: 31508-00-6 Formula: C12-H5-Cl5 Synonyms/Common Names: PCB-118 (TOXIC EQUIVALENCY FACTOR EVALUATION) TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 118) TOXIC EQUIVALENCY FACTOR EVALUATION (2,3',4,4',5-PENTACHLOROBIPHENYL) Known Uses: Polychlorinated biphenyls ...
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Binary mixture; PCB 126/PCB 153) M960055 Link to Data Search (Data is not available for all studies.) Overviews of NTP Protocols http://ntp.niehs.nih.gov/go/ts-m960055 TEF evaluation (Binary mixture; PCB 126/PCB 153) - M960055 CASRN: TEFBINARYMIX Formula: N/A Synonyms/Common Names: BINARY MIXTURE (TOXIC EQUIVALENCY FACTOR EVALUATION) TOXIC EQUIVALENCY FACTOR EVALUATION (BINARY MIXTURE) Secondary: 35065-27-1 - 2,2'-4,4',5,5'-Hexachlorobiphenyl (PCB 153) 57465-28-8 - 3,3,4,4,5-Pentachlorobiphenyl ...
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Polychlorinated biphenyls (PCBs) mixtures (N21405) http://ntp.niehs.nih.gov/go/nm-n21405 Nomination Summary for Polychlorinated biphenyls (PCBs) mixtures (N21405) The Nomination you attempted to access could not be found. Please try your search again.
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PCB 153- 2,2'-4,4',5,5'-hexachlorobiphenyl) M960054 Link to Data Search (Data is not available for all studies.) Chemical ... Toxic equivalency factor evaluation (PCB 153- 2,2'-4,4',5,5'-hexachlorobiphenyl) - M960054 CASRN: 35065-27-1 Related: 2,2',4,4',5,5'-HEXACHLOROBIPHENYL (PCB 153) Formula: C12-H4-Cl6 Synonyms/Common Names: 1,1'-BIPHENYL, 2,2',4,4',5,5'-HEXACHLORO- (9CI) 2,2',4,4',5,5'-HEXACHLOROBIPHENYL (PCB 153) (TOXIC EQUIVALENCY FACTOR EVALUATION) PCB 153 (TOXIC EQUIVALENCY FACTOR ...
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...PCB 126) 3,3',4,4',5-pentachlorobiphenyl) M960052 Link to Data Search (Data is not available for all studies.) Chemical Properties Toxicity Effects (HSDB) Overviews of NTP Protocols http://ntp.niehs.nih.gov/go/ts-m960052 Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) - M960052 CASRN: 57465-28-8 Related: TOXIC EQUIVALENCY FACTOR EVALUATION (PENTACHLOROBIPHENYL) Formula: C12-H5-Cl5 Synonyms/Common Names: 1,1'-BIPHENYL, 3,3',4,4',5-PENTACHLORO- (9CI) PCB 126 PCB 126 ...
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Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) (CASRN 31508-00-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies) Chemical (Study Title) CASRN Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory TEF Evaluation (PCB Mixture; PCB 126/PCB 118) TEFPCBMIX 12/09/2004 One of 2 dioxin-like compounds plus mixtures being tested to determine if the TEFs for these ...
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Toxicology and Carcinogenesis Studies of a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) and 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies) Chemical (Study Title) CASRN Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory TEF evaluation (Binary mixture; PCB 126/PCB 153) TEFBINARYMIX 12/09/2004 Used in the electric industry as dielectric insulating fluids for transformers and ...
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Toxicology and Carcinogenesis Studies of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies) Chemical (Study Title) CASRN Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory Toxic equivalency factor evaluation (PCB 153- 2,2'-4,4',5,5'-hexachlorobiphenyl) 35065-27-1 12/09/2004 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) was produced as a component of some commercial PCB mixtures before 1977 for the electric industry ...
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Target Organs and Levels of Evidence for TR-559 Toxicology and Carcinogenesis Studies of TEF evaluation (PCB 118) (CASRN 31508-00-6) in Harlan Sprague-Dawley Rats (Gavage Studies) Chemical (Study Title) CASRN Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory TEF evaluation (PCB 118) 31508-00-6 02/25/2009 Polychlorinated biphenyls (PCBs) and their mixtures including 2,3',4,4',5-pentachlorobiphenyl (PCB 118) were produced commercially before 1977 for the electric industry as ...
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Nomination Summary for Dioxin toxic equivalence factor studies (N95036) Dioxin toxic equivalence factor studies Specific Substances: 2,2'-4,4',5,5'-Hexachlorobiphenyl (PCB 153), 2,3',4,4',5-Pentachlorobiphenyl, 3,3,4,4,5-Pentachlorobiphenyl (PCB 126), 1,2,3,7,8-Pentachlorodibenzo-p-dioxin, 2,3,4,7,8-Pentachlorodibenzofuran, TEF evaluation (Binary mixture; PCB 126/PCB 153), 2,3,7,8-Tetrachlorodibenzo-p-dioxin, TEF evaluation (Dioxin mixture) Nomination Date: 03/27/1995 Nominator: NIEHS, EPA ...
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... Toxicol Sci. 110, 251-4.[Abstract ] Small is Different: A Science Perspective on the Regulatory Challenges of Nanoscale Report of the Expert Panel on Nanotechnology (2008)[The Council of Canadian Academies ] Jeong, Y.C., Walker, N.J., Burgin, D.E., Kissling, G., Gupta, M., Kupper, L., Birnbaum, L.S., and Swenberg, J.A. (2008) Accumulation of M(1)dG DNA adducts after chronic exposure to PCBs, but not from acute exposure to polychlorinated aromatic hydrocarbons. Free Radic Biol Med. 45, ...
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(PCB 126) ...... 4 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF)...... 4 Dioxin Mixture (TCDD, PeCDF, PCB ... Factor (TEF) evaluation of mixtures of dioxin-like compounds (dioxins, polychlorinated biphenyls [PCB's] and furans). Dr. ... as possible as he envisaged that these reports on TCDD and PCB's would be used in the future as the benchmark description of ...
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Meeting- December 9, 2004...... 2 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) and 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) .. 2 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153)...... 3 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) and 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153)...... 4 Anthraquinone ...
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Toxicology and Carcinogenesis Studies of 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) in Female Harlan Sprague-Dawley Rats (Gavage Studies) Chemical (Study Title) CASRN Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) 57465-28-8 02/17/2004 Dielectric medium in transformers Gavage FEMALE RATS ONLY: PCB-126 -- 0, 10, 30, 100, 175, 300, 550, OR 1000 NG/KG; 100/DOSE Battelle Columbus ...
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status, BMI, and other pollutants (p,p'-DDE, HCB, PCBs, mirex, mercury) Binary Logistic Regression predicting ... Blood Pb ≥1.2 µg/dL 12.7 years (12.2-13.1) Increasing PCB levels were associated with a greater likelihood of having ... Wilrijk=50%; Hoboken=33% development stage), heavy metal, PCB, and other levels in urine or blood, cystatin C and other ... pubic- hair stage), height, weight, phytoestrogen, BPA, DDE, PCB exposure Modified Poisson regression models Adjustments ...
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... QUICKI 1/[log(FG)+log (fasting insulin)]) PCDDs, PCDFs, PCBs (serum, pg-TEQ/g- lipid) adjusted Pearson correlations (r) ... r=-0.21, ns 1,2,3,6,7,8-HxCDF; r=-0.17, ns PCBs 1,2,3,4,6,7,8-HpCDD; r=-0.38, p=0.07 2,3,4,6,7,8-HxCDF; ... TEQ: r=-0.18, ns 2,3,3',4,4'-PeCB 105; r=-0.42, p=0.06 PCBs TEQ: r=-0.42, p=0.02 Total TEQ; r=-0.32, p=0.06 ... diabetes (FG value >125 mg/mL, use of diabetes medication) PCB, PCB153, PCB74, DDE, mirex, HCB (serum, lipid adjusted ng/g ...
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is based on their structural similarity to PCBs, potential toxicity, and pervasiveness in the environment and human tissues. ... and clean-up methods used to identify and quantify PBDEs in various media are similar to methods used for PCBs and PBBs. ... species of the U.S. and Europe, the concentration of total PBDEs equals or has surpassed the concentrations of total PCBs. ... The rate of bioaccumulation of PBDEs in mussels is faster than that of several PCBs. The concentration of PBDEs in biological ...
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Link to Data Search (Data is not available for all studies.) Chemical Properties Toxicity Effects (HSDB) Overviews of NTP Protocols http://ntp.niehs.nih.gov/go/ts-10444-d Biphenyl - 10444-D CASRN: 92-52-4 Formula: C12-H10 Synonyms/Common Names: 1,1'-BIPHENYL (9CI) Known Uses: Intermediate For PCB's, fungistat in packaging citrus fruit, dye asst. For polyesters occurs in coal tar. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or ...
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... NTP (U.S.) National Toxicology Program OECD Organisation for Economic Co-operation and Development PCB Polychlorinated ... 2000) recently showed that polychlorinated biphenyls (PCBs) have more affinity for the binding domain of rainbow trout ... 13 Phthalimide 1 Piperidine 1 Polychlorinated biphenyl (PCB) 93 Polycyclic aromatic hydrocarbon 42 Polyether 1 Pteridine ... Estriol 50-27-1 14* Steroid, phenolic 12 12 2',4',6',-Trichloro-4- biphenylol 14962-28-8 3.6** PCB 4 4 Tamoxifen 10540-29-1 ...
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... phthalate ester; Di-n - butyl phthalate; Dibutyl 1,2- benzenedicarboxylate 84-74-2 Phthalate Plasticizer 2,4'-Dichlorobiphenyl PCB 8 34883-43-7 Polychlorinated biphenyl Dielectric fluid 2,5-Dichlorobiphenyl PCB 9 34883-39-1 Polychlorinated biphenyl Dielectric fluid 3,4-Dichlorobiphenyl PCB 12 2974-92-7 Polychlorinated biphenyl Dielectric fluid 3,5-Dichlorobiphenyl PCB 14 34883-41-5 Polychlorinated biphenyl Dielectric fluid 4,4'-Dichlorobiphenyl PCB 15 2050-68-2 Polychlorinated biphenyl ...
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Bioassay of Aroclor® for Possible Carcinogenicity (CASRN 27323-18-8) Chemical (Study Title) CASRN Peer Review Date Primary Uses Route/Exposure Levels Study Laboratory Aroclor 1254 11097-69-1 11/28/1977 Aroclor® is the registered trademark of the Monsanto Chemical Company for their polychlorinated biphenyls (PCBs). PCBs were developed in 1929 primarily for use as heat transfer fluids and dielectrics (insulators). [Pesticide] Dosed-Feed 0,25,50,100 PPM/24 PER GROUP SRI International Levels of ...
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Toxicology and Carcinogenesis Studies of a Mixture of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) (CASRN 1746-01-6), 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117-31-4), and 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) in ... Used as dielectric insulating fluids in transformers & capacitors and used in hydraulic fluids, plastics, & paints. Gavage FEMALE RATS ONLY: 0, (TCDD) 3.3, 7.3, 15.2, OR 33 NG/KG; (PeCDF) 6.6, 14.5, 30.4, OR 66 NG/KG; (PCB 126) 33.3, 73.3, 153, OR ...
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... and carcinogenicity of DLCs and structurally related poly- chlorinated biphenyls (PCBs) and mixtures of these compounds. ... nated dibenzofurans (PCDFs), and PCBs. The dioxin TEF evaluation includes conducting multiple 2-year rat bioassays to evaluate the relative chronic toxicity and carcinogenicity of DLCs, structurally related PCBs, and mixtures of these compounds. ... the NTP study series on the toxic equivalency factor (TEF) evaluations of dioxin-like compounds (dioxins, PCBs, furans). Dr. ...
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... biphenyls (DL-PCBs), which were used extensively in industrial applications. These AhR ligands are frequently analyzed according to toxic equivalents (TEQs), which multiplies the mass of dioxins, DL-PCBs, and furans by a potency factor that ranks their toxicity relative to TCDD. 35 All PCBs that do not bind AhR are called non-dioxin like (NDL). Most of the prospective studies of developmental exposures to dioxins and PCBs had no association with child, adolescent, or adult obesity (Table 1). ...
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Link to the full study report (1 Mb) in PDF. If you have difficulty accessing the document, please send email to the NTP Webmaster [ Send Email ] and identify documents/pages for which access is required. Chemical Formula: C12H9Cl Aroclor® is the registered trademark of the Monsanto Chemical Company for their polychlorinated biphenyls (PCBs). PCBs were developed in 1929 primarily for use as heat transfer fluids and dielectrics (insulators). Aroclor® 1254, a biphenyl containing approximately ...
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... and carcinogenicity of DLCs and structurally related poly- chlorinated biphenyls (PCBs) and mixtures of these compounds. ... nated dibenzofurans (PCDFs), and PCBs. The dioxin TEF evaluation includes conducting multiple 2-year rat bioassays to evaluate the relative chronic toxicity and carcinogenicity of DLCs, structurally related PCBs, and mixtures of these compounds. ... (PCDFs), polychlorinated biphenyls (PCBs), polychlorinated naphthalenes (PCNs), and polybrominated diphenyl ethers (PBDEs). ...
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Link to Data Search (Data is not available for all studies.) Chemical Properties Toxicity Effects (HSDB) Overviews of NTP Protocols http://ntp.niehs.nih.gov/go/ts-10145-r Octachlorodibenzodioxin (OCDD) - 10145-R CASRN: 3268-87-9 Formula: C12-Cl8-O2 Synonyms/Common Names: DIBENZO(B,E)(1,4)DIOXIN, OCTACHLORO- (9CI) Known Uses: Contaminant of herbicides, PCB's. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or ...
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... Pesticide DDT (technical) 8017-34-3 Organochlorine Pesticide Decachlorobiphenyl PCB 209 2051-24-3 Polychlorinated biphenyl Dielectric fluid 2-sec -Decylphenol ... 1194-65-6 Organochlorine; Nitrile Pesticide 2,5-Dichlorobiphenyl PCB 9 34883-39-1 Polychlorinated biphenyl Dielectric fluid 2,6-Dichlorobiphenyl PCB 10 33146-45-1 Polychlorinated biphenyl Dielectric fluid 3,5-Dichlorobiphenyl PCB 14 34883-41-5 Polychlorinated biphenyl Dielectric fluid 2,5-Dichloro-2',3'-bipheny...
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... Economic Co-operation and Development OPNG o-Nitrophenylgalactoside PCB Polychlorinated biphenyls x ER TA BRD: List of Acronyms and ... A., Balaguer, P. (1997) Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: Structure-activity relationships. ... of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB 155). ...
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Biochemistry: Triglycerides, cholesterol, glucose, Cl, Na, K, PSA, etc. Exposures: Heavy metals, dioxins, PCBs, phenols, phthalates; Infectious Diseases Allergens ... "Novel" Findings: heptachlor γ-tocopherol Known Associations: β-carotene vitamin D PCBs Interesting Patterns: dioxins, pesticides, PCBs EWAS on T2DM ORs adjusted: BMI, SES, ethnicity, age, sex Δ 1SD or vs. negative test Heptachlor Epoxide OR=3.2, 1.8 PCB170 OR=4.5,2.3 γ-tocopherol OR=1.8,1.6 β-carotene OR=0.6,0.6 1999-2000 ...
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... T., Gillesby, B., Joyeux, A., Balaguer, P. (1997) Hydroxylated polychlorinated biphenyls (PCBs) as estrogens and antiestrogens: Structure-activity relationships. ... Sci 59:231-240. Fielden, M.R., Chen, I., Chittim, B., Safe, S.H., Zacharewski, T.R. (1997) Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2'6'-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB 155). ...
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Nomination Summary for Polybrominated diphenyl ethers (N20207) Polybrominated diphenyl ethers Specific Substances: No Specific Substances or Agents are Selected for this Nomination Nomination Date: 11/15/2001 Nominator: Learning Disabilities Association of America Rationale: Proper thyroid function is essential for embryonic and fetal development. Additional research on polybrominated diphenyl ethers, which may disrupt development similar to PCBs, may help reduce the incidence of developmental ...
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......... 3 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) ......The motion was approved unanimously with 8 yes votes, 0 no votes, and 0 abstentions. 2,3',4,4',5-Pentachlorobiphenyl (PCB 118) Dr. Nigel Walker, NIEHS, introduced the technical report on PCB 118 by giving an ... selection for the long-term study on PCB 118, and the body weight, tissue disposition, and histopathologic findings in the study. ...
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