Skip to Main Navigation Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

We welcome your feedback!

Contact us with your comments.

QUICK TIPS
 
of 2

Refine

  • Categories
  • Content Type
  • Reports and Publications
  • Years
  • Formats

Search suggestions for "1,4-dioxane".

  1. Report on Carcinogens 1,4-Dioxane https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/dioxane.pdf
  2. CEBS Data Related to 1,4-Dioxane (123-91-1) https://cebs.niehs.nih.gov/cebs/test_article/123-91-1


54 results found for "1,4-dioxane".

  1. TR-080: 1,4-Dioxane (CASRN 123-91-1) 3.3MB

    https://ntp.niehs.nih.gov/go/tr080

    0 BIOASSAY OF 1,4-DIOXANE FOR POSSIBLE CARCINOGENICITY CAS No. 123-91-1 NCI-CG-TR-80 U.S. ... Institutes of Health BIOASSAY OF 1,4-DIOXANE FOR POSSI-BLE CARCINOGEN ICITY ...

  2. RoC Profile: 1,4-Dioxane; 15th RoC 2021 154KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/dioxane.pdf

    ...4-Dioxane CAS No. 123-91-1 Reasonably anticipated to be a human carcinogen First listed in the Second Annual Report on Carcinogens (1981) O O Carcinogenicity 1,4-Dioxane is ...

  3. 1,4-Dioxane: Target Organs and Levels of Evidence for TR-080 50KB

    https://ntp.niehs.nih.gov/data/tr/000s/tr080levels

    0 1,4-Dioxane: Target Organs and Levels of Evidence for TR-080 Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CASRN 123-91-1) Chemical (Study Title) CASRN Peer Review Date ...

  4. Abstract for TR-80 54KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr080

    Bioassay of 1,4-Dioxane for Possible Carcinogenicity CASRN: 123-91-1 Chemical Formula: C4H8O2 Molecular Weight: 88.1052 Report Date: 1978 Full Report PDF Abstract 1,4-Dioxane, a ...

  5. Abstract for TR-125 53KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr125

    S,S-bis(O,O-diethyl phosphorodithioate; phosphorodithioic acid, S,S'-1,4-dioxane-2,3-diyl O,O,O',O'-tetraethyl ester Report Date: 1978 Full Report PDF Abstract ...

  6. Abstract for T0151 55KB

    https://ntp.niehs.nih.gov/publications/abstracts/dev/t0151

    Two control groups, one receiving deionized/filtered water and the other receiving a vehicle control solution containing 0.05% Tween 80® and 0.9 ppm 1,4-dioxane, a stabilizing ...

  7. 15th Report on Carcinogens 91KB

    https://ntp.niehs.nih.gov/research/assessments/cancer/roc

    ... Dimethylcarbamoyl Chloride 1,1-Dimethylhydrazine Dimethyl Sulfate Dimethylvinyl Chloride 1,4-Dioxane Disperse Blue E Epichlorohydrin Erionite Estrogens, Steroidal Ethylene Oxide ...

  8. Listed Substances; 15th RoC 2021 76KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/listed_substances_508.pdf

    ... National Toxicology Program, Department of Health and Human Services 4 1,4-Dioxane Disperse Blue 1 Dyes Metabolized to 3,3'-Dimethoxybenzidine (3,3'-Dimethoxybenzidine Dye Class) ...

  9. Combining NAM Data and IVIVE for Evaluating Potential Inhalation... 595KB

    https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-chang-poster.pdf

    ... Carbon tetrachloride 34 LDH leakage 14.4 3.4 Hepatic Benzene 5 Regulation of miRNA expression 1.1 0.4 Immuno. 1,4-Dioxane 300 Genotoxicity 4.5 3.1 Ocular 1,2-Dichloroethane 100 ...

  10. Appendix G; 15th RoC 2021 69KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendix_g.pdf

    ... National Toxicology Program, Department of Health and Human Services 2 123-91-1 see 1,4-Dioxane 126-72-7 see Tris(2,3-dibromopropyl) Phosphate 126-99-8 see Chloroprene 127-18-4 see ...

  11. TR-475: Tetrahydrofuran (CASRN 109-99-9) in F344/N Rats and B6C3F1Mice... 9.6MB

    https://ntp.niehs.nih.gov/go/tr475

    ... gland (NTP, 1993). 1,4-Dioxane, another cyclic ether solvent, is carcinogenic in rats and guinea pigs by the oral route of exposure. 1,4-Dioxane produced malignant tumors in ...

  12. Application of In Vitro to In Vivo Extrapolation (IVIVE) to Inform... 2.9MB

    https://ntp.niehs.nih.gov/iccvam/meetings/sot22/poster/mumtaz-sot2022.pdf

    ... 21.1 di-n-butyl phthalate 0.5 50 1.1 - 148.2 hexachlorobenzene 0.008 2.4 141.1 ethylene glycol 0.8 80 9.2 1,4-dioxane 5 500 12.6 Neurotoxicity Hepatotoxicity Developmental Toxicity

  13. Using In Vitro Data and PBPK Models to Predict Inhalation Toxicity... 2.5MB

    https://ntp.niehs.nih.gov/sites/default/files/2023-09/Chang-WC12-poster-FD-V2.pdf

    ... Carbon tetrachloride 34 LDH leakage 14.4 3.4 Hepatic Low Benzene 5 Regulation of miRNA expression 1.1 0.4 Immuno. High 1,4-Dioxane 300 Genotoxicity 4.5 3.1 Ocular Low ...

  14. TR-005: Proflavine (CASRN 952-23-8) 3.1MB

    https://ntp.niehs.nih.gov/go/tr005

    ... Infrared, ultraviolet, visible, and nuclear magnetic resonance spectra also conformed to expectations for this structure. Thin-layer chromatography in a 1,4-dioxane : ammonium ...

  15. TR-109: 4-Nitroanthranilic Acid (CASRN 619-17-0) 4.3MB

    https://ntp.niehs.nih.gov/go/tr109

    ... Analysis by thin-layer chromatography utilized two solvent systems (chloroform: 1,4-dioxane:acetic acid and butanol:diethylamine.-water). Each plate was visualized by ultraviolet ...

  16. TR-125: Dioxathion (CASRN 78-34-2) 1.9MB

    https://ntp.niehs.nih.gov/go/tr125

    ... It is also called 2,3-p-dioxanedithiol S,S-bis(0,0-diethyl phosphorodithioate); phos- phorodithioic acid, S,S'-l,4-dioxane-2,3-diyl 0,0,0',0'-tetraethyl ester; and ...

  17. TR-116: p-Anisidine Hydrochloride (CASRN 20265-97-8) 3.4MB

    https://ntp.niehs.nih.gov/go/tr116

    ... Thin-layer chromatography was performed utilizing two solvent systems (benzene: 1,4-dioxane; and ethyl acetate:ammonium hydroxide). Each plate indicated one nonmotile impurity. ...

  18. TR-113: 2-Chloro-p-phenylenediamine Sulfate (CASRN 61702-44-1... 3.0MB

    https://ntp.niehs.nih.gov/go/tr113

    ... Thin-layer chromatography utilizing two solvent sys- tems (ethyl acetate: ammonium hydroxide and benzene:1,4-dioxane: ammonium hydroxide), each visualized with ultraviolet light ...

  19. TR-179: p-Quinone Dioxime (CASRN 105-11-3) 3.4MB

    https://ntp.niehs.nih.gov/go/tr179

    ... Thin-layer chromatography was performed utilizing two solvent systems (i.e., ethyl acetate: methanol and 1,4-dioxane:benzene). Visualization with ultraviolet light and iodine vapor ...

  20. TR-122: Dibenzo-p-dioxin (CASRN 262-12-4) 3.0MB

    https://ntp.niehs.nih.gov/go/tr122

    ... administered the following test compounds: Drinking Water Studies (CAS 12.3-91-1) 1,4-dioxane Feed Studies (CAS 3268-87-9) 1,2,3,4,6,7,8,9-octachlorodibenzo-p-dioxin (CAS ...

  21. TR-123: 2,7-Dichlorodibenzo-p-dioxin (DCDD) (CASRN 33857-26-0... 3.1MB

    https://ntp.niehs.nih.gov/go/tr123

    ... administered the following test compounds: Drinking Water Studies (CAS 123-91-1) 1,4-dioxane Feed Studies (CAS 3268-87-9) 1,2,3,4,6,7,8,9-octachlorodibenzodioxin (CAS 262-12-4) ...

  22. TR-354: Dimethoxane (CASRN 828-00-2) (Commercial Grade) in F344... 11.7MB

    https://ntp.niehs.nih.gov/go/tr354

    ... Metabolism No information was found on the metabolism of dimethoxane. In rats, 1,4-dioxane ... J . ; Horvath, B.S.; Daniel, R.L. (1976) 1,4-Dioxane and beta-hydroxyethoxyacetic acid ...

  23. TR-374: Glycidol (CASRN 556-52-5) In F344/N Rats and B6C3F1Mice... 11.9MB

    https://ntp.niehs.nih.gov/go/tr374

    ... ether, and 1.1% 2,6-dimeth- anol-1,4-dioxane) in water by gavage to groups of F344/N ... (a-chlorohydrin), 0.4%; diglycidyl ether, 2.8%; and 2,6-dimetha- nol-1,4-dioxane, 1.1%. ...

  24. RoC Background Document: Ethylene Oxide; Dec. 2-3, 1998 4.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/ethyloxide_oneapp_508.pdf

    ... in light of recent toxicity data and information concerning the formation of 1,4- dioxane. ... in light of recent toxicity data and information concerning the formation of 1,4- dioxane. ...

  25. CERHR Monograph: Potential Human Reproductive and Developmental... 4.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/egpg/ethylene/eg_monograph.pdf

    ... Possible trace impurities of ethylene glycol in- clude formaldehyde, ethylene oxide, and 1,4-dioxane (3). Appendix II II-1 Appendix II I 5 a o i Some trade names for ethylene ...

  26. TOX-105: Usnea Lichens Containing (+/-)-Usnic Acid (CASRN 125... 4.2MB

    https://ntp.niehs.nih.gov/go/tox105

    ... reported that a 1,4-dioxane extract of U. barbata collected in northern Russia inhibited the growth of both Gram-positive B. subtilis and Gram- negative Pseudomonas fluorecens. ...

  27. TR-201: Carcinogenesis 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN... 5.2MB

    https://ntp.niehs.nih.gov/go/tr201

    ... J. , McCollister, S. B. , Park, C. Torkelson, T. R. , and Gehring, P - J . , 1,4-Dioxane. ... ApjxL. NCI, National Cancer Institute, Bioassay of_ 1,4-Dioxane for Possible Carcin- ...

  28. NTP Technical Reports Index 1.5MB

    https://ntp.niehs.nih.gov/data/tr

    ... P Clear Evidence N No Evidence N No Evidence P Clear Evidence TR-080 03/07/78 1,4-Dioxane 123-91-1 P Clear Evidence P Clear Evidence P Clear Evidence P Clear Evidence TR-078 ...

  29. TR-259: Ethyl Acrylate (CASRN 140-88-5) in F344/N Rats and B6C3F1Mice... 12.2MB

    https://ntp.niehs.nih.gov/go/tr259

    ... An aqueous solution (50 ~L) containing 1 mg of 1,4-dioxane, the internal standard, per mL ... Acrylate: 3.27 min Internal Standard: 1,4-Dioxane Retention Time of the Internal Standard: ...

  30. Appendices A-G; 15th RoC 2021 433KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendices_508.pdf

    ... National Toxicology Program, Department of Health and Human Services 2 123-91-1 see 1,4-Dioxane 126-72-7 see Tris(2,3-dibromopropyl) Phosphate 126-99-8 see Chloroprene 127-18-4 see ...

  31. Study Reports 1.0MB

    https://ntp.niehs.nih.gov/publications/reports

    ... TR-080 PDF (3.31 MB) Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CASRN 123-91-1) 1978 Technical Report TR-079 No report issued Dulcin (CAS: 150-69-6) - No report issued. ...

  32. Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf

    ... II chloride 36.4 14.2 2251.0 332 1,4-Dioxane 38.1 47.7 4203.3 333 Lithium I chloride ... furano dione 17 27.1 4014.1 332 1,4-Dioxane 38.1 47.7 4203.3 124 Acetazolamide 8.49 ...

  33. TR-209: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6... 8.5MB

    https://ntp.niehs.nih.gov/go/tr209

    ... R. J., McCollister, S. B., Park, C., Torkelson, T. R., and Gehring, P. J., 1,4-Dioxane. ... Pharmacol. 50:241-252, 1979. NCI, National Cancer Institute, Bioassay of_ 1,4-Dioxane for ...

  34. Technical Reports 856KB

    https://ntp.niehs.nih.gov/publications/reports/tr

    ... TR-080 PDF (3.31 MB) Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CASRN 123-91-1) 1978 Technical Report TR-079 No report issued Dulcin (CAS: 150-69-6) - No report issued. ...

  35. Toxicology/Carcinogenicity 1.1MB

    https://ntp.niehs.nih.gov/research/apptoxres/cartox

    ... (3.31 MB) Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CASRN 123-91-1) 1978 Long-Term Carcinogenicity TR-079 Not yet available Dulcin (CAS: 150-69-6) - No report issued. ...

  36. XDS Submission of the LUMI-CELL ER Test Method 3.2MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/iccvamsubmission28jan05.pdf

    ... - 3.29E-09 > 95% Sigma Powder 1,4 Dioxane 123-91-1 environmental contaminant ... X X Non-Active ND Non-Active N/A N/A 1,4 Dioxane 123-91-1 X X X X X Non-Active ND ...

  37. Submission of XDS's LUMI-CELL ER High-Throughput System for Screening... 2.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexa/xds-sub.pdf

    ... - 3.29E-09 > 95% Sigma Powder 1,4 Dioxane 123-91-1 environmental contaminant ... X X Non-Active ND Non-Active N/A N/A 1,4 Dioxane 123-91-1 X X X X X Non-Active ND ...

  38. TR-205: 4,4'-Oxydianiline for Possible Carcinogenicity (CASRN... 4.4MB

    https://ntp.niehs.nih.gov/go/tr205

    ... THIN-LAYER CHROMATOGRAPHY Plates: Silica gel 60 F-254 Amount spotted: 100 and 30/^1, 10 JLfg/ pi in 1,4-dioxane System 1: Acetonitrile, dioxane (50:50) Rf: 0.79, major 0.91 R st. ...

  39. TR-278: 2,6-Xylidine (2,6-Dimethylaniline) (CASRN 87-62-7) in... 9.4MB

    https://ntp.niehs.nih.gov/go/tr278

    ... in drink- ing water (Hoch-Ligeti et al., 1970) or by gavage (NCI, 1978) and by administering phenacetin (Isaka et al,, 1979) and quinoxaline 1,4-dioxane (Tucker, 1975) in the diet. ...

  40. RoC Background Document for Naphthalene; Sept. 19, 2002 4.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc11/naphthalenepub_508.pdf

    ... + M F Skin paint Adenoma Adenoma Dimethylvinyl chloride 316 + + M F Gavage (c) (c) 1,4-Dioxane 080 + + M F Water (c) (c) 1,2-Epoxybutane 329 + E M F Inhalation Adenoma Adenoma ...

  41. DART-03: Prenatal Development Studies of Vinpocetine (CASRN 42971... 1.2MB

    https://ntp.niehs.nih.gov/go/dart03

    ... authentic standards of non-halogenated (hexane, benzene, diethyl ether, acetone, 1,4-dioxane, and toluene), and halogenated (chloroform, carbon tetrachloride, trichloroethylene, ...

  42. TR-381: d-Carvone (CASRN 2244-16-8) in B6C3F1Mice (Gavage Studies... 6.3MB

    https://ntp.niehs.nih.gov/go/tr381

    ... Thin-layer chromatography was performed on silica gel plates with n-hexane:1,4-dioxane (9:1), saturated, under nitrogen, and in the dark (solvent system 1) or ethyl acetate:hexanes ...

  43. Report: International Workshop on In Vitro Methods for Assessing... 25.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf

    ... 14.2 3107.0 19.6 158.52 14.2 332 1,4- Dioxane 123-91-1 3357.37 38.1 4203.3 47.7 ... 27.1 1999.6 13.5 148.12 27.1 332 1,4- Dioxane 123-91-1 3357.37 38.1 4203.3 47.7 ...

  44. TR-234: Allyl Isothiocyanate (CASRN 57-06-7) in F344/N Rats and... 11.0MB

    https://ntp.niehs.nih.gov/go/tr234

    ... I00 and 300 f..lg System I: 95% Ethanol Rr: 0.86 Rst: 1.13 System 2: Chloroform: I ,4-Dioxane (95:5) Rr: 0.55 Rst: 0.61 N s 14.13 32.34 14.10 32.13 14.18 32.27 Literature Values ...

  45. TR-287: Dimethyl Hydrogen Phosphite (CASRN 868-85-9) in F344... 9.9MB

    https://ntp.niehs.nih.gov/go/tr287

    ... Results: Spot intensity Rf Rst System 1 : Methano1:water (9O:lO) Major 0.84 1.10 System 2: 1,4-Dioxane (100%) Major 0.74 0.82 2. Gas Chromatography Instrument: Varian 3700 ...

  46. TR-250: Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1Mice... 8.5MB

    https://ntp.niehs.nih.gov/go/tr250

    ... Visualization: Ultraviolet, 254 and 366 nm, and iodine vapor Amount Spotted: 10 and 30 J.il, 1% solution in methanol System I: Benzene: I ,4-Dioxane (85: 15) System 2: Methylene ...

  47. TR-309: Decabromodiphenyl Oxide (CASRN 1163-19-5) In F344/N Rats... 17.4MB

    https://ntp.niehs.nih.gov/go/tr309

    ... Results: See Figure 6 No literature reference found. Consistent with structure. b. Ultraviolet/visible Instrument: Cary 118 Solvent: 1,4-dioxane Results: No maximum from 800 to No ...

  48. TR-315: Oxytetracycline Hydrochloride (CASRN 2058-46-0) in F344... 10.3MB

    https://ntp.niehs.nih.gov/go/tr315

    ... Amine group: Titration of one basic proton with 0.1 N perchloric: acid in glacial acetic acid. The compound was dissolved in anhydrous formic acid: glacial acetic acid:l,4-dioxane ...

  49. Public Health Impact 1.4MB

    https://ntp.niehs.nih.gov/media/impact

    ... Type: Final Rule September 13, 1989 54 FR 37799 96-29-7 1989 EPA Reportable Quantity Adjustments: 1,4-dioxane, 2-ethoxyethanol, ethylene oxide, 2-nitropropane, perchloroethylene, ...

  50. TR-426: Corn Oil, Safflower Oil, and Tricaprylin (CASRNs. 8001... 18.8MB

    https://ntp.niehs.nih.gov/go/tr426

    ... TLC was performed on silica gel plates with two solvent systems: A) cyclohexane:1,4-dioxane (9O:lO for lot A15 and 9 5 5 for lots A l l and 8312-806876), and B) carbon ...

 
of 2