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Search suggestions for "1,4-dioxane".

  1. Report on Carcinogens 1,4-Dioxane https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/dioxane.pdf
  2. CEBS Data Related to 1,4-Dioxane (123-91-1) https://cebs.niehs.nih.gov/cebs/test_article/123-91-1


53 results found for "1,4-dioxane".

  1. TR-080: 1,4-Dioxane (CASRN 123-91-1) 3.3MB

    https://ntp.niehs.nih.gov/go/tr080

    0 BIOASSAY OF 1,4-DIOXANE FOR POSSIBLE CARCINOGENICITY CAS No. 123-91-1 NCI-CG-TR-80 U.S. ... Institutes of Health BIOASSAY OF 1,4-DIOXANE FOR POSSI-BLE CARCINOGEN ICITY ...

  2. RoC Profile: 1,4-Dioxane; 15th RoC 2021 154KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/dioxane.pdf

    ...4-Dioxane CAS No. 123-91-1 Reasonably anticipated to be a human carcinogen First listed in the Second Annual Report on Carcinogens (1981) O O Carcinogenicity 1,4-Dioxane is ...

  3. 1,4-Dioxane: Target Organs and Levels of Evidence for TR-080 58KB

    https://ntp.niehs.nih.gov/data/tr/000s/tr080levels

    0 1,4-Dioxane: Target Organs and Levels of Evidence for TR-080 Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CASRN 123-91-1) Chemical (Study Title) CASRN Peer Review Date ...

  4. Abstract for TR-80 62KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr080

    Bioassay of 1,4-Dioxane for Possible Carcinogenicity CASRN: 123-91-1 Chemical Formula: C4H8O2 Molecular Weight: 88.1052 Report Date: 1978 Full Report PDF Abstract 1,4-Dioxane, a ...

  5. Abstract for TR-125 61KB

    https://ntp.niehs.nih.gov/publications/reports/tr/tr125

    S,S-bis(O,O-diethyl phosphorodithioate; phosphorodithioic acid, S,S'-1,4-dioxane-2,3-diyl O,O,O',O'-tetraethyl ester Report Date: 1978 Full Report PDF Abstract ...

  6. Abstract for T0151 64KB

    https://ntp.niehs.nih.gov/publications/abstracts/dev/t0151

    Two control groups, one receiving deionized/filtered water and the other receiving a vehicle control solution containing 0.05% Tween 80® and 0.9 ppm 1,4-dioxane, a stabilizing ...

  7. 15th Report on Carcinogens 99KB

    https://ntp.niehs.nih.gov/research/assessments/cancer/roc

    ... Dimethylcarbamoyl Chloride 1,1-Dimethylhydrazine Dimethyl Sulfate Dimethylvinyl Chloride 1,4-Dioxane Disperse Blue E Epichlorohydrin Erionite Estrogens, Steroidal Ethylene Oxide ...

  8. Listed Substances; 15th RoC 2021 76KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/listed_substances_508.pdf

    ... National Toxicology Program, Department of Health and Human Services 4 1,4-Dioxane Disperse Blue 1 Dyes Metabolized to 3,3'-Dimethoxybenzidine (3,3'-Dimethoxybenzidine Dye Class) ...

  9. Combining NAM Data and IVIVE for Evaluating Potential Inhalation... 595KB

    https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-chang-poster.pdf

    ... Carbon tetrachloride 34 LDH leakage 14.4 3.4 Hepatic Benzene 5 Regulation of miRNA expression 1.1 0.4 Immuno. 1,4-Dioxane 300 Genotoxicity 4.5 3.1 Ocular 1,2-Dichloroethane 100 ...

  10. Appendix G; 15th RoC 2021 69KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendix_g.pdf

    ... National Toxicology Program, Department of Health and Human Services 2 123-91-1 see 1,4-Dioxane 126-72-7 see Tris(2,3-dibromopropyl) Phosphate 126-99-8 see Chloroprene 127-18-4 see ...

  11. TR-475: Tetrahydrofuran (CASRN 109-99-9) in F344/N Rats and B6C3F1Mice... 9.6MB

    https://ntp.niehs.nih.gov/go/tr475

    ... gland (NTP, 1993). 1,4-Dioxane, another cyclic ether solvent, is carcinogenic in rats and guinea pigs by the oral route of exposure. 1,4-Dioxane produced malignant tumors in ...

  12. Application of In Vitro to In Vivo Extrapolation (IVIVE) to Inform... 2.9MB

    https://ntp.niehs.nih.gov/iccvam/meetings/sot22/poster/mumtaz-sot2022.pdf

    ... 21.1 di-n-butyl phthalate 0.5 50 1.1 - 148.2 hexachlorobenzene 0.008 2.4 141.1 ethylene glycol 0.8 80 9.2 1,4-dioxane 5 500 12.6 Neurotoxicity Hepatotoxicity Developmental Toxicity

  13. TR-005: Proflavine (CASRN 952-23-8) 3.1MB

    https://ntp.niehs.nih.gov/go/tr005

    ... Infrared, ultraviolet, visible, and nuclear magnetic resonance spectra also conformed to expectations for this structure. Thin-layer chromatography in a 1,4-dioxane : ammonium ...

  14. TR-109: 4-Nitroanthranilic Acid (CASRN 619-17-0) 4.3MB

    https://ntp.niehs.nih.gov/go/tr109

    ... Analysis by thin-layer chromatography utilized two solvent systems (chloroform: 1,4-dioxane:acetic acid and butanol:diethylamine.-water). Each plate was visualized by ultraviolet ...

  15. TR-125: Dioxathion (CASRN 78-34-2) 1.9MB

    https://ntp.niehs.nih.gov/go/tr125

    ... It is also called 2,3-p-dioxanedithiol S,S-bis(0,0-diethyl phosphorodithioate); phos- phorodithioic acid, S,S'-l,4-dioxane-2,3-diyl 0,0,0',0'-tetraethyl ester; and ...

  16. TR-116: p-Anisidine Hydrochloride (CASRN 20265-97-8) 3.4MB

    https://ntp.niehs.nih.gov/go/tr116

    ... Thin-layer chromatography was performed utilizing two solvent systems (benzene: 1,4-dioxane; and ethyl acetate:ammonium hydroxide). Each plate indicated one nonmotile impurity. ...

  17. TR-113: 2-Chloro-p-phenylenediamine Sulfate (CASRN 61702-44-1... 3.0MB

    https://ntp.niehs.nih.gov/go/tr113

    ... Thin-layer chromatography utilizing two solvent sys- tems (ethyl acetate: ammonium hydroxide and benzene:1,4-dioxane: ammonium hydroxide), each visualized with ultraviolet light ...

  18. TR-179: p-Quinone Dioxime (CASRN 105-11-3) 3.4MB

    https://ntp.niehs.nih.gov/go/tr179

    ... Thin-layer chromatography was performed utilizing two solvent systems (i.e., ethyl acetate: methanol and 1,4-dioxane:benzene). Visualization with ultraviolet light and iodine vapor ...

  19. TR-122: Dibenzo-p-dioxin (CASRN 262-12-4) 3.0MB

    https://ntp.niehs.nih.gov/go/tr122

    ... administered the following test compounds: Drinking Water Studies (CAS 12.3-91-1) 1,4-dioxane Feed Studies (CAS 3268-87-9) 1,2,3,4,6,7,8,9-octachlorodibenzo-p-dioxin (CAS ...

  20. TR-123: 2,7-Dichlorodibenzo-p-dioxin (DCDD) (CASRN 33857-26-0... 3.1MB

    https://ntp.niehs.nih.gov/go/tr123

    ... administered the following test compounds: Drinking Water Studies (CAS 123-91-1) 1,4-dioxane Feed Studies (CAS 3268-87-9) 1,2,3,4,6,7,8,9-octachlorodibenzodioxin (CAS 262-12-4) ...

  21. TR-354: Dimethoxane (CASRN 828-00-2) (Commercial Grade) in F344... 11.7MB

    https://ntp.niehs.nih.gov/go/tr354

    ... Metabolism No information was found on the metabolism of dimethoxane. In rats, 1,4-dioxane ... J . ; Horvath, B.S.; Daniel, R.L. (1976) 1,4-Dioxane and beta-hydroxyethoxyacetic acid ...

  22. TR-374: Glycidol (CASRN 556-52-5) In F344/N Rats and B6C3F1Mice... 11.9MB

    https://ntp.niehs.nih.gov/go/tr374

    ... ether, and 1.1% 2,6-dimeth- anol-1,4-dioxane) in water by gavage to groups of F344/N ... (a-chlorohydrin), 0.4%; diglycidyl ether, 2.8%; and 2,6-dimetha- nol-1,4-dioxane, 1.1%. ...

  23. RoC Background Document: Ethylene Oxide; Dec. 2-3, 1998 4.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/ethyloxide_oneapp_508.pdf

    ... in light of recent toxicity data and information concerning the formation of 1,4- dioxane. ... in light of recent toxicity data and information concerning the formation of 1,4- dioxane. ...

  24. CERHR Monograph: Potential Human Reproductive and Developmental... 4.3MB

    https://ntp.niehs.nih.gov/ntp/ohat/egpg/ethylene/eg_monograph.pdf

    ... Possible trace impurities of ethylene glycol in- clude formaldehyde, ethylene oxide, and 1,4-dioxane (3). Appendix II II-1 Appendix II I 5 a o i Some trade names for ethylene ...

  25. TOX-105: Usnea Lichens Containing (+/-)-Usnic Acid (CASRN 125... 4.2MB

    https://ntp.niehs.nih.gov/go/tox105

    ... reported that a 1,4-dioxane extract of U. barbata collected in northern Russia inhibited the growth of both Gram-positive B. subtilis and Gram- negative Pseudomonas fluorecens. ...

  26. TR-201: Carcinogenesis 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN... 5.2MB

    https://ntp.niehs.nih.gov/go/tr201

    ... J. , McCollister, S. B. , Park, C. Torkelson, T. R. , and Gehring, P - J . , 1,4-Dioxane. ... ApjxL. NCI, National Cancer Institute, Bioassay of_ 1,4-Dioxane for Possible Carcin- ...

  27. NTP Technical Reports Index 1.5MB

    https://ntp.niehs.nih.gov/data/tr

    ... P Clear Evidence N No Evidence N No Evidence P Clear Evidence TR-080 03/07/78 1,4-Dioxane 123-91-1 P Clear Evidence P Clear Evidence P Clear Evidence P Clear Evidence TR-078 ...

  28. TR-259: Ethyl Acrylate (CASRN 140-88-5) in F344/N Rats and B6C3F1Mice... 12.2MB

    https://ntp.niehs.nih.gov/go/tr259

    ... An aqueous solution (50 ~L) containing 1 mg of 1,4-dioxane, the internal standard, per mL ... Acrylate: 3.27 min Internal Standard: 1,4-Dioxane Retention Time of the Internal Standard: ...

  29. Appendices A-G; 15th RoC 2021 433KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendices_508.pdf

    ... National Toxicology Program, Department of Health and Human Services 2 123-91-1 see 1,4-Dioxane 126-72-7 see Tris(2,3-dibromopropyl) Phosphate 126-99-8 see Chloroprene 127-18-4 see ...

  30. Study Reports 1.0MB

    https://ntp.niehs.nih.gov/publications/reports

    ... TR-080 PDF (3.31 MB) Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CASRN 123-91-1) 1978 Technical Report TR-079 No report issued Dulcin (CAS: 150-69-6) - No report issued. ...

  31. Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf

    ... II chloride 36.4 14.2 2251.0 332 1,4-Dioxane 38.1 47.7 4203.3 333 Lithium I chloride ... furano dione 17 27.1 4014.1 332 1,4-Dioxane 38.1 47.7 4203.3 124 Acetazolamide 8.49 ...

  32. TR-209: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6... 8.5MB

    https://ntp.niehs.nih.gov/go/tr209

    ... R. J., McCollister, S. B., Park, C., Torkelson, T. R., and Gehring, P. J., 1,4-Dioxane. ... Pharmacol. 50:241-252, 1979. NCI, National Cancer Institute, Bioassay of_ 1,4-Dioxane for ...

  33. Technical Reports 865KB

    https://ntp.niehs.nih.gov/publications/reports/tr

    ... TR-080 PDF (3.31 MB) Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CASRN 123-91-1) 1978 Technical Report TR-079 No report issued Dulcin (CAS: 150-69-6) - No report issued. ...

  34. Toxicology/Carcinogenicity 1.1MB

    https://ntp.niehs.nih.gov/research/apptoxres/cartox

    ... (3.31 MB) Bioassay of 1,4-Dioxane for Possible Carcinogenicity (CASRN 123-91-1) 1978 Long-Term Carcinogenicity TR-079 Not yet available Dulcin (CAS: 150-69-6) - No report issued. ...

  35. XDS Submission of the LUMI-CELL ER Test Method 3.2MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/iccvamsubmission28jan05.pdf

    ... - 3.29E-09 > 95% Sigma Powder 1,4 Dioxane 123-91-1 environmental contaminant ... X X Non-Active ND Non-Active N/A N/A 1,4 Dioxane 123-91-1 X X X X X Non-Active ND ...

  36. Submission of XDS's LUMI-CELL ER High-Throughput System for Screening... 2.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexa/xds-sub.pdf

    ... - 3.29E-09 > 95% Sigma Powder 1,4 Dioxane 123-91-1 environmental contaminant ... X X Non-Active ND Non-Active N/A N/A 1,4 Dioxane 123-91-1 X X X X X Non-Active ND ...

  37. TR-205: 4,4'-Oxydianiline for Possible Carcinogenicity (CASRN... 4.4MB

    https://ntp.niehs.nih.gov/go/tr205

    ... THIN-LAYER CHROMATOGRAPHY Plates: Silica gel 60 F-254 Amount spotted: 100 and 30/^1, 10 JLfg/ pi in 1,4-dioxane System 1: Acetonitrile, dioxane (50:50) Rf: 0.79, major 0.91 R st. ...

  38. TR-278: 2,6-Xylidine (2,6-Dimethylaniline) (CASRN 87-62-7) in... 9.4MB

    https://ntp.niehs.nih.gov/go/tr278

    ... in drink- ing water (Hoch-Ligeti et al., 1970) or by gavage (NCI, 1978) and by administering phenacetin (Isaka et al,, 1979) and quinoxaline 1,4-dioxane (Tucker, 1975) in the diet. ...

  39. RoC Background Document for Naphthalene; Sept. 19, 2002 4.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc11/naphthalenepub_508.pdf

    ... + M F Skin paint Adenoma Adenoma Dimethylvinyl chloride 316 + + M F Gavage (c) (c) 1,4-Dioxane 080 + + M F Water (c) (c) 1,2-Epoxybutane 329 + E M F Inhalation Adenoma Adenoma ...

  40. DART-03: Prenatal Development Studies of Vinpocetine (CASRN 42971... 1.2MB

    https://ntp.niehs.nih.gov/go/dart03

    ... authentic standards of non-halogenated (hexane, benzene, diethyl ether, acetone, 1,4-dioxane, and toluene), and halogenated (chloroform, carbon tetrachloride, trichloroethylene, ...

  41. TR-381: d-Carvone (CASRN 2244-16-8) in B6C3F1Mice (Gavage Studies... 6.3MB

    https://ntp.niehs.nih.gov/go/tr381

    ... Thin-layer chromatography was performed on silica gel plates with n-hexane:1,4-dioxane (9:1), saturated, under nitrogen, and in the dark (solvent system 1) or ethyl acetate:hexanes ...

  42. Report: International Workshop on In Vitro Methods for Assessing... 25.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf

    ... 14.2 3107.0 19.6 158.52 14.2 332 1,4- Dioxane 123-91-1 3357.37 38.1 4203.3 47.7 ... 27.1 1999.6 13.5 148.12 27.1 332 1,4- Dioxane 123-91-1 3357.37 38.1 4203.3 47.7 ...

  43. TR-234: Allyl Isothiocyanate (CASRN 57-06-7) in F344/N Rats and... 11.0MB

    https://ntp.niehs.nih.gov/go/tr234

    ... I00 and 300 f..lg System I: 95% Ethanol Rr: 0.86 Rst: 1.13 System 2: Chloroform: I ,4-Dioxane (95:5) Rr: 0.55 Rst: 0.61 N s 14.13 32.34 14.10 32.13 14.18 32.27 Literature Values ...

  44. TR-287: Dimethyl Hydrogen Phosphite (CASRN 868-85-9) in F344... 9.9MB

    https://ntp.niehs.nih.gov/go/tr287

    ... Results: Spot intensity Rf Rst System 1 : Methano1:water (9O:lO) Major 0.84 1.10 System 2: 1,4-Dioxane (100%) Major 0.74 0.82 2. Gas Chromatography Instrument: Varian 3700 ...

  45. TR-250: Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1Mice... 8.5MB

    https://ntp.niehs.nih.gov/go/tr250

    ... Visualization: Ultraviolet, 254 and 366 nm, and iodine vapor Amount Spotted: 10 and 30 J.il, 1% solution in methanol System I: Benzene: I ,4-Dioxane (85: 15) System 2: Methylene ...

  46. TR-315: Oxytetracycline Hydrochloride (CASRN 2058-46-0) in F344... 10.3MB

    https://ntp.niehs.nih.gov/go/tr315

    ... Amine group: Titration of one basic proton with 0.1 N perchloric: acid in glacial acetic acid. The compound was dissolved in anhydrous formic acid: glacial acetic acid:l,4-dioxane ...

  47. TR-309: Decabromodiphenyl Oxide (CASRN 1163-19-5) In F344/N Rats... 17.4MB

    https://ntp.niehs.nih.gov/go/tr309

    ... Results: See Figure 6 No literature reference found. Consistent with structure. b. Ultraviolet/visible Instrument: Cary 118 Solvent: 1,4-dioxane Results: No maximum from 800 to No ...

  48. Public Health Impact 1.4MB

    https://ntp.niehs.nih.gov/media/impact

    ... Type: Final Rule September 13, 1989 54 FR 37799 96-29-7 1989 EPA Reportable Quantity Adjustments: 1,4-dioxane, 2-ethoxyethanol, ethylene oxide, 2-nitropropane, perchloroethylene, ...

  49. TR-426: Corn Oil, Safflower Oil, and Tricaprylin (CASRNs. 8001... 18.8MB

    https://ntp.niehs.nih.gov/go/tr426

    ... TLC was performed on silica gel plates with two solvent systems: A) cyclohexane:1,4-dioxane (9O:lO for lot A15 and 9 5 5 for lots A l l and 8312-806876), and B) carbon ...

  50. TR-431: Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1Mice... 15.3MB

    https://ntp.niehs.nih.gov/go/tr431

    ... TLC was performedl on Silica Gel 60 F-254 plates with two solvent systems: A) toluene:1,4-dioxane (85:15) and B) methylene chloride. Visualization was accomplishedwith ultraviolet ...

 
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