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TR-417: p-Nitrophenol (CASRN 100-02-7) in Swiss Webster Mice... 7.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr417.pdf
... NO. 100-02-7 Chemical Formula: C,H,NO, Molecular Weight: 139.11 Synonyms: 4-hydroxynitrobenzene, p-hydroxynitrobenzene, 4-nitrophenol, paranitrophenol, PNP, Niphen p-Nitrophenol ...
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Abstract for TR-417 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr417
Abstract for TR-417 Toxicology and Carcinogenesis Studies of p-Nitrophenol in Swiss-Webster Mice (Dermal Studies) CASRN: 100-02-7 Chemical Formula: C6H5NO3 Molecular Weight: 139.11 ...
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Target Organs and Levels of Evidence for TR-417 56KB
https://ntp.niehs.nih.gov/data/tr/400s/tr417levels
Target Organs and Levels of Evidence for TR-417 Toxicology and Carcinogenesis Studies of p-Nitrophenol (CASRN 100-02-7) in Swiss Webster Mice (Dermal Studies) Chemical (Study ...
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RoC Background Document for Nitrobenzene; Sept. 19, 2002 1.3MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/nbpub_no_appendices_508.pdf
... Figure 1-2. Structures of p-nitrophenol (4-nitrophenol) and p-aminophenol ... of nitrobenzene are p-nitrophenol (4-nitrophenol) and p-aminophenol (4-aminophenol). ...
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Eye, Anterior Chamber - Hemorrhage - Nonneoplastic Lesion Atlas 289KB
https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/AnteriorChamber-Hemorrhage
National Toxicology Program. 1993. NTP TR-417. Toxicology and Carcinogenesis Studies of p-Nitrophenol (CAS No. 100-02-7) in Swiss Webster Mice (Dermal Studies). NTP, Research ...
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Eye, Anterior Chamber - Hemorrhage 241KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/achemor/eye-anterior-chamber-hemorrhage_508.pdf
.../15/7/538.short National Toxicology Program. 1993. NTP TR-417. Toxicology and Carcinogenesis Studies of p-
Nitrophenol (CAS No. 100-02-7) in Swiss Webster Mice (Dermal Studies). ...
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Adrenal glands - Amyloid - Nonneoplastic Lesion Atlas 300KB
https://ntp.niehs.nih.gov/atlas/nnl/endocrine-system/adrenal-gland/Amyloid
... National Toxicology Program. 1993. NTP TR-417. Toxicology and Carcinogenesis Studies of p-Nitrophenol (CAS No. 100-02-7) in Swiss Webster Mice (Dermal Studies). NTP, Research ...
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Adrenal Gland - Amyloid 554KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/endocrine/adrenal/amyloid/adrenal-gland-amyloid-pdf_508.pdf
... References: National Toxicology Program. 1993. NTP TR-417. Toxicology and Carcinogenesis Studies of p-
Nitrophenol (CAS No. 100-02-7) in Swiss Webster Mice (Dermal Studies). ...
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Minutes: BSC TRRS; July 9, 1991 979KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1991/july/trrs9july1991mins_508.pdf
... o one no votes (Zeise). p-Nitrophenol. Dr. C.C. Shackelford, NIEHS, introduced t h e t o x i c o l o g y and carcinogenesis s t u d i e s o f p-nitrophenol by d i s c u s s i n g t ...
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CERHR Monograph: 1-Bromopropane 1.1MB
https://ntp.niehs.nih.gov/ntp/ohat/bromopropanes/1-bromopropane/1bp_monograph.pdf
... erythrocyte pnd postnatal day pNPH p-nitrophenol hydroxylase PPE personal protective ... of NADH b 5 reductase and p-nitrophenol hydroxylase (pNPH) in high-dose males and females. ...
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TR-510: Urethane + Ethanol (CASRNs. 51-79-6 & 64-17-5) in F344... 17.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr510.pdf
... activity was assessed by measuring the oxida- tion of p-nitrophenol to 4-nitrocatechol. ... chloride, 2.5 mM; NADPH, 1 mM; p-nitrophenol, 0.1 mM; and microsomal protein, 0.14 ...
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TR-516: 2-Methylimidazole (CASRN 693-98-1) in F344/N Rats and... 9.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr516.pdf
... higher K i for inhibition of p-nitrophenol hydroxylase (a cytochrome P4502E1 ... and Gescher, A. (1994). Inhibition of p-nitrophenol hydrox- ylase in rat liver microsomes ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... Tested in Species/Sex EE Equivocal Evidence NE No Evidence TR-417 07/09/91 p-Nitrophenol 100-02-7 NT Chemical Not Tested in Species/Sex NT Chemical Not Tested in Species/Sex NE ...
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TOX-99: A Gum Guggul Extract Formulation Administered by Gavage... 1.1MB
https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox99_508.pdf
... mg), (S)-mephenytoin (0.1 mM) CYP2E1 e p-Nitrophenol hydroxylation Ascorbate (1 mM), NADPH (1 mM), microsomal protein (1 mg), p-nitrophenol (0.1 M) CYP2D6 f Dextromethorphan ...
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TOX-99: A Gum Guggul Extract Formulation Administered by Gavage... 1.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox99_508.pdf
... mg), (S)-mephenytoin (0.1 mM) CYP2E1 e p-Nitrophenol hydroxylation Ascorbate (1 mM), NADPH (1 mM), microsomal protein (1 mg), p-nitrophenol (0.1 M) CYP2D6 f Dextromethorphan ...
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TOX-7: 1,2,4,5-Tetrachlorobenzene (CASRN 95-94-3) 4.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox007.pdf
... The 1,2,4,5-isomer is more potent as a hepatic enzyme inducer than are the other two isomers (Chu et al., 1984b). In vitro glucuronidation of p-nitrophenol and phenolphthalein did ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... Report TR-417 PDF (7.44 MB) Toxicology and Carcinogenesis Studies of p-Nitrophenol (CASRN 100-02-7) in Swiss-Webster Mice (Dermal Studies) 1993 Technical Report TR-416 PDF ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... Report TR-417 PDF (7.44 MB) Toxicology and Carcinogenesis Studies of p-Nitrophenol (CASRN 100-02-7) in Swiss-Webster Mice (Dermal Studies) 1993 Technical Report TR-416 PDF ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... TR-417 PDF (7.44 MB) Toxicology and Carcinogenesis Studies of p-Nitrophenol (CASRN 100-02-7) in Swiss-Webster Mice (Dermal Studies) 1993 Long-Term Carcinogenicity ...
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Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf
... Oxyphenbutazone 0.19 3.08 999.2 210 p-Nitrophenol 0.2 2.52 350.6 67 15 Malathion 0.2 ... * HCl 4.16 1.72 350.3 210 p-Nitrophenol 0.2 2.52 350.6 246 37 Barium II ...
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TR-535: 4-Methylimidazole (CASRN 822-36-6) in F344/N Rats and... 10.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr535.pdf
... Hargreaves et al. (1994) reported that 4-methylimid- azole was a strong inhibitor of p-nitrophenol hydrolase in rat liver. p-Nitrophenol is a cytochrome P450 2E1 substrate. ...
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Report: International Workshop on In Vitro Methods for Assessing... 25.4MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf
... 1.48 324.41 3.08 66 Cortisone 53-06-5 68.49 0.19 NA NA NA NA 360.49 210 p-
Nitrophenol 100-02-7 27.82 0.2 350.6 2.52 467.4 3.36 139.12 2.52 67 15 Malathion 121-75-5 66.08 0.2 ...
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RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf
... 88-75-5 139.11 4-Nitrophenol 100-02-7 139.11 N-Nitrosodimethylamine 62-75-9 ... 2-Nitrophenol 88-75-5 4-Nitrophenol 100-02-7 N-Nitrosodimethylamine 62-75-9 ...
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RoC Monograph: 1-Bromopropane; September 2013 1.9MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/1bromopropane_508.pdf
... There is some evidence that there are sex differences in enzymatic activity in 1- bromopropane-exposed rats. p-Nitrophenol hydroxylase (pNPH), associated with CYP2E1 expression, ...
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TR-438: Benzethonium Chloride (CASRN 121-54-0) in F344/N Rats... 10.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr438.pdf
... Toxicology Program, Research Triangle Park, NC. National Toxicology Program (NTP) (1993). Toxicology and Carcinogenesis Studies of p-Nitrophenol (CAS No. 100-02-7) in Swiss-Webster ...
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TOX-67: 2-Methylimidazole and 4-Methylimidazole 5.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox067.pdf
... JNCI 62, 957-974. Hargreaves, M.B., Jones, B.C., Smith, D.A., and Gescher, A. (1994). Inhibition of p-nitrophenol hydroxylase in rat liver microsomes by small aromatic and ...
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TR-444: Initiation/Promotion Study of o-Benzyl-p-Chlorophenol... 6.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr444.pdf
... Acid Ethylene Glycol Pentachloroanisole Polysorbate 80 o-Nitroanisole p-Nitrophenol p-Nitroaniline HC Yellow 4 Triamterene Talc Coumarin Dihydrocoumarin ...
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TR-255: 1,2-Dichlorobenzene (o-Dichlorobenzene) (CASRN 95-50... 8.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr255.pdf
... Phosphatase activity at pH 10.2 is determined by kinetic measurement of the conver- sion of p-nitrophenyl phosphate to p-nitrophenol (Wilkinson et al., 1969). Serum Glutamic ...
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TR-351: para-Chloroaniline Hydrochloride (CASRN 20265-96-7) in... 12.2MB
https://ntp.niehs.nih.gov/go/tr351
... Spectrophotometric-grade p-nitrophenol was obtained from Sigma Chemical Co. (Milwaukee, ... and p-nitrophenol prior to high-performance liq- uid chromatographic analysis. ...
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TR-518: Triethanolamine (CASRN 102-71-6) in B6C3F1Mice (Dermal... 5.0MB
https://ntp.niehs.nih.gov/go/tr518
... 416 p-Nitrobenzoic Acid 442 Nitrofurantoin 341 Nitrofurazone 337 Nitromethane 461 p-Nitrophenol 417 o-Nitrotoluene 504 p-Nitrotoluene 498 Ochratoxin A 358 Oleic Acid ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 6.3MB
https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf
... As determined in an assay using p-
nitrophenol-b-d-glucuronide as a substrate, B70% of total b-glucuronidase activity was present in the cecum and 30% in the colon. Western blot ...
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TR-319: 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and... 17.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr319.pdf
... Phosphatase activity at pH 10.2 was determined by kinetic measurement of the conversion of p-nitrophenyl phosphate to p-nitrophenol (Wilkinson et al., 1969). Serum Glutamic Pyruvic ...
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TR-400: 2,3-Dibromo-1-Propanol (CASRN 96-13-9) in F344/N Rats... 11.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr400.pdf
... 80 369 Alpha-Methylbenzyl Alcohol 416 o-Nitroanisole 370 Benzofuran 417 p-Nitrophenol 371 Toluene 418 p-Nitroaniline 372 3,3-Dimethoxybenzidine Dihydrochloride 419 HC ...
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TR-479: Coconut Oil Acid Diethanolamine Condensate (CASRN 68603... 7.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr479.pdf
... o-Nitroanisole p-Nitrobenzoic Acid Nitrofurantoin Nitrofurazone Nitromethane p-Nitrophenol Ochratoxin A 388 223 208 402 382 482 356 492 252 490 374 229 227 271 293 281 419 ...
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TR-502: Chloral Hydrate (CASRN 302-17-0) in B6C3F1Mice (Gavage... 8.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr502.pdf
... 500 451 454 453 418 416 442 Nitrofurantoin 341 Nitrofurazone 337 Nitromethane 461 p-Nitrophenol 417 o-Nitrotoluene 504 Ochratoxin A 358 Oleic Acid Diethanolamine Condensate 481 ...
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TR-398: Polybrominated Biphenyls (CASRN 67774-32-7)(Firemaster... 14.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr398.pdf
... 80 371 Toluene 416 o-Nitroanisole 372 3,3-Dimethoxybenzidine Dihydrochioride 417 p-Nitrophenol 373 Sueeinie Anhydride 418 p-Nitroaniline 374 Glyeidol 419 HC Hellow 4 375 Vinyl ...
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TR-421: Talc (CASRN 14807-96-6)(Non-Asbestiform) in F344/N Rats... 16.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr421.pdf
... Ethylene Glycol 414 Pentachloroanisole 415 Polysorbate $0 416 o-Nitroanisole 417 p-Nitrophenol 418 p-Nitroaniline 419 HC Hellm 4 427 Turmeric Oleoresin 434 1,3-Butadiene 443 ...
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TR-424: o-Benzyl-p-Chlorophenol (CASRN 120-32-1) in F344/N Rats... 15.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr424.pdf
... 80 368 Nalidixic Acid 416 o-Nitroanisole 369 Alpha-Methylknzyl Alcohol 417 p-Nitrophenol 370 Benzofuran 418 p-Nitroaniline 371 Toluene 419 HC Hellow 4 372 ...
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TR-427: Turmeric Oleoresin (CASRN 8024-37-1) (Major Component... 16.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr427.pdf
... 80 371 Toluene 416 o-Nitroanisole 372 3,3-Dimetha#ykozidine Dihydrochloride 417 p-Nitrophenol 373 Succinic Anhydride 418 p-Nitroaniline 374 Glycidol 419 HC Hellow 4 375 Vinyl ...
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TR-429: Diethylphthalate (CASRN 84-66-2) in F344/N Rats and B6C3F1Mice... 12.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr429.pdf
... 6G (C.I. Basic Red 1) 416 o-Nitroanisole Pentaerythritol Tetranitrate 417 p-Nitrophenol Hydroquinone 418 p-Nitroaniline Phenylbutazone 419 HC Yellow 4 Nalidixic Acid 420 ...
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TR-431: Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1Mice... 15.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr431.pdf
... Alcohol 415 Polysorbate 80 370 Benzofuran 416 o-Nitroanisole 371 Toluene 417 p-Nitrophenol 372 3,3-Dimethoxybenzidine Dihydrochlol ide 418 p-Nitroaniline 373 Succinic ...
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TR-437: Hexachlorocyclopentadiene (CASRN 77-47-4) in F344/N Rats... 15.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr437.pdf
... Ethylene Glycol 414 Pentachloroanis,le 415 Polysorbate 80 416 o-Nitroanisole 417 p-Nitrophenol 418 p-Nitroaniline 419 HC Yellow 4 420 Triamterene 421 Talc 422 Coumarin 423 ...
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TR-439: Methylphenidate Hydrochloride (CASRN 298-59-9) in F344... 15.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr439.pdf
... Ethylene Glycol 414 Pentachloroanisole 415 Polysorbate 80 416 o-Nitroanisole 411 p-Nitrophenol 418 p-Nitroaniline 419 HCYellow 4 420 Triamterene 421 Talc 422 coumarin 423 ...
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TR-498: p-Nitrotoluene (CASRN 99-99-0) in F344/N Rats and B6C3F1Mice... 10.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr498.pdf
... 396 266 368 410 500 451 454 453 418 416 442 341 Nitrofurazone 337 Nitromethane 461 p-Nitrophenol 417 o-Nitrotoluene 504 p-Nitrotoluene 498 Ochratoxin A 358 Oleic Acid ...
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TR-508: Riddelliine (CASRN 23246-96-0) in F344/N Rats and B6C3F1Mice... 9.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr508.pdf
... 416 p-Nitrobenzoic Acid 442 Nitrofurantoin 341 Nitrofurazone 337 Nitromethane 461 p-Nitrophenol 417 o-Nitrotoluene 504 p-Nitrotoluene 498 Ochratoxin A 358 Oleic Acid ...
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TR-511: Dipropylene Glycol (CASRN 25265-71-8) in F344/N Rats... 10.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr511.pdf
... 416 p-Nitrobenzoic Acid 442 Nitrofurantoin 341 Nitrofurazone 337 Nitromethane 461 p-Nitrophenol 417 o-Nitrotoluene 504 p-Nitrotoluene 498 Ochratoxin A 358 Oleic Acid ...
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TR-426: Corn Oil, Safflower Oil, and Tricaprylin (CASRNs. 8001... 18.8MB
https://ntp.niehs.nih.gov/go/tr426
... 415 Polysorbate 80 366 Hydroquinone 416 o-Nitroanisole 367 Phenylbutazone 417 p-Nitrophenol . 23 Acid p-Nitroaniline Nalidixic 418 369 Alpha-Methylbenzyl Alcohol 419 HC Yellow ...
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TR-404: 5,5-Diphenylhydantoin (CASRN 57-41-0) (Phenytoin) in... 16.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr404.pdf
... 80 368 Nalidixic Acid 416 o-Nitroanisole 369 Alpha-Methylbenzyl Alcohol 417 p-Nitrophenol 370 Benzofuran 418 p-Nitroaniline 371 Toluene 419 HC Hellow 4 372 ...
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TR-420: Triamterene (CASRN 396-01-0) in F344/N Rats and B6C3F1Mice... 20.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr420.pdf
... Ethylene Glycol 414 Pentachloroanisole 415 Polysorbate 80 416 o-Nitroanisole 417 p-Nitrophenol 418 p-Nitroaniline 419 HC Hellaw 4 421 Talc 422 Coumarin 423 Dihydmumarin 427 ...
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TR-430: C.I. Direct Blue 218 (CASRN 28407-37-6) in F344/N Rats... 16.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr430.pdf
... Acid Ethylene Glycol Pentachloroanisole Polysorbate 80 o-Nitroanisole p-Nitrophenol p-Nitroaniline HC Hellow 4 Triamterene Talc Coumarin Dihydmumarin ...