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Background Document: RoC: Styrene; 2010 4.3MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/styrene_final_508.pdf
Styrene September 29, 2008 U.S. Department of Health and Human Services Public Health ... Left Blank RoC Background Document for Styrene 9/29/08 i FOREWORD The Report on ...
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Styrene Expert Panel Report Part A; RoC; July 21-22, 2008 756KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2008/expertpanelmtgs/styrene_panelreportparta_508.pdf
Styrene Expert Panel Report Part A - Peer Review of the draft background document on styrene The Report on Carcinogens (RoC) expert panel for styrene met at the Radisson Hotel, ...
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CERHR Monograph: Potential Human Reproduction Effects of Styrene 6.0MB
https://ntp.niehs.nih.gov/go/styrene_monograph
and Developmental Effects of Styrene February 2006 NIH Publication No. 06 - ... NTP.Brief.on.Styrene.. ......
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RoC Profile: Styrene; 15th RoC 2021 252KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/styrene.pdf
Styrene CAS No. 100-42-5 Reasonably anticipated to be a human carcinogen First listed in the Twelfth Report on Carcinogens (2011) HC CH 2 Carcinogenicity Styrene is reasonably ...
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Background Document: Styrene oxide; BSC RoC, Jan. 20-21, 2000 267KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc10/bg_styrene_oxide_508.pdf
Report on Carcinogens Background Document for Styrene-7,8-oxide Meeting of the NTP Board ... NOI-ES-85421 RoC Background Document for Styrene-7,8-oxide i Criteria for Listing Agents, ...
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TR-573: Styrene-acrylonitrile trimer in F344/N Rats (Perinatal... 2.8MB
https://ntp.niehs.nih.gov/go/tr573
sTyReNe-acRyloNiTRile TRimeR iN f344/N RaTs (PeRiNaTal aNd PosTNaTal feed sTudies) NTP TR 573 JULY 2012 NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDY OF STYRENE-A...
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TR-185: Styrene (CASRN100-42-5) 3.5MB
https://ntp.niehs.nih.gov/go/tr185
C/J National Cancer Institute .< CARCINOGENESIS JO m Technical Report Series Z m No. 185 1979 BIOASSAY OF STYRENE FOR POSSIBLE CARCINOGENICITY O 6 H 30 9 CAS No. 100-42-5 00 Ul ...
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Styrene Expert Panel Report Part B; RoC; July 21-22, 2008 237KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2008/expertpanelmtgs/styrene_panelreportpartb_508.pdf
Styrene Expert Panel Report Part B -- Recommendation for listing status for "styrene" in the Report on Carcinogens and scientific justification for the recommendation The Report ...
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RoC Profile: Styrene-7,8-oxide; 15th RoC 2021 144KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/styreneoxide.pdf
Edition For Table of Contents, see home page: http://ntp.niehs.nih.gov/go/roc Styrene-7,8-... Also known as 1,2-epoxyethylbenzene O Carcinogenicity Styrene-7,8-oxide is reasonably ...
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Styrene: Target Organs and Levels of Evidence for TR-185 54KB
https://ntp.niehs.nih.gov/data/tr/100s/tr185levels
3 Styrene: Target Organs and Levels of Evidence for TR-185 Bioassay of Styrene for Possible Carcinogenicity (CASRN100-42-5) Chemical (Study Title) CASRN Peer Review Date Route/...
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TR-170: a Solution of -Nitrostyrene and Styrene (CASRN 102-96... 4.8MB
https://ntp.niehs.nih.gov/go/tr170
170 1979 BIOASSAY OF A SOLUTION OF ß-NITROSTYRENE AND STYRENE FOR POSSIBLE CARCINOGENICITY CAS No. 102-96-5 CAS No. 100-42-5 NCI-CG-TR-170 U.S. DEPARTMENT OF HEALTH, EDUCATION, ...
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Background Document: RoC: Styrene, Erratum and Addendum; 2010 100KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2010/finalbds/styreneerratumaddendum_508.pdf
Background Document for Styrene The following corrections are made to the Final Report on Carcinogens Background Document for Styrene. 1. Table 3-10, page 187. The ...
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Agenda: RoC Styrene Expert Panel Meeting; July 21-22, 2008 105KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2008/expertpanelmtgs/styrene_agenda20080722.pdf
Styrene Expert Panel Meeting July 21 & 22, 2008 Radisson Hotel Research Triangle Park, NC ... Ruth Lunn, Director, RoC 8:50 Meeting Process - Dr. David Phillips, Chair, Styrene Expert ...
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Abstract for TR-185 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr185
5abs Abstract for TR-185 Bioassay of Styrene for Possible Carcinogenicity CASRN: 100-42-5 Chemical Formula: C8H8 Molecular Weight: 104.151 Synonyms/Common Names: ethenylbenzene; ...
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Minutes: BSC; Feb. 24, 2009 209KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2009/february/minutes022409.pdf
......... 9 Styrene ......Manufacturers Association Jack Snyder, Styrene Information & Research Center II. ...
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Abstract for TR-573 68KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr573
Study of Styrene-Acrylonitrile Trimer in F344/N Rats (Perinatal and Postnatal Feed Studies) CASRN: SANTRIMER2 Report Date: July 2012 Full Report PDF Abstract Styrene-acrylonitri...
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Abstract for TR-170 - Solution of beta-Nitrostyrene and Styrene... 59KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr170
0abs Abstract for TR-170 - Solution of beta-Nitrostyrene and Styrene (CASRN 102-96-5, CASRN 100-42-5) Abstract Bioassay of a Solution of b-Nitrostyrene and Styrene for Possible ...
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NTP Response to BSC Peer Review Comments on the Draft Substances... 339KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2011/response022409bsc2011.pdf
Scientific and Technical Issues 9 Styrene 10 BSC Comments and NTP Responses: ... were reviewed: aristolochic acids, captafol, ortho-nitrotoluene, riddelliine, and styrene. ...
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Abstract for TR-506 69KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr506
Acrylonitrile is used in the production of acrylic and modacrylic fibers, elastomers, acrylonitrile-butadiene-styrene and styrene-acrylonitrile resins, nitrile rubbers, gas barrier ...
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Target Organs and Levels of Evidence for TR-573 55KB
https://ntp.niehs.nih.gov/data/tr/500s/tr573levels
Styrene-Acrylonitrile Trimer (CASRN SANTRIMER2) in F344/N Rats (Perinatal and Postnatal Feed Studies) Chemical CASRN Peer Review Date Route/Exposure Levels Study Laboratory Styrene...
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RoC Background Document: 1,3-Butadiene; Oct. 30-31, 1997 9.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/butadiene_508.pdf
... among production workers in a study of styrene-butadiene rubber workers in eight plants ... exposure to 1 ,3-butadiene and not to styrene in a case-control study within the cohort ...
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Abstract for TR-466 70KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr466
Full Report PDF Abstract Ethylbenzene is mainly used in the manufacture of styrene. Ethylbenzene is also a major component of mixed xylenes used as solvents in agricultural and ...
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Abstract for TR-543 72KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr543
Full Report PDF Abstract α-Methylstyrene is used in the production of acrylonitrile-butadiene-styrene resins and copolymers, which improve the impact and heat-resistant properties ...
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Response to Expert Panels' Peer-Review Comments on Background... 354KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/2011/responseexpertpanelreport2011.pdf
Peer-Review Comments 19 References 20 Styrene 21 Expert Panel Meeting 21 NTP Response ... the Expert Panels' Peer-Review Comments Styrene 21 Styrene Expert Panel Meeting The NTP ...
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Abstract for TOX-70 63KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox070
Abstract p-tert-Butylcatechol is used as an antioxidant, stabilizer, and polymerization inhibitor for styrene, butadiene, neoprene, and other olefins and reactive monomers. ...
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Abstract for TR-215 60KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr215
A carcinogenesis bioassay of bisphenol A, an intermediate used in the manufacture of epoxy, polycarbonate, and polyester-styrene resins, was conducted by feeding diets containing ...
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Abstract for TR-288 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr288
Of the 1,3-butadiene used in 1978, 44% was used to manufacture styrene-butadiene rubber (a substitute for natural rubber, produced by copolymerization of 1,3-butadiene with styrene...
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Abstract for TR-587 73KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr587
Tetrabromobisphenol A is a flame retardant used in epoxy resin circuit boards, in electronic enclosures (of polycarbonate-acrylonitrile-butadiene-styrene plastics), in paper, and ...
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Abstract for TR-151 59KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr151
The lead salt of bis(dimethyldithiocarbamic) acid is used commercially as a rubber accelerator in applications involving natural rubber, and styrene-butadiene, ...
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Abstract for TR-456 75KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr456
Full Report PDF Abstract 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) is used as an antioxidant in styrene-butadiene and nitrile-butadiene rubbers and latexes. It was nominated ...
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beta-Nitrostyrene: Target Organs and Levels of Evidence for TR... 54KB
https://ntp.niehs.nih.gov/data/tr/100s/tr170levels
Bioassay of a Solution of ß-Nitrostyrene and Styrene for Possible Carcinogenicity (CASRN 102-96-5, CASRN 100-42-5) Chemical (Study Title) CASRN Peer Review Date Route/Exposure ...
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Abstract for TR-164 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr164
N-Nitrosodiphenylamine is a nitrosoamine which is used as a vulcanization retarder in curing natural rubber and the synthetic elastomers styrene-butadiene and nitrile-butadiene. ...
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TR-543: Toxicology and Carcinogenesis Studies of alpha-Methylstyrene... 3.2MB
https://ntp.niehs.nih.gov/go/tr543
... is used to make heat-resistant acrylonitrile-butadiene-styrene resins and polymers. ... production of acryloni- trile-butadiene-styrene resins and copolymers, which improve the ...
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Abstract for TR-166 59KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr166
ethyl tuads where it is used in compounding natural rubber and the synthetic elastomers isobutylene-isoprene, butadiene, styrene-butadiene, isoprene, and nitrile-butadiene rubber. ...
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Abstract for TR-534 71KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr534
Divinylbenzene-HP was nominated for study by the National Cancer Institute because of the potential for worker exposure and the structural similarity of divinylbenzene to styrene, ...
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RoC Profile: 1,3-Butadiene; 15th RoC 2021 162KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/butadiene.pdf
1,3-butadiene monomer, (2) a study of styrene-butadiene rubber workers in eight plants ... case-control study within the cohort of styrene-butadiene rubber workers showing a large ...
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Abstract for TR-190 60KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr190
also used as an intermediate in the manufacture of dyes and pharmaceutical compounds and as an inhibitor of polymerization during the production of vinyl monomers such as styrene. ...
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Minutes: TRPRP; Jan. 26, 2011 168KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2011/january/minutes20110126.pdf
Toxicology and Carcinogenesis Study of Styrene-Acrylonitrile Trimer (TR 573) 10 VII. ... Klaunig and Novak would not participate in the discussion or voting on the styrene-acrylon...
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Abstract for TR-289 67KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr289
billion pounds in 1982. This simplest aromatic chemical in used in the synthesis of styrene (polystyrene plastics and synthetic rubber), phenol (phenolic resins), cyclohexane ...
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Abstract for TOX-47 63KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox047
This aliphatic nitrile is also used as a replacement for acrylonitrile in the manufacture of an acrylonitrile/butadiene/styrene-like polymer. Methacrylonitrile was nominated for ...
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Abstract for TR-497 66KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr497
Methacrylonitrile is also used as a replacement for acrylonitrile in the manufacture of an acrylonitrile/butadiene/styrene-like polymer that provides improved barrier properties to ...
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TR-534: Divinylbenzene-HP (CASRN 1321-74-0) in F344/N Rats and... 4.4MB
https://ntp.niehs.nih.gov/go/tr534
... and the structural similarity of divinylbenzene to styrene, a potential human carcinogen. ... monomer for copolymerization with styrene or with acrylic and methacrylic acids to ...
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RoC Concept: Cumene 251KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/thirteenth/concepts/cumeneconcdocroc8-30-12_508.pdf
Cumene is structurally similar to benzene, toluene, styrene, xylene, and ethylbenzene. It ... Sixteen metabolites have been identified, including alpha methyl styrene (AMS) and other ...
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Historical Controls: Pathology Tables by Oral/Feed for Fischer344N... 105KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2013/ratsf344peripostoralfeed2013_508.pdf
.../12/05 726 50(3) 36(685) 522.7 Styrene-acrylonitrile trimer Female Battelle Columbus Laboratory 059901305 05/13/05 727 50(5) 41(699) 371.2 Styrene-acrylonitrile trimer NOTE: The ...
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RoC Background Document: Ethylene Oxide; Dec. 2-3, 1998 4.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/ethyloxide_oneapp_508.pdf
......... 52 6.5.3 Styrene Oxide ......organ sites in rats and mice. 6.5.3 Styrene oxide In vitro studies showed binding of ...
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Historical Controls: Pathology Tables by Perinatal and Postnatal... 131KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/historical_controls/ntp2000_2011/ratsperipostoralfeed.pdf
.../12/05 726 50(3) 36(685) 522.7 Styrene-acrylonitrile trimer Female Battelle Columbus Laboratory 059901305 05/13/05 727 50(5) 41(699) 371.2 Styrene-acrylonitrile trimer NOTE: The ...
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Agenda: BSC; Feb. 24, 2009 40KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2009/february/fnlagenda.pdf
Ruth Lunn, NIEHS . Draft Substance Profile on Styrene o Public Comments o BSC Discussion Dr. Ruth Lunn 12:30 PM LUNCH 1:15 . Draft Substance Profile on Styrene (continued) 3:00 ...
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Minutes; BSC; Dec. 15, 2011 258KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2011/december/minutesbsc20111215.pdf
... Procter & Gamble Company Jack Snyder, Styrene Information and Research Center Summary ... As a result of the listing of styrene in the 12 th RoC as being reasonably anticipated to ...
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RoC Profile: Acrylonitrile; 15th RoC 2021 145KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/acrylonitrile.pdf
... Of total acrylonitrile production, reported uses were 38% for the production of adiponitrile, 22% for acrylo- nitrile-butadiene-styrene and styrene-acrylonitrile resins, 17% for ...
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TOX-40: b-Bromo-b-Nitrostyrene (CASRN 7166-19-0) 2.6MB
https://ntp.niehs.nih.gov/go/tox040
... However, it is known that styrene distributes throughout the body, and high concentrations ... In gavage studies, a mixture of styrene and nitrostyrene produced a marginal increase in ...
