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TR-378: Benzaldehyde (CASRN 100-52-7) in F344/N Rats and B6C3F1Mice... 14.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr378.pdf
8 TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZALDEHYDE (CAS NO. 100-52-7) IN F344/N RATS AND B6C3F 1 MICE (GAVAGE STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public ...
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Abstract for TR-378 64KB
https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr378
Abstract for TR-378 Toxicology and Carcinogenesis Studies of Benzaldehyde in F344/N Rats and B6C3F1 Mice (Gavage Studies) CASRN: 100-52-7 Chemical Formula: C7H6O Molecular Weight: ...
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Target Organs and Levels of Evidence for TR-378 57KB
https://ntp.niehs.nih.gov/data/tr/300s/tr378levels
Target Organs and Levels of Evidence for TR-378 Toxicology and Carcinogenesis Studies of Benzaldehyde (CASRN 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) Chemical ...
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Minutes: BSC TRRS; Jun 27, 1989 1.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1989/june/89jun27trrsmins_508.pdf
Technical Report CAS No. Route Page Number Long Term Studies Allyl G1ycidyl Ether 106-92-3 Inhalation Benzaldehyde 100-52-7 Gavage 3 d-Carvone 2244-16-8 Gavage 5 ...
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TOX-40: b-Bromo-b-Nitrostyrene (CASRN 7166-19-0) 2.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox040.pdf
... rapidly hydrolyzed to benzaldehyde and bromonitromethane (Friend and Whitekettle, 1980). ... Benzaldehyde and bromonitromethane, products of the aqueous hydrolysis of -bromo- ...
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Ear, Canal - Dilation - Nonneoplastic Lesion Atlas 288KB
https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/ear/Canal-Dilation
National Toxicology Program. 1990. NTP TR-378. Toxicology and Carcinogenesis Studies of Benzaldehyde (CAS No. 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, ...
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Eye, Cornea - Cyst - Nonneoplastic Lesion Atlas 287KB
https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/CorneaCyst
National Toxicology Program. 1990. NTP TR-378. Toxicology and Carcinogenesis Studies of Benzaldehyde (CAS No. 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, ...
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Ear, Canal - Dilation 314KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/ear/cdilat/ear-canal-dilation_508.pdf
References: National Toxicology Program. 1990. NTP TR-378. Toxicology and Carcinogenesis Studies of Benzaldehyde (CAS No. 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies). ...
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Eye, Cornea - Cyst 245KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/crcyst/eye-cornea-cyst_508.pdf
National Toxicology Program. 1990. NTP TR-378. Toxicology and Carcinogenesis Studies of Benzaldehyde (CAS No. 100-52-7) in F344/N Rats and B6C3F 1 Mice (Gavage Studies). ...
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TR-527: Malachite Green Chloride and Leucomalachite Green (CASRNs... 7.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr527.pdf
... names: Aniline Green; Benzal Green; Benzaldehyde Green; China Green; C.I. Basic Green ... names: Aniline Green; Benzal Green; Benzaldehyde Green; China Green; C.I. Basic Green ...
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Adrenal Gland, Cortex - Vacuolization, Cytoplasmic - Nonneoplastic... 294KB
https://ntp.niehs.nih.gov/atlas/nnl/endocrine-system/adrenal-gland/Cortex-VacuolizationCytoplasmic
... National Toxicology Program. 1990. NTP TR-378. Toxicology and Carcinogenesis Studies of Benzaldehyde (CAS No. 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies). NTP, ...
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TR-343: Benzyl Alcohol (CASRN 100-51-6) in F344/N Rats and B6C3F1Mice... 8.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr343.pdf
... by the Cannizzaro reaction between benzaldehyde and potassium hydroxide but is now ... for which such data are available in- clude benzaldehyde, benzoic acid, and hippuric acid. ...
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Adrenal Gland, Cortex - Vacuolization, Cytoplasmic 452KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/endocrine/adrenal/cxvacuol/adrenal-gland-cortex-vacuolization-cytoplasmic-pdf_508.pdf
.../16641540 National Toxicology Program. 1990. NTP TR-378. Toxicology and Carcinogenesis Studies of Benzaldehyde (CAS No. 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies). ...
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Final RoC Background Document for Formaldehyde 5.8MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/formaldehyde_bd_final.pdf
... and benzaldehyde have also been tested for carcinogenicity in 2-year bioassays by the NTP. Glutaraldehyde was not considered to be carcinogenic in rats or mice, and benzaldehyde ...
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TOX-71: Malachite Green Chloride and Leucomalachite Green (CASRNs... 2.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox071.pdf
... names: Aniline Green; Benzal Green; Benzaldehyde Green; China Green; C.I. Basic Green ... It is prepared in a stepwise reaction that involves the condensation of benzaldehyde with ...
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TR-371: Toluene (CASRN108-88-3) in F344/N Rats and B6C3F1Mice... 15.6MB
https://ntp.niehs.nih.gov/go/tr371
... chlorina- tion, toluene may be chlorinated and subse- quently hydrolyzed to benzaldehyde. ... The benzyl alcohol is rapidly converted to benzaldehyde by an NAD- dependent alcohol ...
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Validation of an In Vitro Gastrointestinal Digestion and Co-culture... 19.2MB
https://ntp.niehs.nih.gov/sites/default/files/2023-12/Wksp_06_Sayes_GutModels2023_508.pdf
... (mM) 0.0 0.2 0.4 0.6 0.8 0.0 0.5 1.0 1.5 2.0 2.5 3,5-Dibromo-4-hydroxy- benzaldehyde (mM) 3,5-Dibromo-4-hydroxybenzoic acid (mM) (F) Synergism Additivity Synergism ...
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RoC Background Document: Wood Dust; Dec. 13-14, 2000 1.2MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/wd_no_appendices_508.pdf
... 10 H 10 O 3 458-36-6 178.19 Syringaldehyde 134-96-3 182.18 C 9 H 10 O 4 p-Hydroxy- benzaldehyde C 7 H 6 O 2 123-08-0 122.12 Vanillin C 8 H 8 O 3 121-33-5 152.15 Eugenol C 10 H 12 ...
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TOX-84: Toxicity Studies of o-Phthalaldehyde (CASRN 643-79-8... 5.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox084_508.pdf
... produced by heating pure benzaldehyde and chloroform with potassium hydroxide solution 3 . ... that included toluene, phthalide, benzaldehyde, phthalan, N-hydroxyphthalimide, ...
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RoC Background Document for Nitromethane; March 25, 2002 1.2MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/nmpub_no_appendices_508.pdf
...droxymethyl)nitromethane widely used biocide (bronopol) β-nitrostyrene reaction of benzaldehyde and nitromethane and dehydration used as a chain transfer agent (lowers molecular ...
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TR-514: trans-Cinnamaldehyde (Microencapsulated) (CASRN 14371... 8.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr514.pdf
... Cinnamaldehyde is manufactured synthetically by the condensation of benzaldehyde and ... A/D Barium Chloride Dihydrate Benzaldehyde Benzene Benzethonium Chloride ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... Evidence EE Equivocal Evidence NE No Evidence NE No Evidence TR-378 06/27/89 Benzaldehyde 100-52-7 NE No Evidence NE No Evidence SE Some Evidence SE Some Evidence TR-377 11/20/89 ...
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Background Document: Styrene oxide; BSC RoC, Jan. 20-21, 2000 267KB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/bg_styrene_oxide_508.pdf
... The test material was 96.6% pure, with unspecified amounts of benzaldehyde, benzene, and ... The SO study material was 96.6% pure, with unspecified amounts of benzaldehyde, benzene, ...
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Captafol/o-Nitrotoluene Expert Panel Report Part A; RoC expert... 162KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2007/expertpanelmtgs/captafol_report_parta_508.pdf
... Extension Toxicology Network, Pesticide Information Profiles. http://extoxnet.orst.edu/pips/captafol.htm. Accessed on 10/6/04. 6. FR. 2006. Benzaldehyde, captafol, hexaconazole, ...
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TR-406: g-Butyrolactone (CASRN 96-48-0) in F344/N Rats and B6C3F1Mice... 11.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr406.pdf
... Study Historical Incidence at Southern Research Institute Benzaldehyde Dichlorvos F U r a ... at Southern Research Institute Benzaldehyde Dichlorvos Furan Furfural ...
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TR-438: Benzethonium Chloride (CASRN 121-54-0) in F344/N Rats... 10.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr438.pdf
... Impurities may include benzyl chloride, benzal chloride, benzyl alcohol, benzaldehyde, and benzyl- amine derivatives (CIR, 1982). PRODUCTION, USE, AND HUMAN EXPOSURE Benzethonium ...
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TR-572: Methyl trans-styryl ketone (CASRN 1896-62-4) in F344... 8.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr572_508.pdf
... Methyl trans-styryl ketone can be synthesized by a high yield Claisen-Schmidt conden- sation of benzaldehyde with acetone using activated barium hydroxide as a catalyst (Edwards et ...
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ICCVAM Evaluation of In Vitro Test Methods for Assessing Dermal... 3.1MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/cwgfinal02/cwgfinal.pdf
... NC 3R34/3R35 NC N/A 33 4-(Methylthio)-benzaldehyde ELECTRO NC NC NC N/A 39 2-Ethoxyethyl ... NC 3R34/3R35 NC N/A 33 4-(Methylthio)-benzaldehyde ELECTRO NC NC NC N/A 39 2-Ethoxyethyl ...
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Cumene: Preliminary Literature Search Strategy and List of References 698KB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/cumene-litsearch&references5oct2012_508.pdf
... Toxicology 15(3): 219-232. 61. Foster P, Laffond M, Baussand P, Jacob V, Denis I. 1991. VOC measurements in the Grenoble area and study of the benzaldehyde behavior in a simulation ...
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TR-402: Furan (CASRN 110-00-9) in F344 Rats and B6C3F1 Mice(Gavage... 31.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr402.pdf
... at Southern Research Institute Benzaldehyde 2150 0/50 2/50 Dichlmvos 0!50 1/50 1/... at Southern Research Institute Benzaldehyde Dichlorvos Furan Furfural ...
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TR-431: Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1Mice... 15.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr431.pdf
... namely ; benzyl alcohol (NTP, 1989)and benzaldehyde (Kluwe I / et al., 1983; NTP, 1990). ... nephropathy in rats and mice after subchronic oral exposure t o benzaldehyde. Food Chem. ...
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TR-466: Ethylbenzene (CASRN 100-41-4) in F344/N Rats and B6C3F1Mice... 11.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr466.pdf
... Toluene is metabolized by the liver cytochrome P 450 enzyme system to benzyl alcohol, benzaldehyde, and benzoic acid via methyl hydroxylation and is excreted in the urine as ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... Report TR-378 PDF (14.17 MB) Toxicology and Carcinogenesis Studies of Benzaldehyde (CASRN 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1990 Technical Report ...
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CERHR Monograph: Potential Human Reproduction Effects of Styrene 6.0MB
https://ntp.niehs.nih.gov/ntp/ohat/styrene/styrene_monograph.pdf
... have.been.detected.in.styrene.include.benzaldehyde,.hydrogen.peroxides,.benzene,.sulfur,.chlorides,. alpha-methylstyrene,.vinyltoluene,.phenylacetylene,.and.p-divinylbenzene.(4). ...
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TR-377: CS2 (94 o-Chlorobenzalmalononitrile, CASRN 2698-41-1... 12.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr377.pdf
... With rats in the chambers, the average percentage of o-chloro- benzaldehyde in the 0.15, 0.56, and 1.9 mg/m3 (total organics) chambers were 31%, 25%, and 21%, respectively, For ...
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Background Review Document: In Vitro Test Methods for Assessing... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/epis_brd0801.pdf
... NC 3R34/3R35 NC N/A 33 4-(Methylthio)-benzaldehyde ELECTRO NC NC NC N/A 39 2-Ethoxyethyl ... NC 3R34/3R35 NC N/A 33 4-(Methylthio)-benzaldehyde ELECTRO NC NC NC N/A 39 2-Ethoxyethyl ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... TR-378 PDF (14.17 MB) Toxicology and Carcinogenesis Studies of Benzaldehyde (CASRN 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1990 Long-Term ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... Report TR-378 PDF (14.17 MB) Toxicology and Carcinogenesis Studies of Benzaldehyde (CASRN 100-52-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1990 Technical Report ...
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TR-414: Pentachloroanisole (CASRN 1825-21-4) in F344 Rats and... 15.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr414.pdf
... at Southern Research Institute Benzaldehyde Dichlorvos Fulran Furfural ... Historical Incidence at Southern Research Institute Benzaldehyde Dichlorvos Furan Furfural ...
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ICCVAM Test Method Evaluation Report on the Reduced LLNA 21.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ld/tmer.pdf
... chemicals GSK 2-Bromo-5-hydroxy- benzaldehyde - 2973-80-0 201.02 2.45 Solid ... - - Liquid Lipids Lalko & Api Benzaldehyde - 100-52-7 106.12 1.80 Liquid ...
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TR-473: Theophylline (CASRN 58-55-9) in F344/N Rats and B6C3F1Mice... 11.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr473.pdf
... at Southern Research Institute Benzaldehyde 10/50 Furan 8/50 Furfural 13/50 ... at Southern Research Institute Benzaldehyde 28/50 1/50 28/50 Furan 15/50 1/50 15/...
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TR-550: Cresols (CASRN 1319-77-3) in Male F344/N Rats and Female... 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr550.pdf
... oxidation to p-hydroxybenzoic acid through p-hydroxy- benzaldehyde (Bray et al., 1950). ... following inhalation exposure to 500 ppm benzaldehyde for 14 days (Laham et al., 1991). ...
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Performance Standards for In Vitro Test Methods for Skin Corrosion 6.3MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/ps/ps044510.pdf
... organic base NC 5.5 4-(methylthio)-Benzaldehyde 3446-89-7 electrophile NC 6.8 Sodium ... organic base NC 5.5 4-(methylthio)-Benzaldehyde 3446-89-7 electrophile NC 6.8 Sodium ...
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TR-418: p-Nitroaniline (CASRN 100-01-6) in B6C3F1Mice (Gavage... 10.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr418.pdf
... at Southern Research Institute Benzaldehyde Dichlorvos Furan Furfural ' ... at Southern Research Institute Benzaldehyde Dichlorvos Furan Furfural ...
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TR-354: Dimethoxane (CASRN 828-00-2) (Commercial Grade) in F344... 11.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr354.pdf
... Benzaldehyde - + + - - Diiinethoxane, NTP TR 354 64 V. REFERENCES 65 Dimethoxane, NTP TR 354 V. REFERENCES 1. Ames, B.N.; McCann, J.; Yamasaki, E. (1975) Methods for detecting ...
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RoC Monograph: Cumene; September 2013 2.3MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/cumene_508.pdf
... Fed Regist. 77(36):10754-10755. Foster P, Laffond M, Baussand P, Jacob V, Denis I. 1991. VOC measurements in the Grenoble area and study of the benzaldehyde behavior in a ...
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Background Document: RoC: Captafol; 2010 1.1MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/captafol_final_508.pdf
... Accessed on 10/5/06. 48. FR. 2006. Benzaldehyde, captafol, hexaconazole, paraformaldehyde, sodium dimethyldithiocarbamate and tetradifon: tolerance actions. Fed Regist 71(80): ...
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TR-494: Anthraquinone (CASRN 84-65-1) in F344/N Rats and B6C3F1Mice... 10.7MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr494.pdf
REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANTHRAQUINONE (CAS NO. 84-65-1) IN F344/N RATS AND B6C3F 1 MICE (FEED STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 ...
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TR-503: Chloral Hydrate (Ad Libitum and Dietary Controlled) ... 5.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr503.pdf
... Feed 366 Hydroquinone Gavage 378 Benzaldehyde Gavage 381 d-Carvone Gavage 382 ... Toxicology and Carcinogenesis Studies of Benzaldehyde (CAS No. 100-52-7) in F344/N Rats ...
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RoC Background Document: Diesel Exhaust Particulates; Dec. 2... 5.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/dieselexhaust_508.pdf
... (IARC 1989; ARB 1989) benzacenaphthylene (IARC 1989) benzacridines (IARC 1989) benzaldehyde (Volkswagen 1989) benz[a]anthracene (ARB 1993; IARC 1989; Schuetzle 1983; ...