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TR-440: Ozone (CASRN 10028-15-6) and Ozone/NNK (CASRN 10028-15... 16.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr440.pdf
440 TOXICOLOGY AND CARCINOGENESIS STUDIES OF OZONE (CAS NO. 10028-15-6) AND OZONE/NNK (CAS NO. 10028-15-6/64091-91-4) IN F344/N RATS AND B6C3Fl MICE (INHALATION STUDIES) FOREWORD ...
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Abstract for TR-440 74KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr440
40abs Abstract for TR-440 Toxicology and Carcinogenesis Studies of Ozone and Ozone/NNK in F344/N Rats and B6C3F1 Mice (Inhalation Studies) Substances: Ozone (CASRN 10028-15-6) ...
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Minutes: BSC TRRS; Nov. 16, 1993 800KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1993/nov/trrs16nov1993mins_508.pdf
NTP/HEI (Health Effects Institute) Collaborative Ozone Studies and Peer Review of Draft ... Hart, 9191541-3971. Contents NTPIHEI Collaborative Ozone Studies Title Page Number ...
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Target Organs and Levels of Evidence for TR-440 65KB
https://ntp.niehs.nih.gov/data/tr/400s/tr440levels
Target Organs and Levels of Evidence for TR-440 Toxicology and Carcinogenesis Studies of Ozone (CASRN 10028-15-6) and Ozone/NNK (CASRN 10028-15-6/64091-91-4) in F344/N Rats and ...
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Minutes: BSC TRRS; April 18, 1988 4.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1988/apr/88apr18trrsmins_508.pdf
Plans for Toxicologic Evaluation of Ozone Route Gavage Feed Feed Feed Gavage Gavage ... time period for comments. 19 Proposed Plans for Toxicologic Evaluation of Ozone Or. ...
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Abstract for TR-544 74KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr544
nitrogen-containing organic compounds, in water containing bromine; it is also a by-product of ozone disinfection. Dibromoacetonitrile is not produced on a large industrial scale. ...
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RoC Concept:1-Bromopropane 268KB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/concepts/1-bp_concdocroc8-30-12_508.pdf
substituted for substances identified as suspect carcinogens or ozone-depleting chemicals. ... substances that have been identified as suspect carcinogens or ozone-depleting chemicals. ...
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TR-564: 1-Bromopropane (CASRN 106-94-5) in F344/N Rats and B6C3F1... 9.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr564.pdf
... has been marketed as a replacement for ozone depleting refrigerants. 1-Bromopropane was ... it is considered to have a relatively low ozone depletion potential and has been marketed ...
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RoC Monograph: 1-Bromopropane; September 2013 1.9MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/1bromopropane_508.pdf
... for substances identified as suspected carcinogens or ozone-depleting chemicals. ... for substances identified as suspect carcinogens or ozone- depleting chemicals. ...
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RoC Background Document: Ultraviolet (UV) Radiation, Broad Spectrum... 3.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/uv_no_appendices_508.pdf
... UVC is absorbed by the ozone layer and does not contribute to solar exposure, and studies ... UVB normally is absorbed by the ozone layer; it constitutes 5% of solar UVR and is the ...
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Agenda: BSC TRRS; Nov. 19, 2009 31KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2009/november/agenda111909.pdf
Used as a relatively nonflammable, nontoxic, fast-drying, and inexpensive solvent for adhesive resins, and as a replacement for ozone-depleting refrigerants. Inhalation, male and ...
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Minutes: BSC; April 6, 1994 2.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1994/april/19940406bscmins_508.pdf
... Boorman concluded by commenting on the results of two-year and lifetime studies with ozone ... In response to a question from Dr. Hoel about pulmonary effects of ozone and implications ...
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Abstract for TR-564 79KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr564
inexpensive solvent for adhesive resins, and has been marketed as a replacement for ozone depleting refrigerants. 1-Bromopropane was nominated for study by the Occupational ...
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Nose - Hyperplasia, Goblet Cell - Nonneoplastic Lesion Atlas 294KB
https://ntp.niehs.nih.gov/atlas/nnl/respiratory-system/nose/HyperplasiaGobletCell
Harkema JR, Hotchkiss JA, Henderson RF. 1989. Effects of 0.12 and 0.80 ppm ozone on rat ... 1994. Consequences of Prolonged Inhalation of Ozone on F344/N Rats: Collaborative Studies. ...
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Studies on Historical Control Reports for NIH-07 Feed 312KB
https://ntp.niehs.nih.gov/ntp/historical_controls/nih-07_1999/histcont_1999_by_list_of_studies_508.pdf
Rats Fischer344 Inhalation Air Ozone Rats Fischer344 Inhalation Air ... Nitromethane Mice B6C3F1 Inhalation Air Ozone Mice B6C3F1 Inhalation Air Tetrahydrofuran ...
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Nose - Hyperplasia, Goblet Cell 339KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/respiratory/nose/hypgc/nose-hyperplasia-goblet-cell-pdf_508.pdf
... RF. 1989. Effects of 0.12 and 0.80 ppm ozone on rat nasal and nasopharyngeal epithelial ... 1994. Consequences of Prolonged Inhalation of Ozone on F344/N Rats: Collaborative Studies. ...
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CERHR Monograph: 1-Bromopropane 1.1MB
https://ntp.niehs.nih.gov/ntp/ohat/bromopropanes/1-bromopropane/1bp_monograph.pdf
... by the EPA as a possible replacement for ozone-depleting substances such as CFC-113 and ... in identifcation of substitutes for ozone-depleting substances (20). 1-BP is being ...
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RoC Profile: Ultraviolet-Radiation-Related Exposures; 15th RoC... 169KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/ultravioletradiationrelatedexposures.pdf
... UVC is absorbed by the ozone layer and does not contribute to UVR exposure from solar ... UV wavelengths are completely absorbed by ozone, molecular oxygen, and water vapor in the ...
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Nose, Epithelium - Hyperplasia - Nonneoplastic Lesion Atlas 300KB
https://ntp.niehs.nih.gov/atlas/nnl/respiratory-system/nose/Epithelium-Hyperplasia
... National Toxicology Program. 1994. NTP TR-440. Toxicology and Carcinogenesis Studies of Ozone (CAS No. 10028-15-6) and Ozone/NNK (CAS No. 10028-15-6/ 64091-91-4) in F344/N Rats and ...
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TR-467: Chloroprene (CASRN 126-99-8) in F344/N Rats and B6C3F1Mice... 14.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr467.pdf
... generated hydroxyl radicals or reaction with ozone (ACGIH, 1985). Reaction of chloroprene with hydroxyl radicals or ozone may form formaldehyde, 1-chloroacrolein, glyoxal, ...
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TR-544: Dibromoacetonitrile (CASRN 3252-43-5) in F344/N Rats... 7.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr544.pdf
... compounds, in water containing bromine; it is also a by- product of ozone disinfection. ... containing bromine; it is also a by- product of ozone disinfection (Huang et al., 2003). ...
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Nose, Turbinate - Atrophy - Nonneoplastic Lesion Atlas 291KB
https://ntp.niehs.nih.gov/atlas/nnl/respiratory-system/nose/Turbinate-Atrophy
Academic Press, San Diego, 315-337. Harkema JR, Catalano PJ, Hotchkiss JA. 1997. Consequences of Prolonged Inhalation of Ozone on F344/N Rats: Collaborative Studies. Part XII: ...
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BSC Meeting: Draft RoC Concept: Di- and Tri- Haloacetic Acids... 240KB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2016/april/haa_508.pdf
... Disinfectants used for drinking water include chlorine, chloramines, ozone, chlorine ... by disinfection with chloramines, chlorine dioxide, and ozone (Richardson et al. 2007). ...
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RoC Background Document: Isoprene; Dec. 2-3, 1998 2.2MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/isoprene_oneapp_508.pdf
... radicals (HO.) and tropospheric ozone (0 3 ) and may act as photochemical smog precursors. ... hours and 1 to 2 hours based on its rates of reactions with ozone and hydroxyl radicals. ...
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Literature Search Results: Systematic Review of Traffic-Related... 275KB
https://ntp.niehs.nih.gov/ntp/ohat/airpollchildhealth/literature_results_508.pdf
... AND ("sulfur dioxide"[mh] OR "sulfur dioxide"[tiab] OR S02[tiab] OR ozone[mh] OR ozone[tiab] OR O3[tiab] OR "hydrogen sulfide"[mh] OR "hydrogen sulfide"[tiab] OR ...
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Nose, Epithelium - Hyperplasia 482KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/respiratory/nose/ephyp/nose-epithelium-hyperplasia-pdf_508.pdf
... NTP TR-440. Toxicology and Carcinogenesis Studies of Ozone (CAS No. 10028-15-6) and Ozone/NNK (CAS No. 10028-15-6/ 64091-91-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies). ...
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Nose, Turbinate - Atrophy 305KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/respiratory/nose/tratrophy/nose-turbinate-atrophy-pdf_508.pdf
Academic Press, San Diego, 315-337. Harkema JR, Catalano PJ, Hotchkiss JA. 1997. Consequences of Prolonged Inhalation of Ozone on F344/N Rats: Collaborative Studies. Part XII: ...
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Nomination Background: 2,3-Butanedione (CASRN: 431-03-8) 1.8MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/artificial_butter_flavoring_508be.pdf
... Lung damage caused by ozone has also been suggested from the formation of reactive free ... Lung damage caused by ozone has also been suggested to be due to the formation of reactive ...
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Agenda: Adverse Outcome Pathways: From Research to Regulation 157KB
https://ntp.niehs.nih.gov/sites/default/files/iccvam/meetings/aop-wksp-2014/aop-wkspprogram-07292014-draft.pdf
... Exposure and Dosimetry Considerations for AOPs John Wambaugh, EPA 11:15-11:45: Ozone-Induced Lung Inflammation and Injury: From Mechanism to Adversity in Humans 2 Robert ...
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RoC Profile: Dimethylvinyl Chloride; 15th RoC 2021 171KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dimethylvinylchloride.pdf
... with a half-life of about 21 hours by reaction with photochemically produced hydroxyl radicals or 26 hours by reaction with atmospheric ozone, or to be removed by wet deposition. ...
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Peer Review Report: TRPRP; July 13, 2017 156KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2017/july/panel_report20170713.pdf
... Georgia Roberts briefed the panel on the draft NTP Technical Report on p-chloro-α,α,α-trifluorotoluene (PCTFT). PCTFT is a non-ozone-depleting solvent used in automobile body ...
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All Past Events 1004KB
https://ntp.niehs.nih.gov/events/past
... Session 4: The Risk Context Exposure and Dosimetry Considerations for AOPs John Wambaugh, EPA Ozone-Induced Lung Inflammation and Injury: From Mechanism to Adversity in Humans ...
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Adverse Outcome Pathways: From Research to Regulation 76KB
https://ntp.niehs.nih.gov/whatwestudy/niceatm/3rs-meetings/past-meetings/aop-wksp-2014
... Session 4: The Risk Context Exposure and Dosimetry Considerations for AOPs John Wambaugh, EPA Ozone-Induced Lung Inflammation and Injury: From Mechanism to Adversity in Humans ...
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Revised Draft ROC Monograph: Haloacetic Acids; Oct. 30, 2017 4.2MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/haadraftmonograph20171030.pdf
... in current use (chlorine, chloramine, ozone, and chlorine dioxide) (Richardson 2016, ... In disinfection, application of oxidants (chlorine, chloramine, chlorine dioxide, or ozone...
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1-Bromopropane: Preliminary Literature Search Strategy and List... 639KB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/1-bp-litsearch&references5oct2012_508.pdf
... U.S. Environmental Protection Agency. 260 pp. 22. EPA. 2007a. Protection of stratospheric ozone: listing of substitutes for ozone- depleting substances n-propyl bromide in solvent ...
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Lung - Emphysema - Nonneoplastic Lesion Atlas 292KB
https://ntp.niehs.nih.gov/atlas/nnl/respiratory-system/lung/Emphysema
... Triantaphyllopoulos K, Hussain F, Pinart M, Zhang M, Li F, Adcock I, Kirkham P, Zhu J, Chung KF. 2011. A model of chronic inflammation and pulmonary emphysema after multiple ozone ...
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Public Health Impact 1.5MB
https://ntp.niehs.nih.gov/media/impact
... The EPA finalizing a program to further reduce air pollution, including ozone and ... vehicles and engines, including ozone, particulate matter, and greenhouse gases. ...
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RoC Profile: 3-Chloro-2-methylpropene; 15th RoC 2021 123KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chloromethylpropene.pdf
... the vapor phase and be degraded by reaction with hydroxyl rad- icals, with an estimated half-life of 10 hours, and with ozone, with an estimated half-life of 27 hours (HSDB 2009). ...
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Draft ROC Monograph: Haloacetic Acids; June 6, 2017 3.1MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/haadraftmonograph.pdf
... in current use (chlorine, chloramine, ozone, and chlorine dioxide) (Richardson 2016, ... In disinfection, application of oxidants (chlorine, chloramine, chlorine dioxide, or ozone...
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Protocol: Evidence Map of Inflammation-Based Atherosclerosis... 643KB
https://ntp.niehs.nih.gov/sites/default/files/2023-07/protocol_atherosclerosis_supplementaljuly2023_508.pdf
... AND (sulfur-dioxide[mh] OR sulfur- dioxide[tiab] OR S02[tiab] OR ozone[mh] OR ozone[tiab] OR O3[tiab] OR hydrogen- sulfide[mh] OR hydrogen-sulfide[tiab] OR H2S[tiab] ...
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Stomach, Glandular Stomach, Epithelium - Hyperplasia 285KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/respiratory/lung/emphysem/lung-emphysema-508.pdf
... K, Hussain F, Pinart M, Zhang M, Li F, Adcock I, Kirkham P, Zhu J, Chung KF. 2011. A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice. ...
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RoC Profile: 1,4-Dioxane; 15th RoC 2021 156KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dioxane.pdf
... Because use of 1,1,1-trichloroeth- ane has been limited under the Montreal Protocol on Substances that Deplete the Ozone Layer, this use is not expected to be significant. ...
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RoC Profile: Isoprene; 15th RoC 2021 158KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/isoprene.pdf
... by re- action with hydroxyl radicals, and 19 hours by reaction with ozone (HSDB 2009). ... resi- dential, and rural areas as an indicator of the potential for ozone for- mation. ...
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RoC Profile: Tetrafluoroethylene; 15th RoC 2021 132KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tetrafluoroethylene.pdf
... If released to air, tetrafluoroethylene will exist in the vapor phase and react with photochemically produced hydroxyl radicals and ozone. If released to water or soil, it is not ...
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RoC Profile: 1,1-Dimethylhydrazine; 15th RoC 2021 131KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dimethylhydrazine.pdf
... If released to air, 1,1-dimethylhydrazine will exist entirely in the vapor phase and will react quickly with ozone, with a half-life of about 16.5 minutes, or with hydroxyl ...
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RoC Background Document: Chloroprene; Oct. 30-31, 1997 5.9MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/chloroprene1_508be.pdf
... generated hydroxyl radicals with smaller amounts removed by reaction with ozone. ... with photochemically gen- erated hydroxyl radicals or reaction with ozone (ACGIH, 1985). ...
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RoC Background Document: Solar Radiation & Exposure to Sunlamps... 3.7MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/solar_rad_sunlamps_2apps_508.pdf
... The short wavelength UVC rays are absorbed by ozone, molecular oxygen, and water vapor in ... Decreases in the stratospheric ozone caused by chemicals generating free radicals increase ...
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RoC Profile: 1-Bromopropane; 15th RoC 2021 194KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/bromopropane.pdf
... and commercial uses as a substitute for ozone-depleting chemicals or suspected ... EPA SNAP program reviews alternatives to ozone-depleting substances and approves the use ...
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TR-106: Trichlorofluoromethane (CASRN 75-69-4) 3.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr106.pdf
... depletion of the Earth's stratospheric ozone * The CAS registry number is 75-69-4. ... Sink for Chlorofluoro- methanes: Chlorine Atom-Catalysed Destruction of Ozone." ...
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TR-129: Trimethylthiourea (CASRN 2489-77-2) 2.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr129.pdf
... et al., 1976); and as an inhibitor of ozone fading of dyed polyamides (Lofquist and ... and P.R. Saunders, "Water-Soluble Thioureas to Inhibit Ozone Fading of Dyed Polyamides." ...
