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TR-154: Azobenzene (CASRN 103-33-3) 3.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr154.pdf
National Cancer Institute CARCINOGENESIS Technical Report Series No. 154 1979 BIOASSAY OF AZOBENZENE FOR POSSIBLE CARCINOGENICITY CAS No. 103-33-3 NCI-CG-TR-154 U.S. DEPARTMENT OF ...
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Azobenzene: Target Organs and Levels of Evidence for TR-154 57KB
https://ntp.niehs.nih.gov/data/tr/100s/tr154levels
1 Azobenzene: Target Organs and Levels of Evidence for TR-154 Bioassay of Azobenzene for Possible Carcinogenicity (CASRN 103-33-3) Chemical (Study Title) CASRN Peer Review Date ...
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Abstract for TR-154 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr154
4abs Abstract for TR-154 Bioassay of Azobenzene for Possible Carcinogenicity CASRN: 103-33-3 Chemical Formula: C12H10N2 Molecular Weight: 182.225 Synonyms/Common Names: ...
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Mechanistic Insights from Profiling Chemical-Mediated Transcription... 6.9MB
https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-medvedev-poster.pdf
Identifying Profile Characteristics Associated with Predicting Toxicity Azobenzene's ... Figure 6: The transcription factor activation profile for azobenzene was compared to all ...
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RoC Profile: 4-Dimethylaminoazobenzene; 15th RoC 2021 183KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dimethylaminoazobenzene.pdf
azobenzene in newborn mice, males developed liver tumors by 1 year of age. In dogs of unspecified sex, oral exposure to 4-dimethyl- amino azobenzene caused benign ...
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Abstract for TOX-65 65KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox065
CASRN: 14047-09-7 Chemical Formula: C12H6Cl4N2 Molecular Weight: 320.0 Synonyms/Common Names: Azobenzene, 3,3',4,4'-tetrachloro-(8CI); diazene, bis(3,4-dichlorophenyl)-(9CI); TCAB ...
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Abstract for TR-558 90KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr558
CASRN: 14047-09-7 Chemical Formula: C12H6C14 N2 Molecular Weight: 320.0 Synonyms/Common Names: Azobenzene, 3,3',4,4'-tetrachloro-(8CI); 3,3',4,4'-tetrachloroazobenzene diazene, ...
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TR-558: 3,3',4,4'-Tetrachloroazobenzene (TCAB) (CASRN 14047-09... 22.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr558.pdf
... Chemical Formula: C 12 H 6 C l4 N 2 Molecular Weight: 320.0 Synonyms: Azobenzene, ... Chemical Formula: C 12 H 6 C l4 N 2 Molecular Weight: 320.0 Synonyms: Azobenzene, ...
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Spleen - Adipocyte Metaplasia - Nonneoplastic Lesion Atlas 288KB
https://ntp.niehs.nih.gov/atlas/nnl/immune-system/spleen/AdipocyteMetaplasia
Goodman DG, Ward JM, Reichardt WD. 1984. Splenic fibrosis and sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine ...
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Spleen - Adipocyte Metaplasia 314KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/immune/spleen/admetap/spleen-adipocyte-metaplasia-pdf_508.pdf
sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine hydrochloride, 4,4'- sulfonyldianiline, or D&C red no. 9. J Natl Cancer ...
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Spleen - Fibrosis - Nonneoplastic Lesion Atlas 292KB
https://ntp.niehs.nih.gov/atlas/nnl/immune-system/spleen/Fibrosis
Goodman DG, Ward JM, Reichardt WD. 1984. Splenic fibrosis and sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine ...
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Spleen - Fibrosis 442KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/immune/spleen/fibrosis/spleen-fibrosis-pdf_508.pdf
... References: Goodman DG, Ward JM, Reichardt WD. 1984. Splenic fibrosis and sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine ...
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TOX-73: Diazoaminobenzene (CASRN 136-35-6) 2.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox073.pdf
... benzene, o- and p-aminodiphenyl, diphenylamine, and azobenzene (Mortimore et al., 1979). ... Classification Mutagenicity Data Azobenzene CAS Number: 103-33-3 p-Aminoazobenzene ...
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TR-225: D & C Red No. 9 (CASRN 5160-02-1) in F344 Rats and B6C3F1Mice... 7.1MB
https://ntp.niehs.nih.gov/go/tr225
... Swenberg suggested that the discussion on page 60, which notes that azobenzene produces ... In reports on the bioassay of aniline (NCI, 1978), azobenzene (NCI, 1979), and ...
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RoC Profile: Nitrobenzene; 15th RoC 2021 133KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitrobenzene.pdf
... Most nitrobenzene (97%) is used in the manufacture of aniline (IARC 1996, HSDB 2009). Miscellaneous uses include the manufacture of benzidine, quinoline, azobenzene, pyroxylin ...
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TOX-43: o-,m-, and p-Chloroanilines (CASRNs 95-51-2; 108-42-9... 5.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox043.pdf
... Azobenzene, D & C Red No. 9, dapsone, and o-toluidine hydrochloride, all structurally ... 1990). o-Toluidine hydrochloride and azobenzene, compounds structurally related to ...
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RoC Background Document for Diazoaminobenzene; Nov. 22, 2002 1.3MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/daab_rg2_public_correct_no_app_508.pdf
... products of DAAB include benzene, o- and p-aminodiphenyl, diphenylamine, and azobenzene. ... and p-aminodiphenyl, diphenylamine, and azobenzene Mortimore et al. 1979 1.3 ...
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TR-360: N,N-Dimethylaniline (CASRN 121-69-7) in F344/N Rats and... 10.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr360.pdf
... otliei- compounds such as Dapsone, azobenzene, p-ichloroaniline, o-toluidine ... D & C Red No. 9 (NTP, 1'382), p-chloroaniline hydrochloride (NTP, 198'3), azobenzene (NCI, ...
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TOX-65: 3,3',4,4'-Tetrachloroazobenzene 2.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox065.pdf
... 6 4 2 Molecular Weight: 320.0 Synonyms: Azobenzene, 3,3N,4,4N-tetrachloro-(8CI); diazene, ... azoxybenzene and azobenzene: Potent inducers of aryl hydrocarbon hydroxylase. ...
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TR-351: para-Chloroaniline Hydrochloride (CASRN 20265-96-7) in... 12.2MB
https://ntp.niehs.nih.gov/go/tr351
... Azobenzene (NCI, 1979a), D & C Red No. 9 (NTP, 1982a), dapsone (NCI, 1977a), and a-tolui- ... 85 other aniline compounds, except for azobenzene and o-toluidine hydrochloride studies ...
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RoC Profile: Hydrazobenzene; 15th RoC 2021 129KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/hydrazobenzene.pdf
... Deg- radation of hydrazobenzene is reversible; hydrazobenzene undergoes oxidation to azobenzene under aerobic solutions, catalyzed by com- mon environmental cations such as ...
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TR-124: Piperonyl Sulfoxide (CASRN 120-62-7) 3.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr124.pdf
... All control and dosed rats were housed in the same room as rats on feeding studies of the following chemicals: (CAS 103-33-3) azobenzene (CAS 72-56-0) p,p'-ethyl-DDD All control ...
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TR-156: p,p'-Ethyl-DDD (CASRN 72-56-0) 3.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr156.pdf
... Rats administered p,p'-ethyl-DDD and their corresponding controls were housed in the same room as rats on feeding studies of the following chemicals: (CAS 103-33-3) azobenzene (CAS ...
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RoC Background Document for Nitrobenzene; Sept. 19, 2002 1.3MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/nbpub_no_appendices_508.pdf
... Nitrobenzene also is used in the manufacture of benzidine, quinoline, azobenzene, and ... to [ 14 C]nitrobenzene for the presence of azoxybenzene, azobenzene, and benzidine. ...
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TR-134: C.I. Vat Yellow 4 (CASRN 128-66-5) 3.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr134.pdf
... in the same room as mice on feeding studies of the following chemicals: (CAS 103-33-3) azobenzene (CAS 20941-65-5) ethyl tellurac (CAS 298-00-0) methyl parathion (CAS 88-06-2) ...
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TR-159: Phthalic Anhydride (CASRN 85-44-9) 3.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr159.pdf
... in the same room as mice on feeding studies of the following chemicals: (CAS 103-33-3) azobenzene (CAS 72-56-0) p,p'-ethyl-DDD (CAS 20941-65-5) ethyl tellurac (CAS 298-00-0) ...
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RoC Profile: Benzidine and Dyes Metabolized to Benzidine; 15th... 163KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/benzidineanddyesmetabolized.pdf
... Impurities, such as benzidine, 4-amino biphenyl, and 2,4-diamino- azobenzene, may be present in these dyes as a result of thermal or enzymatic decomposition (NIOSH 1980). There are ...
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TR-120: Piperonyl Butoxide (CASRN 51-03-6) 3.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr120.pdf
... of the following chemicals: (CAS 128-66-5) C. I. vat yellow 4 (amanthrene) (CAS 103-33-3) azobenzene (CAS 20941-65-5) ethyl tellurac (CAS 88-06-2) 2,4,6-trichlorophenol (CAS ...
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TR-152: Ethyl Tellurac (CASRN 20941-65-5) 3.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr152.pdf
... in the same room as mice on feeding studies of the following chemicals: (CAS 103-33-3) azobenzene (CAS 72-56-0) p,p'-ethyl-DDD (CAS 298-00-0) methyl parathion (CAS 85-44-9) ...
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TR-155: 2,4,6-Trichlorophenol (CASRN 88-06-2) 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr155.pdf
... in the same room as mice on feeding studies of the following chemicals: (CAS 103-33-3) azobenzene (CAS 128-66-5) C.I. vat yellow 4 (CAS 20941-65-5) ethyl tellurac (CAS 298-00-0) ...
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TR-157: Methyl Parathion (CASRN 298-00-0) 3.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr157.pdf
... in the same room as mice on feeding studies of the following chemicals: (CAS 103-33-3) azobenzene (CAS 128-66-5) C. I. vat yellow 4 (CAS 72-56-0) p,p'-ethyl-DDD (CAS 20941-65-5) ...
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TR-226: C.I. Solvent Yellow 14 (CASRN 842-07-9) in F344/N Rats... 7.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr226.pdf
... Details of these studies and of azobenzene and aniline hydrochloride are given in Table ... 103 Water Soluble (B6C3F1) 25,000 103 Azobenzene Rat M 400 105-106 (NCI, 1979) (F344) F ...
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RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf
... Anthracene, 2-methyl- 613-12-7 192.26 Anthracene, 9-methyl- 779-02-2 192.26 Azobenzene 103-33-3 182.23 Benz(a)anthracene 56-55-3 228.29 Benzamide, N-N-diethyl-3-methyl- (DEET) ...
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RoC Background Document: Dyes Metabolized to Benzidine (Benzidine... 8.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/dyesmetabenzidine_508.pdf
... in 1845 by reduction of azobenzene with ammonium sulphide, followed by treatment of the hydrazobenzene with sulphuric acid and treatment with a base to release the free benzidine. ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... Clear Evidence N No Evidence P Clear Evidence P Clear Evidence TR-154 12/13/78 Azobenzene 103-33-3 P Clear Evidence P Clear Evidence N No Evidence N No Evidence TR-153 10/25/78 ...
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TOX-33: 2-Chloronitrobenzene (CASRN 88-73-3) and 4-Chloronitrobenzene... 10.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox33.pdf
... The samples of 2-chloronitrobenzene and 4-chloronitrobenzene were screened for 0 1,2-dichlorobenzene, azobenzene, and isomers of nitrophenol, nitroaniline, chloroanifine, and ...
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Draft RoC Monograph for ortho-Toluidine: Literature Search Strategy... 1.1MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/otol_literaturesearch20130815_508.pdf
... sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine hydrochloride, 4,4'-sulfonyldianiline, or D & C red No. 9. J Natl ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... 1979 Technical Report TR-154 PDF (3.56 MB) Bioassay of Azobenzene for Possible Carcinogenicity (CASRN 103-33-3) 1979 Technical Report TR-153 PDF (2.5 MB) Bioassay of ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... 1979 Technical Report TR-154 PDF (3.56 MB) Bioassay of Azobenzene for Possible Carcinogenicity (CASRN 103-33-3) 1979 Technical Report TR-153 PDF (2.5 MB) Bioassay of ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... Long-Term Carcinogenicity TR-154 PDF (3.56 MB) Bioassay of Azobenzene for Possible Carcinogenicity (CASRN 103-33-3) 1979 Long-Term Carcinogenicity TR-153 PDF (2.5 MB) Bioassay ...
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TR-201: Carcinogenesis 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN... 5.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr201.pdf
... Elsevier/North-Holland Biomedical Press, 5_: 109-150, 1980. Mercier, M., Gilbert, P., Roberfroid, M., and Poncelet, F., Mutagenic study of chlorinated derivatives of azobenzene. ...
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TR-418: p-Nitroaniline (CASRN 100-01-6) in B6C3F1Mice (Gavage... 10.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr418.pdf
... hydrochloride (NCI, 1979b), and azobenzene (NCI, 1979c), and in a carcinogenicity ... Bioassay of Azobenzene for Possible Carcinogenicity (CAS No. 103-33-3). Technical Report ...
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TOX-23: o-,m-, and p- Nitrotoluenes (CASRNs 88-72-2, 99-08-1... 15.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox023.pdf
...methyl-4-dimethylamino-azobenzene (Dempo et al., 1975) and furan (Maronpot, et al., 1991). ... aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine hydrochloride, ...
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TR-092: Hydrazobenzene (CASRN 122-66-7) 4.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr092.pdf
... that the compound could readily oxidize to azobenzene, a known hepatocarcinogen. A Subgroup member noted that, in any case, Hydrazobenzene probably is metabolized to azobenzene. ...
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TOX-44: o-Nitrotoluene (CASRN 88-72-2) ando-Toluidine Hydrochloride... 1.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox044.pdf
... Splenic fibrosis and sarcomas i n F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, azobenzene, o-toluidine hydrochloride, 4,4 -sulfonyldianiline, or D & C Red ...
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TR-209: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6... 8.5MB
https://ntp.niehs.nih.gov/go/tr209
... Biomedical Press, 5.: 109-150, 1980. Mercier, M . , Gilbert, P., Roberfroid, M . , and Poncelet, F., Mutagenic study of chlorinated derivatives of azobenzene. Arch. Int. Physiol. ...
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TR-278: 2,6-Xylidine (2,6-Dimethylaniline) (CASRN 87-62-7) in... 9.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr278.pdf
... Public Health Service, National Institutes of Health, Bethesda, MD. 53 p. 54. National Cancer Institute (NCI) (1979~) Bio- assay of Azobenzene for Possible Carcinogenici- ty. ...
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TR-442: p-Nitrobenzoic Acid (CASRN 62-23-7) in F344/N Rats and... 15.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr442.pdf
... Splenic fibrosis and sarcomas in F344 rats fed diets containing aniline hydrochloride, p-chloroaniline, o-toluidine azobenzene, hydrochloride, 4,4'-sulfonyldianiline, or D & C Red ...
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TOX-66: 3,3',4,4'-Tetrachloroazoxybenzene 3.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox066.pdf
... Toxicol. 22, 517-554. Poland, A., Glover, E., Kende, A.S., DeCamp, M., and Giandomenico, C.M. (1976). 3,4,3N,4N-Tetrachloro azoxybenzene and azobenzene: Potent inducers of aryl ...