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Target Organs and Levels of Evidence for TR-394 56KB
https://ntp.niehs.nih.gov/data/tr/300s/tr394levels
103-90-2) in F344 Rats and B6C3F1 Mice (Feed Studies) Chemical (Study Title) CASRN Peer Review Date Route/Exposure Levels Study Laboratory Acetaminophen (4-hydroxyacetanilide) ...
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Developing an in vitro integrated organ model for pharmacokinetic... 3.3MB
https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2023/20230130-iccvam-cop-mckim-508.pdf
... Model Intestine Liver Kidney APAP - Kinetics and Toxicity logP = 0.5 0 200 400 600 800 1000 1200 1400 1600 1800 2000 0 5 10 15 20 25 30 35 40 45 50 APAP Concentration (µM) ...
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Validation of In Vitro Cytotoxicity Test Methods: Test Chemicals 188KB
https://ntp.niehs.nih.gov/iccvam/methods/acutetox/invitrocyto/ivcytodocs/valstdchm.pdf
Test Chemicals Test Chemical CAS # Molecular Weight Supplier Product Code Purity (%) Acetaminophen 103-90-2 151.20 SIGMA A7085 99 Acetonitrile 75-05-8 41.05 SIGMA A3396 99.5 ...
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Abstract for TR-394 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr394
Toxicology and Carcinogenesis Studies of Acetaminophen in F344/N Rats and B6C3F1 Mice (Feed Studies) CASRN: 103-90-2 Chemical Formula: C8H9NO2 Molecular Weight: 151.16 Synonyms/...
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Abstract for RACB83079 58KB
https://ntp.niehs.nih.gov/publications/abstracts/repro/racb83079
Acetaminophen: Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed CASRN: 103-90-2 Chemical Formula: C8H9NO2 Molecular Weight: 151.16 Report Date: Nov. ...
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Application of CATMoS to Ecological Risk Assessment 2.4MB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2021/ppt/2021_sacatm_s2b-1_mansouri_v3_508.pdf
... Ns,me CASRN .!.J .!.J Acetaminophen 103-90-2 Endosu lfan 115-29-7 3.Phenylprop.2-enal ... CASRN User CASRNs 104-55-2 78 -70- 6 103-90-2 101-02 -a 115-29-7 Add chemicals w ith ...
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Minutes: BSC TRRS; Nov. 19, 1990 1.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1990/nov/trrs19nov1990mins_508.pdf
... Long-Term S t u d i e s 103-90-2 7782-50-5 10599-90-3 2429-74-5 74-83-9 79-11-8 57-66-9 1271-19-8 Short-Term T o x i c i t v S t u d i e s 28300-74-5 8001-79-4 1319-77-3 100-41-4 I ...
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Developmental Neurotoxicity Screening Assay Chemical List | National... 429KB
https://www.niehs.nih.gov/research/atniehs/dtt/strategic-plan/health/developmental/chemical-list
... 14611-52-0 DTXSID9044584 Selegiline hydrochloride Neg Control 103-90-2 DTXSID2020006 Acetaminophen (4-hydroxyacetanilide) (paracetamol) Neg Control 62571-86-2 DTXSID1037197 ...
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TR-394: Acetaminophen (CASRN 103-90-2) in F344 Rats and B6C3F1Mice... 14.2MB
https://ntp.niehs.nih.gov/go/tr394
TOXICOLOGY AND CARCINOGENESIS STUDIES OF ACETAMINOPHEN (CAS NO. 103-90-2) IN F344/N RATS ... TOXICOLOGY AND CARCINOGENESIS STUDIES OF ACETAMINOPHEN (CAS NO. 103-90-2) IN F344/N RATS ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... No Evidence NE No Evidence SE Some Evidence TR-394 11/19/90 Acetaminophen (4-Hydroxyacetanilide) 103-90-2 NE No Evidence EE Equivocal Evidence NE No Evidence NE No Evidence TR-393 ...
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Report: International Workshop on In Vitro Methods for Assessing... 25.4MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf
... 6.66 165.4 2.9 113 1 Acetaminophen 103-90-2 409.70 2.71 2403.8 15.9 338.6 2.24 ... 19.6 158.52 14.2 113 1 Acetaminophen 103-90-2 409.70 2.71 2403.8 15.9 338.6 2.24 ...
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OECD Guidance Document 129: Using Cytotoxicity Tests to Estimate... 1.4MB
https://ntp.niehs.nih.gov/iccvam/suppdocs/feddocs/oecd/oecd-gd129.pdf
... acid 89-57-6 1667 46.7 3429 Organic compound; Carboxylic acid; Phenol Acetaminophen 103-90-2 47.7 518 2163 Organic compound; Amide Acetonitrile 75-05-8 7951 9528 3598 Organic ...
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ICCVAM Test Method Evaluation Report: In Vitro Cytotoxicity Test... 14.6MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/at-tmer-complete.pdf
... NHK IC 50 mg/kg mmole/kg µg/mL mM µg/mL mM 2000 < LD 50 ≤5000 mg/kg Acetaminophen 103-90-2 2404 15.90 47.66 0.3152 518.0 3.426 Potassium chloride 7447-40-7 2602 34.90 3555 ...
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ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf
... in NHK Assay (µg/mL) Acetaminophen 103-90-2 99 Sigma 8.1 4.7-1000 7.7 11.8-4000 ... f Mechanism of Lethaliy f Acetaminophen 103-90-2 2404 151.20 Organic compound; Amide ...
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MFDS NAMs Report: Regulatory Acceptance and Research Outcomes 20.5MB
https://ntp.niehs.nih.gov/sites/default/files/2024-01/MFDS_NAMs_Report-2023-508.pdf
... Image analysis for acetaminophen (APAP)-induced liver necrosis in SD rat using ... histopathology analysis of APAP-induced rat liver injury in preclinical ...
