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TR-514: trans-Cinnamaldehyde (Microencapsulated) (CASRN 14371... 8.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr514.pdf
THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF trans-CINNAMALDEHYDE (MICROENCAPSULATED) (CAS ... NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF trans-CINNAMALDEHYDE ...
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Abstract for TR-514 71KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr514
Toxicology and Carcinogenesis Studies of trans-Cinnamaldehyde in F344/N Rats and B6C3F1 ... Names: trans-Benzenepropenal; (E)-cinnamaldehyde; cinnamaldehyde; trans-cinnamic ...
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Target Organs and Levels of Evidence for TR-514 57KB
https://ntp.niehs.nih.gov/data/tr/500s/tr514levels
Toxicology and Carcinogenesis Studies of trans-Cinnamaldehyde (Microencapsulated) (CASRN ... Levels Study Laboratory trans-Cinnamaldehyde 14371-10-9 09/05/2002 ...
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Minutes: BSC TRRS; Sept. 5, 2002 128KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2002/sept/trrs5sept2002mins_508.pdf
.........6 V. trans-Cinnamaldehyde......The motion was approved unanimously with 10 votes. trans-Cinnamaldehyde Dr. Hooth, NIEHS, ...
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Historical Controls: All Routes and Vehicles for Mice; Studies... 255KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2006/m_hcrpt_allrte2006_508.pdf
.../24/97 728 100(1) 91(705) 46.0 trans-Cinnamaldehyde Battelle Columbus Laboratory .../25/97 733 100(5) 84(711) 45.6 trans-Cinnamaldehyde Battelle Columbus Laboratory ...
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Historical Controls: All Routes and Vehicles for Rats; Studies... 270KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2006/r_hcrpt_allrte2006_508.pdf
.../08/97 731 100(3) 60(689) 487.9 trans-Cinnamaldehyde Battelle Columbus Laboratory .../09/97 735 100(5) 70(706) 337.8 trans-Cinnamaldehyde Battelle Columbus Laboratory ...
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Historical Controls: All Routes and Vehicles for Mice; Studies... 317KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2007/m_hcrpt_allrte20070300_508.pdf
.../24/97 728 100(1) 91(705) 46.0 trans-Cinnamaldehyde Battelle Columbus Laboratory .../25/97 733 100(5) 84(711) 45.6 trans-Cinnamaldehyde Battelle Columbus Laboratory ...
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Historical Controls: All Routes and Vehicles for Rats; Studies... 252KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2007/r_hcrpt_allrte20070300_508.pdf
.../08/97 731 100(3) 60(689) 487.9 trans-Cinnamaldehyde Battelle Columbus Laboratory .../09/97 735 100(5) 70(706) 337.8 trans-Cinnamaldehyde Battelle Columbus Laboratory ...
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Cover Letter for Nomination of IVSA to ICCVAM (2012) 531KB
https://ntp.niehs.nih.gov/iccvam/methods/immunotox/ivsa/ivsa-iccvamsubmissionletter-092712-508.pdf
... 4J SSL 1.41 - 73.1% 05/18/12 H 2 O 0.003% 6J SSL 2.29 + 81.9% 05/18/12 2 Cinnamaldehyde CA 104-55-2 SAFC EtOH 0.6% 4.34 + 32.5% 03/08/12 EtOH, H2O C 9 H 8 O 132.16 liquid ...
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ICCVAM Test Method Evaluation Report: LLNA BrdU-ELISA 35.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-elisa/tmer.pdf
... Phenols 0.8 (6.7) 1.081 (4.0) trans-Cinnamaldehyde Food additive; Fragrance agent ... 17.00, 17.00, 17.60, 20.00 trans-Cinnamaldehyde (4,1) AOO 3.37, 3.50, 4.11, 5.86 ...
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Application of CATMoS to Ecological Risk Assessment 2.4MB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2021/ppt/2021_sacatm_s2b-1_mansouri_v3_508.pdf
... 104-55-2 Acrolein 107-02.8 linalool 78.70.6 Union or lnter~ection Union Chemical Inp ut Select Ch emicals Quick List CASRN User CASRNs 104-55-2 78 -70- 6 ...
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Advancing Flexibility for Defined Approach Guidelines: Developing... 1.2MB
https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Sullivan-poster.pdf
... Human GHS LLNA GHS 2o3 pred. (hazard) ITS pred. (GHS) Benzylidene acetone* 122-57-6 Y 1A 1 1 1A Cinnamaldehyde* 104-55-2 Y 1A 1A 1 1A Diethyl maleate 141-05-9 N 1A 1B 1 1A DNCB* ...
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Validation of the Electrophilic Allergen Screening Assay (EASA... 1.3MB
https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-gordon-poster.pdf
... Benzyl salicylate Neg/Pos/Pos Neg/Pos/Pos Neg/Pos/Pos Neg/Pos/Pos Pos Pos-Neg/Pos Cinnamaldehyde Pos/Pos/Pos Pos/Pos/Pos Pos/Pos/Pos Pos/Pos/Pos Pos Pos/Pos Imidazolidinyl urea ...
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National Institute of Environmental Health Sciences: Michelle... 161KB
https://www.niehs.nih.gov/research/atniehs/dtt/assoc/opo/staff/michelle
... D. P., Fuciarelli, A. F., Graves, S. W., Johnson, J. D. and Bucher, J. R. (2004) Toxicology and carcinogenesis studies of microencapsulated trans-cinnamaldehyde in rats and mice. ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... Evidence NE No Evidence P Clear Evidence P Clear Evidence TR-514 09/05/02 trans-Cinnamaldehyde 14381-10-9 NE No Evidence NE No Evidence NE No Evidence NE No Evidence TR-513 09/...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... Report TR-514 PDF (8.54 MB) Toxicology and Carcinogenesis Studies of trans-Cinnamaldehyde (Microencapsulated) (CASRN 14381-10-9) in F344/N Rats and B6C3F1 Mice (Feed ...
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Minutes: BSC; Dec. 13, 1996 288KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1996/december/19961213_bsc_508.pdf
... Schwetz discussed the rationale for study and status of NTP studies on D & C Yellow No. 11, t-butylhydroquinone, polyvinyl alcohol, cinnamaldehyde, and ethoxyquin. He noted the ...
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Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf
... + Basketter et al. (1994); Basketter et al. (1996a) Cinnamic aldehyde// cinnamaldehyde 104-55-2 potential Michael- reactive agent fragrance// food additive (bakery series kit) ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... TR-514 PDF (8.54 MB) Toxicology and Carcinogenesis Studies of trans-Cinnamaldehyde (Microencapsulated) (CASRN 14381-10-9) in F344/N Rats and B6C3F1 Mice (Feed ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... Report TR-514 PDF (8.54 MB) Toxicology and Carcinogenesis Studies of trans-Cinnamaldehyde (Microencapsulated) (CASRN 14381-10-9) in F344/N Rats and B6C3F1 Mice (Feed ...
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ICCVAM Evaluation of In Vitro Test Methods for Assessing Dermal... 3.1MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/cwgfinal02/cwgfinal.pdf
... methacrylate ELECTRO NC NC NC N/A 46 Cinnamaldehyde ELECTRO NC NC NC N/A 37 Sodium ... methacrylate ELECTRO NC NC NC N/A 46 Cinnamaldehyde ELECTRO NC NC NC N/A 37 Sodium ...
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ICCVAM Test Method Evaluation Report on the LLNA: DA 30.4MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-da/tmer.pdf
... the allergic potency of alpha-hexyl cinnamaldehyde (HCA) and 2- mercaptobenzothiazole ... or 5% cinnamic aldehyde (CASRN: 104-55-2) were used as positive controls (Idehara ...
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TR-516: 2-Methylimidazole (CASRN 693-98-1) in F344/N Rats and... 9.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr516.pdf
... Incidence: Feed Studies trans-Cinnamaldehyde 1/50 1/50 2/50 Citral 3/50 1/50 4/50 ... Incidence: Feed Studies trans-Cinnamaldehyde 1/50 0/50 1/50 Citral 0/50 0/50 0/50 ...
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RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf
... g 99.8 Colorless Liquid Ambient Trans-Cinnamaldehyde (3- phenyl-2propanal) 1,2 BCBP7078V ... 126.58 Chrysene 218-01-9 228.29 Cinnamaldehyde 14371-10-9 132.16 Cycloheptane ...
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Background Review Document: In Vitro Test Methods for Assessing... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/epis_brd0801.pdf
... methacrylate ELECTRO NC NC NC N/A 46 Cinnamaldehyde ELECTRO NC NC NC N/A 37 Sodium ... methacrylate ELECTRO NC NC NC N/A 46 Cinnamaldehyde ELECTRO NC NC NC N/A 37 Sodium ...
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TR-518: Triethanolamine (CASRN 102-71-6) in B6C3F1Mice (Dermal... 5.0MB
https://ntp.niehs.nih.gov/go/tr518
... (gavage) 0/50 2/50 0/50 trans-Cinnamaldehyde (feed) 0/100 0/100 0/100 Citral ... (gavage) 2/50 3/50 5/50 trans-Cinnamaldehyde (feed) 3/100 2/100 5/100 Citral ...
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TR-513: Decalin (CASRN 91-17-8) in F344/N Rats and B6C3F1Mice... 11.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr513.pdf
... Controls Given NTP-2000 Diet a trans-Cinnamaldehyde (feed) 0/100 0/100 0/100 Citral ... Controls Given NTP-2000 Diet a trans-Cinnamaldehyde (feed) 5/100 0/100 5/100 Citral ...
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TR-533: Benzophenone (CASRN 119-61-9) in F344/N Rats and B6C3F1Mice... 10.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr533.pdf
... sulfone 0/50 trans-Cinnamaldehyde 0/100 2-Methylimidazole 0/49 ... sulfone 27/50 trans-Cinnamaldehyde 40/100 2-Methylimidazole 15/50 ...
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TR-551: Isoeugenol (CASRN 97-54-1) in F344/N Rats and B6C3F1... 6.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr551.pdf
... 1-propenyl analogs anethole, 3N-hydroxy-trans-anethole, isosafrole, and trans-cinnamaldehyde did not induce hepatic tumors, but cis- and trans-asarone were active; ...
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TOX-76: 2,4-Decadienal (CASRN 25152-84-5) 3.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox076.pdf
... Inhibition of steel corrosion in HCl by derivatives of cinnamaldehyde. Part II: ... Nasal and other tumours in rats given 3,4,5-trimethyoxy-cinnamaldehyde, a derivative of ...
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Minutes: BSC; Sept. 17, 2002 762KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2002/september/20020917bscsummmins_508.pdf
... in female rats and male mice. . trans-Cinnamaldehyde - used in flavors and fragrances - exposure by microencapsulation in feed - no evidence in male and female rats or mice. ...
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Performance Standards for In Vitro Test Methods for Skin Corrosion 6.3MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/ps/ps044510.pdf
... acid NA NC NC 3.7 Chromium(III) fuoride 7788-97-8 acid derivative 97 NC NC 3.9 Cinnamaldehyde 14371-10-9 electrophile 100 NC NC 3.9 Ethyl triglycol methacrylate 39670-09-2 acid ...
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ICCVAM Test Method Evaluation Report on the Reduced LLNA 21.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ld/tmer.pdf
... alcohol - 104-54-1 134.18 2.29 Solid Alcohols Gerberick Cinnamic aldehyde Cinnamaldehyde 104-55-2 132.16 2.29 Liquid Aldehydes Gerberick cis-4-Cyano-4-[3- (cyclopentyloxy)-4- ...
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TR-505: Citral (Microencapsulated) (CASRN 5392-40-5) in F344... 10.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr505.pdf
... (1994). Comparison of the toxicity of cinnamaldehyde when administered by ... Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, cur- cumin, ethacrynic acid, ...
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Application of Non-animal Test Methods and Defined Approaches... 22.2MB
https://ntp.niehs.nih.gov/iccvam/methods/immunotox/it/niceatm-it-report-june2020-final-wappx-508.pdf
... Lysine peptide (Ac-RFAAKAA-COOH), Store at ≤-20˚C, (RS synthesis, Louisville, KY) . Cinnamic Aldehyde, ~95% purity, (CAS# 104-55-2, Sigma-Aldrich #W228613 or equivalent) ...
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ICCVAM Report: Corrositex: An In Vitro Method for Assessing Dermal... 5.1MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf
... 1 II II p18, 19 p89 1-3-70841, #20 37 Cinnamaldehyde Aldehyde Neat NA NA NC NC ECVAM ECVAM ... 171.67 171.52 1 7 1 . 6 0 0 . 1 1 cinnamaldehyde 14371-10-9 Source: ECVAM Validation ...
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Usefulness and Limitations of the LLNA for Potency Categorization... 25.3MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-pot/tmer.pdf
... 5 1 V e h i c l e AOO AOO DMF C A S # 104-55-2 14371-10- 9 87-69-4 CHEMICAL STRUCTURE O ... Project No. 58H0508/062114. Report by BASF. ECPA. 2007b. Hexyl Cinnamaldehyde (HCA), ...
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TR-512: Elmiron (CASRN 37319-17-8) in F344/N Rats and B6C3F1Mice... 12.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr512.pdf
... (gavage) 2/50 23/50 14/50 32/50 trans-Cinnamaldehyde (feed) 0/100 14/100 13/100 26/100 ... (gavage) 0/50 4/50 4/50 trans-Cinnamaldehyde (feed) 4/100 1/100 5/100 Citral ...
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TR-535: 4-Methylimidazole (CASRN 822-36-6) in F344/N Rats and... 10.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr535.pdf
... Feed Studies Benzophenone 19/50 trans-Cinnamaldehyde 21/100 Citral 24/100 ... Benzophenone 14/50 2/50 16/50 trans-Cinnamaldehyde 9/100 7/100 14/100 Citral 12/100 9/...
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TR-550: Cresols (CASRN 1319-77-3) in Male F344/N Rats and Female... 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr550.pdf
... Benzophenone 0/50 1/50 trans-Cinnamaldehyde 0/100 0/100 Cresols 0/50 0/50 ... Benzophenone 1/50 Chromium picolinate monohydrate 0/50 trans-Cinnamaldehyde 1/100 Cresols ...
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TOX-14: p-Chloro-a,a,a-Trifluorotoluene (CASRN 98-56-6) 2.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox014.pdf
... and volatile chemicals such as trichloroethane, 2-ethylhexanol, cinnamaldehyde, and citral were successfully encapsulated using a starch-and-geletin mixture as the shell material. ...
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TR-378: Benzaldehyde (CASRN 100-52-7) in F344/N Rats and B6C3F1Mice... 14.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr378.pdf
... num (cis-DDP) induced cell inactivation by al- dehydes: Protection by benzaldehyde (Benz); po- tentiation by cinnamaldehyde (Cinn). Proc. Annu. Meet. Am. Assoc. ...
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TR-523: Diisopropylcarbodiimide (CASRN 693-13-0) in F344/N Rats... 10.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr523.pdf
... water) 8/50 2/50 1/50 11/50 trans-Cinnamaldehyde (feed) 5/100 0/100 0/100 5/100 Citral ... (drinking water) 1/50 trans-Cinnamaldehyde (feed) 2/100 Citral (feed) 6/99 ...
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TOX-55: trans-1,2-Dichloroethylene (CASRN 156-60-5) 3.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox055.pdf
... Hébert, C.D., Yuan, J., and Dieter, M.P. (1994). Comparison of the toxicity of cinnamaldehyde when administered by microencapsulation in feed or by corn oil gavage. Food Chem. ...
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RoC Background Document: Wood Dust; Dec. 13-14, 2000 1.2MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/wd_no_appendices_508.pdf
... Arbeitsmed Sozialmed Umweltmed 21:13-17. 74. Schoental,R. and S.Gibbard. (1972). Nasal and other tumours in rats given 3,4,5- trimethoxy-cinnamaldehyde, a derivative of ...
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TR-381: d-Carvone (CASRN 2244-16-8) in B6C3F1Mice (Gavage Studies... 6.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr381.pdf
... (3:7), saturated, under nitrogen, and in the dark (solvent sys- tem 2). trans-Cinnamaldehyde was the reference standard, and visualization was with a spray of 5% (w/v) ...
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TR-509: 2,4-Hexadienal (89% trans,trans Isomer, CASRN 142-83... 10.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr509.pdf
... Invest. 101, 1210-1218. Growcock, F.B., Frenier, W.W., and Andreozzi, P.A. (1989). Inhibition of steel corrosion in HCl by deriva- tives of cinnamaldehyde. Part II. ...
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Recommended Performance Standards for the LLNA 2.2MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ps/llnaperfstds.pdf
... 47 X X X X X 2-Mercaptobenzothiazole 149-30-4 Sol DMF 1.7 1 X X X X Cinnamic aldehyde 104-55-2 Liq AOO 3.0 1 X Only need HCA (since it is an OECD positive control, and also because ...
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Historical Controls: By Route and Vehicle for Mice; Studies started... 775KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2006/m_hcrpt_rte2006_508.pdf
.../24/97 728 100(1) 91(705) 46.0 trans-Cinnamaldehyde Battelle Columbus Laboratory .../25/97 733 100(5) 84(711) 45.6 trans-Cinnamaldehyde Battelle Columbus Laboratory ...
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Historical Controls: By Route and Vehicle for Rats; Studies started... 733KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2006/r_hcrpt_rte2006_508.pdf
.../08/97 731 100(3) 60(689) 487.9 trans-Cinnamaldehyde Battelle Columbus Laboratory .../09/97 735 100(5) 70(706) 337.8 trans-Cinnamaldehyde Battelle Columbus Laboratory ...