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TR-214: Caprolactam (CASRN 105-60-2) in F344 Rats and B6C3F1Mice... 4.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr214.pdf
NATIONAL TOXICOLOGY PROGRAM Technical Report Series No. 214 CARCINOGENESIS BIOASSAY OF CAPROLACTAM (CAS NO. 105-60-2) F344 RATS AND B6C3F1 MICE (FEED STUDY) U.S. DEPARTMENT OF ...
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Caprolactam: Target Organs and Levels of Evidence for TR-214 56KB
https://ntp.niehs.nih.gov/data/tr/200s/tr214levels
90 Caprolactam: Target Organs and Levels of Evidence for TR-214 Carcinogenesis Bioassay of Caprolactam (CASRN 105-60-2) in F344 Rats and B6C3F1 Mice (Feed Study) Chemical (Study ...
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Abstract for TR-214 60KB
https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr214
4abs Abstract for TR-214 Carcinogenesis Bioassay of Caprolactam in F344 Rats and B6C3F1 Mice (Feed Study) CASRN: 105-60-2 Chemical Formula: C6H11NO Molecular Weight: 113.16 ...
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Abstract for TOX-50 62KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox050
Cyclohexanone oxime is used primarily as a captive intermediate in the synthesis of caprolactam for the production of polycaprolactam (Nylon-6) fibers and plastics and also in a ...
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Abstract for TR-203 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr203
Approximately 90% of the phenol produced is used in the manufacture of phenolic (phenol formaldehyde) resins, caprolactam, bisphenol A, alkyl phenol, and adipic acid. The remainder ...
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TOX-50: Cyclohexanone Oxime 2.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox050.pdf
... intermediate in the synthesis of caprolactam for the production of polycaprolactam ... Primarily, it is used as a captive intermediate in the synthesis of caprolactam, which is ...
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Estimated Human Exposures and Comparison to Doses Used in Testing... 1.5MB
https://ntp.niehs.nih.gov/iccvam/meetings/kmd-symp-2020/ppt/09-dawson-508.pdf
... Number of NAICS Industries 4-Methyl-2- pentanone 108-10-1 326 0.67 18.30 445.62 2157.25 mg/m3 12 Caprolactam 105-60-2 68 0.82 6.72 57.85 57.85 mg/m3 1 Carbaryl 63-25-2 3 0.67 2.01 ...
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TR-216: 11-Aminoundecanoic Acid (CASRN 2432-99-7) in F344 Rats... 7.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr216.pdf
... ammoundecanoic acid were housed in rooms with mice on feeding studies of caprolactam (CAS No 105-60-2) (NTP TR 214, Rev 1982), bisphenol A (CAS No 80-05-7) (NTP TR 215, 1982), ...
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TR-203: Phenol for Possible Carcinogenicity (CASRN108-95-2) 4.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr203.pdf
... Approximately PHENOL of the phenol produced is used in the manufacture of phenolic (phenol formaldehyde) resins, caprolactam, bisphenol A, alkyl phenols, and adipic acid (NIOSH, ...
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TR-215: Bisphenol A (CASRN 80-05-7) in F344 Rats and B6C3F1Mice... 4.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr215.pdf
... studies on caprolactarn (CAS 105-60-2) were also being carried out. Mice fed bisphenol A were housed in a room in which feeding studies on caprolactam (CAS 105-60-2), ...
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TR-219: 2,6-Dichloro-p-Phenylenediamine (CASRN 609-20-1) in F344... 4.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr219.pdf
... were housed in a room in which feeding studies were being conducted on bisphenol A (CAS 80-05-7), 11- aminoundecanoic acid (CAS 2432-99-7), and caprolactam (CAS 105-60-2). ...
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TOX-24: 1,6-Hexanediamine Dihydrochloride (CASRN 6055-52-3) 1.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox024.pdf
... converted to 6-aminohexanoic acid and caprolactam by rat and rabbit liver aldehyde ... vitro metabolic conversion of 1,6-diaminohexane to 6-aminohexanoic acid and caprolactam. ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... E Equivocal Evidence E Equivocal Evidence N No Evidence TR-214 06/27/80 Caprolactam 105-60-2 N No Evidence N No Evidence N No Evidence N No Evidence TR-213 06/23/81 Butyl ...
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TR-251: Commercial Grade 2,4 (80)- and 2,6 (20)- Toluene Diisocyanate... 8.9MB
https://ntp.niehs.nih.gov/go/tr251
... Rats: diallyl phthalate, 2,6-dichloro- p-phenylenediamine, caprolactam; Mice: diallyl phthalate, 2,6-dichloro-p-phenylene- diamine, caprolactam Toluene diisocyanate was dissolved ...
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RoC Monograph: Cumene; September 2013 2.3MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/cumene_508.pdf
... Other applications for phenol include phenolic resins to bond construction materials (e.g., plywood and composition board), caprolactam to produce nylon-6 (e.g., carpet fibers and ...
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Nomination Background: 1-Butyl-3-methylimidazolium chloride ... 1.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/ionic_liquids_508.pdf
... This French patent relates to manufacture of nitriles used in the production of adiponitrile, which is a precursor for synthesis of hexamethylenediamine, ε-caprolactam, and nylon ...
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RoC Background Document: Tetrafluoroethylene; March 1999 4.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/tetrafluoroethylene1.pdf
... Vinyl chloride, polyvinyl chloride and vinyl chloride-vinyl acrylonitrile copolym.ers ...... 73 Caprolactam and nylon 6 . . . . . . . . . . . . . . ...
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TR-245: Melamine (CASRN 108-78-1) in F344/N Rats and B6C3F1Mice... 8.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr245.pdf
... -26' C ; 3Wp7Wo relative humidity Rats: toluene diisocyanate; diallyl phthalate; caprolactam; diphenylmethane diisocyanate; 2,6dichloro-p-phenylene- diamine; Mice: bisphenol A; ...
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TR-310: Marine Diesel Fuel (NO CAS) and JP-5 Navy Fuel (CASRN... 10.1MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr310.pdf
... Caprolactam 0/60 0150 Bisphenol A 0149 0/60 11-Aminoundecanoic acid 0/60 (b) 1/60 ... Incidence at Litton Bionetics, Inc. Caprolactam Bisphenol A 11-Aminoundecanoic acid ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... 1982 Technical Report TR-214 PDF (4.06 MB) Carcinogenesis Bioassay of Caprolactam (CASRN 105-60-2) in F344 Rats and B6C3F1 Mice (Feed Study) 1982 Technical Report TR-213 PDF ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... Long-Term Carcinogenicity TR-214 PDF (4.06 MB) Carcinogenesis Bioassay of Caprolactam (CASRN 105-60-2) in F344 Rats and B6C3F1 Mice (Feed Study) 1982 Long-Term Carcinogenicity ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... 1982 Technical Report TR-214 PDF (4.06 MB) Carcinogenesis Bioassay of Caprolactam (CASRN 105-60-2) in F344 Rats and B6C3F1 Mice (Feed Study) 1982 Technical Report TR-213 PDF ...
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TR-411: C.I. Pigment Red 23 (CASRN 6471-49-4) in F344 Rats and... 15.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr411.pdf
... 59 3 2 0 . 9 60 2 1 . 3 102 60 21.2 101 60 21.2 101 59 4 2 1 . 3 60 2 2 . 3 105 60 2 2 . 4 105 60 2 2 . 3 105 59 5 2 2 . 6 60 2 2 . 7 100 60 2 2 . 9 101 60 2 2 . 9 101 59 6 2 3 . ...
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TR-415: Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1Mice... 12.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr415.pdf
... 0 . 3 92 60 21.6 98 60 9 2 1 . 9 60 23.0 105 60 2 2 . 8 104 60 10 22.8 60 23.4 103 60 23.3 ... Butyl Benzyl Phthalate Caprolactam Bisphenol A 11-Aminoundecanoic Acid ...
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TR-541: Formamide (CASRN 75-12-7) in F344/N rats and B6C3F1 Mice... 2.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr541.pdf
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF FORMAMIDE (CAS NO. 75-12-7) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. ...
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TR-326: Ethylene Oxide (CASRN 75-21-8) in B6C3F1Mice (Inhalation... 6.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr326.pdf
... (Inhalation) C.I. Acid Orange 10 Di(2-ethylhexy1)adipate Butylbenzyl Phthalate Caprolactam Bisphenol A 11-Aminoundecanoic Acid Di@-ethylhexy1)phthalate 2,6-Dichloro-p-phenylen...
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TR-417: p-Nitrophenol (CASRN 100-02-7) in Swiss Webster Mice... 7.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr417.pdf
... 1,2-Dibromoethane C.I. Acid Orange 10 Di(2ethylhexyl)adipate Butyl Benzyl Phthalate Caprolactam Bisphenol A 11-Aminoundecanoic Acid Di(2-Ethylhexy1)phthalate 2,6-Dichloro-p-phenyle...
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TR-444: Initiation/Promotion Study of o-Benzyl-p-Chlorophenol... 6.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr444.pdf
... 211 C.I. Acid Orange 10 212 Di(2-ethylhexy1)adipate 213 Butyl Benzyl Phthalate 214 Caprolactam 215 Bisphenol A 216 11-Aminoundecanoic Acid 217 Di(2ethylhexyl)phthalate 219 ...
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TR-410: Naphthalene (CASRN 91-20-3) in B6C3F1Mice (Inhalation... 8.6MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr410.pdf
... ButylBenzylPhthalate Caprolactam Bisphenol A 11-Aminoundecanoic Acid Di(2ethylhexyl)phthalate 2,6-Dichloro-p-phenylenediamine C.I.AcidRed14 Locust Bean Gum G I . ...
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TR-266: Monuron (CASRN 150-68-5) in F344/N Rats and B6C3F1Mice... 11.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr266.pdf
... 9 Monohydrochloride 213 Butylbenzyl Phthalate 287 Dimethyl Hydrogen Phosphite 214 Caprolactam 288 1 ,3-Butadiene 215 BisphenolA 289 Benzene 216 11-Aminoundecanoic Acid 291 ...
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TR-335: C.I. Acid Orange 3 (CASRN 6373-74-6) in F344/N Rats and... 12.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr335.pdf
... Di(2-ethylhexyl)adipate 288 1,3-Butadiene 213 Butylbenzyl Phthalate 289 Benzene 214 Caprolactam 291 Isophorone 215 Bisphenol A 293 HC Blue No.2 216 11-Aminoundecanoic Acid 294 ...
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TR-359: 8-Methoxypsoralen (CASRN 298-81-7) in F344/N Rats (Gavage... 7.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr359.pdf
... 211 C.I. Acid Orange 10 212 Di(2-ethylhexyl)adipate 213 Butylbenzyl Phthalate 214 Caprolactam 215 BisphenolA 216 11 Aminoundecanoic Acid 217 Di(2-ethy!hexyl)phthalate 219 ...
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TR-389: Sodium Azide (CASRN 26628-22-8) in F344 Rats (Gavage... 8.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr389.pdf
... 211 C.I. Acid Orange 10 212 Di(2-ethylhexyl)adipate 213 Butyl Benzyl Phthalate 214 Caprolactam 215 Bisphenol A 216 11-Aminoundecanoic Acid 217 Di(2-ethylhexyl)phthalate 219 ...
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TR-409: Quercetin (CASRN 117-39-5) in F344 Rats (Feed Studies... 9.6MB
https://ntp.niehs.nih.gov/go/tr409
... 1,2-Dibromoethane C.I. Acid Orange 10 Di(2-ethylhexyl)adipte Butyl Benzyl Phthalate Caprolactam Bisphenol A 11-Aminoundecanoic Acid Di(2ethylhexyl)phthalate 2,6-Dichloro-p-phenylen...
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TR-278: 2,6-Xylidine (2,6-Dimethylaniline) (CASRN 87-62-7) in... 9.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr278.pdf
... FD & C Yellow No. 6 2,3,7,8-Tetrachlorodibenzo-pdioxin(Gavage) 1,2-Dibromoethane (Inhalation) C.I. Acid Orange 10 Di(2-ethyl hexy 1)adipate Butylbenzyl Phthalate Caprolactam ...
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TR-320: Rotenone (CASRN 83-79-4) in F344/N Rats and B6C3F1Mice... 11.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr320.pdf
... 211 C.I. Acid Orange 10 212 Di(2-ethylhexyl)adipate 213 Butylbenzyl Phthalate 214 Caprolactam 215 Bisphenol A 216 11-Aminoundecanoic Acid 217 Di(2-ethylhexyl)phthalate 219 ...
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TR-330: 4-Hexylresorcinol (CASRN 136-77-6) in F344/N Rats and... 9.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr330.pdf
... 211 C.I. Acid Orange 10 212 Di(2-ethylhexy1)adipate 213 Butylbenzyl Phthalate 214 Caprolactam 215 Bisphenol A 216 11-Aminoundecanoic Acid 217 Di(2-ethylhexy1)phthalate 219 ...
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TR-333: N-Phenyl-2-naphthylamine (CASRN 135-88-6) in F344/N Rats... 9.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr333.pdf
... (Inhalation) C.I. Acid Orange 10 Di(2-ethylhexy1)adipate Butylbenzyl Phthalate Caprolactam Bisphenol A 11-Aminoundecanoic Acid Di(2-ethylhexy1)phthalate 2,6-Dichloro-p-phenyle...
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TR-334: 2-Amino-5-Nitrophenol (CASRN 121-88-0) in F344/N Rats... 9.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr334.pdf
... Di(2-ethy1hexyl)adipate H.C. Red No. 3 Butylbenzyl Phthalate Chlorodibromornethane Caprolactam Diallylphthalate (Rats) Bisphenol A C.I. Basic Red 9 Monohydrochloride 11 ...
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TR-399: Titanocene Dichloride (CASRN 1271-19-8) in F344/N Rats... 8.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr399.pdf
... 2-Chloroethanol Tris(2ethylhexyl)phosphate 216 215 214 213 21 2 211 210 209 11-Aminoundecanoic Acid Bisphenol A Caprolactam ButylBenzyl Phthalate Di(2ethylhexyl)adipate C I . ...
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TR-413: Ethylene Glycol (CASRN 107-21-1) in B6C3F1Mice (Feed... 11.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr413.pdf
... 26.9 106 60 4 27.3 60 28.9 106 60 28.6 105 60 28.3 104 60 5 28.4 60 29.6 104 60 28.7 101 ... 213 Butyl Benzyl Phthalate 214 Caprolactam 215 Bisphenol A 216 11-Aminoundecanoic ...
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TR-518: Triethanolamine (CASRN 102-71-6) in B6C3F1Mice (Dermal... 5.0MB
https://ntp.niehs.nih.gov/go/tr518
... Butyl Benzyl Phthalate n-Butyl Chloride t-Butylhydroquinone (-Butyrolactone Caprolactam d-Carvone Chloral Hydrate Chloral Hydrate Chlorinated and Chloraminated Water ...
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TR-323: Dimethyl Methylphosphonate (CASRN 756-79-6) in F344/N... 9.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr323.pdf
... 211 C.I. Acid Orange 10 212 Di(2-ethylhexyl)adipate 213 Butylbenzyl Phthalate 214 Caprolactam 215 Bisphenol A 216 11 Aminoundecanoic Acid 217 Di(2-ethylhexyl)phthalate 219 ...
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TR-329: 1,2-Epoxybutane (CASRN 106-88-7) in F344/N Rats and B6C3F1Mice... 10.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr329.pdf
... (Inhalation) (2.1. Acid Orange 10 Di(2-ethylhexy1)adipate Butylbenzyl Phthalate Caprolactam Bisphenol A 1 1-Aminoundecanoic Acid Di(2-ethylhexy1)phthalate 2,6-Dichloro-p-phenyl...
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TR-331: Malonaldehyde, Sodium Salt (3-Hydroxy-2-propenal, Sodium... 7.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr331.pdf
... Ac1d Orange 10 287 Dimethyl Hydrogen Phosphite 212 DI(2-ethy lhexy I ladipate 288 1,3-Butadlene 213 Butylbenzyl Phthalate 289 Benzene 214 Caprolactam 291 Isophorone 215 B1sphenol A ...
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TR-332: 2-Mercaptobenzothiazole (CASRN 149-30-4) in F344/N Rats... 10.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr332.pdf
... 287 Dimethyl Hydrogen Phosphite 213 Butylbenzyl Phthalate 288 1,3-Butadiene 214 Caprolactam 289 Benzene 216 Bisphenol A 291 Isophorone 216 11-Aminoundecanoic Acid 293 HC Blue ...
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TR-336: Penicillin VK (CASRN 132-98-9) in F344/N Rats and B6C3F1Mice... 9.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr336.pdf
... 287 Dimethyl Hydrogen Phosphite 213 Butylbenzyl Phthalate 288 1,J-Butadiene 214 Caprolactam 289 Benzene 215 Bisphenol A 29 1 Isophorone 216 i 1-Aminoundecanoic Acid 293 HC Blue ...
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TR-338: Erythromycin Stearate (CASRN 643-22-1) in F344/N Rats... 10.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr338.pdf
... Di(2-ethylhexy1)adipate 288 1,3-Butadiene 213 Butylbenzyl Phthalate 289 Benzene 214 Caprolactam 291 Isophorone 215 Bisphenol A 293 HC Blue No. 2 216 11-Aminoundecanoic Acid 294 ...
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TR-339: 2-Amino-4-Nitrophenol (CASRN 99-57-0) in F344/N Rats... 11.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr339.pdf
... Basic Red 9 Monohydrochloride 212 Di(2-ethylhexyl)adipate 287 Dimethyl Hydrogen Phosphite 213 Butylbenzyl Phthalate 288 1,3-Butadiene 214 Caprolactam 289 Benzene 215 Bisphenol A ...
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TR-373: Succinic Anhydride (CASRN 108-30-5) in F344/N Rats and... 21.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr373.pdf
... 213 Butylbenzyl Phthalate 214 Caprolactam 215 BisphenolA 216 11-Aminoundecanoic Acid 217 Di(2-ethylhexyl)phthalate 219 2,6-Dichloro-p-phenylenediamine 220 C.l. ...