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Search suggestions for "10540-29-1".

  1. Report on Carcinogens Tamoxifen https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/tamoxifen.pdf


65 results found for "10540-29-1".

  1. RoC Background Document: Tamoxifen; Oct. 30-31, 1997 2.3MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/tamoxifen2_2apps_508.pdf

    N01-ES-25346 NTP Report on Carcinogens 1997 Background Document for Tamoxifen TABLE OF CONTENTS NTP Report on Carcinogens Listing for Tamoxifen ......

  2. RoC Profile: Tamoxifen; 15th RoC 2021 149KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tamoxifen.pdf

    Tamoxifen CAS No. 10540-29-1 Known to be a human carcinogen First listed in the Ninth Report on Carcinogens (2000) Also known as (Z)-2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N- ...

  3. Abstract for RACB95003 62KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro/racb95003

    Abstract for RACB95003 Reproductive Toxicity of Tamoxifen Citrate Administered by Gavage ... To assess potential effect of "long-term" exposure to tamoxifen citrate prior to and ...

  4. NTP Monograph: Developmental Effects and Pregnancy Outcomes Associated... 23.8MB

    https://ntp.niehs.nih.gov/ntp/ohat/cancer_chemo_preg/chemopregnancy_monofinal_508.pdf

    ......... 149 5.30 Tamoxifen ......Table 72: Pharmacology of tamoxifen in adult humans ......

  5. BG1Luc ER TA Protocol Standardization Study Report (Annex C of... 2.9MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexc/c0-prot-stand.pdf

    ... C-121 12.2.8 N0016 - Tamoxifen ......C-163 16.3 Alteration of Testing Concentrations for Tamoxifen Comprehensive Testing ...... ...

  6. Appendices for NTP Monograph on Developmental Effects and Pregnancy... 11.1MB

    https://ntp.niehs.nih.gov/ntp/ohat/cancer_chemo_preg/cancerchemo_appendfinal_508.pdf

    ... NA NA C Streptozotocin 2B NA D Tamoxifen 1 Known D Teniposide 2A NA D Trastuzumab ... OR sunitinib OR sunrabin OR sutent OR tamoxifen OR tarceva OR tasigna OR taxol OR ...

  7. Uterus - Dilation - Nonneoplastic Lesion Atlas 291KB

    https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/uterus/Dilation

    Administration of progestins, estrogens, and tamoxifen in rats has been associated with uterine dilation. Luminal dilation is normally observed at proestrus and estrus in cycling ...

  8. XDS Submission of the LUMI-CELL ER Test Method 3.2MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/iccvamsubmission28jan05.pdf

    ... Tamoxifen/17b-estradiol standards, 2 cell viability QC points, 4 DMSO controls, 1 No DMSO ... A Tamoxifen / 17b-estradiol mixture was used in the antagonistic response test and ...

  9. Submission of XDS's LUMI-CELL ER High-Throughput System for Screening... 2.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexa/xds-sub.pdf

    ... Tamoxifen/17b-estradiol standards, 2 cell viability QC points, 4 DMSO controls, 1 No DMSO ... A Tamoxifen / 17b-estradiol mixture was used in the antagonistic response test and ...

  10. Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf

    ... Substances 28 September 06 . tamoxifen citrate, proposed by the EPA for in vitro testing, was excluded because its parent compound, tamoxifen, has been tested much more ...

  11. Uterus - Dilation 331KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/female_reproductive/uterus/dilat/uterus-dilation-pdf-508.pdf

    Administration of progestins, estrogens, and tamoxifen in rats has been associated with uterine dilation. Luminal dilation is normally observed at proestrus and estrus in cycling ...

  12. ICCVAM Test Method Evaluation Report on the BG1Luc ER TA Test... 17.5MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/bg1lucer-ta-tmer-combined.pdf

    ... Flutamide . Procymidone . Resveratrol . Tamoxifen It should be emphasized that the ... procymidone, resveratrol, and tamoxifen) represent eight chemical classes (two ...

  13. Listed Substances; 15th RoC 2021 76KB

    https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf

    Strong Inorganic Acid Mists Containing Sulfuric Acid Sunlamps or Sunbeds, Exposure to (see Ultraviolet Radiation Related Exposures) Tamoxifen 2,3,7,8-Tetrachlorodibenzo-p-dioxin ...

  14. Expert Panel Evaluation of the Validation Status of In Vitro... 1.1MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/expertpanfinalrpt/panelrpt1102.pdf

    ... A substance (e.g., tamoxifen, coumestrol, estriol) with a binding affinity of two or three ... estrogen, such as estriol or coumestrol, or a synthetic estrogen mimic, like tamoxifen. ...

  15. ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf

    ... endocrine disruptor assays; and . tamoxifen citrate, proposed by the EPA for in vitro testing, was excluded because its parent compound, tamoxifen, has been tested much more ...

  16. Food Antigen Transport Across the Intestinal Epithelium: Outcomes... 5.1MB

    https://ntp.niehs.nih.gov/sites/default/files/2023-12/Wb3_02_Hogan_GutModels2023_508.pdf

    ... Food reaction i.v. IL-13 Anti-TNP-IgE o.g. TNP-BSA IL-9Tg Atoh CreERT2 IL-4Rα Fl/Fl mice ( 3 x Tamoxifen / every other day) Intestinal mast cells (IL-9) ± IL-4Rα secretory ...

  17. Reproductive Abstracts 202KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro

    ... to Sprague-Dawley Rats in the Diet 2002 Reproductive RACB95003 Tamoxifen Citrate Reproductive Toxicity of Tamoxifen Citrate (CASRN: 54965-24-1) Administered by Gavage to ...

  18. Study Abstracts 375KB

    https://ntp.niehs.nih.gov/publications/abstracts

    ... to Sprague-Dawley Rats in the Diet 2002 Reproductive RACB95003 Tamoxifen Citrate Reproductive Toxicity of Tamoxifen Citrate (CASRN: 54965-24-1) Administered by Gavage to ...

  19. Appendix G; 15th RoC 2021 73KB

    https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf

    ... Exposures 10141-05-6 (cobalt nitrate) see Cobalt-Related Exposures 10540-29-1 see Tamoxifen 10588-01-9 (sodium dichromate) see Chromium Hexavalent Compounds 11104-61-3 ...

  20. Minutes: BSC RoC; Dec. 13-15, 2000 205KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/draftbackgrounddocs/minutes20001213.pdf

    ... Frederick agreed alluding to a similar discussion in the review of tamoxifen for the 9th ... Frederick emphasized that like the issue with tamoxifen, the wording has to be carefully ...

  21. NICEATM Validation Study Report on the MCF-7 Cell Proliferation... 1.8MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/mcf7/mcf7-valstudyreport-19jun12-wcv2-draft.pdf

    ... 2 Resveratrol POS (2/2) POS (1/1) POS 2 Tamoxifen NEG (1/1) NT NEG 2 Vinclozolin POS (3/3) ... POS (3/3) NEG (1/1) NEG (1/1) NEG NEG 2 Tamoxifen POS (3/4) POS (3/3) POS (1/1) POS (1/1) ...

  22. Appendix B: Overview of experimental animal studies: Carcinogenicity 208KB

    https://ntp.niehs.nih.gov/ntp/roc/meetings/2016/alan/appendix_b_508.pdf

    ... A, Frasch T, Rowan BG, Blask DE, Hill SM. 2014. Circadian and melatonin disruption by exposure to light at night drives intrinsic resistance to tamoxifen therapy in breast cancer. ...

  23. Presentation: Decision Analytic Approach to Advance Application... 911KB

    https://ntp.niehs.nih.gov/iccvam/meetings/aop-wksp-2014/presentations/jarabek-508.pdf

    ... An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride. Crit Rev Toxicol 44(4), 348 - 391. ...

  24. 15th RoC: Appendix F 174KB

    https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf

    ... dimethylethanamine see Tamoxifen diphenylhydantoin see Phenytoin and ... dimethylethanamine see Tamoxifen Zanosar see Streptozocin zeolites see ...

  25. TOX-79: Genistein (CASRN 446-72-0) 2.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox079.pdf

    ... estrogen receptor-mediated responses to tamoxifen than the F344 rat (Bailey and Nephew, ... (2002). Strain differences in tamoxifen senstivity of Sprague-Dawley and Fischer 344 rats. ...

  26. Completed RoC Evaluations 119KB

    https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/roc

    ... Background Documents Appendix A Appendix B Appendix C Appendix D Appendix E Request Archived Materials Tamoxifen Known to be a human carcinogen Background Document Appendix A ...

  27. Minutes: BSC; Oct. 18, 1994 174KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1994/october/19941018_bsc_508.pdf

    ... Hoel inquired as to what gain was expected from studies on tamoxifen. Dr. Lucier said a good study of the agonist actions of tamoxifen and reported beneficial effects as in ...

  28. NICEATM Update 5.1MB

    https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2020/ppt/04-niceatm-kleinstreuer-508.pdf

    ... Tamoxifen Diethylstilbestrol Gentian Violet Fluorouracil Bisphenol A Reserpine Leveraging human cell-based in vitro systems COVID-19 Therapeutic Work . HEK293 and MVECs . ...

  29. Minutes: BSC; May 14, 1997 1.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1997/may/bsc_mins1997may14_508.pdf

    ... Specialized assays are developed when needed, e .g ., recently, for tamoxifen and ... Some of the chemicals studied include tamoxifen, water disinfection byproducts, ...

  30. Appendices A-G; 15th RoC 2021 448KB

    https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf

    ... dimethylethanamine see Tamoxifen diphenylhydantoin see Phenytoin and ... dimethylethanamine see Tamoxifen Zanosar see Streptozocin zeolites see ...

  31. RoC Profile: Diethylstilbestrol; 15th RoC 2021 141KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/diethylstilbestrol.pdf

    ... Cancer Causes Control 13(8): 753-758. Peethambaram PP, Ingle JN, Suman VJ, Hartmann LC, Loprinzi CL. 1999. Randomized trial of diethyl- stilbestrol vs. tamoxifen in postmenopausal ...

  32. Minutes: MPRP; Oct. 1-2, 2012 559KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2012/october/minutes20121002_508.pdf

    ... Greene noted his preference was to refer to tamoxifen as a "partial agonist" as opposed to an antagonist. Dr. Birnbaum suggested removing reference to tamoxifen as an antiestrogen. ...

  33. Endocrine Disruptors Low-Dose Peer Review, October 10-12, 2000 17.3MB

    https://ntp.niehs.nih.gov/ntp/pressctr/mtgs_wkshps/2000/lowdosepeerfinalrpt.pdf

    ... Jefferson, et al. (1997). "Uterine carcinoma in mice treated neonatally with Tamoxifen." ... 87. 2 Newbold, Newbold, R. R., W. N. Tamoxifen Perinatal Uterine Tumors Retha ...

  34. TR-585: Green Tea Extract in F344/NTac Rats and B6C3F1/N Mice... 3.6MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr585_508.pdf

    ... many drugs such as sunitinib, midazolam, tamoxifen, and verapamil in rats and mice 46-48 . ... downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line. ...

  35. TR-585: Green Tea Extract in F344/NTac Rats and B6C3F1/N Mice... 3.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr585_508.pdf

    ... many drugs such as sunitinib, midazolam, tamoxifen, and verapamil in rats and mice 46-48 . ... downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line. ...

  36. OHAT Evaluation: Protocol for a Systematic Review to Evaluate... 1018KB

    https://ntp.niehs.nih.gov/ntp/ohat/aheaoecca/protocol201510_508.pdf

    ... agents, synthetic hormones (e.g., tamoxifen), monoclonal antibodies and other ... OR sunrabin[tiab] OR sutent[tiab] OR tamoxifen[tiab] OR tarceva[tiab] OR tasigna[tiab] ...

  37. OHAT Evaluation: Protocol for a Systematic Review to Evaluate... 1.1MB

    https://ntp.niehs.nih.gov/ntp/ohat/aheaoecca/protocol201812_508.pdf

    ... agents, synthetic hormones (e.g., tamoxifen), monoclonal antibodies and other ... OR sunrabin[tiab] OR sutent[tiab] OR tamoxifen[tiab] OR tarceva[tiab] OR tasigna[tiab] ...

  38. DART-04: Prenatal Development Studies of Dimethylaminoethanol... 1006KB

    https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart04_508.pdf

    ... including a variety of antihistamines, antiemetics, local anesthetics, and tamoxifen. 9 A number of dietary supplements on the market contain dimethylaminoethanol, most ...

  39. CERHR Monograph: Potential Human Reproductive and Developmental... 6.3MB

    https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf

    ... (EC 10 13.9 ng/L); blocked by Oehlmann et al. exposed in water Faslodex and tamoxifen. ... The effects of 4-tert-octylphenol, genistein, Antarelix, flutamide, and tamoxifen were ...

  40. CERHR Update on the Reproductive and Developmental Toxicity of... 4.5MB

    https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dehp/dehp-monograph.pdf

    ...apoptosis.in.MCF-7.cells.in.culture..Tamoxifen.caused.a.concentration-related.decrease.in. ...lls..Coadministration.of.DEHP.10µM.and.tamoxifen.for.24.hours.resulted. ...

  41. Minutes: BSC; Nov. 2008 308KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2008/november/minutes_final.pdf

    ... Dr. Friedman-Jiménez made an analogy to tamoxifen that was developed and used for the ... He thought the discussion on tamoxifen was interesting, but he wondered if the search for ...

  42. TR-476: Primidone (CASRN 125-33-7) in F344/N Rats and B6C3F1Mice... 13.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr476.pdf

    ... Phenobarbital "promotes" liver tumors in rats after initiation by tamoxifen (Carthew et ... Tamoxifen induces short-term cumulative DNA damage and liver tumors in rats: Promotion by ...

  43. TR-587: Tetrabromobisphenol A (CASRN 79-94-7) in F344/NTac Rats... 3.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr587_508.pdf

    ... exogenous estrogen therapies, nulliparity, tamoxifen therapy, and pelvic irradiation. ... Tamoxifen treatment (given on days 2 to 5 after birth at 1 mg/kg body weight per day) ...

  44. NTP Cancer Hazard Report: Night Shift Work and Light at Night... 10.1MB

    https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal20210400_508.pdf

    ... to light at night drives intrinsic resistance to tamoxifen therapy in breast cancer. ... to light at night drives intrinsic resistance to tamoxifen therapy in breast cancer. ...

  45. Minutes: BSC; April 17, 1996 335KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1996/april/19960417_bsc_508.pdf

    ... He noted that definitive hazard identification data had been generated for more than 100 compounds and special studies were ongoing on tamoxifen, nonylphenol, drinking water ...

  46. Submission of the CertiChem Cell Proliferation Test Method for... 3.1MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/submdoc.pdf

    ... Endocr Rev 11: 578-610. Jordan, V.C. (2000). Tamoxifen: personal retrospective. Lancet ... 4.3E-07 + ND + ER agonist A-9 4-Hydroxy-tamoxifen 68047-06-3 Triphenylethylene; ...

  47. RoC Background Document: 2,3,7,8-Tetrachlorodibenzo-p-dioxin... 7.0MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/tetrachl_tcdd_4apps_508.pdf

    ... Toxicol. 25:264-270. Demby, K. B., and G. W. Lucier. 1996. Receptor-mediated carcinogenesis: The role of biological effect modeling for risk assessment of dioxin and tamoxifen. Pro ...

  48. Monograph: Summary of NTP Cancer Hazard Conclusions: Exposure... 870KB

    https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal_summary20210400_508.pdf

    ... A, Frasch T, Rowan BG, Blask DE, Hill SM. 2014. Circadian and melatonin disruption by exposure to light at night drives intrinsic resistance to tamoxifen therapy in breast cancer. ...

  49. TR-567: Ginseng (CASRN 50647-08-0) in F344/N Rats and B6C3F1... 6.7MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr567.pdf

    ... The expression of pS2 induced by ginseng and Rb1 was inhibited by tamoxifen. These results support the evidence sugges- tive of a steroidal effect for ginseng seen in some human ...

  50. Background: Dimethylethanolamine (DMAE) [108-01-0] and Selected... 1.3MB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dmae_update_110002_508.pdf

    ... Quotane ® is the hydrochloride), hydroxytetracaine, and tetracaine hydrochloride (of which DMAE is a metabolite); and the antiestrogens/antineoplastic agent tamoxifen (Dow, ...

 
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