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TR-506: Acrylonitrile (CASRN 107-13-1) in B6C3F1Mice (Gavage... 7.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr506.pdf
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ACRYLONITRILE (CAS NO. 107-13-1) IN B6C3F 1 MICE (GAVAGE STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 ...
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TR-573: Styrene-acrylonitrile trimer in F344/N Rats (Perinatal... 5.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr573_508.pdf
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDY OF STYRENE-ACRYLONITRILE ... AND CARCINOGENESIS STUDY OF STYRENE-ACRYLONITRILE TRIMER IN F344/N RATS (PERINATAL AND ...
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RoC Profile: Acrylonitrile; 15th RoC 2021 145KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acrylonitrile.pdf
Acrylonitrile CAS No. 107-13-1 Reasonably anticipated to be a human carcinogen First listed in the Second Annual Report on Carcinogens (1981) H 2 C H C C N Carcinogenicity ...
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Abstract for TR-506 71KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr506
Abstract for TR-506 Toxicology and Carcinogenesis Studies of Acrylonitrile in B6C3F1 Mice (Gavage Studies) CASRN: 107-13-1 Chemical Formula: C3H3N Molecular Weight: 53.06 Synonyms/...
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Abstract for TR-573 71KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr573
Styrene-Acrylonitrile Trimer in F344/N Rats (Perinatal and Postnatal Feed Studies) CASRN: SANTRIMER2 Report Date: July 2012 Full Report PDF Abstract Styrene-acrylonitrile trimer ...
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Target Organs and Levels of Evidence for TR-506 58KB
https://ntp.niehs.nih.gov/data/tr/500s/tr506levels
Target Organs and Levels of Evidence for TR-506 Toxicology and Carcinogenesis Studies of Acrylonitrile (CASRN 107-13-1) in B6C3F1 Mice (Gavage Studies) Chemical (Study Title) CASRN ...
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Abstract for TR-272 64KB
https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr272
acrylonitrile, isopropyl alcohol, propylene oxide, butyraldehyde, cumene, dodecane, nonene, and allyl chloride. The major derivatives are polypropylene (25%), acrylonitrile ...
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Target Organs and Levels of Evidence for TR-573 57KB
https://ntp.niehs.nih.gov/data/tr/500s/tr573levels
Toxicology and Carcinogenesis Study of Styrene-Acrylonitrile Trimer (CASRN SANTRIMER2) in ... Levels Study Laboratory Styrene-acrylonitrile trimer SANTRIMER2 01/26/2011 ...
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Abstract for TR-543 74KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr543
Full Report PDF Abstract α-Methylstyrene is used in the production of acrylonitrile-butadiene-styrene resins and copolymers, which improve the impact and heat-resistant properties ...
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Abstract for TOX-47 65KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox047
isopropenyl nitrile; MAN; methyl acrylonitrile; 2-methyl-2-propenenitrile Report ... This aliphatic nitrile is also used as a replacement for acrylonitrile in the manufacture ...
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Abstract for TR-497 69KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr497
Methacrylonitrile is also used as a replacement for acrylonitrile in the manufacture of an acrylonitrile/butadiene/styrene-like polymer that provides improved barrier properties to ...
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Abstract for TR-587 75KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr587
Tetrabromobisphenol A is a flame retardant used in epoxy resin circuit boards, in electronic enclosures (of polycarbonate-acrylonitrile-butadiene-styrene plastics), in paper, and ...
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Minutes: BSC TRRS; May 3, 2001 62KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2001/may/trrs3may2001mins_508.pdf
88-72-2 Feed Rats, Mice 2 p-Nitrotoluene 99-99-0 Feed Rats, Mice 4 Acrylonitrile 107-13-1 Gavage, mice 5 Methacrylonitrile 126-98-7 Gavage Rats, Mice 6 Citral 5392-40-5 ...
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Minutes: TRPRP; Jan. 26, 2011 168KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2011/january/minutes20110126.pdf
and Carcinogenesis Study of Styrene-Acrylonitrile Trimer (TR 573) 10 VII. Toxicology and ... or voting on the styrene-acrylonitrile trimer report due to conflicts of interest. ...
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TR-497: Methacrylonitrile (CASRN 126-98-7) in F344/N Rats and... 10.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr497.pdf
... Methacrylonitrile is also used as a replacement for acrylonitrile in the manufacture of an acrylonitrile/butadiene/styrene-like polymer that pro- vides improved barrier properties ...
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Abstract for TR-487 70KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr487
In addition, it is used in the production of isooctane, high-octane aviation gasoline, methyl-t-butyl ether, and copolymer resins with butadiene and acrylonitrile. Isobutene was ...
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TOX-47: Methacrylonitrile 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox047.pdf
... isopropenyl nitrile; MAN; methyl acrylonitrile; 2-methyl-2-propenenitrile ... This aliphatic nitrile is also used as a replacement for acrylonitrile in the manufacture ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 4.8MB
https://ntp.niehs.nih.gov/ntp/ohat/acrylamide/acrylamide_monograph.pdf
... Acrylamide is produced commercially in three ways: from acrylonitrile by a catalytic ... In this method, acrylonitrile is hydrated with a fi xed copper catalyst. Unreacted ...
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Historical Controls: Pathology Tables by Oral/Feed for Fischer344N... 105KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/ratsf344peripostoralfeed2013_508.pdf
50(3) 36(685) 522.7 Styrene-acrylonitrile trimer Female Battelle Columbus Laboratory 059901305 05/13/05 727 50(5) 41(699) 371.2 Styrene-acrylonitrile trimer NOTE: The text on page ...
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CERHR Monograph: Potential Human Reproduction Effects of Styrene 6.0MB
https://ntp.niehs.nih.gov/ntp/ohat/styrene/styrene_monograph.pdf
... tion of polystyrene resins and as a co-polymer with acrylonitrile and 1,3-butadiene. ... resins. and.as.a.co-polymer.with.acrylonitrile.and.1,3- butadiene..Styrene.is.found.i...
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Historical Controls: Pathology Tables by Perinatal and Postnatal... 131KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2011/ratsperipostoralfeed.pdf
50(3) 36(685) 522.7 Styrene-acrylonitrile trimer Female Battelle Columbus Laboratory 059901305 05/13/05 727 50(5) 41(699) 371.2 Styrene-acrylonitrile trimer NOTE: The text on page ...
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Target Organs and Levels of Evidence for TR-582 61KB
https://ntp.niehs.nih.gov/data/tr/500s/tr582levels
Laboratory Vinylidene Chloride 75-35-4 10/29/2013 Copolymerized with vinychloride or acrylonitrile for saran and saran fibers. A widely used chemical intermediate and monomer. ...
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RoC Background Document: 1,3-Butadiene; Oct. 30-31, 1997 9.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/butadiene_508.pdf
... latex (9.9%), chloroprene (6.6%), acrylonitrile-butadiene- styrene (ABS) resins ... polybutadiene, neoprene, acrylonitrile-butadiene-styrene (ABS) copolymer, ...
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Abstract for TR-288 65KB
https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr288
Commercial nitrile rubber, used largely in rubber hoses, seals, and gaskets for automobiles, is a copolymer of 1,3-butadiene and acrylonitrile. Acrylonitrile- butadiene- styrene ...
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Historical Controls: All Routes and Vehicles for Mice; Studies... 255KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2006/m_hcrpt_allrte2006_508.pdf
Battelle Columbus Laboratory 055021503 03/04/97 730 50(1) 38(707) 53.4 Acrylonitrile ... Battelle Columbus Laboratory 055021503 03/03/97 729 50(5) 39(709) 62.7 Acrylonitrile ...
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Historical Controls: All Routes and Vehicles for Mice; Studies... 317KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2007/m_hcrpt_allrte20070300_508.pdf
Battelle Columbus Laboratory 055021503 03/04/97 730 50(1) 38(707) 53.4 Acrylonitrile ... Battelle Columbus Laboratory 055021503 03/03/97 729 50(5) 39(709) 62.7 Acrylonitrile ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... Some Evidence TR-573 01/26/11 Styrene-Acrylonitrile Trimer SANTRIMER2 NE No Evidence NE No ... P Clear Evidence TR-506 05/03/01 Acrylonitrile 107-13-1 NT Chemical Not Tested in ...
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Historical Controls: Pathology Tables for All Routes/Vehicles... 189KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/histcont2013_ratsf344_allroutes_508.pdf
.../05 726 50(3) 36(685) 522.7 Styrene-acrylonitrile trimer Battelle Northwest 059302507 .../05 727 50(5) 41(699) 371.2 Styrene-acrylonitrile trimer Battelle Northwest 059302507 ...
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Harderian gland - Hyperplasia - Nonneoplastic Lesion Atlas 293KB
https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/harderian-gland/Hyperplasia
Abstract: http://www.cacheriverpress.com/books/pathmouse.htm Ghanayem BI, Nyska A, Haseman JK, Bucher JR. 2002. Acrylonitrile is a multisite carcinogen in male and female B6C3F1 ...
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Background Document: RoC: Styrene; 2010 4.3MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/styrene_final_508.pdf
... 9/29/08 xxiii Abbreviations ABS: acrylonitrile-butadiene-styrene ACGIH: American ... paper coatings, floor tile, adhesives Acrylonitrile-butadiene-styrene 10 Appliances, ...
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Historical Controls: Chemicals by Sex/Species/Route/Vehicle for... 15KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/histcont_2013_by_list_of_studies_508.pdf
beta-Picoline Rats F 344/N Male and Female Perinatal and postnatal Feed Styrene-acrylonitrile trimer Rats F 344/N Male and Female Skin Acetone Trimethylolpropane triacrylate ...
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Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf
... Reasonably Anticipated To Be Human Carcinogens Acetaldehyde 2-Acetylaminofluorene Acrylamide Acrylonitrile Adriamycin 2-Aminoanthraquinone o-Aminoazotoluene 1-Amino-2,4-dibromoanth...
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Panel Actions: TRPRP; Jan. 26, 2011 65KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2011/january/actions20110126.pdf
... Styrene-Acrylonitrile Trimer (TR 573) The Panel accepted (6 yes, 1 no, 0 abstentions) the conclusion, no evidence of carcinogenic activity of SAN Trimer in female F344/N rats. The ...
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Harderian Gland - Hyperplasia 401KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/harderian/hyperpl/harderian-gland-hyperplasia_508.pdf
Cache River Press, Vienna, IL, 49-79. Abstract: http://www.cacheriverpress.com/books/pathmouse.htm Ghanayem BI, Nyska A, Haseman JK, Bucher JR. 2002. Acrylonitrile is a multisite ...
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Historical Controls: Pathology Tables All Routes/Vehicles for... 309KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2011/histcont2011_rats_allroutes.pdf
.../05 726 50(3) 36(685) 522.7 Styrene-acrylonitrile trimer Battelle Northwest 059302507 .../05 727 50(5) 41(699) 371.2 Styrene-acrylonitrile trimer Battelle Northwest 059302507 ...
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Historical Controls: Chemicals by Sex/Species/Route/Vehicle for... 83KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2011/histcont_2011_studies.pdf
... dihydrate (VI) Rats F 344/N Male and Female Perinatal and Postnatal Feed Styrene-acrylonitrile trimer Rats F 344/N Male and Female Skin Acetone Trimethylolpropane triacrylate ...
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Appendix G; 15th RoC 2021 73KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
... see 1-Bromopropane 106-99-0 see 1,3-Butadiene 107-06-2 see 1,2-Dichloroethane 107-13-1 see Acrylonitrile 107-30-2 (chloromethyl methyl ether) see Bis(chloromethyl) Ether and ...
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RoC Profile: Acrylamide; 15th RoC 2021 154KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acrylamide.pdf
... When heated to decomposition, acrylamide emits acrid fumes and nitrogen oxides (HSDB 2009). Commercial acrylamide monomer contains residual levels of acrylonitrile (1 to 100 mg/kg) ...
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Combining NAM Data and IVIVE for Evaluating Potential Inhalation... 595KB
https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-chang-poster.pdf
... Toluene 114 Cell viability 16.4 4.8 Neuro. Styrene 50 Genotoxicity 4.3 1.3 Neuro. n-Hexane 10 AChE activity 1.3 0.3 Neuro. Acrylonitrile 117 Cell transformation 3.2 1.9 Neuro. ...
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RoC Profile: 1,3-Butadiene; 15th RoC 2021 162KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/butadiene.pdf
... (12% to 15%), styrene-butadiene latex (10%), neo- prene rubber (5% to 6%), acrylonitrile-butadiene-styrene resins (5% to 6%), and nitrile rubber (3%), exports (4%), and ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... and Carcinogenesis Study of Styrene-Acrylonitrile Trimer in F344/N Rats (Perinatal and ... and Carcinogenesis Studies of Acrylonitrile (CASRN 107-13-1) in B6C3F1 Mice ...
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TR-487: Isobutene (CASRN 115-11-7) in F344/N Rats and B6C3F1Mice... 11.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr487.pdf
... gasoline, methyl-t-butyl ether, and copolymer resins with butadiene and acrylonitrile. ... with butadiene and acrylonitrile (Merck Index, 1989; Hawley's, 1993; Patty's, 1994). ...
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TR-543: alpha-Methylstyrene (CASRN 98-83-9) in F344/N Rats and... 8.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr543.pdf
... is used to make heat-resistant acrylonitrile-butadiene-styrene resins and polymers. ... The primary use of "-methyl- styrene is in the production of acrylonitrile-butadiene- ...
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TR-316: Dimethylvinyl Chloride (1-Chloro-2-Methylpropene) (CASRN... 15.1MB
https://ntp.niehs.nih.gov/go/tr316
... KD090967 Lot No.1103BH Acetone Acrylonitrile t-Butanol t-Butyl chloride Chloroform ... However, the dose of acrylonitrile given unintentionally in these studies was very low, ...
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RoC Background Document: Vinyl Bromide; Jan. 20-21, 2000 220KB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/vb_no_appendices_508.pdf
... with various materials, such as acrylonitrile, vinyl acetate, and styrene, to form ... As a comonomer with acrylonitrile, it is used in the production of fabrics and fabric ...
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TR-185: Styrene (CASRN100-42-5) 3.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr185.pdf
... acrylonitrile-butadiene-styrene resins (9.3 percent), styrene- butadiene resins (6.2 percent), unsaturated polyester resins (6.7 percent), and styrene-acrylonitrile resins ...
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Adrenal glands - Hyperplasia - Nonneoplastic Lesion Atlas 309KB
https://ntp.niehs.nih.gov/atlas/nnl/endocrine-system/adrenal-gland/Hyperplasia
... National Toxicology Program. 2012. NTP TR-573 Toxicology and Carcinogenesis Studies of Styrene-Acrylonitrile Trimer in F344/N Rats (Perinatal and Postnatal Feed Studies). NTP, ...
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RoC Profile: Ethylene Oxide; 15th RoC 2021 133KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/ethyleneoxide.pdf
... Before 1966, ethylene oxide was used as an intermediate in the production of acrylonitrile. Production Ethylene oxide was first produced in the United States in 1921. Until 1937, ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... and Carcinogenesis Study of Styrene-Acrylonitrile Trimer in F344/N Rats (Perinatal and ... and Carcinogenesis Studies of Acrylonitrile (CASRN 107-13-1) in B6C3F1 Mice ...
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TR-447: Acetonitrile (CASRN 75-05-8) in F344/N Rats and B6C3F1Mice... 14.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr447.pdf
... in the commercial synthesis of acrylonitrile by a process involving a catalytic ... acetonitrile, propionitrile, allyl alcohol, and acrylonitrile using gas chromatography. ...
