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TR-261: Chlorobenzene (CASRN 108-90-7) in F344/N Rats and B6C3F1Mice... 10.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr261.pdf
... with the structurally similar chemical bromobenzene, for which it has been demon- strated ... The reactive bromobenzene metabolite appears to interact with endogenous, cellular reduced ...
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Nomination Background: Dichloroacetic acid (CASRN: 79-43-6) 6.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dcaa_508.pdf
... DCA can also be separated from chloroacetic acid by the addition of azeotrope-forming hydrocarbons such as bromobenzene [Kirk- Othmer, 1978] . In addition, DCA has been prepared by ...
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TR-255: 1,2-Dichlorobenzene (o-Dichlorobenzene) (CASRN 95-50... 8.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr255.pdf
... In the Sprague- Dawley rat, 42% of the dose is excreted as urinary metabolites in 24 hours (Reid and Krishna, 1973). Chlorobenzene, bromobenzene, iodobenzene, and ...
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RR-05: National Toxicology Program Approach to Genomic Dose-Response... 574KB
https://ntp.niehs.nih.gov/ntp/results/pubs/rr/reports/rr05_508.pdf
... a 28-Day Subchronic Toxicity Study of Bromobenzene (BB) to the Most Sensitive Gene-Set ... a 28-Day Subchronic Toxicity Study of Bromobenzene (BB) to the Most Sensitive Gene-Set ...
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CERHR Monograph: 1-Bromopropane 1.1MB
https://ntp.niehs.nih.gov/ntp/ohat/bromopropanes/1-bromopropane/1bp_monograph.pdf
... Follow- ing soil excavation and continuous groundwater pumping for 7 years, substantial concentrations of bromobenzene and chlorobenzene were found, but neither 1-BP, nor 2-BP, nor ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 1.0MB
https://ntp.niehs.nih.gov/ntp/ohat/bromopropanes/2-bromopropane/2bp_monograph.pdf
... Following soil excavation and continuous groundwater pumping for 7 years, substantial concentrations of bromobenzene and chlorobenzene were found, but neither 1- nor 2-BP nor their ...
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TR-319: 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and... 17.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr319.pdf
... The mean concentration in 34 samples of human fat taken from residents in the Tokyo area was 2 ppm. Chlorobenzene, bromobenzene, iodobenzene, and 1,2-dichlorobenzene bind ...
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RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf
... CAS No. Analytical Conc. (μg/mL) Benzene LC03683 71-43-2 1878.0 Bromobenzene LB99843 108-86-1 1935.2 n-Butylbenzene LB81630 104-51-8 1947.3 Ethylbenzene LB69556 100-41-4 1960.5 ...
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Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf
... 272 Salicylic acid 3.38 6.45 890.9 273 Bromobenzene 3.46 17.2 2700.7 274 L-Cysteine 3.56 ... 158 Dichlorophene 0.0083 10 2691.3 273 Bromobenzene 3.46 17.2 2700.7 295 2,5-Hexanedione ...
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Report: International Workshop on In Vitro Methods for Assessing... 25.4MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf
... 272 Salicylic acid 69-72-7 466.88 3.38 890.9 6.45 479.3 3.47 138.13 6.45 273 Bromobenzene 108-86-1 543.29 3.46 2700.7 17.2 NA NA 157.02 17.2 274 L- Cysteine 52-90-4 431.37 3.56 NA ...
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TR-400: 2,3-Dibromo-1-Propanol (CASRN 96-13-9) in F344/N Rats... 11.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr400.pdf
... The centrilobular hepatocellular necrosis produced by bromobenzene is believed to be ... Similar to bromobenzene, 2,3-dibromo-l-propanol is believed to be metabolized by ...
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Background Review Document: Frog Embryo Teratogenesis Assay ... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/fetax2000/brd/fetax-brd-all.pdf
... No + + 0.01 Nicotine + + 0.01 Hydrazine No + + 0.03 Acetylhydrazide + + 0.06 4-Bromobenzene + - 0.13 Cytochalasin D No + - 0.38 Sodium iodoacetate - - 0.42 Theophylline No + ...
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ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf
... Menthol 156.3 0.95 148.5 20.3 3172.9 Bromobenzene 157.02 3.46 543.3 17.2 2700.7 ... -1.176 260 Coumarin -0.427 273 Bromobenzene 0.374 279 Thioacetamide -0.294 281 ...
