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References Relevant to Evaluation of In Vitro Ocular Test Methods 38KB
https://ntp.niehs.nih.gov/iccvam/methods/ocutox/antimicro/references.pdf
... Toxicologic Pathology 29:308-319. Maurer JK, Molai A, Parker RD, Li L, Carr GJ, Petroll WM, et al. 2001. Pathology of ocular irritation with acetone, cyclohexanol, ...
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Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf
... 4.78 Benzoic acid 65-85-0 3.09 1.67 Isobenzoic furano dione 85-44-9 2.47 0.63 Cyclohexanol 108-93-0 1.89 2.07 Toluene 108-88-3 1.72 3.96 Salicylic acid 69-72-7 1.63 2.04 Tin(II) ...
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ICCVAM Test Method Evaluation Report: Low Volume Eye Test 2.8MB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/lvet/tmer-all.pdf
... The alcohols, cyclohexanol and parafluoroaniline, were moderate to severe irritants in the LVET. Only cyclohexanol was tested in the Draize test, and it was a severe irritant/...
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TOX-50: Cyclohexanone Oxime 2.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox050.pdf
... the oxime to cyclohexanone which is then reduced to cyclohexanol and eliminated as the glucuronide conjugate. The cyclohexanol, in tum could be metabolized to cis. and ...
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TR-557: beta-Myrcene (CASRN 123-35-3) in F344/N Rats and B6C3F1... 16.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr557.pdf
... (IV), 1-hydroxymethyl-4- isopropenyl cyclohexanol (VI), 10-carboxylinalool (III), and ... VI. 1-hydroxymethyl-4-isopropenyl cyclohexanol 20 $-Myrcene, NTP TR 557 metabolite) ...
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ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 42.0MB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol1.pdf
... Cutting fluid (conc.) #2 - Formulation Cutting fluid; Petrochemical product Cyclohexanol 108-93-0 Alcohol Solvent; Chemical intermediate Cyclohexanone 108-94-1 Ketone, ...
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TR-291: Isophorone (CASRN 78-59-1) in F344/N Rats and B6C3F1Mice... 9.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr291.pdf
... Iso- (USEPA, 1980). phorone is also a chemical intermediate in the manufacture of 3,5-xylenolI 3,3,5- trimethyl- Production: Since only two companies manufac- cyclohexanol, and ...
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RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf
... 1569-69-3 116.22 Cyclohexane, 1,1,3-trimethyl- 3073-66-3 126.24 Cyclohexanol 108-93-0 100.16 Cyclohexanone 108-94-1 98.15 Cyclohexyl isothiocyanate 1122-82-3 141.23 ...
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ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 34.8MB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol2.pdf
... Degussa 3 3 3 53.13 1 I R41 Balls et al. (1995) Chlorhexidine 55-56-1 solid I* neat n.p. Degussa 4 3 4 - 1 I R41 Balls et al. (1995) Cyclohexanol 108-93-0 liquid S undiluted 97% ...
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Comparison of devTOX quickPredict Assay With Other Methods 1.0MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/comparisonspreadsheet-508.pdf
... aniline, N-methylaniline, N,N-dimethylaniline, quinone, chloroacetaldehyde, or cyclohexanol. 1993 Bulletin of environmental contamination and toxicology 50(6) 878-82 ZET 16 ...
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TR-574: Pyrogallol (CASRN 87-66-1) in F344/N Rats and B6C3F1... 13.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr574_508.pdf
... Other chemical synthesis methods can be used including the chlorination of cyclohexanol to form tetrachlorocyclohexanone, followed by hydrolysis (Allen, 1907; Leston, 2000). As of ...
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Comparison of the Stemina devTOX quickPredict system with other... 2.1MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2018-09961/palmer-stemina-spreadsheet.pdf
... isopropylamine, aniline, N-methylaniline, N,N-dimethylaniline, quinone, chloroacetaldehyde, or cyclohexanol. 1993 Bull Environ Contam Toxicol 50(6) 878-82 ZET 16 Ali et al. ...
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Report: International Workshop on In Vitro Methods for Assessing... 25.4MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf
... 2- Butoxyethanol 111-76-2 3073.20 26 1477.5 12.5 1229.3 10.4 118.2 12.5 325 Cyclohexanol 108-93-0 2634.73 26.3 2063.7 20.6 NA NA 100.18 20.6 326 Halothane 151-67-7 6138.83 31.1 ...
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TR-306: Dichloromethane (Methylene Chloride) (CASRN 75-09-2)... 13.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr306.pdf
... + + + + + + + + + + + + + + + + + + + + + + + + Adeaom.. NOS X X X X X X X X X X X X Adronal + + + + + + + +. + + + + + + + + + + + + + + + + + Pheochromocytoma X ...
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TR-304: Chlorendic Acid (CASRN 115-28-6) in F344/N Rats and B6C3F1Mice... 14.6MB
https://ntp.niehs.nih.gov/go/tr304
... + + + + + + + + + + + + + + + + + + + + + + + + + + + + + ENDOCRINE SYStEM Pltu1tary Adronal Thyro1d Parathyroid + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + ...
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ICCVAM Test Method Evaluation Report: In Vitro Ocular Toxicity... 5.9MB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf
... Fisher Scientific soluble (3.6 International, Inc. Category 1 2 Cyclohexanol 108-93-0 ECETOC Sigma-Aldrich Corp. Alcohol Solvent 100% 0.1 mL 97% 100.2 4.5 noncorrosive 4 1.23 ...
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TR-319: 1,4-Dichlorobenzene (CASRN 106-46-7) in F344/N Rats and... 17.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr319.pdf
... SYSTEM PItuitary - + + + + + + + + + + + + + + + + + + + + + + + + Adenoma, NOS X X Adronal - + + + + + + + + + + + + + + + + + + + + + + + + Cortical ado noma Pheochromocytoma, ...
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TR-349: Two Pentachlorophenol Technical-Grade Mixtures (CASRN... 30.4MB
https://ntp.niehs.nih.gov/go/tr349
... metastatic, spleen 1 ENDOCRINE SYSTEM Adronal gland 49 + + + + + + + + + + + + + + + + + + + + + + + + + Adronal gland, cortex 49 Adranalgland, medulla + + + + + + + ...
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ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf
... VI trioxide 100 0.0027 0.27 0.8 80.0 2-Ethylbutanal 100.18 13.2 1322.4 39.7 3977.1 Cyclohexanol 100.18 26.3 2634.7 20.6 2063.7 Tetrahydrofurfuryl alcohol 102.15 111 11338.7 24.5 ...
