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TR-203: Phenol for Possible Carcinogenicity (CASRN108-95-2) 4.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr203.pdf
National Cancer Institute CARCINOGENESIS Technical Report Series No. 203 NTP No. 80-15 1980 BIOASSAY OF PHENOL FOR POSSIBLE CARCINOGENICITY CAS No. 108-95-2 NCI-CG-TR-203 NTP-80-15 ...
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Phenol: Target Organs and Levels of Evidence for TR-203 57KB
https://ntp.niehs.nih.gov/data/tr/200s/tr203levels
10320 Phenol: Target Organs and Levels of Evidence for TR-203 Bioassay of Phenol for Possible Carcinogenicity (CASRN108-95-2) Chemical (Study Title) CASRN Peer Review Date Route/...
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Abstract for TR-203 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr203
3abs Abstract for TR-203 Bioassay of Phenol for Possible Carcinogenicity CASRN: 108-95-2 Chemical Formula: C6H6O Molecular Weight: 94.1124 Report Date: August 1980 Full Report PDF ...
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Abstract for TER80129 59KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter80129
0129abs Abstract for TER80129 Teratologic Evaluation of Phenol in CD-1 Mice CASRN: 108-95-2 Chemical Formula: C6H6O Molecular Weight: 94.1124 Report Date: July 29, 1983 Abstract ...
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Abstract for TER81104 59KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter81104
4abs Abstract for TER81104 Teratologic Evaluation of Phenol in CD Rats CASRN: 108-95-2 Chemical Formula: C6H6O Molecular Weight: 94.1124 Report Date: July 29, 1983 Abstract The ...
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RoC Background Document: Phenolphthalein; Oct. 30-31, 1997 2.1MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/phenolphthalein1_508.pdf
... Phenolphthalein is produced commercially by condensation of phthalic anhydride with phenol ... [37811-54-4]),p,p'-diaminodiphenylmethane (DDPM) [101-77-9], and phenol red [143-74-8]. ...
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Abstract for TOX-09 66KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox009
Cresols are monomethyl derivatives of phenol, and are found as constituents of coal tar, in various industrial solvents and resins, and in some essential oils. In 28-day toxicity ...
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RoC Profile: Pentachlorophenol and By-products of Its Synthesis... 220KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/pentachlorophenol.pdf
dioxins and furans, polychlorinated phenols, hexachloro benzene, and other ... The body of literature with risk estimates specific for pentachloro- phenol exposure ...
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RoC Profile: Phenolphthalein; 15th RoC 2021 147KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/phenolphthalein.pdf
Dietary administration of phenol- phthalein caused thymic lymphoma and connective-tissue ... Most of the studies had limited statistical power (IARC 2000). Since phenol phthalein was ...
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Abstract for TR-542 78KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr542
Cumene is the principal chemical used in the production of phenol and acetone. Cumene is used to produce acetophenone, α-methylstyrene, diisopropylbenzene, and dicumylperoxide; as ...
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TR-353: 2,4-Dichlorophenol (CASRN 120-83-2) in F344/N Rats and... 10.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr353.pdf
... fed diets containing 0, 2,500, 5,000, 10,000, 20,000, or 40,000 ppm 2,4-dichloro- phenol. ... draft Technical Report on 2,4-tlichloro- phenol on April 18,1988,a r e listed below Panel ...
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Abstract for TOX-78 71KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox078
Triethylamine is used primarily as a catalyst to cure the resin systems incorporated into sand cores for foundry molds. It is also used as a curing catalyst in phenol-formaldehyde ...
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Abstract for TR-89 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr089
Abstract o-Anisidine is used chiefly in the manufacture of dyes, one method being the diazotization of o-anisidine and coupling with other aromatic amines or phenols to yield a ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 6.3MB
https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf
... This.monograph.includes.the.NTP.Brief.on.Bis- phenol.A,.a.list.of.the.expert.panel.members....majority.of."free".bis- phenol.A.circulating.in.human.blood.is.bound.to. plasma.proteins. ...
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RoC Profile: 2,4,6-Trichlorophenol; 15th RoC 2021 140KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/trichlorophenol.pdf
Administered in the diet, 2,4,6-trichloro phenol caused benign or malignant liver tumors ... Most uses of 2,4,6-trichloro phenol were canceled in the United States; however, it ...
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Abstract for TR-550 69KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr550
methylphenol, mixed; mixed cresols; phenol, methyl-, mixed; 3-Cresol; ... m-methylphenylol; m-oxytoluene; m-toluol; phenol, 3-methyl-; 4-Cresol; ...
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TR-349: Two Pentachlorophenol Technical-Grade Mixtures (CASRN... 30.4MB
https://ntp.niehs.nih.gov/go/tr349
... exposed to technical-grade pentachloro- phenol, as shown by increased incidences of ... the draft Technical Report on pentachloro- phenol on April18, 1988, are listed below. ...
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National Institute of Environmental Health Sciences: NIEHS-05 152KB
https://www.niehs.nih.gov/research/atniehs/dtt/assoc/reports/niehs-reports/niehs-05
Phenol Phosphate (CASRN 68937-417) in Male Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies) NIEHS-05 Full Report (3MB) Abstract Background: Isopropylated phenol ...
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RoC Concept: Cumene 251KB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/concepts/cumeneconcdocroc8-30-12_508.pdf
in the United States with the majority of its use in the synthesis of acetone and phenol. ... The primary use of cumene is in the production of acetone and phenol. Occupational ...
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Abstract for TR-289 70KB
https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr289
in used in the synthesis of styrene (polystyrene plastics and synthetic rubber), phenol (phenolic resins), cyclohexane (nylon), aniline, maleic anhydride (polyester resins), ...
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Submission of the CertiChem Cell Proliferation Test Method for... 3.1MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/submdoc.pdf
... Briefly, MCF-7 cells are maintained at 37 o C in RMPI with Phenol Red for routine culture. An aliquot of cells maintained at 37 o C are grown for two days in phenol-free media ...
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Japanese Minimum Requirements for Biological Products 2.0MB
https://ntp.niehs.nih.gov/iccvam/methods/biologics/vaccine/japan-minreqs.pdf
.........303 Test for Phenol Content......cell growth-promoting substances, phenol red at a concentration not higher than ...
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Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf
... for the second two substances, and resorcylic acid lactone/phenol for the last substance). ... es 1 P P P Onium Compoun ds 1 P P P Phenols 8 4 1 3 1 1 1 Phthalic Acids 3 2 1 1 1 1 ...
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TOX-9: Cresols (CASRNs 95-48-7, 108-39-4, 106-44-5) 6.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox009.pdf
... Weight: 108.13 o-cresol synonyms: phenol, 2-methyl- (9CI); 2-cresol; o-cresylic ... o-toluol; UN 2076 m-cresol synonyms: phenol, 3-methyl- (9CI); 3-cresol; m-cresole; ...
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TR-465: Phenolphthalein (CASRN 77-09-8) in F344 Rats and B6C3F1Mice... 18.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr465.pdf
... finding attributed to exposure to phenol- phthalein.Theabsolute right cauda weight ... given 0, 12,000, 25,000, or 50,000ppm phenol- phthalein (equivalent to average daily ...
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TR-550: Cresols (CASRN 1319-77-3) in Male F344/N Rats and Female... 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr550.pdf
... methylphenol, mixed; mixed cresols; phenol, methyl-, mixed Synonyms for m-cresol ... m-methylphenylol; m-oxytoluene; m-toluol; phenol, 3-methyl- Synonyms for p-cresol (40%): ...
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TOX-35: Chemical Mixture of 25 Groundwater Contaminants 11.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox35.pdf
... 37.5 Nickel 0 .5 0 .204 0 .68 2 .04 6 .8 Phenol 3 .27 0 .87 2 .9 8 .7 29 ... 0 .5 0 .204 0 .68 2 .04 6 .8 Phenol 108-95-2 3 .27 0 .87 2 .9 8 .7 29 ...
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RoC Review of Cumene 71KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/cumene
Used primarily to produce phenol and acetone (accounting for 98% of all use). People are ... Michael Klein-Boymann CEFIC Phenol & Acetone Producers Sector Group Other Back to Top Note ...
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Comment: Draft Report 05 Dated March 21, 2021; J.C. DiNardo;... 243KB
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/october/publiccomm/dinardo_oxybenzone20210928_trprp_508.pdf
... - "After adjustment, phenol biomarkers were not associated with percent fat mass. ... Although we did not observe strong evidence that prenatal environmental phenols exposures ...
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Final RoC Background Document for Formaldehyde 5.8MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/formaldehyde_bd_final.pdf
... resins (mainly urea-formaldehyde, phenol-formaldehyde, polyacetal, and melamine- ... limit PET: polyethylene terephthalate PF: phenol-formaldehyde PGA: phenylglyoxylic acid ...
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GMM-12: Genetically Modified Model Report on Phenolphthalein... 768KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm12_508.pdf
... Male and female haploinsuffi- cient p16 Ink4a /p19 Arf mice were exposed to phenol- ... no evidence of carcinogenic activity* of phenol- phthalein in male or female ...
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Cumene: Preliminary Literature Search Strategy and List of References 698KB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/cumene-litsearch&references5oct2012_508.pdf
... its use in the manufacture of acetone and phenol, and those search terms were combined ... Toxicity Mechanism Exposure scenario (Phenol/ Acetone manufacturing) ("phenol" and ...
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Draft RoC Monograph for Pentachlorophenol: Literature Search... 2.0MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/pcpliteraturesearch20130815_508.pdf
... Desmurs & Ratton 2000 Polyhalogenated Phenols- NF Wood Preservatives- NF ... class synonyms chlorophenols/chlorinated phenols/polychlorinated phenols Cancer studies in ...
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Presentation: Conducting and Interpreting the BCOP Test Method 2.5MB
https://ntp.niehs.nih.gov/iccvam/meetings/implement-2011/ocular-present/7-raabe.pdf
... serum added - pH indicator, phenol red removed from incubation medium . Reduces background absorbance (opacity) . Eliminate color change - Phenol red used in the rinsing medium ...
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Abstract for TR-424 72KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr424
2-Benzyl-4-chlorophenol; 4-chloro-2-benzylphenol; 4-chloro-2-(phenylmethyl)phenol; 4-chloro-alpha-phenol o-cresol; p-chloro-o-benzylphenol; 2-hydroxy-5-chlorodiphenylmethane Report ...
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Abstract for TR-444 70KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr444
Names: 4-Chloro-a-phenol- o -cresol; p -chloro- o -benzylphenol; 2-benzyl-4-chlorophenol; 2-hydroxy-5-chlorodiphenylmethane; 4-chloro-2-(phenylmethyl)phenol; ...
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TR-483: Pentachlorophenol (CASRN 87-86-5) in F344/N Rats (Feed... 7.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr483.pdf
... Chinese hamster ovary cells, pentachloro- phenol was weakly positive for induction of ... In the chromosomal aberrations test, pentachloro- phenol was negative without S9 but ...
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TR-301: ORTHO-Phenylphenol (CASRN 90-43-7) Alone and with 7,12... 15.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr301.pdf
... DMBNacetone (15/100) was similar to that in mice dosed with DMBNo-phenyl- phenol (17/100). ... Cats are more sensitive to o-phenyl- phenol than are other species tested, the acute oral ...
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Abstract for TR-551 73KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr551
...y-4-hydroxyphenyl)-1-propene; 2-methoxy-4-prop-1-enylphenol (IUPAC); phenol, 2-methoxy-4-propenyl (8CI); phenol, 2-methoxy-4-(1-propenyl) (9CI); 4-propenylguaiacol Report Date: ...
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RoC Monograph: Cumene; September 2013 2.3MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/cumene_508.pdf
... is a high-production chemical with 98% of it used in the production of acetone and phenol. ... in the United States with the majority of its use in the synthesis of acetone and phenol. ...
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RoC Monograph: Pentachlorophenol and By-products of Its Synthesis... 2.9MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/pentachlorophenol_508.pdf
... are higher-chlorinated dioxins and furans, polychlorinated phenols, and hexachlorobenzene. ... dioxins and furans, polychlorinated phenols, hexachlorobenzene and other by- products. ...
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Background Review Document: In Vitro Test Methods for Assessing... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/epis_brd0801.pdf
... acids, organic bases, neutral organics, phenols, inorganic acids, inorganic bases, ... neutral organic bases, phenols, inorganic acids and bases, electrophiles, and surfactants. ...
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Abstract for DART-08 153KB
https://ntp.niehs.nih.gov/publications/reports/dart/dart08
2,2-bis(4-hydroxyphenyl)hexafluoropropane; 2,2-bis(4-hydroxyphenyl)perfluoropropane; phenol, 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis-; hexafluorobisphenol a ...
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ECVAM Statement on the Scientific Validity of the EPISKIN Test 68KB
https://ntp.niehs.nih.gov/iccvam/methods/dermal/epiderm/epiddocs/episkin_statement.pdf
acids, inorganic bases, inorganic salts, electrophiles, phenols and soaps/ surfactants. ... groups of chemicals (e.g. organic acids, phenols) and/or all chemicals (single chemical ...
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RoC Profile: Cumene; 15th RoC 2021 170KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cumene.pdf
... Arene oxides can form phenols, and when the para isomers of methylphenol, ethylphenol, and ... Cumene is used primarily in the manufacture of phenol and acetone (accounting for 98% of ...
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TR-424: o-Benzyl-p-Chlorophenol (CASRN 120-32-1) in F344/N Rats... 15.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr424.pdf
... 2-benzyl4chlorophenol, 4chloro-2-benzylphenol, 4chloro-2-(phenylmethyl)phenol, 4chloro-a-phenol-ocresol, pchloro- o-benzylphenol, 2-hydroxydchlorodiphenylmethane Trade ...
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TR-444: Initiation/Promotion Study of o-Benzyl-p-Chlorophenol... 6.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr444.pdf
... 1; 4-Chloro-a-phenol+-cresol;p-ch1oro-o-benzylphenol; 2-benzyl-4-chlorophenol;2-hydroxy-5-chlorodiphenylmethane; Septiphene 4-chloro-2-(phenylmethyl)phenol;4-chloro-2-benzylp...
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ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf
... for the second two substances, and resorcylic acid lactone/phenol for the last substance). ... 1 Peptide 1 Chlorinated hydrocarbon 1 Phenol 14 Chlorinated triphenylethylene 1 ...
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TR-417: p-Nitrophenol (CASRN 100-02-7) in Swiss Webster Mice... 7.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr417.pdf
... The primary use o f p-nitro- phenol, however, has shifted from the manufacture of ... direct skin contact are also possible, especially fromp-nitro- phenol-based fungicides. ...
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Protocol: Evaluation of Human Cancer Studies on Exposure to Pentachlor... 363KB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/protocols/pcphumanstudies20130815_508.pdf
and other higher chlorinated phenols (tetrachlorophenol, trichlorophenol). ... 7 OR chlorophenols OR chlorinated phenols OR polychlorinated phenols OR (wood and ...
