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TR-402: Furan (CASRN 110-00-9) in F344 Rats and B6C3F1 Mice(Gavage... 31.9MB
https://ntp.niehs.nih.gov/go/tr402
2 TOXICOLOGY AND CARCINOGENESIS STUDIES OF FURAN (CAS NO. 110-00-9) IN F344/N RATS AND B6C3F 1 MICE (GAVAGE STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health ...
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RoC Background Document: Furan; Nov. 18-19, 1996 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/furan1_508.pdf
FURAN FINAL MARCH 1999 Prepared for the November 18-19, 1996, Meeting of the Report on ... NOI-ES-25346 NTP Report on Carcinogens 1996 Background Document for Furan TABLE OF ...
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RoC Profile: Furan; 15th RoC 2021 152KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/furan.pdf
Furan CAS No. 110-00-9 Reasonably anticipated to be a human carcinogen First listed in the Eighth Report on Carcinogens (1998) O Carcinogenicity Furan is reasonably anticipated to ...
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Abstract for TR-402 67KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr402
Abstract for TR-402 Toxicology and Carcinogenesis Studies of Furan in F344/N Rats and B6C3F1 Mice(Gavage Studies) CASRN: 110-00-9 Chemical Formula: C4H4O Molecular Weight: 68.08 ...
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Target Organs and Levels of Evidence for TR-402 58KB
https://ntp.niehs.nih.gov/data/tr/400s/tr402levels
Target Organs and Levels of Evidence for TR-402 Toxicology and Carcinogenesis Studies of Furan (CASRN 110-00-9) in F344 Rats and B6C3F1 Mice (Gavage Studies) Chemical (Study Title) ...
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Abstract for TR-337 65KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr337
Full Report PDF Abstract Nitrofurazone is a synthetic furan derivative, active against a broad spectrum of bacteria, which has been widely used in veterinary and human medicine. ...
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Abstract for TR-382 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr382
Full Report PDF Abstract Furfural is used as a precursor for the manufacture of furan, furfuryl alcohol, tetrahydrofuran, and their derivatives and as an industrial solvent. ...
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Minutes: BSC; June 12, 2008 280KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2008/june/minutes20080612.pdf
......... 30 Furan ......melamine and cyanuric acid and furan, food contaminants that have been ...
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Minutes: BSC RoC; Nov. 18-19, 1996 149KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1996/dec/brc_minutes19961119_508.pdf
and its hydrochloride salt Chlorozotocin Furan Nitroarenes 1-Nitropyrene 4-Nitropyrene ... The motion was accepted unanimously with five votes. Furan -- Furan is proposed to be ...
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Abstract for TR-482 76KB
https://ntp.niehs.nih.gov/publications/reports/tr/tr482
Furfuryl alcohol-based resins are used as binding agents in foundry sand and as corrosion inhibitors in mortar, grout, and cement. Because of their heat resistance, furan resins ...
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TR-382: Furfural (CASRN 98-01-1) in F344/N Rats and B6C3F1Mice... 11.6MB
https://ntp.niehs.nih.gov/go/tr382
... as a precursor for the manufacture of furan, furfuryl alcohol, tetrahydrofuran, and ... The smaller stabilization energy of furan (23 zk 1 kcal/mol) compared with that of benzene ...
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Abstract for RoC MGRAPH-03 59KB
https://ntp.niehs.nih.gov/publications/roc/rocmgraph03
The most predominant by-products are higher-chlorinated dioxins and furans, polychlorinated phenols, and hexachlorobenzene. In the United States, PCP is no longer produced, and its ...
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TR-370: Benzofuran (CASRN 271-89-6) in F344/N Rats and B6C3F1Mice... 12.5MB
https://ntp.niehs.nih.gov/go/tr370
... or 120mgkg benzofuran 0,120, or 240 m g k g benzo- furan in corn oil, 5 d/wk in corn oil, 5d/wk in corn oil, 5 d/wk furan in corn oil, 5 d/wk Body weights in the 2-year study ...
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TR-482: Furfural Alcohol (CASRN 98-00-0) in F344/N Rats and B6C3F1... 27.3MB
https://ntp.niehs.nih.gov/go/tr482
... Clinical findings included grout, and cement. Because of their heat resistance, furan ... alcohol as part of a class study with furan and furfural, noting that ...
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RoC Profile: Pentachlorophenol and By-products of Its Synthesis... 220KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/pentachlorophenol.pdf
includes higher-chlorinated dioxins and furans, polychlorinated phenols, hexachloro ... relationships among residues of pentachlorophenol, dioxins, and furans in wood and beef. ...
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TR-337: Nitrofurazone (CASRN 59-87-0) in F344/N Rats and B6C3F1Mice... 10.7MB
https://ntp.niehs.nih.gov/go/tr337
... ABSTRACT Nitrofurazone is a synthetic furan derivative, active against a broad ... and Production Nitrofurazone, a synthetic furan derivative ac- tive against a broad ...
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Minutes: BSC TRRS; March 11, 1991 723KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1991/mar/trrs11mar1991mins_508.pdf
Pigment Red 23 2,4-Diaminophenol D i h y d r o c h l o r i d e Furan Naphthalene Q u e r c ... Long-Term S t u d i e s 6459-94-5 Water 6471-49-4 Feed 137-09-7 Gavage 110-00-9 Gavage ...
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RoC Background Document: 2,3,7,8-Tetrachlorodibenzo-p-dioxin... 7.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/other_background/tetrachl_tcdd_4apps_508.pdf
... TCDD has the highest affinity of the chlorinated dioxins and furans for both rodent and ... of TCDD and other chlorinated dioxins and furans in humans and rodents which involves ...
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TR-475: Tetrahydrofuran (CASRN 109-99-9) in F344/N Rats and B6C3F1Mice... 9.6MB
https://ntp.niehs.nih.gov/go/tr475
... Mirer said that a structural analogy of tetrahydrofuran to furan is misplaced; rather it ... by the catalytic hydro- genation of maleic anhydride or furan (Merck Index online, 1993). ...
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Protocol: Evaluation of Human Cancer Studies on Exposure to Pentachlor... 363KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/thirteenth/protocols/pcphumanstudies20130815_508.pdf
...orodibenzo-p-dioxins), higher chlorinated furans hexachlorobenzene and other higher ... The use of levels of polychlorinated dibenzodioxins and furans, which have longer ...
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RoC Profile: 2,3,7,8-Tetrachlorodibenzo-p-dioxin; 15th RoC 2021 154KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tetrachlorodibenzodioxin.pdf
... Of all the chlorinated dioxins and furans, TCDD has the highest affinity for both rodent ... Act Mobile Source Air Toxics: Dioxin and furans are listed as a mobile-source air toxic ...
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RoC Monograph: Pentachlorophenol and By-products of Its Synthesis... 2.9MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/pentachlorophenol_508.pdf
... The most predominant by-products are higher-chlorinated dioxins and furans, ... dioxins and furans, polychlorinated phenols, hexachlorobenzene and other by- products. ...
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Harderian gland - Dilation - Nonneoplastic Lesion Atlas 283KB
https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/harderian-gland/Dilation
National Toxicology Program. 1993. NTP TR-402. Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344 Rats and B6C3F1 Mice (Gavage Studies). NTP, Research ...
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Harderian Gland - Dilation 413KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/harderian/dilat/harderian-gland-dilation_508.pdf
.../MED/10987121 National Toxicology Program. 1993. NTP TR-402. Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344 Rats and B6C3F 1 Mice (Gavage Studies). ...
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Protocol: Evaluation of Cancer Studies in Experimental Animals... 294KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/thirteenth/protocols/pcpanimalcancer20130815_508.pdf
... Some of these by-products are dioxins and furans, which have dioxin-like equivalency ... Calculate TEQ value for dioxins, furans, etc., having toxic equivalent factors (TEF) ...
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Adrenal glands - Extramedullary Hematopoiesis - Nonneoplastic... 294KB
https://ntp.niehs.nih.gov/atlas/nnl/endocrine-system/adrenal-gland/ExtramedullaryHematopoiesis
... National Toxicology Program. 1993. NTP TR-402. Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344 Rats and B6C3F1 Mice (Gavage Studies). NTP, Research ...
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TR-589: Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade... 7.3MB
https://ntp.niehs.nih.gov/go/tr589
... of brominated dioxins and furans and contribute to ambient air exposure to the PBDEs 24 . ... of a number of brominated dioxins and furans that are components of DE-71, with regard ...
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Appendix G; 15th RoC 2021 69KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/appendix_g.pdf
... see Bis(chloromethyl) Ether and Technical-Grade Chloromethyl Methyl Ether 110-00-9 see Furan 115-28-6 see Chlorendic Acid 116-14-3 see Tetrafluoroethylene 117-10-2 see ...
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15th Report on Carcinogens 97KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/roc
... Steroidal Ethylene Oxide Ethylene Thiourea Ethyl Methanesulfonate F Formaldehyde Furan G Certain Glass Wool Fibers (Inhalable) Glycidol H Haloacetic Acids Helicobacter pylori ...
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NTP at the SOT; March 6, 2005 308KB
https://ntp.niehs.nih.gov/ntp/meetings/2005/ntpsot2_508.pdf
... Marjo Using Observed Variability as a Criterion for Cellular Kinetics Models after Furan Exposure 1302 6:00 pm Special Session: The Great Debate 229 Portier, Christopher The 2-yr. ...
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Adrenal Gland - Extramedullary Hematopoiesis 644KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/endocrine/adrenal/emh/adrenal-gland-emh-pdf_508.pdf
.../book/9780702035197 National Toxicology Program. 1993. NTP TR-402. Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344 Rats and B6C3F1 Mice (Gavage Studies). ...
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TR-341: Nitrofurantoin (CASRN 67-20-9) in F344/N Rats and B6C3F1Mice... 10.0MB
https://ntp.niehs.nih.gov/go/tr341
... A derivative of 5-nitrofuran, ni- trofurantoin is structurally related to furan and to ... The 5-nitro- furan derivatives have been used extensively in topically and parenterally ...
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TR-554: 5-(Hydroxymethyl)-2-furfural (CASRN 67-47-0) in F344... 4.4MB
https://ntp.niehs.nih.gov/go/tr554
... compounds structurally related to 5-(hydroxymethyl)-2- furfural: furan, furfural, and furfuryl alcohol. Furan administered by gavage was a potent carcinogen in both rats and ...
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Completed RoC Evaluations 122KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/roc
... Formaldehyde Known to be a human carcinogen Background Document Request Archived Materials Furan Reasonably anticipated to be a human carcinogen Background Document Request ...
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Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/listed_substances_508.pdf
... to 3,3'-Dimethylbenzidine) Epichlorohydrin Ethylene Thiourea Ethyl Methanesulfonate Furan Glass Wool Fibers (Inhalable), Certain Glycidol Hexachlorobenzene Hexachloroethane ...
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Minutes: BSC TRRS; June 23, 1992 1.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1992/june/trrs23june1992mins_508.pdf
... He noted that in the NTP studies on furan, stop studies had shown that these lesions ... would indicate the number of brornines but not their position on the furan ring. Dr. ...
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Minutes: BSC TRRS; April 18, 1988 4.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1988/apr/88apr18trrsmins_508.pdf
... The link with other furans such as furfural recently reported to be carcinogenic might be ... Ashby pointed out this was another chemical containing a furan moiety which was clearly ...
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TR-525: 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117... 4.3MB
https://ntp.niehs.nih.gov/go/tr525
... equivalency factor (TEF) evaluations of dioxin-like compounds (dioxins, PCBs, furans). Dr. ... The other two impurities (1.4% combined) had none of the characteristics of PCBs, furans, ...
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TR-526: Mixture of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD... 6.6MB
https://ntp.niehs.nih.gov/go/tr526
... factor (TEF) evaluations of mixtures of dioxin-like compounds (dioxins, PCBs, furans). Dr. ... Two of the impurities (1%) had characteristics of other furans, while the other two ...
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Draft RoC Monograph for Pentachlorophenol: Literature Search... 2.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/thirteenth/litsearchstrategy/pcpliteraturesearch20130815_508.pdf
... 1996. Pharmacokinetic model of dioxin and furan levels in adipose tissue from sawmill work ... AJ, Clark JJ, Rosenfeld PE. 2011. Dioxin furan blood lipid and attic dust concentrations ...
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Minutes: BSC; July 14, 1987 1.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1987/december/19871214bsc_minutes_508be.pdf
... n i c i t y o f various d i o x i n s and furans i n t h e developing mouse embryo, and on ... i t r a l ; m e t h a l l y l c h l o r i d e ; dimethylvinyl c h l o r i d e ; and furan. ...
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ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 42.0MB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol1.pdf
... formulation Fomesafen 72128-02-0 Imide, Ether, Nitro compound Pesticide Furan 110-00-9 Heterocyclic Chemical intermediate Gel Cleanser (HZE) 100% - Formulation ...
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TR-398: Polybrominated Biphenyls (CASRN 67774-32-7)(Firemaster... 14.8MB
https://ntp.niehs.nih.gov/go/tr398
... the test mixture with brominated dibenzo- furans, compounds for which there had been ... would indicate the number of bromines but not their position on the furan ring. Dr. ...
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Minutes: BSC TRRS; Dec. 9, 1997 1.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1997/dec/trrs9dec1997mins_508.pdf
... as part of a class study with furan and furfural, noting that cholangiocarcinomas and other hepatocellular neoplasms were significant neoplastic findings with furan and furfural. ...
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TR-531: Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl (PCB... 7.2MB
https://ntp.niehs.nih.gov/go/tr531
... Factor evaluations of mixtures of dioxin- like compounds (dioxins, PCBs, furans). Dr. ... Other chemicals, including furan, have increased the incidence of lesions similar to those ...
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Peer Review Report: RoC Peer Review; Dec. 12-13, 2013 287KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2013/december/peerreviewrpt20131213_508.pdf
... grade) pentachlorophenol; these include the tri- and tetra-chlorinated phenols, hexachlorobenzene, and dioxins and furans (primarily hexa-, hepta-, and octa- dioxins and furans). ...
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TR-356: Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1Mice... 11.6MB
https://ntp.niehs.nih.gov/go/tr356
... The link with other furans such as furfural, recently reported ta be carcinogenic, tnight ... suggesting an arene oxide intermediate involving the furan ring (Wirth et al., 1976). ...
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TR-359: 8-Methoxypsoralen (CASRN 298-81-7) in F344/N Rats (Gavage... 7.8MB
https://ntp.niehs.nih.gov/go/tr359
... J. Ashby pointed out that this was another chemical containing a furan moi- ety which was ... takes place at the 2',3' position of the furan ring (Schmid et al., 1980). ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... NE No Evidence NE No Evidence NE No Evidence NE No Evidence TR-402 03/11/91 Furan 110-00-9 P Clear Evidence P Clear Evidence P Clear Evidence P Clear Evidence TR-401 03/11/...
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TR-509: 2,4-Hexadienal (89% trans,trans Isomer, CASRN 142-83... 2.9MB
https://ntp.niehs.nih.gov/go/tr509
... di- and epoxyalde- hydes, lactones, furans, ketones, oxo- and hydroxyacids, and ... Eugenol FD&C Yellow No. 6 Fumonisin B 1 Furan Furfural Furfuryl Alcohol Furosemide ...