TR-402: Furan (CASRN 110-00-9) in F344 Rats and B6C3F1 Mice(Gavage... 31.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr402.pdf

2 TOXICOLOGY AND CARCINOGENESIS STUDIES OF FURAN (CAS NO. 110-00-9) IN F344/N RATS AND B6C3F 1 MICE (GAVAGE STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health ...

RoC Background Document: Furan; Nov. 18-19, 1996 3.0MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/furan1_508.pdf

FURAN FINAL MARCH 1999 Prepared for the November 18-19, 1996, Meeting of the Report on ... NOI-ES-25346 NTP Report on Carcinogens 1996 Background Document for Furan TABLE OF ...

RoC Profile: Furan; 15th RoC 2021 152KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/furan.pdf

Furan CAS No. 110-00-9 Reasonably anticipated to be a human carcinogen First listed in the Eighth Report on Carcinogens (1998) O Carcinogenicity Furan is reasonably anticipated to ...

Abstract for TR-402 69KB

https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr402

Abstract for TR-402 Toxicology and Carcinogenesis Studies of Furan in F344/N Rats and B6C3F1 Mice(Gavage Studies) CASRN: 110-00-9 Chemical Formula: C4H4O Molecular Weight: 68.08 ...

Target Organs and Levels of Evidence for TR-402 60KB

https://ntp.niehs.nih.gov/data/tr/400s/tr402levels

Target Organs and Levels of Evidence for TR-402 Toxicology and Carcinogenesis Studies of Furan (CASRN 110-00-9) in F344 Rats and B6C3F1 Mice (Gavage Studies) Chemical (Study Title) ...

Abstract for TR-337 68KB

https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr337

Full Report PDF Abstract Nitrofurazone is a synthetic furan derivative, active against a broad spectrum of bacteria, which has been widely used in veterinary and human medicine. ...

Abstract for TR-382 65KB

https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr382

Full Report PDF Abstract Furfural is used as a precursor for the manufacture of furan, furfuryl alcohol, tetrahydrofuran, and their derivatives and as an industrial solvent. ...

Minutes: BSC; June 12, 2008 280KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2008/june/minutes20080612.pdf

......... 30 Furan ......melamine and cyanuric acid and furan, food contaminants that have been ...

Minutes: BSC RoC; Nov. 18-19, 1996 149KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1996/dec/brc_minutes19961119_508.pdf

and its hydrochloride salt Chlorozotocin Furan Nitroarenes 1-Nitropyrene 4-Nitropyrene ... The motion was accepted unanimously with five votes. Furan -- Furan is proposed to be ...

Abstract for TR-482 78KB

https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr482

Furfuryl alcohol-based resins are used as binding agents in foundry sand and as corrosion inhibitors in mortar, grout, and cement. Because of their heat resistance, furan resins ...

TR-382: Furfural (CASRN 98-01-1) in F344/N Rats and B6C3F1Mice... 11.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr382.pdf

... as a precursor for the manufacture of furan, furfuryl alcohol, tetrahydrofuran, and ... The smaller stabilization energy of furan (23 zk 1 kcal/mol) compared with that of benzene ...

TR-370: Benzofuran (CASRN 271-89-6) in F344/N Rats and B6C3F1Mice... 12.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr370.pdf

... or 120mgkg benzofuran 0,120, or 240 m g k g benzo- furan in corn oil, 5 d/wk in corn oil, 5d/wk in corn oil, 5 d/wk furan in corn oil, 5 d/wk Body weights in the 2-year study ...

TR-482: Furfural Alcohol (CASRN 98-00-0) in F344/N Rats and B6C3F1... 27.3MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr482.pdf

... Clinical findings included grout, and cement. Because of their heat resistance, furan ... alcohol as part of a class study with furan and furfural, noting that ...

RoC Profile: Pentachlorophenol and By-products of Its Synthesis... 220KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/pentachlorophenol.pdf

includes higher-chlorinated dioxins and furans, polychlorinated phenols, hexachloro ... relationships among residues of pentachlorophenol, dioxins, and furans in wood and beef. ...

TR-337: Nitrofurazone (CASRN 59-87-0) in F344/N Rats and B6C3F1Mice... 10.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr337.pdf

... ABSTRACT Nitrofurazone is a synthetic furan derivative, active against a broad ... and Production Nitrofurazone, a synthetic furan derivative ac- tive against a broad ...

RoC Background Document: 2,3,7,8-Tetrachlorodibenzo-p-dioxin... 7.0MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/tetrachl_tcdd_4apps_508.pdf

... TCDD has the highest affinity of the chlorinated dioxins and furans for both rodent and ... of TCDD and other chlorinated dioxins and furans in humans and rodents which involves ...

Minutes: BSC TRRS; March 11, 1991 723KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1991/mar/trrs11mar1991mins_508.pdf

Pigment Red 23 2,4-Diaminophenol D i h y d r o c h l o r i d e Furan Naphthalene Q u e r c ... Long-Term S t u d i e s 6459-94-5 Water 6471-49-4 Feed 137-09-7 Gavage 110-00-9 Gavage ...

TR-475: Tetrahydrofuran (CASRN 109-99-9) in F344/N Rats and B6C3F1Mice... 9.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr475.pdf

... Mirer said that a structural analogy of tetrahydrofuran to furan is misplaced; rather it ... by the catalytic hydro- genation of maleic anhydride or furan (Merck Index online, 1993). ...

Protocol: Evaluation of Human Cancer Studies on Exposure to Pentachlor... 363KB

https://ntp.niehs.nih.gov/ntp/roc/thirteenth/protocols/pcphumanstudies20130815_508.pdf

...orodibenzo-p-dioxins), higher chlorinated furans hexachlorobenzene and other higher ... The use of levels of polychlorinated dibenzodioxins and furans, which have longer ...

RoC Profile: 2,3,7,8-Tetrachlorodibenzo-p-dioxin; 15th RoC 2021 154KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tetrachlorodibenzodioxin.pdf

... Of all the chlorinated dioxins and furans, TCDD has the highest affinity for both rodent ... Act Mobile Source Air Toxics: Dioxin and furans are listed as a mobile-source air toxic ...

RoC Monograph: Pentachlorophenol and By-products of Its Synthesis... 2.9MB

https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/pentachlorophenol_508.pdf

... The most predominant by-products are higher-chlorinated dioxins and furans, ... dioxins and furans, polychlorinated phenols, hexachlorobenzene and other by- products. ...

Harderian gland - Dilation - Nonneoplastic Lesion Atlas 289KB

https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/harderian-gland/Dilation

National Toxicology Program. 1993. NTP TR-402. Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344 Rats and B6C3F1 Mice (Gavage Studies). NTP, Research ...

Harderian Gland - Dilation 413KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/harderian/dilat/harderian-gland-dilation_508.pdf

.../MED/10987121 National Toxicology Program. 1993. NTP TR-402. Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344 Rats and B6C3F 1 Mice (Gavage Studies). ...

Protocol: Evaluation of Cancer Studies in Experimental Animals... 294KB

https://ntp.niehs.nih.gov/ntp/roc/thirteenth/protocols/pcpanimalcancer20130815_508.pdf

... Some of these by-products are dioxins and furans, which have dioxin-like equivalency ... Calculate TEQ value for dioxins, furans, etc., having toxic equivalent factors (TEF) ...

TR-589: Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade... 7.3MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr589_508.pdf

... of brominated dioxins and furans and contribute to ambient air exposure to the PBDEs 24 . ... of a number of brominated dioxins and furans that are components of DE-71, with regard ...

Appendix G; 15th RoC 2021 73KB

https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf

... see Bis(chloromethyl) Ether and Technical-Grade Chloromethyl Methyl Ether 110-00-9 see Furan 115-28-6 see Chlorendic Acid 116-14-3 see Tetrafluoroethylene 117-10-2 see ...

Adrenal glands - Extramedullary Hematopoiesis - Nonneoplastic... 299KB

https://ntp.niehs.nih.gov/atlas/nnl/endocrine-system/adrenal-gland/ExtramedullaryHematopoiesis

... National Toxicology Program. 1993. NTP TR-402. Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344 Rats and B6C3F1 Mice (Gavage Studies). NTP, Research ...

NTP at the SOT; March 6, 2005 308KB

https://ntp.niehs.nih.gov/ntp/meetings/2005/ntpsot2_508.pdf

... Marjo Using Observed Variability as a Criterion for Cellular Kinetics Models after Furan Exposure 1302 6:00 pm Special Session: The Great Debate 229 Portier, Christopher The 2-yr. ...

Adrenal Gland - Extramedullary Hematopoiesis 644KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/endocrine/adrenal/emh/adrenal-gland-emh-pdf_508.pdf

.../book/9780702035197 National Toxicology Program. 1993. NTP TR-402. Toxicology and Carcinogenesis Studies of Furan (CAS No. 110-00-9) in F344 Rats and B6C3F1 Mice (Gavage Studies). ...

TR-341: Nitrofurantoin (CASRN 67-20-9) in F344/N Rats and B6C3F1Mice... 10.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr341.pdf

... A derivative of 5-nitrofuran, ni- trofurantoin is structurally related to furan and to ... The 5-nitro- furan derivatives have been used extensively in topically and parenterally ...

TR-554: 5-(Hydroxymethyl)-2-furfural (CASRN 67-47-0) in F344... 7.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr554.pdf

... compounds structurally related to 5-(hydroxymethyl)-2- furfural: furan, furfural, and furfuryl alcohol. Furan administered by gavage was a potent carcinogen in both rats and ...

Completed RoC Evaluations 119KB

https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/roc

... Formaldehyde Known to be a human carcinogen Background Document Request Archived Materials Furan Reasonably anticipated to be a human carcinogen Background Document Request ...

Listed Substances; 15th RoC 2021 76KB

https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf

... to 3,3'-Dimethylbenzidine) Epichlorohydrin Ethylene Thiourea Ethyl Methanesulfonate Furan Glass Wool Fibers (Inhalable), Certain Glycidol Hexachlorobenzene Hexachloroethane ...

Minutes: BSC TRRS; June 23, 1992 1.4MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1992/june/trrs23june1992mins_508.pdf

... He noted that in the NTP studies on furan, stop studies had shown that these lesions ... would indicate the number of brornines but not their position on the furan ring. Dr. ...

Minutes: BSC TRRS; April 18, 1988 4.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1988/apr/88apr18trrsmins_508.pdf

... The link with other furans such as furfural recently reported to be carcinogenic might be ... Ashby pointed out this was another chemical containing a furan moiety which was clearly ...

NTP 2014: Current Directions & Evolving Strategies 3.3MB

https://ntp.niehs.nih.gov/ntp/pubs/currentdirections2014_508.pdf

... One such constituent is furan, a by-product of some chemical manufacturing processes, ... Furans are of concern because they are considered carcinogenic based on studies in ...

TR-525: 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117... 7.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr525.pdf

... equivalency factor (TEF) evaluations of dioxin-like compounds (dioxins, PCBs, furans). Dr. ... The other two impurities (1.4% combined) had none of the characteristics of PCBs, furans, ...

Presentation: Fundamentals of QSAR Modeling: Basic Concepts and... 7.7MB

https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2016/tropsha-508.pdf

... Slightly improved Example of fragment (alert) interaction 41 Nitro's mutagenic effect is: increased by furan (synergism) decreased by primary alkanes(antagonism) 84% mutagenic ...

TR-526: a Mixture of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD... 9.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr526.pdf

... factor (TEF) evaluations of mixtures of dioxin-like compounds (dioxins, PCBs, furans). Dr. ... Two of the impurities (1%) had characteristics of other furans, while the other two ...

Draft RoC Monograph for Pentachlorophenol: Literature Search... 2.0MB

https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/pcpliteraturesearch20130815_508.pdf

... 1996. Pharmacokinetic model of dioxin and furan levels in adipose tissue from sawmill work ... AJ, Clark JJ, Rosenfeld PE. 2011. Dioxin furan blood lipid and attic dust concentrations ...

Minutes: BSC; July 14, 1987 1.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1987/december/19871214bsc_minutes_508be.pdf

... n i c i t y o f various d i o x i n s and furans i n t h e developing mouse embryo, and on ... i t r a l ; m e t h a l l y l c h l o r i d e ; dimethylvinyl c h l o r i d e ; and furan. ...

ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 42.0MB

https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol1.pdf

... formulation Fomesafen 72128-02-0 Imide, Ether, Nitro compound Pesticide Furan 110-00-9 Heterocyclic Chemical intermediate Gel Cleanser (HZE) 100% - Formulation ...

TR-398: Polybrominated Biphenyls (CASRN 67774-32-7)(Firemaster... 14.8MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr398.pdf

... the test mixture with brominated dibenzo- furans, compounds for which there had been ... would indicate the number of bromines but not their position on the furan ring. Dr. ...

Minutes: BSC TRRS; Dec. 9, 1997 1.8MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1997/dec/trrs9dec1997mins_508.pdf

... as part of a class study with furan and furfural, noting that cholangiocarcinomas and other hepatocellular neoplasms were significant neoplastic findings with furan and furfural. ...

TR-531: a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl ... 12.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr531.pdf

... Factor evaluations of mixtures of dioxin- like compounds (dioxins, PCBs, furans). Dr. ... Other chemicals, including furan, have increased the incidence of lesions similar to those ...

Nomination Background: 2,3-Butanedione (CASRN: 431-03-8) 1.8MB

https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/artificial_butter_flavoring_508be.pdf

... 10 nitrogen- and/or sulfur- containing compounds, 7 alkanes, 6 δ-lactones, and 4 furans comprising 85% of total volatiles recovered when heated at 200 °C (Lee et al., 1991). ...

Peer Review Report: RoC Peer Review; Dec. 12-13, 2013 287KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2013/december/peerreviewrpt20131213_508.pdf

... grade) pentachlorophenol; these include the tri- and tetra-chlorinated phenols, hexachlorobenzene, and dioxins and furans (primarily hexa-, hepta-, and octa- dioxins and furans). ...

TR-356: Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1Mice... 11.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr356.pdf

... The link with other furans such as furfural, recently reported ta be carcinogenic, tnight ... suggesting an arene oxide intermediate involving the furan ring (Wirth et al., 1976). ...

TR-359: 8-Methoxypsoralen (CASRN 298-81-7) in F344/N Rats (Gavage... 7.8MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr359.pdf

... J. Ashby pointed out that this was another chemical containing a furan moi- ety which was ... takes place at the 2',3' position of the furan ring (Schmid et al., 1980). ...

NTP Technical Reports Index 1.5MB

https://ntp.niehs.nih.gov/data/tr

... NE No Evidence NE No Evidence NE No Evidence NE No Evidence TR-402 03/11/91 Furan 110-00-9 P Clear Evidence P Clear Evidence P Clear Evidence P Clear Evidence TR-401 03/11/...