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TOX-2: n-Hexane(CASRN 110-54-3) 2.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox002.pdf
NTP REPORT ON THE TOXICITY STUDIES OF n-HEXANE IN B6C3F 1 MICE (INHALATION STUDIES) ... Triangle Park, NC 27709 (919- 541-3991). n-Hexane,NTPTOX2 TOXICITY STUDIES OF n-HEXANE ...
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Abstract for TER90082 61KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter90082
82abs Abstract for TER90082 Inhalation Developmental Toxicology Studies: N-Hexane in Rats CASRN: 110-54-3 Chemical Formula: C6H14 Molecular Weight: 86.1766 Report Date: December ...
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Abstract for TOX-02 62KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox002
2abs Abstract for TOX-02 Toxicity Studies of n-Hexane in B6C3F1 Mice (Inhalation Studies) CASRN: 110-54-3 Chemical Formula: C6H14 Molecular Weight: 86.2 Synonyms/Common Names: ...
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Abstract for TER90083 60KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter90083
083abs Abstract for TER90083 N-Hexane Inhalation Developmental Toxicology Studies in Mice CASRN: 110-54-3 Chemical Formula: C6H14 Molecular Weight: 86.1766 Report Date: May 1988 ...
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Minutes: BSC TRRS; March 13, 1989 814KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1989/mar/89mar13trrsmins_508.pdf
T o x i c i t y Studies 67-64-1 87-68-3 110-54-3 Route Gavage Gavage Gavage Feed Gavage I ... would pass the Technical Report along w i t h comments t o the Program. n-Hexane. Dr. ...
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Abstract for TOX-24 65KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox024
dihydrochloride; 1,6-hexylenediamine dihydrochloride; 1,6-diamino-n-hexane dihydrochloride; HMDA; HDA; HDDC Report Date: March 1993 Full Report PDF Abstract ...
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RoC Profile: Nitrofen; 15th RoC 2021 125KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitrofen.pdf
It is insoluble in water, soluble in acetone, methanol, xylene, benzene, and n-hexane, and slightly soluble in ethanol (HSDB 2009). It darkens on exposure to light (Akron 2009). ...
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TOX-101: Trimethylsilyldiazomethane (CASRN 18107-18-1) Administered... 6.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox101_508.pdf
... peaks consistent with n-hexane (33.6%) and methylcyclopentane (25.7%) were identified. ... The major peaks for n-hexane, methylcyclopentane, and 3-methylpentane were 64.2%, 17.4%, ...
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Combining NAM Data and IVIVE for Evaluating Potential Inhalation... 595KB
https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-chang-poster.pdf
... Tetrachloroethylene 29 Regulation of gene expression 17.4 4.2 Neuro. Toluene 114 Cell viability 16.4 4.8 Neuro. Styrene 50 Genotoxicity 4.3 1.3 Neuro. n-Hexane 10 AChE activity 1.3 ...
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Advancing Flexibility for Defined Approach Guidelines: Developing... 1.2MB
https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Sullivan-poster.pdf
... Hexyl salicylate* 6259-76-3 Y NC 1 NC 1B Hydrocortisone* 50-23-7 Y NC N/A 1 1B n-Hexane 110-54-3 Y NC NC NC NC Propylene glycol* 57-55-6 Y NC NC NC NC α-Hexylcinnamaldehyde ...
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National Toxicology Program Toxicity Report Series 590KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox037.pdf
... Dosed Feed 91-3120 2 n-Hexane Inhalation 91-3121 3 Acetone Drinking ... Dosed Feed 91-3120 2 n-Hexane Inhalation 91-3121 3 Acetone Drinking ...
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TR-591: TRIM VX in Wistar Han [Crl:WI (Han)] Rats and B6C3F1... 7.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr591_508.pdf
... The total amount of n-hexane extractable material and the amounts of bacteria and fungi ... index, bacteria and fungi, total n-hexane extractable material and organic constituents. ...
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TOX-24: 1,6-Hexanediamine Dihydrochloride (CASRN 6055-52-3) 1.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox024.pdf
... dihydrochloride; 1,6-diamino-n-hexane dihydrochloride; HMDA; HDA; HDDC. 1,6-Hexanediamine (HDA) is an aliphatic amine that is produced in large volumes in the United States. ...
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TR-538: Methyl Isobutyl Ketone (CASRN 108-10-1) in F344/N Rats... 13.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr538.pdf
... Furthermore, methyl iso- butyl ketone strongly synergizes the n-hexane-induced ... leading to the metabolic activation of n-hexane to the potent neurotoxicant ...
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TR-586: CIMSTAR 3800 in F344/NTac Rats and B6C3F1/N Mice and... 2.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr586_508.pdf
... Samples were acidified, serially extracted with n-hexane, chemically dried, solvent ... Method 1664, revision A: n-
Hexane Extractable Material (HEM; oil and grease) and silica ...
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Short-Term Toxicity Reports 224KB
https://ntp.niehs.nih.gov/publications/reports/tox
... Toxicity TOX-02 PDF (1.95 MB) Toxicity Studies of n-Hexane in B6C3F1 Mice (Inhalation Studies) (CASRN 110-54-3) 1991 Short-Term Toxicity TOX-01 PDF (322.25 KB) Toxicity ...
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TR-375: Vinyl Toluene (Mixed Isomers) (65%meta-isomer and 32... 20.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr375.pdf
... was standardized daily by manually in- jecting solutions of vinyl toluene in n-hexane. ... daily by manually injecting prepared solu- tions of vinyl toluene in n-hexane. ...
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TOX-3: Acetone (CASRN 67-64-1) 2.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox003.pdf
... such as isopropanol, sec-butanol, and n-hexane, and the clinical state of ketosis ... hepato- and nephrotoxicity by n-hexane, methyl n-butyl ketone, and 2,5-hexanedione. ...
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ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 42.0MB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol1.pdf
... (acyclic) Not classified Hexane 110-54-3 Hydrocarbon (acyclic) Solvent n-Hexanol ... Severe Gautheron et al. (1994) Hexane 110-54-3 liquid 100% n.p. 1 2 Not Labeled Not ...
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TR-371: Toluene (CASRN108-88-3) in F344/N Rats and B6C3F1Mice... 15.6MB
https://ntp.niehs.nih.gov/go/tr371
... or reactivity to a thermal stimulus. n-Hexane, a known neurotox- icant, had marked ... Therefore, unlike solvents such as n-hexane, there is little evidence that toluene ...
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TR-298: Dimethyl Morpholinophosphoramidate (CASRN 597-25-1) in... 10.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr298.pdf
... Stable 1h 33%loss in 1h 60%lossin 1h Stable 6 months Stable 6 months Soluble in water, propylene, glycol, benzene, ether, n-hexane >99% N-methylmorpholine Morpholine ...
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TR-343: Benzyl Alcohol (CASRN 100-51-6) in F344/N Rats and B6C3F1Mice... 8.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr343.pdf
... Thin-layer chromatography was performed on silica gel plates with two sol- vent systems: n-hexane:acetone (85:15) and ethyl acetate. Gas chromatographic analysis was performed with ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 1.0MB
https://ntp.niehs.nih.gov/ntp/ohat/bromopropanes/2-bromopropane/2bp_monograph.pdf
... That measurement found a 2-BP level of 4,140.7 ppm, as well as 29.8 ppm of n-hexane and < 1 ppm of 1,1,1 trichloroethane. Unaccounted for in this exposure assessment were the two ...
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RoC Profile: Trichloroethylene; 15th RoC 2021 237KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/trichloroethylene.pdf
... Biological exposure indices: Trichloroacetic acid in urine (end of shift at end of workweek) = 15 mg/L; trichloroethanol in blood (without hydrolysis; n-hexane, methyl n-butyl ...
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TR-358: Ochratoxin A (CASRN 303-47-9) in F344/N Rats (Gavage... 8.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr358.pdf
... Benzene, o-xylene, and p - xylene were not present a t the detection limits of 100 ppm for benzene or 70 ppm for 0-or p-xylene hy system 2. n-Hexane was not present at a con- ...
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TOX-40: b-Bromo-b-Nitrostyrene (CASRN 7166-19-0) 2.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox040.pdf
... Toxicity Studies of n-Hexane (CAS No. 110-
54-3) in B6C3F Mice (Inhalation Studies). Toxicity Report Series No. 2. NIH Publication 1 No. 91-3121. U.S. Department of Health and ...
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Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf
... Of these 32 chemicals, three compounds [n-hexane, aluminum hydroxide, and di-(2-ethyl- hexyl)phthalate] showed unacceptably high inter- laboratory variability. For the other 29 ...
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RoC Profile: Formaldehyde; 15th RoC 2021 298KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/formaldehyde.pdf
... AE. 2002. Cytogenetic analysis of buccal cells from shoe-workers and pathology and anatomy laboratory workers exposed to n-hexane, toluene, methyl ethyl ketone and formaldehyde. ...
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ICCVAM Test Method Evaluation Report: LLNA BrdU-ELISA 35.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-elisa/tmer.pdf
... 56-81-5 92.09 0.05 Minimal Liquid Alcohols; Carbohydrates Hexane Hexyl hydride; n-
Hexane 110-54-3 86.1754 1.94 Minimal Liquid Hydrocarbons, acyclic Hexyl cinnamic aldehyde HCA; ...
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Nomination Background: 2,3-Butanedione (CASRN: 431-03-8) 1.8MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/artificial_butter_flavoring_508be.pdf
... Minor NL Furfural; 2-Furaldehyde; 2-Hydroxymethylfuran 98-01-1 7362 x 150 NL Minor (w/ octane) ? Major Major NL Hexane 110-54-3 8058 100 NL ? ? Major Major NL 32 Chemical ...
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Public Health Impact 1.5MB
https://ntp.niehs.nih.gov/media/impact
... National Toxicology Program (NTP). 1991. NTP Technical Report on the Toxicity Studies of n-Hexane (CASRN 110-54-3) in B6C3F1 Mice (Inhalation Studies). Research Triangle Park, NC: ...
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Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf
... + Ashby et al. (1995) Lacrimator Hexane 110-54-3 alkane solvent - - Basketter et al. ... - - - Glycerol 56-81-5 - - - Hexane 110-54-3 - - Hydrocortisone 50-23-7 - - ...
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ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 34.8MB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol2.pdf
... I undiluted 99.5% Aldrich - 2 3.1 55 1 1 I I R41 R41 Prinsen and Koëter (1993) n-Hexane 110-54-3 liquid I undiluted 99% Aldrich - 0.5 0 1 NI NI IV IV NI NI Prinsen and Koëter ...
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TR-226: C.I. Solvent Yellow 14 (CASRN 842-07-9) in F344/N Rats... 7.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr226.pdf
... 0.1 (b) 495(a) 9.31 + 0.08 (5) Solvent: n-Hexane (a) Denotes point of inflection. (3) ... 7.5 430 12.28 462 12.60 492(a) 9.6 Solvent : n-Hexane No literature reference found. ...
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TOX-105: Usnea Lichens Containing (+/-)-Usnic Acid (CASRN 125... 4.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox105_508.pdf
... 23(1):54. http://dx.doi.org/10.3390/molecules23010054 17. Jin J, Rao Y, Bian X, Zeng A, Yang G. Solubility of (+)-usnic acid in water, ethanol, acetone, ethyl acetate and n-hexane. ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... Toxicity TOX-02 PDF (1.95 MB) Toxicity Studies of n-Hexane in B6C3F1 Mice (Inhalation Studies) (CASRN 110-54-3) 1991 Short-Term Toxicity TOX-01 PDF (322.25 KB) Toxicity ...
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TOX-45: Renal Selected Halogenated Ethanes 1.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox045.pdf
... NTP TECHNICAL REPORTS ON TOXICITY STUDIES PRINTED AS OF OCTOBER 1995 Toxicity Chemical Report Number 1 Hexachloro-1,3-butadiene 2 n-Hexane 3 Acetone 4 1,2-Dichloroethane 5 Cobalt ...
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TOX-104: (+)-Usnic Acid (CASRN 7562-61-0) Administered in Feed... 4.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox104_508.pdf
... Station, NJ: Merck Research Laboratories; 2006. 12. Jin JQ, Rao Y, Bian XL, Zeng AG, Yang GD. Solubility of (+)-usnic acid in water, ethanol, acetone, ethyl acetate and n-hexane. ...
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RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf
... 312.53 Hexadecanoic Acid, Methyl Ester 112-39-0 270.46 Hexanal 66-25-1 100.16 Hexane 110-54-3 86.18 Hexane, 2,2,4-trimethyl- 16747-26-5 128.26 Chemical and Physical ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... Toxicity TOX-02 PDF (1.95 MB) Toxicity Studies of n-Hexane in B6C3F1 Mice (Inhalation Studies) (CASRN 110-54-3) 1991 Short-Term Toxicity TOX-01 PDF (322.25 KB) Toxicity ...
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TOX-18: Methyl Ethyl Ketone Peroxide (CASRN 1338-23-4) 4.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox018.pdf
... Report Number 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 19 20 21 22 23 Chemical Hexachloro-1,3-butadiene n-Hexane Acetone 1,2-Dlchloroethane Cobalt Sulfate Heptahydrate ...
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TOX-42: 1,3-Diphenylguanidine (CASRN 102-06-7) 1.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox042.pdf
... NTP TECHNICAL REPORTS ON TOXICITY STUDIES PRINTED AS OF SEPTEMBER 1995 Toxicity Chemical Report Number 1 Hexachloro-1,3-butadiene 2 n-Hexane 3 Acetone 4 1,2-Dichloroethane 5 Cobalt ...
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Background Document: RoC: Styrene; 2010 4.3MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/styrene_final_508.pdf
... The use of alkyl lithium compounds is due to the solubility of this class of organometallics in the hydrocarbon solvents (such as n-hexane or cyclohexane) that are used in the ...
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TOX-44: o-Nitrotoluene (CASRN 88-72-2) ando-Toluidine Hydrochloride... 1.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox044.pdf
... NTP TECHNICAL REPORTS ON TOXICITY STUDIES PRINTED AS OF FEBRUARY 1996 Toxicity Chemical Report Number 1 Hexachloro-1,3-butadiene 2 n-Hexane 3 Acetone 4 1,2-Dichloroethane 5 Cobalt ...
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TOX-57: Benzyltrimethylammonium Chloride (CASRN 56-93-9) 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox057.pdf
... Chemical 1 Hexachloro-1,3-butadiene 2 n-Hexane 3 Acetone 4 1,2-Dichloroethane 5 Cobalt Sulfate Heptahydrate 6 Pentachlorobenzene 7 1,2,4,5-Tetrachlorobenzene 8 D & C Yellow No. 11 ...
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TOX-71: Malachite Green Chloride and Leucomalachite Green (CASRNs... 2.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox071.pdf
... Reports on Toxicity Studies Printed as of June 2004 Chemical Hexachloro-1,3-butadiene n-Hexane Acetone 1,2-Dichloroethane Cobalt Sulfate Heptahydrate Pentachlorobenzene ...
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TOX-32: Methylene bis(thiocyanate), (CASRN 6317-18-6) 3.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox32.pdf
... Dosed Feed 1 2 3 4 5 6 7 8 9 2 0 2 1 2 2 23 24 25 26 28 29 Hexachloro- 1,3-butadiene n-Hexane Acetone 1,2-Dichloroethane Cobalt Sulfate Heptahydrate Pentachlorobenzene 1 .2 .4 ...
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TR-228: Vinylidene Chloride (CASRN 75-35-4) in F344 Rats and... 7.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr228.pdf
... s found X max (nm) 301 0 . 7 293.5 0.9 290 0.9 287.5(s) 0 . 9 284.5(s) 0 . 8 Solvent: n-Hexane No absorbance between 350-800 nm a t c o n c e n t r a t i o n of 10% v / v . 3. ...
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TR-239: Bis(2-chloro-1-methylethyl) Ether (~70%) (CASRN 108-60... 4.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr239.pdf
... ETHER 101 BCPE An aliquot of 1 ml of the sample was diluted, in duplicate, to 100 ml with n-hexane and analyzed directly by VPC-FID on 3% OV-17 100/200 Supelcoport 6 ft. x 114 in. ...
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TR-381: d-Carvone (CASRN 2244-16-8) in B6C3F1Mice (Gavage Studies... 6.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr381.pdf
... Thin-layer chromatography was performed on silica gel plates with n-hexane:1,4-dioxane (9:1), saturated, under nitrogen, and in the dark (solvent system 1) or ethyl acetate:hexanes ...