Eye, Retina - Degeneration - Nonneoplastic Lesion Atlas 301KB

https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Retina-Degeneration

insults, such as physical trauma, retinal detachment, inflammation, infectious ... Numerous heritable retinal degenerations have also been documented in various strains of ...

Eye, Retina - Detachment - Nonneoplastic Lesion Atlas 293KB

https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Retina-Detachment

displacement of the retina from its normal association with the retinal pigment epithelium (RPE). Retinal detachment has many causes, including traumatic retinal tears or ...

Eye, Retina - Gliosis - Nonneoplastic Lesion Atlas 290KB

https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Retina-Gliosis

can occur in various retinal layers with focal to diffuse distribution. It is characterized by increased numbers of glial cells in the retina. Retinal gliosis can occur as a ...

Eye, Retina - Dysplasia - Nonneoplastic Lesion Atlas 288KB

https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Retina-Dysplasia

or rosette-like formations of the retinal layers, sometimes with poorly developed ... Minor cases are of no clinical significance. Retinal dysplasia occurs as a heritable ...

Eye, Retina - Degeneration 356KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/rtdegen/eye-retina-degeneration_508.pdf

Mild retinal degeneration, featuring loss of rod and cone photoreceptor processes, ... Marked retinal degeneration, featuring overall thinning, architectural disruption, loss of ...

Eye, Vitreous - Proteinaceous Fluid - Nonneoplastic Lesion Atlas 286KB

https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Vitreous-ProteinaceousFluid

Causes include (but are not limited to) lens cataract and retinal detachment and degeneration. When there is retinal detachment, there may be similar fluid in the subretinal space ...

Eye, Retina - Dysplasia 252KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/rtdyspl/eye-retina-dysplasia_508.pdf

of the retinal layers (arrow). Figure 2 Eye, Retina - Dysplasia in a female B6C3F1 mouse from a chronic study (higher magnification of Figure 1). There is retinal dysplasia ...

Eye, Retina - Gliosis 271KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/rtglios/eye-retina-gliosis_508.pdf

Comment: Retinal gliosis (Figure 2, compare to normal in Figure 1), the proliferation of astrocytes, Müller cells, and/or microglia, can occur in various retinal layers with focal ...

Eye, Optic Nerve - Degeneration - Nonneoplastic Lesion Atlas 292KB

https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/OpticNerve-Degeneration

Since the optic nerve is composed of the axons of retinal ganglion cells, primary lesions ... T. 2004. A novel neuroprotectant against retinal ganglion cell damage in a glaucoma model ...

Eye, Vitreous - Hemorrhage - Nonneoplastic Lesion Atlas 289KB

https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Vitreous-Hemorrhage

Retinal detachment and/or degeneration are often present concurrently. Vitreous hemorrhage can be due to leakage from persistent fetal (hyaloid) vessels or from retinal vessels, ...

Eye, Vitreous - Hemorrhage 308KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/vthemor/eye-vitreous-hemorrhage_508.pdf

There are intravitreal accumulations of extravasated blood cells (arrow) with retinal ... This higher magnification image shows the intravitreal hemorrhage (arrow) and retinal ...

Eye, Retina - Hemorrhage - Nonneoplastic Lesion Atlas 289KB

https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Retina-Hemorrhage

but can also result from pathology of the retinal vasculature due to metabolic disease or toxins. Recommendations: Retinal hemorrhage should be diagnosed and assigned a ...

Eye, Retina - Detachment 263KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/rtdet/eye-retina-detachment_508.pdf

The retina (R) is detached and degenerate, and he retinal pigment epithelium (arrow) has undergone reactive hypertrophy and hyperplasia. 2 Eye, Retina - Detachment Comment: Retinal ...

Eye, Vitreous - Proteinaceous Fluid 178KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/vtprotfl/eye-vitreous-proteinaceous-fluid_508.pdf

posterior to the lens; there is also retinal detachment and degeneration (arrow) and ... Causes include (but are not limited to) lens cataract and retinal detachment and ...

Eye, Retina - Hemorrhage 285KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/rthemor/eye-retina-hemorrhage_508.pdf

also result from pathology of the retinal vasculature due to metabolic disease or toxins. 2 Eye, Retina - Hemorrhage Recommendation: Retinal hemorrhage should be diagnosed and ...

Eye, Lens - Cataract - Nonneoplastic Lesion Atlas 301KB

https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Lens-Cataract

disease, such as severe inflammation, iridial synechiae, and/or retinal degeneration. ... of the anterior lens epithelium; there is also retinal degeneration and detachment (R

Eye, Vitreous - Fibrosis - Nonneoplastic Lesion Atlas 298KB

https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Vitreous-Fibrosis

Reactive retinal pigment epithelium (RPE) cells may migrate transretinally into the ... activated resident vitreal hyalocytes, retinal Müller cells and astrocytes, immigrant ...

Eye, Vitreous - Fibrosis 529KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/vtfibr/eye-vitreous-fibrosis_508.pdf

epithelial cells (arrow) from the retinal pigment epithelium (arrowhead) in the ... Reactive retinal pigment epithelium (RPE) cells may migrate transretinally into the ...

TR-368: Nalidixic Acid (CASRN 389-08-2) in F344/N Rats and B6C3F1Mice... 13.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr368.pdf

... . n - a .* .rn . a m * .. 177 APPENDIX J RETINAL DEGENERATION AND CATARACTS AND CAGE ... Retinal degeneration and cataracts of the eye were observed a t increased incidences in ...

Eye, Optic Nerve - Degeneration 299KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/ondegen/eye-optic-nerve-degeneration_508.pdf

Since the optic nerve is composed of the axons of retinal ganglion cells, primary lesions ... T. 2004. A novel neuroprotectant against retinal ganglion cell damage in a glaucoma model ...

Eye, Lens - Cataract 425KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/lncat/eye-lens-cataract_508.pdf

of the anterior lens epithelium; there is also retinal degeneration and detachment (R). ... disease, such as severe inflammation, iridial synechiae, and/or retinal degeneration. ...

Session 4 Presentation Abstracts: Collaborative Workshop on Aquatic... 390KB

https://ntp.niehs.nih.gov/iccvam/meetings/aquatictox-2014/speakers-session-4-508.pdf

These deficits include altered behavioral response to visual stimuli, changes in retinal electrophysiology, hyperactivity and learning deficits. We are working to develop higher ...

Notices 241KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/pressctr/frn/2020/85frn205bsc20201022.pdf

... for Use in Therapeutic Treatment of Retinal Degenerative Diseases in Humans AGENCY: ... entitled, ''Druggable Targets to Treat Retinal Degeneration'' filed September 13, 2019 ...

TR-387: dl-Amphetamine Sulfate (CASRN 60-13-9) in F344/N Rats... 10.4MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr387.pdf

... Studies: Myelofibrosis, cataracts, and retinal atrophy in female rats, and ovarian ... Eye: Cataracts and retinal atrophy were observed at increased incidences in high-dose ...

TR-331: Malonaldehyde, Sodium Salt (3-Hydroxy-2-propenal, Sodium... 7.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr331.pdf

... forestomach; inflammation of the cornea, retinal atrophy, and cataracts of the crystalline ... the forestomach; corneal inflammation, retinal atrophy, and cataracts of the crystalline ...

Eye - Inflammation - Nonneoplastic Lesion Atlas 318KB

https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Inflammation

... It can also occur secondary to other ocular lesions, such as cataracts and retinal ... mice and in animal models of retinal autoimmunity: Relevance to human pathologies. ...

National Institute of Environmental Health Sciences: Pei-Li Yao... 157KB

https://www.niehs.nih.gov/research/atniehs/dtt/assoc/opo/staff/yao

Her prior research examined the mechanisms of chemical-induced testicular injury, cancer, and age-related retinal diseases using animal models and human cell lines. Yao received ...

Eye, Optic Nerve - Gliosis - Nonneoplastic Lesion Atlas 293KB

https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/OpticNerve-Gliosis

Maeda K, Sawada A, Matsuhara M, Nakai Y, Hara A, Yamamoto T. 2004. A novel neuroprotectant against retinal ganglion cell damage in a glaucoma model and an optic nerve crush model ...

Eye, Optic Nerve - Gliosis 328KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/onglios/eye-optic-nerve-gliosis_508.pdf

A, Matsuhara M, Nakai Y, Hara A, Yamamoto T. 2004. A novel neuroprotectant against retinal ganglion cell damage in a glaucoma model and an optic nerve crush model in the rat. ...

TR-210: 1,2-Dibromoethane (CASRN 106-93-4) in F344 Rats and B6C3F1Mice... 6.5MB

https://ntp.niehs.nih.gov/go/tr210

... testicular degeneration in male rats, retinal degeneration in female rats, and ... Retinal degeneration was noted in 1 male and 1 female control; retinal atrophy occurred in ...

TR 590 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS... 18.8MB

https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2016/february/tr590_peerdraft.pdf

... Incidences of retinal atrophy were significantly increased in all exposed groups of ... In the 2-year study, the incidences of retinal atrophy were significantly increased in ...

Abstract for TR-210 64KB

https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr210

... Exposure to 1,2-dibromoethane was also associated with hepatic necrosis and toxic nephropathy in rats of either sex, testicular degeneration in male rats, retinal degeneration in ...

Abstract for TR-368 65KB

https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr368

... Retinal degeneration and cataracts of the eye were observed at increased incidences in ... The cause of these cataracts and retinal degeneration is uncertain because cages were not ...

TR-571: Kava Kava Extract (CASRN 9000-38-8) in F344/N Rats and... 12.2MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr571.pdf

... The incidences of retinal degeneration in the eye were significantly increased in 1.0 g/kg ... Eye: The incidences of retinal degeneration were significantly increased in 1.0 g/kg males ...

Abstract for TR-331 67KB

https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr331

... forestomach; inflammation of the cornea, retinal atrophy, and cataracts of the crystalline ... the forestomach; corneal inflammation, retinal atrophy, and cataracts of the crystalline ...

Abstract for TR-387 64KB

https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr387

... Nonneoplastic and neoplastic effects Myelofibrosis, cataracts, and retinal atrophy in female rats, and ovarian atrophy in female mice occurred in a larger proportion of high-dose ...

Eye - Inflammation 955KB

https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/inflamm/eye-inflammation_508.pdf

... It can also occur secondary to other ocular lesions, such as cataracts and retinal ... mice and in animal models of retinal autoimmunity: Relevance to human pathologies. ...

Session Abstract 265KB

https://ntp.niehs.nih.gov/ntp/roc/meetings/2016/alan/session_abstract20160311_508.pdf

... Light exposure transmits time information (time of day, duration of the day, and day of the year) from the photorec eptors (primarily the retinal cells in the eye, via the ...

TR-527: Malachite Green Chloride and Leucomalachite Green (CASRNs... 7.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr527.pdf

... He thought the retinal degeneration was potentially compound related. He also questioned ... Dr. Culp said the retinal degeneration was central rather than peripheral and was not ...

Minutes: BSC TRRS; Feb. 17, 2004 661KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2004/feb/trrs17feb2004mins_508.pdf

... He asked for more explanation of the interpretation of retinal degeneration and for some ... He thought the retinal degeneration is potentially compound-related. He also questioned ...

TR-590: Antimony Trioxide (CASRN 1309-64-4) in Wistar Han [Crl... 6.8MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr590_508.pdf

... Incidences of retinal atrophy were significantly increased in all exposed groups of ... Eye: In the 2-year study, the incidences of retinal atrophy were significantly increased ...

TR-231: Stannous Chloride (CASRN 7772-99-8) in F344/N Rats and... 8.4MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr231.pdf

... He also noted that increased retinal degeneration effects in certain dosed groups were ... Eyes: Retinal degeneration was increased con- siderably in high-dose male rats and in ...

Abstract for TR-571 75KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr571

... Incidences of transitional epithelial hyperplasia of the pelvis of the kidney were significantly increased in 1.0 g/kg males and 0.3 and 1.0 g/kg females. The incidences of retinal ...

Abstract for TR-590 93KB

https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr590

... The incidence of nephropathy was significantly increased in 30 mg/m3 females in the 2-year study. Incidences of retinal atrophy were significantly increased in all exposed groups ...

TOX-78: Triethylamine (CASRN 121-44-8) Administered by Inhalation... 3.8MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox078_508.pdf

... Retinal degeneration was also noted in one 50 ppm male, one 25 ppm female, two 100 ppm females, and one 200 ppm female. The etiology of the retinal changes was not certain because ...

Monograph: Night Shift Work and Light at Night; August 24, 2018 6.2MB

https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/landraftmonograph20180824.pdf

... called intrinsically photosensitive retinal ganglion cells that are anatomically and ... Takao M. 2002. Phototransduction by retinal ganglion cells that set the circadian clock. ...

TR-568: Photocarcinogenesis Studies of Retinoic Acid and Retinyl... 18.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr568_508.pdf

... Activities of retinol (alcohol) dehydrogenase were decreased and of retinal oxidase were ... Retinals and reti- nol, frozen (-196° C) in acetone, were induced to form their ...

Research Concept: Shift Work; 2014 756KB

https://ntp.niehs.nih.gov/ntp/roc/concept_docs/2014/shiftworkconcept_508.pdf

... Light exposure transmits time information (time of day, duration of the day, and day of the year) from the retinal cells in the eye (via the photopigment melanopsin) to the master ...

TR-117: 6-Nitrobenzimidazole (CASRN 94-52-0) 4.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr117.pdf

... There appeared to be a dose-related increase in the incidence of retinal atrophy and ... Retinal atrophy, cataract, and other associated changes, together with inflammation and/or ...

TR-318: Ampicillin Trihydrate (CASRN 7177-48-2) in F344/N Rats... 10.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr318.pdf

... dose, 36/47,77%). 1II.RESULTS:RATS Eye: Retinal degeneration, cataracts, hemor- rhage, ... of animals examined grossly Cataract Retinal degeneration Posterior synechia ...