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TR-533: Benzophenone (CASRN 119-61-9) in F344/N Rats and B6C3F1Mice... 10.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr533.pdf
BENZOPHENONE (CAS NO. 119-61-9) IN F344/N RATS AND B6C3F 1 MICE (FEED STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle Park, NC 27709 February 2006 NTP TR 533 ...
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TOX-61: Benzophenone 2.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox061.pdf
National Toxicology Program Toxicity Report Series Number 61 NTP Technical Report on the Toxicity Studies of Benzophenone (CAS No. 119-61-9) Administered in Feed to F344/N Rats and ...
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Abstract for TR-533 72KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr533
Abstract for TR-533 Toxicology and Carcinogenesis Studies of Benzophenone in F344/N Rats and B6C3F1 Mice (Feed Studies) CASRN: 119-61-9 Chemical Formula: C13H10O Molecular Weight: ...
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Abstract for TOX-61 63KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox061
1abs Abstract for TOX-61 Toxicity Studies of Benzophenone Administered in Feed to F344/N Rats and B6C3F1 Mice CASRN: 119-61-9 Chemical Formula: C12H10O Molecular Weight: 182.22 ...
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Abstract for TER98005 62KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter98005
Developmental Toxicity Evaluation for Benzophenone Administered by Gavage to Sprague Dawley (CD) Rats on Gestational Days 6 Through 19 CASRN: 119-61-9 Chemical Formula: C13H10O ...
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Abstract for TER99001 62KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter99001
Developmental Toxicity Evaluation for Benzophenone Administered by Gavage To New Zealand White Rabbits on Gestational Days 6 Through 29 CASRN: 119-61-9 Chemical Formula: C13H10O ...
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Target Organs and Levels of Evidence for TR-533 60KB
https://ntp.niehs.nih.gov/data/tr/500s/tr533levels
Target Organs and Levels of Evidence for TR-533 Toxicology and Carcinogenesis Studies of Benzophenone (CASRN 119-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) Chemical (Study ...
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Comment: Draft Report 05 Dated March 21, 2021; J.C. DiNardo;... 243KB
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/october/publiccomm/dinardo_oxybenzone20210928_trprp_508.pdf
(2H4MBP), also known as oxybenzone and benzophenone-3, is approved by the U.S. Food and ... For example: in the Scientific Committee on Consumer Safety (SCCS) opinion on benzophenone...
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Abstract for TOX-21 64KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox021
CASRN: 131-57-7 Chemical Formula: C14H12O3 Molecular Weight: 228.26 Synonyms/Common Names: Oxybenzone; 4-methoxy-2-hydroxy-benzophenone; (2-hydroxy-4-methoxyphenyl)phenyl-methanone...
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TOX-21: 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) 21.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox021.pdf
... Oxybenzone; 4-Methoxy-2- hydroxy-benzophenone; Cyasorb UV; Uvinul M 40; ... studies of 2-hydroxy-4-methoxy- benzophenone (HMB) by reviewing the natural ...
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Oviduct - Mesonephric Duct Remnant - Nonneoplastic Lesion Atlas 287KB
https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/oviduct/MesonephricDuctRemnant
National Toxicology Program. 2006. NTP TR-533. Toxicology and Carcinogenesis Studies of Benzophenone (CAS No. 119-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, Research ...
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Ovary - Infiltration Cellular - Nonneoplastic Lesion Atlas 288KB
https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/ovary/InfiltrationCellular
National Toxicology Program. 2006. NTP TR-533. Toxicology and Carcinogenesis Studies of Benzophenone (CAS No. 119-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, Research ...
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Minutes: BSC TR; Nov. 21, 1991 728KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1991/minutesbsctrrs19911121_508.pdf
68-12-2 Inhalation 2-Hydroxy-4-Methoxy-Benzophenone 131-57-7 Dermal/Feed o-,m-, and ... and as a representative benzophenone derivative used as a UV screen and UV stabilizer. ...
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Historical Controls: All Routes and Vehicles for Mice; Studies... 255KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2006/m_hcrpt_allrte2006_508.pdf
09/14/99 730 50(1) 44(717) 46.0 Benzophenone Battelle Columbus Laboratory 055611104 ... 09/13/99 729 50(5) 40(706) 46.2 Benzophenone Battelle Columbus Laboratory 055611104 ...
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Historical Controls: All Routes and Vehicles for Rats; Studies... 270KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2006/r_hcrpt_allrte2006_508.pdf
Battelle Columbus Laboratory 058813803 08/16/99 729 50(3) 22(681) 501.7 Benzophenone ... Battelle Columbus Laboratory 058813803 08/17/99 729 50(5) 32(688) 348.7 Benzophenone ...
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Historical Controls: All Routes and Vehicles for Mice; Studies... 317KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2007/m_hcrpt_allrte20070300_508.pdf
09/14/99 730 50(1) 44(717) 46.0 Benzophenone Southern Research Institute 059902704 ... 09/13/99 729 50(5) 40(706) 46.2 Benzophenone Southern Research Institute 059902704 ...
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Historical Controls: All Routes and Vehicles for Mice; Studies... 211KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2007/m_hcrpt_allrte20071000_508.pdf
Battelle Columbus Laboratory 058813804 09/14/99 730 50(1) 44(717) 46.0 Benzophenone ... Battelle Columbus Laboratory 058813804 09/13/99 729 50(5) 40(706) 46.2 Benzophenone ...
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Historical Controls: All Routes and Vehicles for Rats; Studies... 252KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2007/r_hcrpt_allrte20070300_508.pdf
Battelle Columbus Laboratory 058813803 08/16/99 729 50(3) 22(681) 501.7 Benzophenone ... Battelle Columbus Laboratory 058813803 08/17/99 729 50(5) 32(688) 348.7 Benzophenone ...
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Historical Controls: All Routes and Vehicles for Rats; Studies... 225KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2007/r_hcrpt_allrte20071000_508.pdf
Battelle Columbus Laboratory 058813803 08/16/99 729 50(3) 22(681) 501.7 Benzophenone ... Battelle Columbus Laboratory 058813803 08/17/99 729 50(5) 32(688) 348.7 Benzophenone ...
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Historical Controls: All Route and Vehicles for Rats; Studies... 162KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2008/r_hcrtp_allrte_20081100.pdf
08/16/99 729 50 (3) 22(681) 501.7 Benzophenone Battelle Columbus Laboratory 059902805 ... 08/17/99 729 50 (5) 32(688) 348.7 Benzophenone Battelle Columbus Laboratory 059902805 ...
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Ovary - Infiltration Cellular 286KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/female_reproductive/ovary/infilt/ovary-infiltration-cellular-pdf-508.pdf
Reference: National Toxicology Program. 2006. NTP TR-533. Toxicology and Carcinogenesis Studies of Benzophenone (CAS No. 119-61-9) in F344/N Rats and B6C3F 1 Mice (Feed Studies). ...
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Draft DART-05: Modified One-Generation Study of 2-Hydroxy-4-methoxyben... 3.3MB
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/october/dart05_508.pdf
... also known as oxybenzone and 2 benzophenone-3, is approved by the U.S. Food and ... Expected estrogenic responses were observed in the 15 EE group. 16 Synonyms: Benzophenone-...
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DART-05: Modified One-Generation Study of 2-Hydroxy-4-methoxybenzophen... 6.0MB
https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart05_508.pdf
... (2H4MBP), also known as oxybenzone and benzophenone-3, is approved by the U.S. Food and ... Expected estrogenic responses were observed in the EE group. Synonyms: benzophenone-3; ...
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TR-597: 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered... 3.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr597_508.pdf
... with exposure to 2H4MBP. Synonyms: Benzophenone-3; (2-hydroxy-4-methoxyphenyl)-phenylm... ; Molecular Weight: 228.25) Synonyms: Benzophenone-3; (2-hydroxy-4-methoxyphenyl)-phenylm...
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Ovary - Mineral - Nonneoplastic Lesion Atlas 288KB
https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/ovary/Mineral
National Toxicology Program. 2006. NTP TR-533. Toxicology and Carcinogenesis Studies of Benzophenone (CAS No. 119-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies). NTP, Research ...
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Oviduct - Mesonephric Duct Remnant 288KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/female_reproductive/oviduct/mdremn/oviduct-mesonephric-duct-remnant-pdf-508.pdf
Program. 2006. NTP TR-533. Toxicology and Carcinogenesis Studies of Benzophenone (CAS No. 119-61-9) in F344/N Rats and B6C3F 1 Mice (Feed Studies). NTP, Research Triangle ...
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UV Filters 75KB
https://ntp.niehs.nih.gov/whatwestudy/topics/uvfilters
Oxybenzone Benzophenone-3 Type of filter: UVB, UVA Two-year chronic toxicity studies: Completed Findings: In rats, NTP found uncertain evidence of the toxicity and carcinogenicity ...
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Ovary - Mineral 306KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/female_reproductive/ovary/mineral/ovary-mineral-pdf-508.pdf
.../go/6018 National Toxicology Program. 2006. NTP TR-533. Toxicology and Carcinogenesis Studies of Benzophenone (CAS No. 119-61-9) in F344/N Rats and B6C3F 1 Mice (Feed Studies). ...
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Presentation: Using Adverse Outcome Pathway Analysis to Identify... 2.2MB
https://ntp.niehs.nih.gov/iccvam/meetings/aop-wksp-2014/presentations/paul-508.pdf
... NIS T4, T3 Propylthiouracil, methimazole, Benzophenone-2, isoflavones, etc. Perchlorate, bromate, some small organics PCBs, PTU, FD&C Red No3 dye, etc. ? Figure reproduced from ...
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RoC Profile: Michler's Ketone; 15th RoC 2021 122KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/michlersketone.pdf
Also known as 4,4'-(dimethylamino)benzophenone C O N N H 3 C CH 3 CH 3 CH 3 ... Part 2. Survey for residues of dialkylamino benzophenone UV-cure ink photoinitiators. Food ...
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Minutes: BSC; Oct. 26, 2004 769KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2004/october/bscmins2004oct26_508.pdf
... two water disinfection by-products (bromodichloromethane and sodium chlorate), and benzophenone. 5. Center for the Evaluation of Risk to Human Reproduction The Center for the ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... Evidence NE No Evidence NE No Evidence EE Equivocal Evidence TR-533 12/09/04 Benzophenone 119-61-9 SE Some Evidence EE Equivocal Evidence SE Some Evidence SE Some Evidence TR-532 ...
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Short-Term Toxicity Reports 224KB
https://ntp.niehs.nih.gov/publications/reports/tox
... Hamsters 2007 Short-Term Toxicity TOX-61 PDF (2.12 MB) Toxicity Studies of Benzophenone (CASRN 119-61-9) Administered in Feed to F344/N Rats and B6C3F1 Mice 2000 Short-Term ...
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Comment: Draft Report 06 Dated March 21, 2021; J.C. DiNardo;... 151KB
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/october/publiccomm/dinardo_octinoxate20210928_trprp_508.pdf
... Based on keyword analysis, benzophenone-3, 4-methylbenzylidene-camphor, 3- benzylidene camphor, and ethylhexyl-methoxycinnamate are the most studied OUVFs, and effects on ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... Report TR-533 PDF (10.78 MB) Toxicology and Carcinogenesis Studies of Benzophenone (CASRN 119-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2006 Technical Report TR-532 ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... Report TR-533 PDF (10.78 MB) Toxicology and Carcinogenesis Studies of Benzophenone (CASRN 119-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2006 Technical Report TR-532 ...
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Poster Abstracts: In Vitro to In Vivo Extrapolation for High... 132KB
https://ntp.niehs.nih.gov/iccvam/meetings/ivive-wksp-2016/posterabstracts-all-508.pdf
... and 6-propylthiouracil) to moderate (benzophenone-2 and 2- mercaptobenzothiazole) to low ... For example, benzophenone-2 and triclosan exhibited small MOE values due to slow clearance ...
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Minutes: BSC; Aug. 18, 2005 1.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2005/august/bscmins2005aug18_508.pdf
... on December 9, 2004. The Subcommittee reviewed reports on 3'-azido-3'thymidine, benzophenone, bromodichloromethane, 2,2',4,4',5,5'-hexachloro-biphenyl (PCB 153), a PCB mixture ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... TR-533 PDF (10.78 MB) Toxicology and Carcinogenesis Studies of Benzophenone (CASRN 119-61-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) 2006 Long-Term ...
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Public Health Impact 1.5MB
https://ntp.niehs.nih.gov/media/impact
... to no longer authorize the use of benzophenone, ethyl acrylate, eugenyl methyl ether, ... Because of evidence that benzophenone causes cancer in animals, FDA also is amending the ...
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Public Comment: Pulegone Christie Harman; RoC; Sept. 20, 2013 126KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2013/publiccomm/harman20131018_508.pdf
... Toxicology 55, 327-337. Page | 9 National Toxicology Program (NTP) (2006) NTP Technical Report on the Toxicology and Carcinogenesis Studies of Benzophenone (CAS NO. 119-61-9) in ...
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Minutes: BSC; June 29, 2004 883KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2004/june/20040629_508.pdf
... mixture of 2,3,4,4',5, pentachlorobiphenyl (PCB 118) and PCB 126, sodium chlorate, benzophenone, bromodichloromethane, a transplacental azidothymidine (AZT) study, and a genistein ...
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TR-562: Goldenseal Root Powder (GOLDENSEALRT) in F344/N Rats... 6.4MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr562.pdf
... Historical Incidence: Feed Studies Benzophenone 2/50 2/50 Chromium picolinate monohydrate ... Study Incidence in Controls Historical Incidence: Feed Studies Benzophenone 10/50 Chromium ...
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TR-550: Cresols (CASRN 1319-77-3) in Male F344/N Rats and Female... 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr550.pdf
... National Toxicology Program (NTP) (2006). NTP Technical Report on the Toxicology and Carcinogenesis Studies of Benzophenone (CAS No. 119-61-9) in F344/N Rats and B6C3F 1 Mice (Feed ...
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TR-568: Photocarcinogenesis Studies of Retinoic Acid and Retinyl... 18.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr568_508.pdf
... octyl methoxycinnamate, avobenzone, and 4-methylbenzilidene camphor or a photostable UV-filter combination that contained octyl methoxycinnamate, benzophenone-3, and octocrylene. ...
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TR-535: 4-Methylimidazole (CASRN 822-36-6) in F344/N Rats and... 10.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr535.pdf
... Historical Incidence: Feed Studies Benzophenone 19/50 trans-Cinnamaldehyde 21/100 ... Historical Incidence: Feed Studies Benzophenone 14/50 2/50 16/50 trans-Cinnamaldehyde ...
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TR-556: Chromium Picolinate Monohydrate (CASRN 27882-76-4) in... 6.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr556.pdf
... Historical Incidence in Feed Controls Given NTP-2000 Diet Benzophenone 0/50 Chromium ... Historical Incidence in Feed Controls Given NTP-2000 Diet Benzophenone 3/50 Chromium ...
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TR-523: Diisopropylcarbodiimide (CASRN 693-13-0) in F344/N Rats... 10.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr523.pdf
... NOS Historical Incidence: All Routes Benzophenone (feed) 8/50 0/50 0/50 8/50 ... All Routes Acrylonitrile (gavage) 2/50 Benzophenone (feed) 1/50 Bromodichloromethane ...
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TR-595: Sprague Dawley (Hsd:Sprague Dawley SD) Rats Exposed to... 5.6MB
https://ntp.niehs.nih.gov/go/tr595
... perfluorooctanoic acid, dietary zinc, p-chloro- α,α,α-trifluorotoluene, dibutyl phthalate, 2-hydroxy-4-methoxy-benzophenone, and diethylhexyl phthalate (2 studies). ...
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Historical Controls: By Route and Vehicle for Mice; Studies started... 644KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2007/m_hcrpt_rte20071000_508.pdf
... Battelle Columbus Laboratory 058813804 09/14/99 730 50(1) 44(717) 46.0 Benzophenone ... Battelle Columbus Laboratory 058813804 09/13/99 729 50(5) 40(706) 46.2 Benzophenone ...