RoC Profile: Polycyclic Aromatic Hydrocarbons: 15 Listings; 15th... 373KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/polycyclicaromatichydrocarbons.pdf

Benz[a]anthracene, benzo[b]fluoranthene, benzo[j]- fluoranthene, benzo[a]pyrene, dibenz[a,h]acridine, dibenz[a,j] acridine, dibenz[a,h]anthracene, 7H-dibenzo[c,g]- carbazole, ...

Poster: An Evaluation of The Performance of Survey Sampling in... 953KB

https://ntp.niehs.nih.gov/sites/default/files/2024-03/Wang_SOT20240310.pdf

analysis: benz[a]anthracene, dibenzo[a,l]pyrene, fluoranthene, phenanthrene, and pyrene. . ... Fluoranthene Dibenzo[a,l]pyrene Benz[a]anthracene Number of references Include (with ...

Mechanistic Insights from Profiling Chemical-Mediated Transcription... 6.9MB

https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-medvedev-poster.pdf

a similarity to polyaromatic hydrocarbon (PAH) compounds, namely benz[a]anthracene. ... Azobenzene+CYPs 33.3uM 0.95 2-Naphthalenol 66.7uM 0.95 Benz[a]anthracene 20uM 0.93 ...

15th RoC: Appendix F 174KB

https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf

... BA see Polycyclic Aromatic Hydrocarbons: 15 Listings, Benz[a] anthracene B[a]P see ... Hydrocarbons: 15 Listings, Benz[a]anthracene benz[a]anthracene see Polycyclic ...

RoC Background Document: Danthron; Nov. 18-19, 1996 1.9MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/danthron1_508.pdf

... 20 6.6.1.1 7,12-Dimethylbenz[a]anthracene (DMBA) and Danthron ... When evaluated in skin painting studies in mice given 7,12-dimethylbenz[a]anthracene, or ...

RoC Background Document: Tobacco Smoking; Dec. 2-3, 1998 3.5MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/environmentalts_noapps_508.pdf

... Hoffmann and Hecht (1989) Benz[a] anthracene 40-200 ng 20-50 ng CIB (1991) Hoffmann ... 123.15 N H 2 O 2B CEPA (1997) Benz[a]anthracene C 18 H 12 201 ng/cig (P) 2.5 ng/cig (V) ...

Poster: Use of Survey Sampling to Develop an Evidence Map of... 1.7MB

https://ntp.niehs.nih.gov/ntp/results/pubs/posters/wang_gems_20221101.pdf

... Anthracene 8 (1.17 - 37.22) 23 (7.08 - 59.82) 0 (0 - 24.03) 0 (0 - 24.03) 30 (11.2 - ... Benz[a]anthracene 98 (71.75 - 132.83) 124 (94.15 - 161.12) 0 (0 - 11.98) 0 (0 - 11.98) 26 ...

RoC Background Document: Diesel Exhaust Particulates; Dec. 2... 5.5MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/dieselexhaust_508.pdf

... 50 Dibenzothiophene 184 132-65-0 129-246 Phenanthrene 178 85-01-8 2186-4883 Anthracene 178 120-12-7 155-356 Methyldibenzothiophene 198 30995-64-3 520-772 Methylphenanthrene 192 ...

BG1Luc ER TA Protocol Standardization Study Report (Annex C of... 2.9MB

https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexc/c0-prot-stand.pdf

... of variation DBA Dibenzo[a,h]anthracene DMEM Dulbecco's modification of Eagle's ... (butylbenzyl phthalate, dibenzo[a,h] anthracene, flavone, genistein, nonylphenol, ...

TR-494: Anthraquinone (CASRN 84-65-1) in F344/N Rats and B6C3F1Mice... 10.7MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr494.pdf

... present in anthra- quinone manufactured by processes other than oxi- dation of anthracene. ... and that pro- duced by oxidation of anthracene, and he suggested that all the observed ...

Comment: Meat-related exposures, Shalene McNeill, The Beef Checkoff... 74KB

https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/mcneill20180911-2.pdf

and 8 PAH [BaP, Chrysene (Chy), Benzo[a]Anthracene (BaA), Benzo[k]Fluoranthene (BkF), Benzo[b]Fluoranthene (BbF), Dibenzo[a,h]Anthracene (DahA), Indeno[1,2,3,c,d]Pyrene (IP) and ...

RoC Profile: Soots; 15th RoC 2021 115KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/soots.pdf

... cadmium, chromium, nickel, and several polycyclic aromatic hydrocarbons (PAHs), including benz[a]anthracene, benzo[a]pyrene, dibenz[a,h]anthracene, and indeno[1,2,3-cd] pyrene. ...

Polycyclic Aromatic Compounds 83KB

https://ntp.niehs.nih.gov/whatwestudy/topics/pacs

Benzo(a)pyrene Pyrene Dibenz(a,h)anthracene Benzo(b)fluoranthene ... 205-99-2 Ongoing Dibenzo[a,h]anthracene 53-70-3 Ongoing Benz[j]aceanthrylene ...

Listed Substances; 15th RoC 2021 76KB

https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf

... Basic Red 9 Monohydrochloride Benz[a]anthracene (see Polycyclic Aromatic Hydrocarbons: ... Hydrocarbons: 15 Listings) Dibenz[a,h]anthracene (see Polycyclic Aromatic Hydrocarbons: ...

RoC Profile: Danthron; 15th RoC 2021 121KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/danthron.pdf

However, danthron did not promote the induction of tumors when either painted on the skin of mice pretreated with 7,12-dimethylbenz[a]anthracene or fed to rats pretreated with ...

RoC Profile: Progesterone; 15th RoC 2021 138KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/progesterone.pdf

In rats, subcuta- neous or intramuscular injection of progesterone following expo- sure to 7,12-dimethylbenz[a] anthracene or 3-methylcholanthrene resulted in increased incidence ...

NICEATM Validation Study Report on the MCF-7 Cell Proliferation... 1.8MB

https://ntp.niehs.nih.gov/iccvam/methods/endocrine/mcf7/mcf7-valstudyreport-19jun12-wcv2-draft.pdf

... Dibenzo[a,h]anthracene (DBA, CASRN 53-70-3) is used as the weak positive control for ... = concentration; DBA = dibenzo[a,h]anthracene; E2 = 17β-estradiol; 2P = cell ...

Public Comment: Carbon black; Carol Eisenmann; RoC; Jan. 19,... 3.3MB

https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/eisenmann20120227.pdf

... (5 parts per billion). 10. Dibenz[a,h]anthracene, not more than 0.005 mg/kg (5 parts per ... setting specifications for total PAHs, benzo[a)pyrene (B[a)P), and dibenz(a,h)anthracene. ...

Abstract for TR-301 65KB

https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr301

and with 7,12-Dimethylbenz(a)anthracene in Swiss CD-1 Mice (Dermal Studies) Substances: o-Phenylphenol (CASRN 90-43-7) 7,12-Dimethylbenz(a)anthracene (CASRN 57-97-6) Report Date: ...

Public Health Impact 1.5MB

https://ntp.niehs.nih.gov/media/impact

... State of California to Cause Cancer: Anthracene, 2-Bromopropane, and Dimethyl Hydrogen ... Assessment (OEHHA) intends to list anthracene (CASRN 120-12-7), 2-bromopropane (CASRN ...

Poster: Scoping review of polycyclic aromatic hydrocarbons (PAH... 19.6MB

https://ntp.niehs.nih.gov/ntp/results/pubs/posters/wang_sot20200315.pdf

... (CDC) 12 listed since 1980s Benz[a]anthracene Benzo[k]fluoranthene Dibenzo[a,e]pyrene ... Dibenzo[a,h]pyrene Indeno[1,2,3-cd]pyrene Benzo[j]fluoranthene Dibenz[a,h]anthracene ...

RoC Background Document for 1-Amino-2,4-dibromoanthraquinone... 941KB

https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/adbaqpub_no_appendices_508.pdf

... that can be derived from aromatic molecules such as benzene, naphthalene, and anthracene. ... Chemicals used in the anthraquinone dye/epichlorohydrin (AQ/ECH) area included anthracene, ...

RoC Profile: Coal Tars and Coal-Tar Pitches; 15th RoC 2021 134KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/coaltars.pdf

... pitch, and crude naphthalene and anthracene oils from the distillation of crude coal tar. ... recovery of benzene, production of anthracene paste, briquetting of smokeless solid ...

Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB

https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf

... diethylhexyl phthalate, dibenzo[a,h]anthracene, fluoranthene, and zearalenone) belong ... Studies g,h,I,j Comments Dibenzo[a,h] anthracene 53-70-3 Polycyclic Compound Laboratory ...

Cancer Studies in Experimental Animals; Gloria Jahnke; ROCPRP... 488KB

https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/presentations/07jahnke_rocprp_508.pdf

... Xenografts, injected cells Breast xenograft (4/4) Breast xenograft (4/4) Mammary gland Spontaneous Mammary gland (transgenic model) DMBA = dimethylbenz[a]anthracene; NMU = ...

ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB

https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf

... diethylhexyl phthalate, dibenzo[a,h]anthracene, fuoranthene, and zearalenone) belong ... 2 Flavone 4 Anilide 3 Fluorene 1 Anthracene 1 Glutaramide 1 Aromatic amine 1 ...

Minutes: BSC TRRS; Feb. 17, 2004 661KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2004/feb/trrs17feb2004mins_508.pdf

... and that produced by oxidation of anthracene and suggested that all the observed ... Dr. Butterworth suggested calling it "anthracene-based anthraquinone". Drs. McQueen and ...

Presentation: Setting the Stage: Purpose, Definitions, Scope... 2.1MB

https://ntp.niehs.nih.gov/iccvam/meetings/ivive-wksp-2016/webinar-slides/1-wetmore-07oct2015-fd-508.pdf

... 1 0.7088 57-97-6 7,12-Dimethylbenz(a)anthracene 3.9083 APR_CellCycleArrest 1 0.2559 ... 2.1423 APR_MitoticArrest 1 0.4668 120-12-7 Anthracene 0.5800 APR_MitoMembPot 1 ...

Minutes: BSC; June 29, 2004 883KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2004/june/20040629_508.pdf

... title be changed to "anthracene-derived anthraquinone" instead of simply anthraquinone. ... technical report appears to only address anthraquinone manufactured from anthracene. ...

Protocol: Systematic Review of Inflammation-based Atherosclerosis... 1001KB

https://ntp.niehs.nih.gov/sites/default/files/2023-07/protocol_atherosclerosisjuly2023_508.pdf

... OR 'xylene':ti,ab OR "Benz(a)Anthracene":ti,ab OR "Benz(a)Anthracenes":ti,ab OR ...ibenzoanthracene":ti,ab OR "1,2- Benz(a)anthracene":ti,ab OR "1,2-Benzanthracene":ti,ab OR ...

RoC Background Document: Cyclosporin A; Nov. 18-19, 1996 4.9MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/cyclosporin_a1_508.pdf

... Treatment with CsA also increased the incidence of cervical lymph node metastasis in Syrian golden hamsters treated with dimethylbenz[a]anthracene (DMBA) (Yamada et al., 1992), and ...

Appendices A-G; 15th RoC 2021 448KB

https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf

... BA see Polycyclic Aromatic Hydrocarbons: 15 Listings, Benz[a] anthracene B[a]P see ... Hydrocarbons: 15 Listings, Benz[a]anthracene benz[a]anthracene see Polycyclic ...

TR-029: 2-Methyl-1-Nitroanthraquinone (CASRN 129-15-7) 3.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr029.pdf

... The Chemical Abstracts Service (CAS) Ninth Collective Index (1977) name for this compound is 2-methyl-l-nitro-9,10-anthracene- * dione. It is also frequently listed as ...

RoC Profile: Ultraviolet-Radiation-Related Exposures; 15th RoC... 169KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/ultravioletradiationrelatedexposures.pdf

... Report on Carcinogens, Fifteenth Edition For definitions of technical terms, see the Glossary. after pretreatment with the carcinogen dimethylbenz[a]anthracene caused the grafts to ...

TR-111: 1-Amino-2-methylanthraquinone (CASRN 82-28-0) 3.8MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr111.pdf

... The Chemical Abstracts Service (CAS) Ninth Collective Index (1977) name for this compound is l-amino-2-methyl-9,10-anthracene- * dione. It is also known as 2-methyl-l-anthraquinony...

TR 577: Nondecolorized Whole Leaf Extract of Aloe Barbadensis... 11.3MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr577_508.pdf

... linked directly to carbon atom 10 of the anthracene ring in a β-configuration (Figure 2). ... Aloe vera latex contains a mixture of anthracene compounds including O- and C-glycosides ...

TR-441 Comparative Initiation/Promotion Skin Paint Studies of... 11.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr441.pdf

... The combination o f 7,12-dimethylbenz(a)anthracene (DMBA)initiation and ... was observed. 7,12-Dimethylbenz(a)anthracene (CASNO.57-97-6) 7,12-Dimethylbenz(a)ant...

RoC Background Document on Human Papillomaviruses: Genital-Mucosal... 2.9MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/hpv_rg2_public_508.pdf

... Types DMBA 7,12-Dimethylbenz[a]anthracene, used as a tumor initiator DMPA Depot ...dimethylbenz[a]anthracene (DMBA), indicating that the E7 protein promoted tumor formation. ...

RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf

... Analytical Conc. (μg/mL) Acenaphthene - 83-32-9 2001 Acenaphthylene - 208-96-8 2001 Anthracene - 120-12-7 2001 Benz(a)anthracene - 56-55-3 1995 Benzo(a)pyrene - 50-32-8 2002 ...

Comment: Meat-related exposures; Jane Pouzou, Solenne Costard... 945KB

https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/pouzou_costard_zagmutt20161011.pdf

... Modified from EFSA. 18 Benzo[a]pyrene Benz[a]anthracene Chrysene Benzo(b)fluoranthene Mean 95th percentile Mean 95th percentile Mean 95th percentile Mean 95th percentile Cocoa ...

ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 42.0MB

https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol1.pdf

... Detergent Amway SA8 limited phos laundry powder - Formulation Detergent Anthracene 120-12-7 Polycyclic Dye manufacturing agent Anti-Dandruff Shampoo (HZY) 100% - ...

TR-409: Quercetin (CASRN 117-39-5) in F344 Rats (Feed Studies... 9.6MB

https://ntp.niehs.nih.gov/go/tr409

... formation a DMBA = 7,12dimethyl[a]anthracene;TPA = 12-0-tetradecanoylphorbol-13-acet... on skin papilloma formation in mice initiated with 7,12- dimethylbenz[a]anthracene. Jpn. ...

TR-044 In Vitro Carcinogenesis: Guide to the Literature, Recent... 18.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr044.pdf

... Adenocarcinoma Induced in Organ Culture by 7,12-dimethylbenz(a)anthracene." J. Natl. ... and Other Derivatives of Benz(a)anthracene and Dibenz(a,h)anthracene to DNA, RNA, ...

RoC Background Document: Vinyl Bromide; Jan. 20-21, 2000 220KB

https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/vb_no_appendices_508.pdf

... Additional groups of 30 mice received a single application of 7,12-dimethylbenz[a]anthracene followed by treatment with TPA (positive controls), treatment with TPA only, or no ...

Minutes: BSC RoC; Nov. 18-19, 1996 149KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1996/dec/brc_minutes19961119_508.pdf

... He said that if a comparison of initiation/promotion studies done with those cited for 7,12-dimethylbenz[a]anthracene or dimethylhydrazine then route of exposure needs to be ...

TR-410: Naphthalene (CASRN 91-20-3) in B6C3F1Mice (Inhalation... 8.6MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr410.pdf

... No controls were used in these studies, but a concurrent study with anthracene administered subcutaneously did produce tumors. Boyland et aL (1964) examined the effects o f ...

TR-355: Diphenhydramine Hydrochloride (CASRN 147-24-0) in F344... 10.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr355.pdf

... on a 10% SP2100 col- umn, with anthracene in acetone (40 pg/mll as a n internal ... gas chromatographic system but with anthracene in acetonitrile as the internal standard. ...

TR-358: Ochratoxin A (CASRN 303-47-9) in F344/N Rats (Gavage... 8.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr358.pdf

... In a dermal study in white mice, ochratoxin A used as a promoter following 7,12- dimethylbenz[a]anthracene initiation did not af- fect the incidence of papillomas (Lindenfelser e t ...

TR-553: Photococarcinogenesis Study of Aloe Vera[CASRN 481-72... 6.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr553.pdf

... The sugar moiety in aloins is D-glu- cose, and studies indicate that carbon atom 1 of the D-glucose moiety is linked directly to carbon atom 10 of the anthracene ring in a ...

TR-584: Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and... 4.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr584_508.pdf

... in ICR/Ha mice and 7,12-dimethylbenz[a]anthracene-induced mammary gland tumor formation ... Activated 2.188 7.93E-08 Benz[a]anthracene Chemical toxicant Activated 2.156 ...