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TR-584: Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and... 4.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr584_508.pdf
ON THE TOXICOLOGY STUDIES OF INDOLE-3-CARBINOL (CASRN 700-06-1) IN F344/N RATS AND B6C3F1/N MICE AND TOXICOLOGY AND CARCINOGENESIS STUDIES OF INDOLE-3-CARBINOL IN HARLAN SPRAGUE ...
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Abstract for TR-584 80KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr584
Abstract for TR-584 Toxicology Studies of Indole-3-carbinol in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Indole-3-carbinol in Harlan Sprague Dawley ...
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Target Organ and Levels of Evidence for TR-584 60KB
https://ntp.niehs.nih.gov/data/tr/500s/tr584levels
Toxicology Studies of Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Indole-3-Carbinol in Harlan Sprague Dawley ...
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Minutes: TR Panel; May 22, 2014 273KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2014/may/minutes20140522_508.pdf
6 VII. Draft NTP Technical Report on Indole-3-Carbinol (TR-584) ......which was used for Green Tea Extract, Indole-3-Carbinol, and CIMSTAR 3800. She ...
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TR Panel: Actions; TRs 583, 584, 585, 586; May 22, 2014 86KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2014/may/actionstrsep20140522_508.pdf
TR---584: Indole---3---carbinol The Panel voted (4 yes, 2 no, 0 abstentions) to accept, as written, the draft NTP conclusions, no evidence of carcinogenic activity of indole---3---...
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Historical Controls: Chemicals by Sex/Species/Route/Vehicle for... 15KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/histcont_2013_by_list_of_studies_508.pdf
B6C3F1 Male and Female Gavage Corn oil Indole-3-carbinol Mice B6C3F1 Male and Female ... Rats Harlan Sprague- Dawley Male and Female Gavage Corn oil Indole-3-carbinol Rats Harlan ...
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P08: Statisitical Analysis of Primary Tumors for Mice (20209... 159KB
https://ntp.niehs.nih.gov/ntp-db/ntp_reports/ntp_pathology_tbls/20209_tables/04_f1_m3_p08.pdf
extract (GAVAGE CORN OIL) 20006-04 -- Indole-3-carbinol (GAVAGE CORN OIL) 20007-06 -- ... tea extract (GAVAGE WATER) 20006-04 -- Indole-3-carbinol (GAVAGE CORN OIL) 20007-06 -- ...
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Historical Controls: Pathology Tables by Gavage/Corn Oil for... 59KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/hiscont2013_hsd_gavage_cornoil_508.pdf
Battelle Columbus Laboratory 052000603 03/14/07 727 50(3) 20(644) 584.8 Indole-3-carbinol ... Battelle Columbus Laboratory 052000603 03/15/07 729 50(5) 21(637) 353.0 Indole-3-carbinol ...
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Historical Controls: Pathology Tables by Gavage/Corn Oil for... 162KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/micegavcornoil2013_508.pdf
052000604 04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Columbus Laboratory ... 052000604 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Columbus Laboratory ...
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Historical Controls: Pathology Tables by Gavage/Corn Oil for... 260KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2014/path_micegavcornoil2014_508.pdf
052000604 04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Columbus Laboratory ... 052000604 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Columbus Laboratory ...
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Historical Controls: Report List of Studies HSD Rats; Aug. 2016 17KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2016/aug-2016-hc-list-of-studies-hsd-rats.pdf
Species Strain Sex Route Vehicle Chemical Rats Harlan Sprague- Dawley Male and Female Gavage Corn oil Indole-3-carbinol Rats Harlan Sprague- Dawley Male and Female Inhalation Air ...
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Historical Controls: Report List of Studies B6C3F1 Mice; Aug... 18KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2016/aug-2016-hc-list-of-studies-mice.pdf
List of Studies - B6C3F1 Mice Species Strain Sex Route Vehicle Chemical Mice B6C3F1 Male and Female Gavage Corn oil Indole-3-carbinol Mice B6C3F1 Male and Female Gavage Corn oil ...
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Historical Controls: Studies on 2014 Reports 20KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2014/histcont2014_studylist_508.pdf
Mice B6C3F1 Male and Female Gavage Corn oil Ginkgo biloba extract Mice B6C3F1 Male and Female Gavage Corn oil Indole-3-carbinol Mice B6C3F1 Male and Female Gavage Corn oil Kava ...
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Historical Controls: List of Studies for Mice; Studies started... 8KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2015/m_hcrpt_list20150700_508.pdf
Mice B6C3F1 Male and Female Gavage Corn oil Ginkgo biloba extract Mice B6C3F1 Male and Female Gavage Corn oil Indole-3-carbinol Mice B6C3F1 Male and Female Gavage Corn oil ...
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Historical Controls: Report List of Studies HSD Rats; April 2019 10KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2019/r_hclist_20190400.pdf
Male and Female Perinatal and postnatal Feed 2-Hydroxy-4-methoxybenzophenone Rats Harlan Sprague- Dawley Male and Female Gavage Corn oil Indole-3-carbinol Rats Harlan Sprague- ...
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Uterus - Hyperplasia, Stromal - Nonneoplastic Lesion Atlas 287KB
https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/uterus/HyperplasiaStromal
TR-584. Toxicology Studies of Indole-3-Carbinol (CAS No. 700-06-1) in F344/N Rats and B6C3F1 Mice and Toxicology and Carcinogenesis Studies of Indole-3-Carbinol in Harlan Sprague ...
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Historical Controls: Report List of Studies B6C3F1/N Mice; April... 10KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2019/m_hclist_20190400.pdf
Feed 2-Hydroxy-4-methoxybenzophenone Mice B6C3F1/N Male and Female Gavage Corn oil Indole-3-carbinol Mice B6C3F1/N Male and Female Inhalation Air Metal Working Fluids: CIMSTAR ...
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P08: Statistical Analysis of Primary Tumors for Male & Female... 180KB
https://ntp.niehs.nih.gov/ntp-db/ntp_reports/ntp_pathology_tbls/20523_tables/04_f1_m3_p08.pdf
ALL ROUTES 60311-06 -- Cobalt (INHALATION AIR) 99031-04 -- Ginkgo biloba extract (GAVAGE CORN OIL) 20203-04 -- Green Tea Extract (GAVAGE WATER) 20006-04 -- Indole-3-carbinol ...
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Uterus - Hyperpalsia, Stromal 264KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/female_reproductive/uterus/hypstr/uterus-hyperplasia-stromal-pdf-508.pdf
TR-584. Toxicology Studies of Indole-3-Carbinol (CAS No. 700-06-1) in F344/N Rats and B6C3F1 Mice and Toxicology and Carcinogenesis Studies of Indole-3- Carbinol in Harlan Sprague ...
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Agenda: TR Peer Review; May 22, 2014 194KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2014/may/agenda2014522_508.pdf
Peer-review comments Panel . Panel discussion Dr. Carpenter Draft NTP Technical Report on Indole-3-Carbinol (TR-584) Study scientist: Dr. Michael Wyde, NIEHS/DNTP Study ...
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Comment: Meat-related exposures; Robert Turesky, University of... 4.6MB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/turesky20161005.pdf
... 9,137-139 2-Amino-9H-pyrido[2,3-b]indole (ARC) occurs in mainstream tobacco smoke ... smoke: 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeARC) forms at 10- fold lower amounts ...
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Historical Controls: All Routes and Vehicles for Harlan Sprague... 149KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2019/r_hcrpt_allrte20190400.pdf
03/14/07 727 50(3) 20(644) 584.8 Indole-3-carbinol Battelle Northwest 051047203 ... 03/15/07 729 50(5) 21(637) 353.0 Indole-3-carbinol Battelle Northwest 051047203 ...
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Historical Controls: Pathology Tables for All Routes/Vehicles... 70KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/histcont2013_hsdrats_allroutes_508.pdf
Battelle Columbus Laboratory 052000603 03/14/07 727 50(3) 20(644) 584.8 Indole-3-carbinol ... Battelle Columbus Laboratory 052000603 03/15/07 729 50(5) 21(637) 353.0 Indole-3-carbinol ...
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Tumor Incidence for Selected Control Animal Groups; Aug. 2016 93KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2016/aug-2016-hc-report-hsd-rats-all-routes.pdf
Battelle Columbus Laboratory 052000603 03/14/07 727 50(3) 20(644) 584.8 Indole-3-carbinol ... Battelle Columbus Laboratory 052000603 03/15/07 729 50(5) 21(637) 353.0 Indole-3-carbinol ...
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Historical Controls: Pathology Tables by Route/Vehicle for Harlan... 69KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/histcont2013_hsdrats_byroute_508.pdf
Battelle Columbus Laboratory 052000603 03/14/07 727 50(3) 20(644) 584.8 Indole-3-carbinol ... Battelle Columbus Laboratory 052000603 03/15/07 729 50(5) 21(637) 353.0 Indole-3-carbinol ...
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Historical Controls: Pathology Tables for All Routes/Vehicles... 276KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/histcont2013_mice_allroutes_508.pdf
... 052000604 04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Columbus Laboratory ... 052000604 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Columbus Laboratory ...
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Historical Controls: Pathology Tables by Route/Vehicle for B6C3F1... 950KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2013/histcont2013_mice_byroute_508.pdf
052000604 04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Columbus Laboratory ... 052000604 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Columbus Laboratory ...
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Historical Controls: Pathology Tables for All Routes/Vehicles... 196KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2014/histcont2014mice_all_routes_508.pdf
052000604 04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Columbus Laboratory ... 052000604 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Columbus Laboratory ...
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Historical Controls: Pathology Tables by Route/Vehicle for B6C3F1... 684KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2014/histcont2014mice_byroute_508.pdf
052000604 04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Columbus Laboratory ... 052000604 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Columbus Laboratory ...
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Historical Controls: All Routes and Vehicles for Mice; Studies... 124KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2015/m_hcrpt_allrte20150700.pdf
052000604 04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Northwest 052051504 ... 052000604 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Northwest 052051504 ...
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Historical Controls: By Route and Vehicle for Mice; Studies started... 285KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2015/m_hcrpt_rte20150700_508.pdf
052000604 04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Southern Research Institute ... 052000604 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Southern Research Institute ...
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Tumor Incidence for Selected Control Animal Groups; Aug. 2016 435KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2016/aug-2016-hc-report-hsd-mice-by-route.pdf
Battelle Columbus Laboratory 052000604 04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol ... Battelle Columbus Laboratory 052000604 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol ...
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Tumor Incidence for Selected Control Animal Groups; Aug. 2016 143KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2016/aug-2016-hc-report-hsd-rats-by-route.pdf
Battelle Columbus Laboratory 052000603 03/14/07 727 50(3) 20(644) 584.8 Indole-3-carbinol Female Battelle Columbus Laboratory 052000603 03/15/07 729 50(5) 21(637) 353.0 Indole-3-ca...
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Tumor Incidence for Selected Control Animal Groups; Aug. 2016 179KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2016/aug-2016-hc-report-mouse-all-routes.pdf
052000604 04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Northwest 052051504 ... 052000604 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Northwest 052051504 ...
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Historical Controls: All Routes and Vehicles for Mice; April... 189KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2019/m_hcrpt_allrte20190400.pdf
052000604 04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol Battelle Northwest 052051504 ... 052000604 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol Battelle Northwest 052051504 ...
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Historical Controls: By Route and Vehicle for Mice; April 2019 664KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2019/m_hcrpt_rte20190400.pdf
Battelle Columbus Laboratory 052000604 04/03/07 730 50(1) 26(663) 55.6 Indole-3-carbinol ... Battelle Columbus Laboratory 052000604 04/02/07 729 50(5) 33(702) 66.6 Indole-3-carbinol ...
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Historical Controls: By Route and Vehicle for Harlan Sprague... 464KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2019/r_hcrpt_rte20190400.pdf
Battelle Columbus Laboratory 052000603 03/14/07 727 50(3) 20(644) 584.8 Indole-3-carbinol Female Battelle Columbus Laboratory 052000603 03/15/07 729 50(5) 21(637) 353.0 Indole-3-ca...
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Lymph node - Lymphatic Sinus, Ectasia - Nonneoplastic Lesion... 288KB
https://ntp.niehs.nih.gov/atlas/nnl/immune-system/lymph-node/LymphaticSinusEctasia
Full Text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892634/ National Toxicology Program. 2004. Short-Term Bioassay of Indole-3-Carbinol (CAS No. 700-06-1) in F344/N Rats and ...
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Lymph Node - Lymphatic Sinus, Ectasia 575KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/immune/lymph_node/lsectasia/lymph-node-lymphatic-sinus-ectasia-pdf_508.pdf
Toxicol Pathol 34:425-454. Full Text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892634/ National Toxicology Program. 2004. Short-Term Bioassay of Indole-3-Carbinol (CAS No. ...
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Presentation: Adverse Outcome Pathway (AOP) for Sustained Aryl... 822KB
https://ntp.niehs.nih.gov/iccvam/meetings/aop-wksp-2014/presentations/simon-508.pdf
AHR activation is considered to be the initial key event for dioxin-induced tumor . However, many ligands activate the AHR and do not produce tumors, e.g. indole-3-carbinol in ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
NE No Evidence NE No Evidence NE No Evidence NE No Evidence TR-584 05/22/14 Indole-3-Carbinol 700-06-1 NE No Evidence SE Some Evidence CE Clear Evidence NE No Evidence ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... MB) Toxicology Studies of Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Indole-3-Carbinol in Harlan Sprague ...
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Nomination Background: 1-Butyl-3-methylimidazolium chloride ... 1.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/ionic_liquids_508.pdf
... Examples include cracking hydrocarbons, the Fischer indole process, preparation of ion- ... been used as a solvent and catalyst in the Fischer indole synthesis of different ketones. ...
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RoC Profile: 2-Acetylaminofluorene; 15th RoC 2021 124KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acetylaminofluorene.pdf
... Role of indole, age, and sex. Invest Urol 14(3): 206-209. NIOSH. 1990. National ... bladder tumorigenesis in hamsters by coadministration of 2-acetylaminofluorene and indole. ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... MB) Toxicology Studies of Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Indole-3-Carbinol in Harlan Sprague ...
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TR-071: L-Tryptophan (CASRN 73-22-3) 2.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr071.pdf
... In subsequent studies in which the tryptophan metabolites indole, indican, or ... tumorigenesis in hamsters by coadministra- tion of 2-acetylaminofluorene and indole. ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... MB) Toxicology Studies of Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Indole-3-Carbinol in Harlan Sprague ...
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TR-595: Sprague Dawley (Hsd:Sprague Dawley SD) Rats Exposed to... 5.6MB
https://ntp.niehs.nih.gov/go/tr595
... tris(chloroisopropyl) phosphate, indole-3-carbinol, perfluorooctanoic acid, ... the studies with three brain sections (indole-3-carbinol, perfluorooctanoic acid, and ...
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Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf
... Reserpine 50-55-5 Heterocyclic Compound, Indole Pharmaceutical, Veterinary Agent † - - ... @ 30 °C - - $76 Heterocyclic Compound, Indole Pharmaceutical, Veterinary Agent Sodium ...
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All Past Events 1004KB
https://ntp.niehs.nih.gov/events/past
... May 22, 2014 NTP Technical Reports Peer Review Meeting: Green Tea Extract, Indole-3-Carbin... NTP Technical Reports Peer Review Meeting: Green Tea Extract, Indole-3-Carbinol, CIMSTAR ...