Advancing Flexibility for Defined Approach Guidelines: Developing... 1.2MB

https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Sullivan-poster.pdf

... 1A 1 1A Resorcinol 108-46-3 N N/A 1B NC 1B Salicylic acid 69-72-7 N N/A 1B NC NC Vanillin 121-33-5 N N/A NC NC NC Method type KE 1 KE 2 KE 3 In silico model Original Direct peptide ...

RoC Background Document: Wood Dust; Dec. 13-14, 2000 1.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc10/wd_no_appendices_508.pdf

... 182.18 C 9 H 10 O 4 p-Hydroxy- benzaldehyde C 7 H 6 O 2 123-08-0 122.12 Vanillin C 8 H 8 O 3 121-33-5 152.15 Eugenol C 10 H 12 O 2 97-53-0 164.20 5 C O HO OH OH OH C O O HO HO ...

TR-360: N,N-Dimethylaniline (CASRN 121-69-7) in F344/N Rats and... 10.2MB

https://ntp.niehs.nih.gov/go/tr360

... N,N-Dimethylaniline is used as a n intermediate in the production of vanillin, Michler's ... W,N-Dimethylaniline, used in the manufacture of' vanillin, Michler's ketone, and methyl ...

TR-223 Carcinogenesis Studies of Eugenol (CASRN 97-53-0) in F344... 6.8MB

https://ntp.niehs.nih.gov/go/tr223

... et Othmer, 1965), and as a starting material in the al., 1980). synthesis of 3-methyl-4-hydroxybenzaldehyde, commonly known as vanillin (Kirk-Othmer, Genetic Toxicity 1970). ...

TR-378: Benzaldehyde (CASRN 100-52-7) in F344/N Rats and B6C3F1Mice... 14.1MB

https://ntp.niehs.nih.gov/go/tr378

... Posi- tive reactions occurred in patients with sensi- tivity to benzoic acid or vanillin (Hjorth, 1961). In short-term studies on the inhibition of peptic activity, an effective ...

TR-495: Sodium Nitrite (CASRN 7632-00-0) in F344/N Rats and B6C3F1... 2.4MB

https://ntp.niehs.nih.gov/go/tr495

... Furthermore, sodium nitrite may react with phenolic antioxidants (e.g., phenol, 3-methoxycatechol, catechol, vanillin, and butylated hydroxyanisole) under acidic conditions to form ...

TR-514: trans-Cinnamaldehyde (Microencapsulated) (CASRN 14371... 7.2MB

https://ntp.niehs.nih.gov/go/tr514

... mutations in V79 cells and recessive spot formations in mice by vanillin. Mutat. ... Y. (1990). Suppressing effects of vanillin, cinnamaldehyde, and anisaldehyde on ...

ICCVAM Test Method Evaluation Report on the Reduced LLNA 21.6MB

https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ld/tmer.pdf

... Liquid Esters; Ethers Gerberick Ethyl vanillin - 121-32-4 166.18 1.52 Solid Aldehydes ... fatty acid ester - - - - - - CESIO Vanillin - 121-33-5 152.15 1.28 Solid Aldehydes ...

Usefulness and Limitations of the LLNA for Potency Categorization... 25.3MB

https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-pot/tmer.pdf

... NA NA NA (Gerberick et al. 2005) Ethyl vanillin AOO 2.5 5 10 25 50 0.65 1.05 0.74 0.36 ... GmbH, D-33178 Borchen (EFfCI 2006) Vanillin AOO 2.5 5 10.0 25 50 0.9 1.4 1.5 1.2 1.4 ...

TR-551: Toxicology and Carcinogenesis Studies of Isoeugenol ... 3.5MB

https://ntp.niehs.nih.gov/go/tr551

... Biotransformation of isoeugenol to vanillin by a newly isolated Bacillus pumilus strain: ... Yamada, M., Okada, Y., Yoshida, T., and Nagasawa, T. (2008). Vanillin production using ...

Background Document for Selected Heterocyclic Amines: PhIP, MeIQ... 3.3MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/newhomeroc/roc11/hcaspub_508.pdf

... The bioantimutagens (e.g., vanillin, caffeine, coumarin) are agents that act on repair and ... However, groups of cells exposed to 0.6 mM PhIP and 5 µg/mL of caffeine, vanillin, or ...

TR-204: Benzoin for Possible Carcinogenicity (CASRN119-53-9) 3.8MB

https://ntp.niehs.nih.gov/go/tr204

... Standard: Phenol Amount Spotted: 100 and 300 it g Visualization: Ultraviolet (254 and 365 nm) and vanillin-sulfuric acid System 1: Carbon tetrachloride: System 2: Diethyl ether: ...

Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB

https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf

... 97-53-0 phenolic// potential epoxide after metabolism fragrances// vanillin manufacture// dental analgesic// bakery series kit + + + 2% pet. ** Kimber et al. ...

TR-381: d-Carvone (CASRN 2244-16-8) in B6C3F1Mice (Gavage Studies... 6.3MB

https://ntp.niehs.nih.gov/go/tr381

... was the reference standard, and visualization was with a spray of 5% (w/v) vanillin in concentrated sulfuric acid, followed by heating until maximum color development oc- curred. ...

TR-444: Initiation/Promotion Study of o-Benzyl-p-Chlorophenol... 6.4MB

https://ntp.niehs.nih.gov/go/tr444

... Visualization was accomplished with ultraviolet light (254 and 366 nm) and a spray o f 1% vanillin in concentrated sulfuric acid. The reference standard used was ...

TR-441 Comparative Initiation/Promotion Skin Paint Studies of... 11.9MB

https://ntp.niehs.nih.gov/go/tr441

... Visualization was at 254 nm (and 366 nm for lot 00411999) with a spray o f 1 % vanillin in concentrated sulfuric acid, followed by heating at 120" C for 10 to 20 minutes. HPLC was ...

TR-589: Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade... 7.3MB

https://ntp.niehs.nih.gov/go/tr589

... Samples were allowed to cool to room temperature and a vanillin reagent (2.5 mL of 1.2 mg vanillin/mL 68% aqueous phosphoric acid) was added to each hydrolysate. Tubes were ...

TR-574: Pyrogallol (CASRN 87-66-1) in F344/N Rats and B6C3F1... 9.3MB

https://ntp.niehs.nih.gov/go/tr574

... The TLC method included vanillin (Aldrich Chemical Company, Inc., Milwaukee, WI) as a reference standard, ethyl acetate (Burdick and Jackson, Morris Township, NJ):ASTM I water ...

TR-429: Diethylphthalate (CASRN 84-66-2) in F344/N Rats and B6C3F1Mice... 12.5MB

https://ntp.niehs.nih.gov/go/tr429

... Visualization was at 254 nm .(and 366 nm for lot 411999) with a spray of 1% (w/v) vanillin in.concentrated sulfuric acid, followed by heating at 120" C for 10 to 20 minutes. ...

TR-456: 1,2-Dihydro-2,2,4-Trimethylquinoline (CASRN 147-47-7... 17.5MB

https://ntp.niehs.nih.gov/go/tr456

... Visualization was at 254 nm and with a spray of 1% vanillin in concentrated sulfuric acid, followed by heating at 120" C for 10to 20 minutes. For lot F-121, HPLC was performed with ...

TR-485: Oxymetholone (CASRN 434-07-1) in F344/N Rats and Toxicology... 12.4MB

https://ntp.niehs.nih.gov/go/tr485

... The plates were examined under ultraviolet light (254 nm) with a spray of 0.5 g vanillin in 100 mL of sulfuric acid:ethanol (4:1). After spraying, the plates were dried at 120E C ...

TR-505: Citral (Microencapsulated) (CASRN 5392-40-5) in F344... 2.1MB

https://ntp.niehs.nih.gov/go/tr505

... The plates were examined using 254 nm ultraviolet light and a spray of 0.4% 2,4-dinitrophenylhydrazine in 2 N hydrochloric acid. Vanillin was used as a reference standard. For lot ...

TR-563: Pulegone (CASRN 89-82-7) in F344/N Rats and B6C3F1 Mice... 6.4MB

https://ntp.niehs.nih.gov/go/tr563

... test article and the reference standard (vanillin) and developed in a tank containing ... (254 and 366 nm) and visible light, iodine vapor, and a vanillin/sulfuric acid spray. ...

TR-426: Corn Oil, Safflower Oil, and Tricaprylin (CASRNs. 8001... 18.8MB

https://ntp.niehs.nih.gov/go/tr426

... Visualization was accomplished with visible light and ultraviolet light (366 nm) following a spray of 1% vanillin in concentrated sulfuric acid and heating at 1.20" C for lot A15.. ...

TR-491: Toxicology and Carcinogenesis Studies of Methyleugenol... 14.5MB

https://ntp.niehs.nih.gov/go/tr491

... TLC was performed on Silica Gel 60 F-254 plates with two solvent systems: 1) ethyl acetate:methanol (80:20) and 2) chloroform (100%). Vanillin was used as a reference standard for ...