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Search suggestions for "123-31-9".

  1. CEBS Data Related to Hydroquinone (123-31-9) https://cebs.niehs.nih.gov/cebs/test_article/123-31-9


131 results found for "123-31-9".

  1. TR-366: Hydroquinone (CASRN 123-31-9) in F344/N Rats and B6C3F1Mice... 14.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr366.pdf

    Report Series No. 3 6 6 'I~OXICOLOGY AND CARCINOGENESIS STUDIES OF HYDROQUINONE (CAS NO. 123-31-9) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) U.S. DEPARTMENT OF HEALTH ...

  2. Abstract for TR-366 68KB

    https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr366

    Abstract for TR-366 Toxicology and Carcinogenesis Studies of Hydroquinone in F344/N Rats and B6C3F1 Mice (Gavage Studies) CASRN: 123-31-9 Chemical Formula: C6H6O2 Molecular Weight: ...

  3. Target Organs and Levels of Evidence for TR-366 58KB

    https://ntp.niehs.nih.gov/data/tr/300s/tr366levels

    Target Organs and Levels of Evidence for TR-366 Toxicology and Carcinogenesis Studies of Hydroquinone (CASRN 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) Chemical ...

  4. Abstract for TR-459 76KB

    https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr459

    Synonyms/Common Names: Tert-butyl-hydroquinone; 2-(1,1-dimethylethyl)-1,4-benzenediol...butyl-1,4-benzenediol; 2-(1,1-dimethyl)hydroquinone; 2-(tert-butyl)-p-hydroquinone; TBHQ; ...

  5. TR-459: t-Butylhydroquinone (CASRN 1948-33-0) in F344 Rats and... 25.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr459.pdf

    ... Tert-butyl-hydroquinone; 2-(l,l-dimethylethyl)-l,4-benzenediol; tert-butyl-l,4-benzenediol; mono-tertiary-butylhydroquinone; 2-(1,1-dimethyl)hydroquinone; TBHQ; MTBHQ Trade ...

  6. Minutes: BSC TRRS; Oct. 3, 1988 964KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1988/oct/88oct3-4trrsmins_508.pdf

    Gavage Diphenhydramine HC1 147-24-0 Feed Hexachloroethane 67-72-1 Gavage Hydroquinone 123-31-9 Gavage ~odinated Glycerol 5634-39-9 Gavage Gavage Pentaerythritol Feed ...

  7. RoC Background Document for Diazoaminobenzene; Nov. 22, 2002 1.3MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/daab_rg2_public_correct_no_app_508.pdf

    ... the urine of rats and mice included hydroquinone, muconic acid, and phenylmercapturic ... Phenol may be oxidized by cytochrome P-450 2E1 to hydroquinone or catechol. Catechol also ...

  8. TR-289: Benzene (CASRN 71-43-2) in F344/N Rats and B6C3F1Mice... 16.4MB

    https://ntp.niehs.nih.gov/go/tr289

    ... GENETIC TOXICOLOGY O F BENZENE. CATECHOL. AND HYDROQUINONE .....223 INDUCTION O F ... 225 MUTAGENICITY OF HYDROQUINONE I N SALMONELLA ......

  9. Minutes: BSC; Dec. 9-10, 2009 394KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2009/december/minutes20091210.pdf

    ... 37 Research Concept for Hydroquinone (HQ) ......for review are: butterbur, evening primrose oil, hydroquinone, silica flour, and valerian. ...

  10. Abstract for TR-272 64KB

    https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr272

    homopolymers that are used as additives in lubricating oils and in the manufacture of hydroquinone. The chemical is also used as an aerosol propellant or component. ...

  11. TOX-73: Diazoaminobenzene (CASRN 136-35-6) 2.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox073.pdf

    ... Five of the urinary metabolites were common metabolites of benzene: hydroquinone ... 13 Diazoaminobenzene, NTP TOX 73 hydroquinone glucuronide, muconic acid, and phenol. ...

  12. RoC Profile: Diazoaminobenzene; 15th RoC 2021 129KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/diazoaminobenzene.pdf

    Metabolites of diazo- aminobenzene in the blood of rats and the urine of rats and mice included hydroquinone, muconic acid, and phenylmercapturic acid, which share benzene oxide as ...

  13. Draft RoC Monograph for Pentachlorophenol: Literature Search... 2.0MB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/pcpliteraturesearch20130815_508.pdf

    ... (TCHQ), tetrachloro-1,2-hydroquinone (TCoHQ), tetrachlorocatechol (TCpCAT), ... metabolite tetrachloro-p-hydroquinone induces the formation of 8-hydroxy-2- ...

  14. TR-403: Resorcinol (CASRN 108-46-3) in F344 Rats and B6C3F1Mice... 15.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr403.pdf

    ... Introduction treated rats, resorcinol, hydroquinone, and o-methyl catechol exhibited no ... of diets containing 0.8% resorcinol, catechol, or hydroquinone for an additional 49 weeks. ...

  15. GMM-08: Genetically Modified Model Report on Benzene (Gavage... 1.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm08_508.pdf

    ... enzymes to phenol, catechol, and hydroquinone, as well as enzyme systems that result ... Phenol is further metabolized (via CYP450) to hydroquinone and catechol. Hydroquinone and ...

  16. TR-460: Effect of Dietary Restriction on Toxicology and Carcinogenesis... 30.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr460.pdf

    .../2X, and IX) for approximately 104 weeks or up.to 128 weeks (t-butyl- hydroquinone study). ... salicylazosulfapyridine, t-butyl- hydroquinone, and scopolamine hydrobromide tri- hydrate. ...

  17. Presentation: New Models in the Validation Pipeline for ACD Hazard... 521KB

    https://ntp.niehs.nih.gov/iccvam/meetings/implement-2011/acd-present/11-mathesonnewmethods.pdf

    ... results from three independent laboratories with three sensitizers (MCI/MI, hydroquinone and ethylene diamine) and two irritants (SDS and lactic acid) indicating a ...

  18. TOX-70: p-tert-Butylcatechol (CASRN 98-29-3) 4.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox070.pdf

    ... studies, the analogs p-methylcatechol, hydroquinone, and resorcinol induced a less ... No lesions were observed in control rats. The carcinogenicity of hydroquinone, resorcinol, ...

  19. Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB

    https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf

    ... Hydroquinone and quinol had the same CAS number and were changed to a single listing. ... a low of 262 to a high of 463, and for hydroquinone from 257 to 781. However, the SIs for ...

  20. TR-576: Trimethylolpropane Triacrylate (Technical Grade) (CASRN... 6.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr576_508.pdf

    ... but may be stabilized with the monoethyl ester of hydroquinone (AIHA, 1981; Lenga, 1988). ... HPLC/UV analysis indicated that neither hydroquinone nor methyl hydro- quinone was ...

  21. RoC Background Document: 1,3-Butadiene; Oct. 30-31, 1997 9.0MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/butadiene_508.pdf

    ... inhibitor such as tert-butylcatechol, hydroquinone, or di-n-butylamine (Kirshenbaum, ... Oxidation/polymerization of 1,3-butadiene is inhibited by addition of hydroquinone, ...

  22. TR-466: Ethylbenzene (CASRN 100-41-4) in F344/N Rats and B6C3F1Mice... 11.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr466.pdf

    ... mice is mainly due to the metabolites hydroquinone and benzoquinone (Zhu et al., 1995). ... of "2µ-globulin is known to lead to hydroquinone, benzoquinone, or benzene diolepoxide ...

  23. RoC Concept: ortho-Toluidine 318KB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/concepts/otolconcdocroc8-30-12_508.pdf

    ... ortho-aminoazotoluene, aniline, 4-chloro-ortho-toluidine, nitrobenzene, hydroquinone, N-phenyl-2-naphthylamine (phenyl-β-naphthylamine), and 2-mercaptobenzothiazole. ...

  24. Presentation: Mechanisms of Acute Toxicity 2.4MB

    https://ntp.niehs.nih.gov/iccvam/meetings/at-wksp-2015/session4/1-wilson-508.pdf

    ... H N N N NH R O O C H 3 C H 3 2H + , 2e - FAD (oxidized quinone form) FADH 2 (reduced hydroquinone form) Fish acute toxicity vs. ToxCast HTS Mitochondrial Electron Transport I II ...

  25. Minutes: BSC TRRS; June 20, 1995 296KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1995/june/trrs20june1995mins_508.pdf

    ... He said the mention of THBQ as being structurally related to hydroquinone and butylated hydroxytoluene which are described as carcinogenic chemicals should be clarified to indicate ...

  26. Public Health Impact 1.5MB

    https://ntp.niehs.nih.gov/media/impact

    ... Report on the Toxicology and Carcinogenesis Studies of Toxicology and Carcinogenesis Studies of Hydroquinone (CASRN 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies). ...

  27. RoC Background Document: Vinyl Bromide; Jan. 20-21, 2000 220KB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/vb_no_appendices_508.pdf

    ... Hydroquinone methyl ether (0.02%, used as stabilizer), ethylene oxide (0.03%), acetylene (0.0007%), and aldehydes and ketones (0.008%) were present in the VB used. The animals in ...

  28. TR-582: Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and... 5.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr582_508.pdf

    ... In the absence of an added inhibitor, monomethyl ether of hydroquinone, vinylidene ... article was stabilized with approximately 300 ppm monomethyl ether hydroquinone (MEHQ). ...

  29. TR-228: Vinylidene Chloride (CASRN 75-35-4) in F344 Rats and... 7.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr228.pdf

    ... b i l i z e r , the monomethylether of hydroquinone (MEHQ), present a t a concentration of ... (d) S Y S T E M 4 (monomethylether of hydroquinone) Instrument: Tracor M T 220 Detection: ...

  30. Draft RoC Monograph for ortho-Toluidine: Literature Search Strategy... 1.1MB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/otol_literaturesearch20130815_508.pdf

    ... 4-Chloro-ortho-toluidine Nitrobenzene Hydroquinone N-Phenyl-2-naphthylamine ... General sources checklist for: Hydroquinone Source Name of document 1) NTP technical ...

  31. NTP Technical Reports Index 1.5MB

    https://ntp.niehs.nih.gov/data/tr

    ... Evidence SE Some Evidence SE Some Evidence NE No Evidence TR-366 10/03/88 Hydroquinone 123-31-9 SE Some Evidence SE Some Evidence NE No Evidence SE Some Evidence TR-365 10/04/...

  32. TR-483: Pentachlorophenol (CASRN 87-86-5) in F344/N Rats (Feed... 7.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr483.pdf

    ... one of its major metabolites, tetrachloro- p-hydroquinone, has been shown to be genotoxic. ... Two pos- sible mechanisms of DNA damage by tetrachloro-p- hydroquinone have been proposed. ...

  33. TR-561: Tetralin (CASRN 119-64-2) in F344/N Rats and B6C3F1 Mice... 13.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr561.pdf

    ... formation is prevented by addition of an antiox- idant such as hydroquinone (Merck, 1996). ... Relationship of hydroquinone- associated rat renal tumors with spontaneous chronic ...

  34. TR-571: Kava Kava Extract (CASRN 9000-38-8) in F344/N Rats and... 12.2MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr571.pdf

    ... of kavain-11,12-hydroquinone and 7,8-dihydrokavain- 11,12-hydroquinone in the urine of a human volunteer administered a single dose of kava kava extract (Johnson et al., 2003). ...

  35. GMM-04: Genetically Modified Model Report on Pentaerythritol... 5.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm04_508.pdf

    ... Pentaerythritol triacrylate may polymerize when exposed to sources of free radicals (Radcure, 1990b), direct light, and heat; it is stabilized with 300 to 400 ppm hydroquinone ...

  36. TR-272: Propylene (CASRN 115-07-1) in F344/N Rats and B6C3F1Mice... 8.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr272.pdf

    ... to form vinyl chloride copolymers and low-molecular- weight homopolymers that are used as additives in lubricating oils and in the manufacture of hydroquinone (IARC, 1979). ...

  37. TOX-77: Hexachlorobenzene (CASRN 118-74-1) Administered by Gavage... 2.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox077_508.pdf

    ... found in rats after exposure to HCB include pentachlorophenol, tetrachloro- 1,4-hydroquinone, and diverse tetra- and tri-chlorophenols. 27 Another major metabolic pathway is ...

  38. RoC Concept: Pentachlorophenol 299KB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/concepts/pcp_concdocroc8-30-12_508.pdf

    ... tetrachlorophydroquinone (TCHQ), tetrachloro-1,2- Cancer Studies in chlorophenol hydroquinone (TCoHQ), tetrachlorocatechol Experimental Animals (for metabolites (TCpCAT), ...

  39. GMM-03: Genetically Modified Model Report on Trimethylolpropane... 7.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm03_508.pdf

    ... Trimethylolpropane triacrylate may undergo spontaneous polymerization when exposed to direct sunlight and heat but may be sta- bilized with the monomethyl ester of hydroquinone ...

  40. TR-259: Ethyl Acrylate (CASRN 140-88-5) in F344/N Rats and B6C3F1Mice... 12.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr259.pdf

    ... The manufacturer listed no purity specifi- cations but indicated the material con- tained 15 ppm of the monoethyl ether of hydroquinone as an inhibitor. Purity and identity ...

  41. TR-428: Manganese (II) Sulfate Monohydrate (CASRN 10034-96-5... 19.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr428.pdf

    ... manganese carbonate ore or manganese II oxide in sulfuric acid; prior to 1986 it was also obtained as a byproduct in the manufacturing process of hydroquinone (Kirk-Othmer, 1981). ...

  42. TR-574: Pyrogallol (CASRN 87-66-1) in F344/N Rats and B6C3F1... 13.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr574_508.pdf

    ... Pyrogallol also produces H 2 O 2 in vitro more than other polyphenols (pyrogallol > 1,2,4-benzenetriol > hydroquinone > catechol) and is one of only two polyphenols able to produce ...

  43. Technical Reports 903KB

    https://ntp.niehs.nih.gov/publications/reports/tr

    ... Report TR-366 PDF (13.99 MB) Toxicology and Carcinogenesis Studies of Hydroquinone (CASRN 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1989 Technical Report ...

  44. Minutes: BSC; June 15, 2006 1.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2006/june/bsc_mins_20060613_508.pdf

    ... Arbutin The BSC questioned the rationale for studying arbutin in rodents as the metabolism may differ in rodents and humans. Hydroquinone (HQ), a rodent carcinogen, is formed from ...

  45. Minutes: BSC RoC; Oct. 14, 2003 1.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/meetings/2003/rocmin101403.pdf

    ... Twenty four hours after a 20 mglkg oral dose to rats, less than one percent of the dose was retained in various tissues. Benzene metabolites, including phenol, hydroquinone ...

  46. TR-314: Methyl Methacrylate (CASRN 80-62-6) in F344/N Rats and... 11.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr314.pdf

    ... PROCUREMENT AND CHARACTERIZATION OF METHYL METHACRYLATE Methyl methacrylate containing 10 ppm of the monomethyl ether of hydroquinone as an inhibi- tor of polymerization was ...

  47. TR-414: Pentachloroanisole (CASRN 1825-21-4) in F344 Rats and... 15.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr414.pdf

    ... Tetrachloro- hydroquinone,ametabolite o f pentachlorophenol, was found to bind covalently t o calf thymus DNA and to induce single strand breaks in bacteriophage PM2 DNA, but these ...

  48. RoC Background Document: Tobacco Smoking; Dec. 2-3, 1998 3.5MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/environmentalts_noapps_508.pdf

    ... MS 31.50 ng/cig Hydrazine SS 94.20 ng/cig Hydroquinone MS 114.00 300.00 µg/cig Hydroquinione SS 91.00 285.00 µg/cig Hydroquinone, methyl- MS 23.00 39.00 µg/cig Hydroquinone, ...

  49. TR-537: Dibromoacetic Acid (CASRN 631-64-1) in F344/N Rats and... 9.3MB

    https://ntp.niehs.nih.gov/go/tr537

    ... 57% 28% 60% 32% Gavage Study (Water) Hydroquinone (TR 366), no evidence b Overall ... 30% 58% 32%* 48% Gavage Study (Water) Hydroquinone (TR 366), some evidence Overall ...

  50. Toxicology/Carcinogenicity 1.1MB

    https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox

    ... TR-366 PDF (13.99 MB) Toxicology and Carcinogenesis Studies of Hydroquinone (CASRN 123-31-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies) 1989 Long-Term ...

 
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