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Search suggestions for "126-99-8".

  1. CEBS Data Related to Chloroprene (126-99-8) https://cebs.niehs.nih.gov/cebs/test_article/126-99-8
  2. Report on Carcinogens Chloroprene https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/chloroprene.pdf


78 results found for "126-99-8".

  1. TR-467: Chloroprene (CASRN 126-99-8) in F344/N Rats and B6C3F1Mice... 14.5MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr467.pdf

    THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLOROPRENE (CAS NO. 126-99-8) IN F344/N RATS AND B6C3F MICE 1 (INHALATION STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research ...

  2. RoC Background Document: Chloroprene; Oct. 30-31, 1997 5.9MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/chloroprene1_508be.pdf

    NOl-ES-25346 NTP Report on Carcinogens 1997 Background Document for Chloroprene TABLE OF CONTENTS NTP Report on Carcinogens Listing for Chloroprene......

  3. RoC Profile: Chloroprene; 15th RoC 2021 140KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chloroprene.pdf

    Chloroprene CAS No. 126-99-8 Reasonably anticipated to be a human carcinogen First listed in the Ninth Report on Carcinogens (2000) Also known as 2-chloro-1,3-butadiene CH 2 C H C ...

  4. Abstract for TR-467 92KB

    https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr467

    Abstract for TR-467 Toxicology and Carcinogenesis Studies of Chloroprene in F344/N Rats and B6C3F1 Mice (Inhalation Studies) CASRN: 126-99-8 Chemical Formula: C4H5Cl Molecular ...

  5. Abstract for TER91042 60KB

    https://ntp.niehs.nih.gov/publications/abstracts/dev/ter91042

    Inhalation Developmental Toxicology Studies: Developmental Toxicity of Chloroprene Vapors in New Zealand White Rabbits CASRN: 126-99-8 Chemical Formula: C4H5Cl Molecular Weight: ...

  6. Minutes: BSC TRRS; Dec. 11, 1996 1.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1996/dec/trrs11dec1996mins_508.pdf

    Chloroprene 126-99-8 Inhalation Cobalt Sulfate Heptahydrate 10026-24-1 Inhalation Ethylbenzene 100-41-4 Inhalation Isobutyraldehyde 78-84-2 Inhalation Oxazepam 604-75-1 Feed ...

  7. Target Organs and Levels of Evidence for TR-467 64KB

    https://ntp.niehs.nih.gov/data/tr/400s/tr467levels

    Target Organs and Levels of Evidence for TR-467 Toxicology and Carcinogenesis Studies of Chloroprene (CASRN 126-99-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) Chemical ...

  8. RoC Background Document: Isoprene; Dec. 2-3, 1998 2.2MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/isoprene_oneapp_508.pdf

    .........25 6.3.2 Chloroprene ......analogue of 1 ,3-butadiene, while chloroprene is the 2-chloro analogue of 1 ,3-butadiene. ...

  9. Abstract for TR-288 65KB

    https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr288

    Chloroprene monomer, derived from 1,3-butadiene, is used exclusively to manufacture neoprene elastomers for non-tire and latex applications. Commercial nitrile rubber, used largely ...

  10. Studies on Historical Control Reports for NIH-07 Feed 312KB

    https://ntp.niehs.nih.gov/ntp/historical_controls/nih-07_1999/histcont_1999_by_list_of_studies_508.pdf

    Rats Fischer344 Inhalation Air Chloroprene Rats Fischer344 Inhalation Air Cobalt ... Mice B6C3F1 Inhalation Air Chloroprene Mice B6C3F1 Inhalation Air Cobalt ...

  11. TR-486: Isoprene (CASRN 78-79-5) in F344/N Rats (Inhalation Studies... 11.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr486.pdf

    ... structural analogues, 1,3-butadiene and chloroprene, from previous 2-year NTP studies. Dr. ... Inhalation toxicology and carcinogenesis studies on chloroprene, the 2-chloro analogue of ...

  12. RoC Background Document: 1,3-Butadiene; Oct. 30-31, 1997 9.0MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/butadiene_508.pdf

    ... styrene-butadiene latex (9.9%), chloroprene (6.6%), acrylonitrile-butadiene- ... Neoprene is made by chlorinating 1,3-butadiene and treating the resultant chloroprene with ...

  13. Completed RoC Evaluations 119KB

    https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/completed/roc

    ... Request Archived Materials Chloramphenicol Delisted Background Document Appendix Request Archived Materials Chloroprene Reasonably anticipated to be a human carcinogen Background ...

  14. Minutes: BSC; Feb. 5, 1998 713KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1998/february/19980205bscmins_508.pdf

    ... carcinogenicity in the p53 def model, chloroprene, N-methyl-o -acrylamide, reserpine, and ... of the transgenic systems -- glycidol, chloroprene, N-methylolacrylamide, and reserpine. ...

  15. Listed Substances; 15th RoC 2021 76KB

    https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf

    ... Agents) Chloroform 3-Chloro-2-methylpropene 4-Chloro-o-phenylenediamine Chloroprene p-Chloro-o-toluidine and Its Hydrochloride Chlorozotocin (see Nitrosourea ...

  16. Appendix G; 15th RoC 2021 73KB

    https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf

    ... National Toxicology Program, Department of Health and Human Services 2 123-91-1 see 1,4-Dioxane 126-72-7 see Tris(2,3-dibromopropyl) Phosphate 126-99-8 see Chloroprene 127-18-4 see ...

  17. Minutes: BSC; Dec. 13, 1996 288KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1996/december/19961213_bsc_508.pdf

    ... that were found to be strongly positive for carcinogenic activity, e. g., chloroprene. Dr. ... With regard to chloroprene, the chemical is being evaluated in the p53 transgenic mouse ...

  18. TOX-31: Isoprene (CASRN 78-79-5) 7.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox031.pdf

    ... Isoprene and chloroprene were studied because the production volumes of these chemicals ... mouse cytogenetic studies on 1,3-butadiene , isoprene, and chloroprene. Environ. ...

  19. RoC Profile: Isoprene; 15th RoC 2021 158KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/isoprene.pdf

    ... 478-483. Lynch J. 2001. Occupational exposure to butadiene, isoprene and chloroprene. ... Comparative carcinogenicity of 1,3-butadiene, isoprene, and chloroprene in rats and mice. ...

  20. 15th RoC: Appendix F 174KB

    https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf

    ...hloro-1,2-benzenediamine see 4-Chloro-o-phenylenediamine 2-chloro-1,3-butadiene see Chloroprene chlorocamphene see Toxaphene 2-chloro-N-(2-chloroethyl)-N-methylethanamine see ...

  21. NTP Technical Reports Index 1.5MB

    https://ntp.niehs.nih.gov/data/tr

    ... Tested in Species/Sex NT Chemical Not Tested in Species/Sex TR-467 12/11/96 Chloroprene 126-99-8 P Clear Evidence P Clear Evidence P Clear Evidence P Clear Evidence TR-466 12/...

  22. RR-05: National Toxicology Program Approach to Genomic Dose-Response... 574KB

    https://ntp.niehs.nih.gov/ntp/results/pubs/rr/reports/rr05_508.pdf

    ... Endpoint BMD from a 2-Year Study of Chloroprene (CHLP) to the Most Sensitive Gene-Set ... Endpoint BMD from a 2-Year Study of Chloroprene (CHLP) to the Most Sensitive Gene-Set ...

  23. Appendices A-G; 15th RoC 2021 448KB

    https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf

    ... 2-chloro-1,3-butadiene see Chloroprene chlorocamphene see Toxaphene ... see Tris(2,3-dibromopropyl) Phosphate 126-99-8 see Chloroprene 127-18-4 see ...

  24. Minutes: BSC TRRS; Dec. 9, 1997 1.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1997/dec/trrs9dec1997mins_508.pdf

    ... structural analogs, 1,3-butadiene and chloroprene, that had been studied previously in ... study (NTP TR 434), and the chloroprene study (NTP TR 467), and has gained ...

  25. Technical Reports 903KB

    https://ntp.niehs.nih.gov/publications/reports/tr

    ... Report TR-467 PDF (14.6 MB) Toxicology and Carcinogenesis Studies of Chloroprene (CASRN 126-99-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1998 Technical Report ...

  26. TR-288: 1,3-Butadiene (CASRN 106-99-0) in B6C3F1Mice (Inhalation... 5.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr288.pdf

    ... Chloroprene monomer, de- rived from 1,3-butadiene, is used exclusively to manufacture neoprene elastomers for non-tire and latex applications. Commercial nitrile rub- ber, used ...

  27. TR-476: Primidone (CASRN 125-33-7) in F344/N Rats and B6C3F1Mice... 13.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr476.pdf

    ... Goldsworthy asked whether it might have been appropriate with the male rat data to use the survival- adjusted "Poly-3" quantal response employed in the chloroprene study. Dr. J.K. ...

  28. Minutes: BSC TRRS; Nov. 16, 1993 800KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1993/nov/trrs16nov1993mins_508.pdf

    ... Studies were undertaken on isoprene as part of the butadiene initiative developed in the 1980s. Isoprene a n d chloroprene were put on study because they a r e high production ...

  29. Toxicology/Carcinogenicity 1.1MB

    https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox

    ... TR-467 PDF (14.6 MB) Toxicology and Carcinogenesis Studies of Chloroprene (CASRN 126-99-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1998 Long-Term ...

  30. Study Reports 1.1MB

    https://ntp.niehs.nih.gov/publications/reports

    ... Report TR-467 PDF (14.6 MB) Toxicology and Carcinogenesis Studies of Chloroprene (CASRN 126-99-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) 1998 Technical Report ...

  31. TR-504: o-Nitrotoluene (CASRN 88-72-2) in F344/N Rats and B6C3F1... 14.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr504.pdf

    ... oxide (NTP, 1985), chloroprene (NTP, 1998), and tetrafluoroethylene (NTP, 1997). ... occurred in the heart; in the chloroprene studies hemangiosarcomas were observed ...

  32. TR-484: 2-Butoxyethanol (CASRN 111-76-2) in F344/N Rats and B6C3F1Mice... 11.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr484.pdf

    ... such as acetonitrile (NTP, 1996), 1,3-butadiene (NTP, 1993c), and chloroprene (NTP, 1998). ... increases in the 1,3-butadiene and chloroprene studies were considered treatment related. ...

  33. RoC Background Document: Tetrafluoroethylene; March 1999 4.5MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/tetrafluoroethylene1.pdf

    ... Caprolactam and nylon 6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 115 Chloroprene and polychloroprene . . . . . . . . . . . . . . . . . . ...

  34. Minutes: BSC; April 17, 1996 335KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1996/april/19960417_bsc_508.pdf

    ... (AZT)/interferon (IFN), chloroprene, cobalt sulfate, ethylbenzene, isobutyraldehyde, oxazepam, polyvinyl alcohol, primaclone, tetrahydrofuran, and theophylline. ...

  35. Cumene: Preliminary Literature Search Strategy and List of References 698KB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/cumene-litsearch&references5oct2012_508.pdf

    ... High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and ...

  36. TR-499: Indium Phosphide (CASRN 22398-80-7) in F344/N Rats and... 19.3MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr499.pdf

    ... 2-Butoxyethanol 1/50 0/50 1/50 0/50 Chloroprene 2/50 0/50 2/50 0/50 Cobalt sulfate ... 4/48 2-Butoxyethanol 15/50 0/50 15/50 Chloroprene 19/50 1/50 19/50 Cobalt sulfate ...

  37. TR-492: Gallium Arsenide (CASRN 1303-00-0) in F344/N Rats and... 23.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr492.pdf

    ... 0/50 1/50 Acetonitrile 1/48 1/48 2/48 Chloroprene 2/50 0/50 2/50 Cobalt sulfate ... 29/50 Acetonitrile 29/48 Chloroprene 33/50 Cobalt sulfate heptahydrate 30/50 ...

  38. TR-575: Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1... 9.9MB

    https://ntp.niehs.nih.gov/go/tr575

    ... acrylamide, 1,3-butadiene, isoprene, chloroprene, and urethane) thought to be ... isoprene, chloroprene, and urethane (Melnick and Sills, 2001; Beland et al., 2005). ...

  39. Minutes: BSC; May 24, 2000 495KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2000/may/2000052400bscsummmins_508.pdf

    ... New entries to the reasonably anticipated category include chloroprene, diesel exhaust particulates, isoprene, phenolphthalein, tetrafluoroethylene, and trichloroethylene. Several ...

  40. TR-500: Naphthalene (CASRN 91-20-3) in F344/N Rats (Inhalation... 8.6MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr500.pdf

    ... Toxicology and Carcinogenesis Studies of Chloroprene (CAS No. 126-99-8) in F344/N Rats and B6C3F 1 Mice (Inhalation Studies). Technical Report Series No. 467. NIH Publication No. ...

  41. TR-507: Vanadium Pentoxide (CASRN 1314-62-1) in F344/N Rats and... 6.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr507.pdf

    ... 2/48 2-Butoxyethanol 1/50 0/50 1/50 Chloroprene 2/50 0/50 2/50 Cobalt sulfate ... 0/48 2-Butoxyethanol 0/50 0/50 0/50 Chloroprene 1/49 0/49 1/49 Cobalt sulfate ...

  42. RoC Background Document for Naphthalene; Sept. 19, 2002 4.0MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/naphthalenepub_508.pdf

    ... chloroprene in rats and mice together with that of the epoxide, ethylene oxide. The authors reported that all four chemicals induced lung tumors in mice, but only chloroprene ...

  43. TR-471: Cobalt Sulfate Heptahydrate (CASRN 10026-24-1) in F344... 13.1MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr471.pdf

    ... studies, cobalt sulfate heptahydrate, chloroprene, and triethanolamine (NTP, 1998a,b,c), ... Toxicology and Carcinogenesis Studies of Chloroprene (CAS No. 126-99-8) in F344/N Rats and ...

  44. TR-228: Vinylidene Chloride (CASRN 75-35-4) in F344 Rats and... 7.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr228.pdf

    ... vinyl chloride, vinylidene chloride, and chloroprene in V79 Chinese hamster cells. Mutat. ... Long-term testing of vinylidene chloride and chloroprene for carcinogenicity in r a t s . ...

  45. TR-464: Technical Grade Sodium Xylene Sulfonate (CASRN 1300-72... 9.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr464.pdf

    ... studies, cobalt sulfate heptahydrate, chloroprene, and triethanolamine (NTP, 1998a,b,c), ... Toxicology and Carcinogenesis Studies of Chloroprene (CAS No. 126-99-8) in F344/N Rats and ...

  46. TR-542: Cumene (CASRN 98-82-8) in F344/N Rats and B6C3F1 Mice... 9.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr542.pdf

    ... Also, chloroprene, which is inactive in Salmonella and mouse micronucleus studies, induced ... T trans- versions caused by adenine adducts related to a specific chloroprene metabolite. ...

  47. TR-471: Cobalt Sulfate Heptahydrate (CASRN 10026-24-1) in F344... 9.0MB

    https://ntp.niehs.nih.gov/sites/default/files/2023-08/tr471_508.pdf

    ... studies, cobalt sulfate heptahydrate, chloroprene, and triethanolamine (NTP, 1998a,b,c), ... Toxicology and Carcinogenesis Studies of Chloroprene (CAS No. 126-99-8) in F344/N Rats and ...

  48. TR-449: Triethanolamine (CASRN 102-71-6) in F344 Rats and B6C3F1Mice... 10.1MB

    https://ntp.niehs.nih.gov/go/tr449

    ... studies, cobalt sulfate heptahydrate, chloroprene, and triethanolamine (NTP, 1998a,b, ... Toxicology and Carcinogenesis Studies of Chloroprene (CAS No. 126-99-8) in F344/N Rats and ...

  49. RoC Monograph: Cumene; September 2013 2.3MB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/cumene_508.pdf

    ... K-ras and K-ras mutations in lung tumors induced by vanadium pentoxide or chloroprene. ... exposed RoC Monograph on Cumene 72 to chloroprene (2-chloro-1,3-butadiene) for 2 years, ...

  50. TR-473: Theophylline (CASRN 58-55-9) in F344/N Rats and B6C3F1Mice... 11.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr473.pdf

    ... studies, cobalt sulfate heptahydrate, chloroprene, and triethanolamine (NTP, 1998a,b,c), ... Toxicology and Carcinogenesis Studies of Chloroprene (CAS No. 126-99-8) in F344/N Rats and ...

 
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