RoC Profile: Polycyclic Aromatic Hydrocarbons: 15 Listings; 15th... 373KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/polycyclicaromatichydrocarbons.pdf

fluoranthene, benzo[a]pyrene, dibenz[a,h]acridine, dibenz[a,j] acridine, dibenz[a,h]anthracene, 7H-dibenzo[c,g]- carbazole, dibenzo[a,h]pyrene, dibenzo[a,i]pyrene, and ...

Polycyclic Aromatic Compounds 83KB

https://ntp.niehs.nih.gov/whatwestudy/topics/pacs

A worker standing in a cloud of fumes from a motorized machine Research Overview Status: Ongoing Substances: Acenaphthenequinone Benzo(a)pyrene Pyrene Dibenz(a,h)anthracene ...

RoC Background Document: Diesel Exhaust Particulates; Dec. 2... 5.5MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/dieselexhaust_508.pdf

... of diesel particulate associated benzo[a]pyrene in rats ......202 76774-50-0 791-1643 Pyrene 202 129-00-0 3532-8002 ...

15th RoC: Appendix F 174KB

https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf

... B[a]P see Polycyclic Aromatic Hydrocarbons: 15 Listings, Benzo[a] pyrene BB-153 ... Hydrocarbons: 15 Listings, Dibenzo[a,i]pyrene benzo[a]pyrene see Polycyclic Aromatic ...

RoC Background Document: Tobacco Smoking; Dec. 2-3, 1998 3.5MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/environmentalts_noapps_508.pdf

... Compounds Benzene Fluoranthene Benzo[a]pyrene o-Toluidine 2-Napthylamine Quinoline ... Np 106-99-0 54.091 C CEPA (1997) Benzo[a]pyrene C 20 H 12 199 ng/cig 44 ng/cig 50-32-8 ...

Poster: An Evaluation of The Performance of Survey Sampling in... 953KB

https://ntp.niehs.nih.gov/sites/default/files/2024-03/Wang_SOT20240310.pdf

and Web of Science literature search for mechanistic data for five PAHs were used in the analysis: benz[a]anthracene, dibenzo[a,l]pyrene, fluoranthene, phenanthrene, and pyrene. . ...

RoC Profile: Nitroarenes (Selected); 15th RoC 2021 233KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitroarenes.pdf

... Administration of 1,6-dinitro- pyrene to female rats by stomach tube caused cancer of the ... in the metabolism of 1,6-dinitro- pyrene to form the DNA adduct ...

Poster: Use of Survey Sampling to Develop an Evidence Map of... 1.7MB

https://ntp.niehs.nih.gov/ntp/results/pubs/posters/wang_gems_20221101.pdf

For example, epigenetic changes were studied in roughly 250 benzo(a)pyrene references , ... NIEHS is updating the benzo(a)pyrene evaluation and is assessing the potential ...

Comment: Meat-related exposures (ORoC3); Shalene McNeill, The... 69KB

https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/mcneill_3oroc20161007.pdf

regarding PAHs, in particular benzo[a]pyrene (BaP), and HCA content in foods, is ... 200 food items for benzo[a]pyrene and estimation of its intake in an epidemiologic study. ...

RoC Background Document: Azacitidine; Nov. 18-19, 1996 3.5MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/azacitidine1_508.pdf

......... 32 6.6.1 Benzo[a]pyrene and 5-AzaC......not specified) administered 10% benzo[a]pyrene (B[a]P) in sustained released implants in ...

Listed Substances; 15th RoC 2021 76KB

https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf

... Hydrocarbons: 15 Listings) Benzo[a]pyrene (see Polycyclic Aromatic Hydrocarbons: 15 ... Hydrocarbons: 15 Listings) Dibenzo[a,e]pyrene (see Polycyclic Aromatic Hydrocarbons: 15 ...

Comment: Meat-related exposures (OHAT4); Shalene McNeill, The... 70KB

https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/mcneill_4ohat20161007.pdf

regarding PAHs, in particular benzo[a]pyrene (BaP), and HCA content in foods, is ... 200 food items for benzo[a]pyrene and estimation of its intake in an epidemiologic study. ...

Abstract for TOX-34 63KB

https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox034

CASRN: 5522-43-0 Chemical Formula: C16H9NO2 Molecular Weight: 247.26 Synonyms/Common Names: 3-Nitropyrene; pyrene; 1-nitro Report Date: April 1996 Full Report PDF Abstract ...

TOX-34: 1-Nitropyrene (CASRN 5522-43-0) 1.1MB

https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox034.pdf

... 247.26 Synonyms 3-Nitropyrene Pyrene, 1-nitro 1-Nitropyrene is a by-product of combustion. ... ric reaction of nitrogen oxide with pyrene in the presence of a trace amount of ...

Poster: Scoping review of polycyclic aromatic hydrocarbons (PAH... 19.6MB

https://ntp.niehs.nih.gov/ntp/results/pubs/posters/wang_sot20200315.pdf

... 12 listed since 1980s Benz[a]anthracene Benzo[k]fluoranthene Dibenzo[a,e]pyrene Dibenzo[a,l]pyrene Benzo[b]fluoranthene Benzo[a]pyrene Dibenzo[a,h]pyrene Indeno[1,2,3-cd]pyrene ...

Protocol: Systematic Review of Inflammation-based Atherosclerosis... 1001KB

https://ntp.niehs.nih.gov/sites/default/files/2023-07/protocol_atherosclerosisjuly2023_508.pdf

... aromatic rings (e.g., benzo[a]pyrene, chrysene, naphthalene), which are ... to the carcinogenic compound benzo[a]pyrene induces larger and phenotypically ...

RoC Profile: Acetaldehyde; 15th RoC 2021 176KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acetaldehyde.pdf

Inhalation of acetal- dehyde also promoted the induction of respiratory-tract tumors by intra tracheal instillation of the known carcinogen benzo[a]pyrene in hamsters of both ...

RoC Background Document: 1,6-Dinitropyrene & 1,8-Dinitropyrene... 4.1MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/dinitropyrene_508.pdf

... called: Pyrene, 1 ,6-dinitro- 1,6-DNP 1 ,8-Dinitropyrene [ 42397 -65-9] o... /.0 -...;:;N,' 1,8-Dinitropyrene (C16HsN20 4 , MW = 292.25 g/mol) is also called: Pyrene, 1 ...

RoC Background Document: 1-Nitropyrene; Nov. 18-19, 1996 4.3MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/nitropyrene-1_508.pdf

... 2 , mol. wt. = 247.25) is also called: Pyrene, 1-nitro- (8CI, 9CI) 3-Nitropyrene 1-NP ... for research purposes at 97% or 99.5% purity with 0.1% total dinitropyrenes and pyrene. ...

RoC Background Document: Saccharin; Oct. 30-31, 1997 8.9MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/saccharin1_3apps_508.pdf

... ......48 4.2.1 Benzo[a]pyrene (BP) ......are presented in Table 4-2. 4.2.1 Benzo[a]pyrene (BP) Saccharin did not enhance the ...

Comment: Meat-related exposures, Shalene McNeill, The Beef Checkoff... 74KB

https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/mcneill20180911-2.pdf

(DahA), Indeno[1,2,3,c,d]Pyrene (IP) and Benzo[g,h,i] Pyrene (BghiP)], in beef, poultry, pork, seafood and bread using published reports of food concentration analysis. ...

RoC Profile: Soots; 15th RoC 2021 115KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/soots.pdf

... cadmium, chromium, nickel, and several polycyclic aromatic hydrocarbons (PAHs), including benz[a]anthracene, benzo[a]pyrene, dibenz[a,h]anthracene, and indeno[1,2,3-cd] pyrene. ...

Background Document: RoC: Glass Wool Fibers; 2010 3.7MB

https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/glasswoolbd20100408_508.pdf

... An increase in mutant frequencies was reported for benzo[a]pyrene and rock wool fibers ... or combined with exposure to benzo[a]pyrene in the lung of male homozygous λ-lacI ...

Poster: Exposure to Polycyclic Aromatic Hydrocarbons (PAHs) and... 12.6MB

https://ntp.niehs.nih.gov/ntp/results/pubs/posters/arroyave_sot20210312.pdf

... with long-term exposure to benzo[a]pyrene air pollution: from the French E3N cohort study. ... . Ronco AL, et al. 2011. Dietary Benzo[a]pyrene, Alcohol Drinking, and Risk of Breast ...

Appendices A-G; 15th RoC 2021 448KB

https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf

... B[a]P see Polycyclic Aromatic Hydrocarbons: 15 Listings, Benzo[a] pyrene BB-153 ... Hydrocarbons: 15 Listings, Dibenzo[a,i]pyrene benzo[a]pyrene see Polycyclic Aromatic ...

RoC Profile: Asbestos; 15th RoC 2021 151KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/asbestos.pdf

... Asbestos and the polycyclic aromatic hydrocarbon benzo[a]- pyrene administered alone by ... and benzo[a] pyrene or asbestos and N-nitrosodiethylamine to hamsters (IARC 1987). ...

Background Document for Selected Heterocyclic Amines: PhIP, MeIQ... 3.3MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/hcaspub_508.pdf

... For example, in S. typhimurium, all three compounds are more potent than benzo[a]pyrene, ... benzo[a]pyrene, dibenzo[a,h]anthracene, and indeno[1,2,3,-c,d]pyrene. ...

Public Comment: Carbon black; Carol Eisenmann; RoC; Jan. 19,... 3.3MB

https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/eisenmann20120227.pdf

... mg/kg (500 parts per billion). 9. Benzo[a]pyrene, not more than 0.005 mg/kg (5 parts per ... setting specifications for total PAHs, benzo[a)pyrene (B[a)P), and dibenz(a,h)anthracene. ...

RoC Profile: Phenolphthalein; 15th RoC 2021 147KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/phenolphthalein.pdf

... It is practically insoluble in water, but is soluble in dilute solutions of alkali hydroxides, ether, acetone, pyrene, chloroform, toluene, and ethanol. It is insoluble in benzene ...

Minutes: BSC; Sept. 27, 1983 638KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1983/september/bsc_mins19830927_508.pdf

... -Cocarcinogenesi s study with benzo-. (a)pyrene -Teratology study Onh .) 2 CAS Number ... of dinitro- (leni -ti -cs tropyrenes as pyrene mixtures -Other appro- a class stud y ...

Final RoC Background Document for Formaldehyde 5.8MB

https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/formaldehyde_bd_final.pdf

... effects when administered with coal tar, benzo[a]pyrene, wood dust, and hydrogen chloride. ... 0.3 mg/m 3 [0.002, 0.02, or 0.24 ppm] either alone or in combination with benzo[a]pyrene. ...

Literature Search Results: Systematic Review of Traffic-Related... 275KB

https://ntp.niehs.nih.gov/ntp/ohat/airpollchildhealth/literature_results_508.pdf

... aromatic[mh:noexp] OR "benzo(a)pyrene"[mh] OR benzene[mh] OR "polycyclic aromatic hydrocarbons"[tiab] OR "benzopyrene"[tiab] OR "benzo a pyrene"[tiab] OR "3,4-benzopyrene"[tiab] ...

RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf

... 83-32-9 Yes Yes Phenanthrene 65996-93-2 Yes Yes Fluoranthene 206-44-0 Yes Yes Pyrene 129-00-0 Yes Yes 2-Methylnaphthalene 91-57-6 No Yes 1-Methylnaphthalene 90-12-0 No Yes ...

TR-494: Anthraquinone (CASRN 84-65-1) in F344/N Rats and B6C3F1Mice... 10.7MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr494.pdf

... Storer, said that chemicals such as benzo[a]pyrene still required activation. He added ... that the 0.1% contaminant, 9-nitroanthracene, could be as potent as benzo[a]pyrene. ...

RoC Background Document: 4-Nitropyrene; Nov. 18-19, 1996 1.4MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/nitropyrene-4_508.pdf

... N0 2 , mol. wt. =247.25) is also called: Pyrene, 4-nitro- 4-NP 1.2 Physical-Chemical ... 9(1 0)-Hydroxy-4-(acetylamino )pyrene [9(1 0)-0H-4-AAP] 9(1 ...

PBPK Modeling to Predict Chemical Distribution in Brain and Adipose... 1.4MB

https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Unnikrishnan-poster.pdf

... To check the effectiveness of the models, predictions of Cmax were compared with observed data for a few chemicals including benzo[a]pyrene, diazepam, trichloroethylene, ...

Mechanistic Insights from Profiling Chemical-Mediated Transcription... 6.9MB

https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-medvedev-poster.pdf

... Cupferron 66.7uM 0.90 Benz(a)anthracene 7.4uM 0.90 Benzo(a)pyrene 60uM 0.90 ... Impact of CYP450 Integration Summary Benzo[a]pyrene trans-Stilbene Azobenzene ...

Comment: Meat-related exposures (ORoC7); Shalene McNeill, The... 80KB

https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/mcneill_7oroc20161007.pdf

... ISBN:978---87---93109---74---2. Available at www.food.dtu.dk Olatunji, O. S., Fatoki, O. S., Opeolu, B. O., Ximba, B. J. (2015). Benzo[a]pyrene and benzo[k]fluoranthene in some ...

RoC Profile: Coal Tars and Coal-Tar Pitches; 15th RoC 2021 134KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/coaltars.pdf

... Another study found that coal-tar pitch workers at a U.S. roofing site inhaled up to 53 μg of benzo[a]pyrene in seven hours (Hammond et al. 1976). The potential for skin expo- ...

TOX-95: Toxicity Studies of Myristicin (CASRN 607-91-0) Administered... 3.8MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox095_508.pdf

... clinical effects. 37 In benzo[α]pyrene-induced tumor female A/J mouse model, ... Zhang J, Lam LK. Inhibition of benzo[a]pyrene-induced tumorigenesis by myristicin, a ...

Final Report on the Cumene (CASRN 98-82-8) Genetoxicity Studies 924KB

https://ntp.niehs.nih.gov/ntp/roc/thirteenth/genotoxstudies/cumenegtox_508.pdf

... Direct- acting positive controls were sodium azide (TA100), 2-nitrofluorene (TA98), and 4- nitroquinoline-N-oxide (E. coli); indirect-acting positive controls were benzo[a]pyrene ...

RoC Profile: Heterocyclic Amines (Selected); 15th RoC 2021 184KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/heterocyclicamines.pdf

... Moreover, compared with other well-known mutagens, such as benzo[a]pyrene, these HCAs show a high degree of potency. MeIQ, MeIQx, IQ, and PhIP also caused sister chromatid ...

TR-044 In Vitro Carcinogenesis: Guide to the Literature, Recent... 18.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr044.pdf

... in Hamsters by Different Dose Levels of Benzo(a)pyrene and Ferric Oxide." £._ Natl. ... Induced by Different Numbers of Administrations of Benzo(a)pyrene and Ferric Oxide." ...

TR-513: Decalin (CASRN 91-17-8) in F344/N Rats and B6C3F1Mice... 11.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr513.pdf

... when benzo[a]pyrene (0.02%) in decalin was applied dermally (Bingham and Falk, 1969); however, skin tumors were observed after dermal appli- cation of benzo[a]pyrene (0.00002%) in ...

Comment: Meat-related exposures; Jane Pouzou, Solenne Costard... 945KB

https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/pouzou_costard_zagmutt20161011.pdf

... Modified from EFSA. 18 Benzo[a]pyrene Benz[a]anthracene Chrysene Benzo(b)fluoranthene Mean 95th percentile Mean 95th percentile Mean 95th percentile Mean 95th percentile Cocoa ...

Protocol for a Systematic Review of Traffic-Related Air Pollution... 1.3MB

https://ntp.niehs.nih.gov/ntp/ohat/airpollchildhealth/protocol_20160616_508.pdf

... dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene. ... aromatic[mh:noexp] OR "benzo(a)pyrene"[mh] OR benzene[mh] OR "polycyclic ...

Protocol: Evidence Map of Inflammation-Based Atherosclerosis... 643KB

https://ntp.niehs.nih.gov/sites/default/files/2023-07/protocol_atherosclerosis_supplementaljuly2023_508.pdf

... OR "2-propanol"/exp OR "3,4-benzopyrene":ti,ab OR "benzo(a)pyrene":ti,ab OR "benzo-a-pyrene":ti,ab OR "Bisphenol-A":ti,ab OR "N,N- diethyltoluamide":ti,ab OR ...

Minutes: BSC; June 15-16, 2016 457KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2016/june/minutes201606_508.pdf

... Boyles summarized risk assessment studies conducted in Italy (2011), Connecticut (2011), and California (2007), which found health risks due to exposure to benzo[a]pyrene, ...

TR-382: Furfural (CASRN 98-01-1) in F344/N Rats and B6C3F1Mice... 11.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr382.pdf

... Respiratory tract neo- plasms were increased in animals receiving benzo[a]pyrene or benzo[a]pyrene plus furfural, but administration of both compounds together caused an earlier ...

Nomination Background: d-Pseudoephedrine (CASRN: 90-82-4) 388KB

https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/ephedrinealkaloids_508.pdf

... E. sinica extract inhibited the mutagenicity of benzo[a]pyrene in S. typhimurium TA98 with ... water of F344/DuCrj male rats that had received benzo[a]pyrene by subcutaneous injection. ...