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TR-507: Vanadium Pentoxide (CASRN 1314-62-1) in F344/N Rats and... 6.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr507.pdf
VANADIUM PENTOXIDE (CAS NO. 1314-62-1) IN F344/N RATS AND B6C3F 1 MICE (INHALATION STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle Park, NC 27709 December ...
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Abstract for TR-507 79KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr507
7abs Abstract for TR-507 Toxicology and Carcinogenesis Studies of Vanadium Pentoxide in F344/N Rats and B6C3F1 Mice (Inhalation Studies) CASRN: 1314-62-1 Chemical Formula: V2O5 ...
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Target Organs and Levels of Evidence for TR-507 62KB
https://ntp.niehs.nih.gov/data/tr/500s/tr507levels
0 Target Organs and Levels of Evidence for TR-507 Toxicology and Carcinogenesis Studies of Vanadium Pentoxide (CASRN 1314-62-1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) ...
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Minutes: BSC TRRS; Oct. 18, 2001 79KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2001/oct/trrs18oct2001mins_508.pdf
NATIONAL TOXICOLOGY PROGRAM BOARD OF SCIENTIFIC COUNSELORS Summary Minutes Peer Review of Draft Technical Reports of Toxicology and Carcinogenesis Studies by the Technical Reports ...
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Properties and Human Exposure; Sanford Garner; RoC; Jan. 24,... 739KB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/january/presentations/properties_508.pdf
Properties and Human Exposure Sanford Garner, PhD Integrated Laboratory Systems, Inc. Contractor supporting the Office of the Report on Carcinogens National Institute of ...
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RoC Profile: Arsenic and Inorganic Arsenic Compounds; 15th RoC... 152KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/arsenic.pdf
Arsenic and Inorganic Arsenic Compounds CAS No. 7440-38-2 (Arsenic) No separate CAS No. assigned for inorganic arsenic compounds Known to be human carcinogens First listed in the ...
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Thymus - Amyloid - Nonneoplastic Lesion Atlas 287KB
https://ntp.niehs.nih.gov/atlas/nnl/immune-system/thymus/Amyloid
Spontaneous and chemically induced amyloid deposition in the thymus is rare in rodents. When present in the thymus, amyloid appears as amorphous, eosinophilic, and hyalinized ...
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Thymus - Amyloid 370KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/immune/thymus/amyloid/thymus-amyloid-pdf_508.pdf
Amyloid Figure Legend: Figure 1 Thymus - Amyloid in a female B6C3F1/N mouse from a chronic study. Normal thymic architecture has been disrupted by deposition of amyloid protein ...
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RoC Monograph: Antimony Trioxide; October 2018 2.6MB
https://ntp.niehs.nih.gov/ntp/roc/monographs/antimony_final20181019_508.pdf
RepoRt on CaRCinogens MonogRaph on antiMony tRioxide ROC MONOGRAPH 13 OCTOBER 2018 Report on Carcinogens Monograph on Antimony Trioxide RoC Monograph 13 October 2018 National ...
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Antimony Draft Monograph; Nov. 29, 2017 3.5MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/january/antimonydraftmonograph.pdf
Draft Report on Carcinogens Monograph on Antimony Trioxide Peer-Review Draft November 29, 2017 Office of the Report on Carcinogens Division of the National Toxicology Program ...
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Antimony Draft Monograph (Revised); Aug. 15, 2018 2.8MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/january/antimonydraftmonograph_revised.pdf
Revised Draft: Report on Carcinogens Monograph on Antimony Trioxide August 15, 2018 Office of the Report on Carcinogens Division of the National Toxicology Program National ...
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Spleen - Atrophy - Nonneoplastic Lesion Atlas 292KB
https://ntp.niehs.nih.gov/atlas/nnl/immune-system/spleen/Atrophy
Atrophy can affect the white pulp and/or red pulp compartments of the spleen. Lymphocyte atrophy of the white pulp is characterized by a loss of lymphocytes in the T-cell areas ...
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Historical Controls: All Routes and Vehicles for Mice; Studies... 255KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2006/m_hcrpt_allrte2006_508.pdf
All Routes and Vehicles MICE 2006 REPORT DESCRIPTION This report shows the tumor rates of control group animals from selected studies. The studies used are shown on the Study ...
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Historical Controls: All Routes and Vehicles for Rats; Studies... 270KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2006/r_hcrpt_allrte2006_508.pdf
All Routes and Vehicles F 344/N RATS 2006 REPORT DESCRIPTION This report shows the tumor rates of control group animals from selected studies. The studies used are shown on the ...
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Historical Controls: All Routes and Vehicles for Mice; Studies... 317KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2007/m_hcrpt_allrte20070300_508.pdf
March 2007 REPORT DESCRIPTION This report shows the tumor rates of control group animals from selected studies. The studies used are shown on the Study Summary page. The report ...
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Historical Controls: All Routes and Vehicles for Rats; Studies... 252KB
https://ntp.niehs.nih.gov/ntp/historical_controls/ntp2000_2007/r_hcrpt_allrte20070300_508.pdf
March 2007 REPORT DESCRIPTION This report shows the tumor rates of control group animals from selected studies. The studies used are shown on the Study Summary page. The report ...
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Spleen - Atrophy 421KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/immune/spleen/atrophy/spleen-atrophy-pdf_508.pdf
Atrophy Figure Legend: Figure 1 Spleen, White pulp - Atrophy in a female F344/N rat from a subchronic study. Overall area and cellularity of the white pulp (periarteriolar ...
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TR-506: Acrylonitrile (CASRN 107-13-1) in B6C3F1Mice (Gavage... 7.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr506.pdf
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ACRYLONITRILE (CAS NO. 107-13-1) IN B6C3F 1 MICE (GAVAGE STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 ...
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TOX-106: Sodium Metavanadate (CASRN 13718-26-8) and Vanadyl Sulfate... 2.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox106_508.pdf
Sodium meTavaNadaTe (caSRN 13718-26-8) aNd vaNadyl SulfaTe (caSRN 27774-13-6) admiNiSTeRed iN dRiNkiNg WaTeR To SPRague daWley (hSd:SPRague daWley ® Sd ® ) RaTS aNd B6c3f1/N mice ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
9433 Conclusion by Sex/Species Report No. Peer Review Date/Target Organs Substance Name CASRN Male Rats Female Rats Male Mice Female Mice TR-603 01/01/23 Black Cohosh 84776-26-1 NE ...
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Peer Review Report: Draft Report on Carcinogens Monograph on... 564KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2018/january/antimonypeerreview_508.pdf
National Toxicology Program Peer Review of Draft Report on Carcinogens Monograph on Antimony Trioxide January 24, 2018 National Institute of Environmental Health Sciences Research ...
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Research Concept: Cobalt; 2014 690KB
https://ntp.niehs.nih.gov/ntp/roc/concept_docs/2014/cobalt_508.pdf
RoC Concept: Cobalt (October 2014) 1 Report on Carcinogens (RoC) Concept: Cobalt Project Leader: Diane L. Spencer, MS, Office of the RoC, DNTP, NIEHS 1 Background and rationale ...
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Public Comment: Cobalt and Certain Cobalt Compounds; Andrew Monnot... 491KB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/publiccomm/monnot20131018_508.pdf
October 18, 2013 Dr. Ruth Lunn, Director, ORoC, DNTP NIEHS, P.O. Box 12233, MD K2-14 Research Triangle Park, NC 27709 lunn@niehs.nih.gov RE: Nominations to the Report on ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
TR-603 PDF (3.02 MB) Toxicology and Carcinogenesis Studies of Black Cohosh Root Extract (CASRN 84776-26-1) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and ...
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Cobalt-Tungsten Carbide Powders and Hard Metals Expert Panel... 700KB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2008/expertpanelmtgs/cobalt_panelreportpartb_508.pdf
B - Recommendation for Listing Status for Cobalt-Tungsten Carbide Powders and Hard Metals and Scientific Justification for the Recommendation The Report on Carcinogens (RoC) expert ...
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TR-504: o-Nitrotoluene (CASRN 88-72-2) in F344/N Rats and B6C3F1... 14.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr504.pdf
THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF o-NITROTOLUENE (CAS NO. 88-72-2) IN F344/N RATS AND B6C3F 1 MICE (FEED STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research ...
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TR-542: Cumene (CASRN 98-82-8) in F344/N Rats and B6C3F1 Mice... 9.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr542.pdf
ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CUMENE (CAS NO. 98-82-8) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research ...
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Cumene: Preliminary Literature Search Strategy and List of References 698KB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/cumene-litsearch&references5oct2012_508.pdf
10/5/12 Cumene Cumene: Preliminary Literature Search Strategy and List of References A. Preliminary literature search strategy This document identifies the data sources, search ...
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RoC Profile: Cobalt-Related Exposures; 15th RoC 2021 409KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cobalt.pdf
Genomic stability Oxidative damage Hypoxia-responsive target genes Resistance to apoptosis Accumulation of critical mutations Dysregulation of cell growth and proliferation Tumor ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
750897 About Technical Reports Long-term NTP toxicology and carcinogenicity studies usually involve exposing laboratory animals (rats and mice) to a substance for a period of two ...
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TR-508: Riddelliine (CASRN 23246-96-0) in F344/N Rats and B6C3F1Mice... 9.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr508.pdf
RIDDELLIINE (CAS NO. 23246-96-0) IN F344/N RATS AND B6C3F 1 MICE (GAVAGE STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle Park, NC 27709 May 2003 NTP TR 508 ...
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TR 590 - NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS... 18.8MB
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2016/february/tr590_peerdraft.pdf
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANTIMONY TRIOXIDE (CAS NO. 1309-64-4) IN WISTAR HAN [Crl:WI (Han)] RATS AND B6C3F1/N MICE (INHALATION STUDIES) ...
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RoC Profile: Antimony Trioxide; 15th RoC 2021 197KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/antimony.pdf
Report on Carcinogens, Fifteenth Edition National Toxicology Program, Department of Health and Human Services For Table of Contents, see home page: http://ntp.niehs.nih.gov/go/roc ...
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RoC Profile: Certain Glass Wool Fibers (Inhalable); 15th RoC... 235KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/glasswoolfibers.pdf
Certain Glass Wool Fibers (Inhalable) CAS No.: none assigned Reasonably anticipated to be a human carcinogen First listed in the Seventh Annual Report on Carcinogens (1994) as ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
ba Toxicology/Carcinogenicity Female scientist looking through a microscope in a laboratory Study Overview Study: Short-term toxicity, long-term carcinogenicity Species: Rats, mice ...
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TR-590: Antimony Trioxide (CASRN 1309-64-4) in Wistar Han [Crl... 6.8MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr590_508.pdf
NTP TechNical RePoRT oN The Toxicology aNd caRciNogeNesis sTudies of aNTimoNy TRioxide (casRN 1309-64-4) iN WisTaR haN [cRl:Wi(haN)] RaTs aNd B6c3f1/N mice (iNhalaTioN sTudies) NTP ...
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TR-510: Urethane + Ethanol (CASRNs. 51-79-6 & 64-17-5) in F344... 17.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr510.pdf
THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF URETHANE, ETHANOL, AND URETHANE/ETHANOL (URETHANE, CAS NO. 51-79-6; ETHANOL, CAS NO. 64-17-5) IN B6C3F 1 MICE (DRINKING WATER STUDIES) ...
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TR-498: p-Nitrotoluene (CASRN 99-99-0) in F344/N Rats and B6C3F1Mice... 10.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr498.pdf
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF p-NITROTOLUENE (CAS NO. 99-99-0) IN F344/N RATS AND B6C3F 1 MICE (FEED STUDIES) NATIONAL TOXICOLOGY PROGRAM ...
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TR-552: Propargyl Alcohol (CASRN 107-19-7) in F344/N Rats and... 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr552.pdf
PROPARGYL ALCOHOL (CAS NO. 107-19-7) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle Park, NC 27709 September 2008 ...
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TOX-84: Toxicity Studies of o-Phthalaldehyde (CASRN 643-79-8... 5.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox084_508.pdf
ToxiciTy S TudieS of o-PhThalaldehyde (caSRN 643-79-8) admiNiSTeRed by iNhalaTioN To SPRague dawley (hSd:SPRague dawley ® Sd ® ) RaTS aNd b6c3f1/N mice NTP TOX 84 JANUARY 2018 ...
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Nomination Background: 1,3-Dichloro-2-propanol (CASRN: 96-23... 1.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dichloropropanol_508.pdf
1,3-Dichloro-2-propanol [CAS No. 96-23-1] Review of Toxicological Literature January 2005 1,3-Dichloro-2-propanol [CAS No. 96-23-1] Review of Toxicological Literature Prepared for ...
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Background Document: RoC: Glass Wool Fibers; 2010 3.7MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/glasswoolbd20100408_508.pdf
Report on Carcinogens Background Document for Glass Wool Fibers September 2009 National Toxicology Program U.S. Department of Health and Human Services Public Health Service ...
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Minutes: BSC; June 12, 2008 280KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2008/june/minutes20080612.pdf
National Toxicology Program Board of Scientific Counselors June 11-12, 2008 National Institute of Environmental Health Sciences Research Triangle Park, NC Summary Minutes June 11 ...
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TR-492: Gallium Arsenide (CASRN 1303-00-0) in F344/N Rats and... 23.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr492.pdf
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF GALLIUM ARSENIDE (CAS NO. 1303-00-0) IN F344/N RATS AND B6C3F 1 MICE (INHALATION STUDIES) NATIONAL TOXICOLOGY ...
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TR-538: Methyl Isobutyl Ketone (CASRN 108-10-1) in F344/N Rats... 13.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr538.pdf
ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF METHYL ISOBUTYL KETONE (CAS NO. 108-10-1) IN F344/N RATS AND B6C3F 1 MICE (INHALATION STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box ...
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TR-543: alpha-Methylstyrene (CASRN 98-83-9) in F344/N Rats and... 8.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr543.pdf
ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF " "-METHYLSTYRENE (CAS NO. 98-83-9) IN F344/N RATS AND B6C3F 1 MICE (INHALATION STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 ...
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TR-518: Triethanolamine (CASRN 102-71-6) in B6C3F1Mice (Dermal... 5.0MB
https://ntp.niehs.nih.gov/go/tr518
THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN B6C3F 1 MICE (DERMAL STUDY) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle Park, NC ...
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TR-509: 2,4-Hexadienal (89% trans,trans Isomer, CASRN 142-83... 10.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr509.pdf
2,4-HEXADIENAL (89% trans,trans isomer, CAS No. 142-83-6; 11% cis,trans isomer) IN F344/N RATS AND B6C3F 1 MICE (GAVAGE STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research ...
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TR-513: Decalin (CASRN 91-17-8) in F344/N Rats and B6C3F1Mice... 11.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr513.pdf
REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF DECALIN (CAS NO. 91-17-8) IN F344/N RATS AND B6C3F 1 MICE AND A TOXICOLOGY STUDY OF DECALIN IN MALE NBR RATS (INHALATION ...
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TR-515: Propylene Glycol Mono-t-Butyl Ether (CASRN 57018-52-7... 9.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr515.pdf
THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF PROPYLENE GLYCOL MONO-t-BUTYL ETHER (CAS NO. 57018-52-7) IN F344/N RATS AND B6C3F 1 MICE AND A TOXICOLOGY STUDY OF PROPYLENE GLYCOL ...