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TR-139: Triphenyltin Hydroxide (CASRN 76-87-9) 2.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr139.pdf
8 National Cancer Institute CARCINOGENESIS Technical Report Series No. 139 BIOASSAY OF TRIPHENYLTIN HYDROXIDE FOR POSSIBLE CARCINOGENIC!! Y CAS No. 76-87-9 NCI-CG-TR-139 U.S. ...
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Triphenyltin hydroxide: Target Organs and Levels of Evidence... 56KB
https://ntp.niehs.nih.gov/data/tr/100s/tr139levels
5 Triphenyltin hydroxide: Target Organs and Levels of Evidence for TR-139 Bioassay of Triphenyltin Hydroxide for Possible Carcinogenicity (CASRN 76-87-9) Chemical (Study Title) ...
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Abstract for TR-139 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr139
9abs Abstract for TR-139 Bioassay of Triphenyltin Hydroxide for Possible Carcinogenicity CASRN: 76-87-9 Chemical Formula: C18H16OSN Molecular Weight: 367.033 Synonyms/Common Names: ...
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ICCVAM Report: Corrositex: An In Vitro Method for Assessing Dermal... 5.1MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf
i Corrositex ® : An In Vitro Test Method for Assessing Dermal Corrosivity Potential of Chemicals The Results of an Independent Peer Review Evaluation Coordinated by the ...
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RoC Background Document: Cadmium; Oct. 30-31, 1997 13.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/cadmium_508.pdf
CADMIUM FINAL MARCH 1999 Prepared for the October 30-31, 1997, Meeting of the Report on Carcinogens Subcommittee of the NTP Board of Scientific Counselors Prepared by Integrated ...
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RoC Background Document: Nickel Compounds; Dec. 2-3, 1998 6.7MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/nickelcompds1_oneapp_508.pdf
NICKEL COMPOUNDS FINAL MARCH 1999 Prepared for the December 2-3, 1998, Meeting of the Report on Carcinogens Subcommittee of the NTP Board of Scientific Counselors Prepared by ...
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RoC Profile: Beryllium and Beryllium Compounds; 15th RoC 2021 149KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/berylliumandberylliumcompounds.pdf
Beryllium and Beryllium Compounds CAS No. 7440-41-7 (Beryllium) No separate CAS No. assigned for beryllium compounds as a class Known to be human carcinogens First listed in the ...
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Abstract for TR-592 69KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr592
2abs Abstract for TR-592 Toxicology and Carcinogenesis Study of Dietary Zinc[1] in Sprague Dawley Rats (Hsd:Sprague Dawley SD) (Feed Study) CASRN: 5263-02-5 Chemical Formula: ...
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Abstract for TR-436 69KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr436
6abs Abstract for TR-436 Toxicology and Carcinogenesis Studies of t -Butyl Alcohol in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) CASRN: 75-65-0 Chemical Formula: C4H10O ...
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Abstract for TOX-53 64KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox053
3abs Abstract for TOX-53 Toxicity Studies of t-Butyl Alcohol Administered by Inhalation to F344/N Rats and B6C3F1 Mice CASRN: 75-65-0 Chemical Formula: C4H10O Molecular Weight: ...
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Presentation: Product-Specific Validation of an In Vitro Assay... 698KB
https://ntp.niehs.nih.gov/iccvam/meetings/leptovaccwksp-2012/present/galvin-508.pdf
1 A Three R's Approach to Development of an in vitro Potency Assay for a Bovine Leptospira Vaccine. Jeffrey Galvin International Workshop on Alternative Methods for Leptospira ...
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RoC Background Document: Metallic Nickel and Certain Nickel Alloys... 1.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/ni_no_appendices_508.pdf
FINAL Report on Carcinogens Background Document for Metallic Nickel and Certain Nickel Alloys December 13 - 14, 2000 Meeting of the NTP Board of Scientific Counselors Report on ...
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TOX-74: Cellulose Insulation 7.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox074_rev.pdf
4 NTP Toxicity Study Report on the Atmospheric Characterization, Particle Size, Chemical Composition, and Workplace Exposure Assessment of Cellulose Insulation (CELLULOSEINS) ...
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Abstract for TOX-74 66KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox074
4abs Abstract for TOX-74 Toxicity Study Report on the Atmospheric Characterization, Particle Size, Chemical Composition, and Workplace Exposure Assessment of Cellulose Insulation ...
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TR592: Dietary Zinc (CASRN 5263-02-5) In Sprague Dawley Rats... 2.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr592_508.pdf
oN The Toxicology aNd caRciNogeNesis sTudy of dieTaRy ZiNc (casRN 5263-02-5) iN sPRague dawley (hsd:sPRague dawley ® sd ® ) RaTs (feed sTudy) NTP TR 592 JANUARY 2019 NTP ...
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RoC Background Document: Beryllium Compounds; Dec. 16-17, 1999 5.3MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/be_no_appendices_508.pdf
FINAL Report on Carcinogens Background Document for Beryllium and Beryllium Compounds December 16 - 17, 1999 Meeting of the NTP Board of Scientific Counselors Report on ...
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RoC Profile: Nickel Compounds and Metallic Nickel; 15th RoC 2021 170KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nickel.pdf
Nickel Compounds and Metallic Nickel Introduction Nickel compounds and metallic nickel have many industrial and com- mercial applications, including use in stainless steel and ...
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RoC Profile: Tetranitromethane; 15th RoC 2021 125KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tetranitromethane.pdf
Tetranitromethane CAS No. 509-14-8 Reasonably anticipated to be a human carcinogen First listed in the Seventh Annual Report on Carcinogens (1994) NO 2 C O 2 N NO 2 O 2 N ...
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RoC Profile: Iron Dextran Complex; 15th RoC 2021 119KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/irondextrancomplex.pdf
Iron Dextran Complex CAS No. 9004-66-4 Reasonably anticipated to be a human carcinogen First listed in the Second Annual Report on Carcinogens (1981) Also known as Infed, a ...
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Public Comment: Methyl isobutyl ketone; Steven Risotto; RoC;... 379KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2013/publiccomm/risotto20131018_508.pdf
October 18, 2013 Dr. Ruth Lunn Director Office of the Report on Carcinogens National Toxicology Program National Institute for Environmental Health Sciences Research Triangle ...
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RoC Profile: Danthron; 15th RoC 2021 121KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/danthron.pdf
Danthron CAS No. 117-10-2 Reasonably anticipated to be a human carcinogen First listed in the Eighth Report on Carcinogens (1998) Also known as 1,8-dihydroxyanthraquinone or ...
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RoC Profile: 2,4-Diaminoanisole Sulfate; 15th RoC 2021 121KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/diaminoanisolesulfate.pdf
2,4-Diaminoanisole Sulfate CAS No. 39156-41-7 Reasonably anticipated to be a human carcinogen First listed in the Third Annual Report on Carcinogens (1983) O NH 3 + NH 3 + O S O O ...
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RoC Profile: o-Nitroanisole; 15th RoC 2021 126KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitroanisole.pdf
o-Nitroanisole CAS No. 91-23-6 Reasonably anticipated to be a human carcinogen First listed in the Eighth Report on Carcinogens (1998) Also known as 2-nitroanisole O NO 2 CH 3 ...
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ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 42.0MB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol1.pdf
ICCVAM Test Method Evaluation Report: Current Validation Status of In Vitro Test Methods Proposed for Identifying Eye Injury Hazard Potential of Chemicals and Products Interagency ...
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RoC Profile: Coal Tars and Coal-Tar Pitches; 15th RoC 2021 134KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/coaltars.pdf
Coal Tars and Coal-Tar Pitches CAS No. 8007-45-2 (Coal Tar) No separate CAS No. is assigned to coal-tar pitches Known to be human carcinogens First listed in the First Annual ...
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RoC Profile: 2,3-Dibromo-1-propanol; 15th RoC 2021 117KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dibromopropanol.pdf
2,3-Dibromo-1-propanol CAS No. 96-13-9 Reasonably anticipated to be a human carcinogen First listed in the Tenth Report on Carcinogens (2002) Also known as 2,3-dibromopropan-1-ol ...
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Poster: Comparison of the Genotoxicity of Glyphosate, (Aminomethyl... 667KB
https://ntp.niehs.nih.gov/ntp/results/pubs/posters/swartz_emgs20190919.pdf
Comparison of the Genotoxicity of Glyphosate, (Aminomethyl)phosphonic Acid, and Glyphosate-Based Formulations Using In Vitro Approaches Swartz, CD 1 , Christy, NC 1 , Sly, JE 1 , ...
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HET-CAM Test Method: ICCVAM Recommended Protocol 85KB
https://ntp.niehs.nih.gov/iccvam/docs/protocols/ivocular-hetcam.pdf
Protocol: Hen's Egg Test - Chorioallantoic Membrane (HET-CAM) Test Method Originally published as Appendix B3 of "ICCVAM Test Method Evaluation Report: Current Validation Status of ...
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Validation of In Vitro Cytotoxicity Test Methods: Test Chemicals 188KB
https://ntp.niehs.nih.gov/iccvam/methods/acutetox/invitrocyto/ivcytodocs/valstdchm.pdf
In Vitro Cytotoxicity Validation Study Test Chemicals Test Chemical CAS # Molecular Weight Supplier Product Code Purity (%) Acetaminophen 103-90-2 151.20 SIGMA A7085 99 ...
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Cobalt Literature Search StrategyRoC Peer Review; July 22, 2015 374KB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/cobalt_litsearchstrategy_508.pdf
Literature Search Strategy for Preparing the Report on Carcinogens Monograph on Cobalt and Certain Cobalt Compounds Introduction and objective The objective of the literature ...
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Background: Dimethylethanolamine (DMAE) [108-01-0] and Selected... 1.3MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dmae_update_110002_508.pdf
Dimethylethanolamine (DMAE) [108-01-0] and Selected Salts and Esters DMAE Aceglutamate [3342-61-8] DMAE p-Acetamidobenzoate [281131-6] and [3635-74-3] DMAE Bitartrate [5988-51-2] ...
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GMM-09: Genetically Modified Model Report on Dicyclohexylcarbodiimide... 1.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm09_508.pdf
STudieS of dicyclohexylcaRbodiiMide (caSRN 538-75-0) iN f344/N RaTS, b6c3f1 Mice, aNd GeNeTically Modified (fVb TG.ac heMizyGouS) Mice aNd caRciNoGeNiciTy STudy of ...
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TR-436: t-Butyl Alcohol (CASRN 75-65-0) in F344/N Rats and B6C3F1Mice... 16.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr436.pdf
TOXICOLOGYPROGRAM Technical Report Series No. 436 TOXICOLOGY AND CARCINOGENESIS STUDIES OF t-BUTYL ALCOHOL (CAS NO. 75-65-0) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES) ...
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TR-510: Urethane + Ethanol (CASRNs. 51-79-6 & 64-17-5) in F344... 17.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr510.pdf
THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF URETHANE, ETHANOL, AND URETHANE/ETHANOL (URETHANE, CAS NO. 51-79-6; ETHANOL, CAS NO. 64-17-5) IN B6C3F 1 MICE (DRINKING WATER STUDIES) ...
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TOX-53: t-Butyl Alcohol 3.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox053.pdf
3 NTP Technical Report on Toxicity Studies of t-Butyl Alcohol (CAS No. 75-65-0) Administered by Inhalation to F344/N Rats and B6C3F 1 Mice Joel Mahler, D.V.M., Study Scientist ...
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Revised Draft RoC Monograph Cobalt: RoC Peer Review; July 22... 3.0MB
https://ntp.niehs.nih.gov/ntp/roc/draftmono/revised_cobalt.pdf
Monograph on Cobalt and Cobalt Compounds That Release Cobalt Ions In Vivo November 6, 2015 Office of the Report on Carcinogens Division of the National Toxicology Program National ...
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RoC Profile: Cadmium and Cadmium Compounds; 15th RoC 2021 162KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cadmium.pdf
Cadmium and Cadmium Compounds CAS No. 7440-43-9 (Cadmium) No separate CAS No. assigned for cadmium compounds as a class Known to be human carcinogens First listed in the First ...
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RoC Profile: Ethylene Oxide; 15th RoC 2021 133KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/ethyleneoxide.pdf
Oxide CAS No. 75-21-8 Known to be a human carcinogen First listed in the Fourth Annual Report on Carcinogens (1985) Also known as oxirane, EtO Carcinogenicity Ethylene oxide is ...
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TR-005: Proflavine (CASRN 952-23-8) 3.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr005.pdf
5 January, 1977 BIOASSAY OF PROFLAVINE FOR POSSIBLE CARCINOGENICITY CAS No. 952-23-8 NCI-CG-TR-5 U.S. DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE Public Health Service National ...
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Draft RoC Monograph Cobalt: RoC Peer Review; July 22, 2015 2.8MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2015/july/cobalt_draftmonograph.pdf
Cobalt and Certain Cobalt Compounds June 5, 2015 Office of the Report on Carcinogens Division of the National Toxicology Program National Institute of Environmental Health ...
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RoC Monograph: Cobalt and Cobalt Compounds; April 2016 3.5MB
https://ntp.niehs.nih.gov/ntp/roc/monographs/cobalt_final_508.pdf
Cobalt and Cobalt CoMpounds that Release Cobalt ions in ViVo ROC MONOGRAPH 06 APRIL 2016 Report on Carcinogens Monograph on Cobalt and Cobalt Compounds That Release Cobalt Ions In ...
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TR-345: Roxarsone (CASRN 121-19-7) in F344/N Rats and B6C3F1... 25.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr345.pdf
5 (/~ <~>~~ TOXICOLOGY AND CARCINOGENESIS STUDIES OF ROXARSONE (CAS NO. 121-19-7) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public ...
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TR-356: Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1Mice... 11.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr356.pdf
6 TOXICOLOGY AND CARCINOGENESIS STUDIES OF FUROSEMIDE (CAS NO. 54-31-9) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES) U.S. DEPARTMENT O F HEALTH AND HUMAN SERVICES Public Health ...
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TR-514: trans-Cinnamaldehyde (Microencapsulated) (CASRN 14371... 8.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr514.pdf
THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF trans-CINNAMALDEHYDE (MICROENCAPSULATED) (CAS NO. 14371-10-9) IN F344/N RATS AND B6C3F 1 MICE (FEED STUDIES) NATIONAL TOXICOLOGY ...
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Peer Review Evaluation Report: Oral Up-and-down Procedure (NIH... 2.1MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/udpproc/udpfin01/vol_2.pdf
HTML NIH Publication No: 02-4501 The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals Results of an Independent Peer Review ...
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Comment: Toxicology and Carcinogenesis Studies of Sodium Tungstate... 143KB
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/april/publiccomm/lemus20210318_trprp_508.pdf
International Tungsten Industry Association Submitted electronically via US NTP portal March 18, 2021 United States National Toxicology Program (US NTP) Public Health Service US ...
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RoC Profile: Cobalt-Related Exposures; 15th RoC 2021 409KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cobalt.pdf
Genomic stability Oxidative damage Hypoxia-responsive target genes Resistance to apoptosis Accumulation of critical mutations Dysregulation of cell growth and proliferation Tumor ...
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RoC Profile: Cyclosporin A; 15th RoC 2021 130KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cyclosporina.pdf
Cyclosporin A CAS No. 59865-13-3 Known to be a human carcinogen First listed in the Eighth Report on Carcinogens (1998) Also known as ciclosporin or cyclosporine N CH 3 CH 3 HO O H ...
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TR-324: Boric Acid (CASRN 10043-35-3) in B6C3F1Mice (Feed Studies... 6.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr324.pdf
PROGRAM Technical Report Series No. 324 TOXICOLOGY AND CARCINOGENESIS STUDIES OF BORIC ACID (CAS NO. 10043-35-3) IN B6C3Fi MICE (FEED STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN ...
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Antimony Draft Monograph (Revised); Aug. 15, 2018 2.8MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/january/antimonydraftmonograph_revised.pdf
Revised Draft: Report on Carcinogens Monograph on Antimony Trioxide August 15, 2018 Office of the Report on Carcinogens Division of the National Toxicology Program National ...