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RoC Concept: ortho-Toluidine 318KB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/concepts/otolconcdocroc8-30-12_508.pdf
... AM, Williams GM. 2008. Assessment of the medicines lidocaine, prilocaine, and their metabolites, 2,6-dimethylaniline and 2-methylaniline, for DNA adduct formation in rat tissues. ...
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TR-278: 2,6-Xylidine (2,6-Dimethylaniline) (CASRN 87-62-7) in... 9.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr278.pdf
... as a metabolite in the urine of rats, guinea pigs, dogs, and humans administered lidocaine, a lo- cal anesthetic that is clinically effective in con- troling ventricular ...
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RoC Monograph: ortho-Toluidine; July 2014 2.4MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/otoluidine_508.pdf
... Prilocaine is also present with lidocaine in a topical local anesthetic cream used to numb ... GM. 2008. Assessment of the medicines lidocaine, prilocaine, and their metabolites, ...
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RoC Profile: o-Toluidine; 15th RoC 2021 192KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/toluidine.pdf
... Toxicology 229(1- 2): 157-164. Gutenberg LL, Chen J-W, Trapp L. 2013. Methemoglobin levels in generally anesthetized pediatric dental patients receiving prilocaine versus lidocaine...
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TR-566: Diethylamine (CASRN 109-89-7) in F344/N Rats and B6C3F1... 8.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr566.pdf
... An unreported amount of diethylamine was used to produce pharmaceuticals (e.g., the alcohol antagonist disulfiram, the hypnotic flurazepam, the anesthetic lidocaine, and the ...
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Draft RoC Monograph for ortho-Toluidine: Literature Search Strategy... 1.1MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/otol_literaturesearch20130815_508.pdf
... Accessed on 2/22/13. 64. Duan JD, Jeffrey AM, Williams GM. 2008. Assessment of the medicines lidocaine, prilocaine, and their metabolites, 2,6-dimethylaniline and 2- methylaniline, ...
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Monograph on Potential Human Reproductive and Developmental Effects... 2.4MB
https://ntp.niehs.nih.gov/ntp/ohat/fluoxetine/fluoxetine_monograph.pdf
... quinidine, erythromycin, and lidocaine and as such, can also contribute to ... were noted for the other drugs tested, including desipramine, GBR 12909, and lidocaine. ...
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Workshop Report: Alternative Methods to Replace Animal Use for... 10.1MB
https://ntp.niehs.nih.gov/iccvam/docs/biologics-docs/bontwkshprept.pdf
... Toxicon 48:246-254. Kaji R, Kohara N, Katayama M, Kubori T, Mezaki T, Shibasaki H, et al. 1995a. Muscle afferent block by intramuscular injection of lidocaine for the treatment of ...
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Report: International Workshop on In Vitro Methods for Assessing... 25.4MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf
... Chemicals evaluated in Seibert et al. (1994a) included 2,4-dinitrophenol, cyclophosphamide, and lidocaine. The paper demonstrated a comparative cell toxicological approach that ...
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Peer Review Evaluation Report: Oral Up-and-down Procedure (NIH... 2.1MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/udpproc/udpfin01/vol_2.pdf
... Diazepam Lower clearance in females as compared with males. Erythromycin Higher clearance in females. Lidocaine Greater half-life and volume of distribution in females. ...
