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TOX-82: 3-Month Estragole (CASRN 140-67-0) 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox082.pdf
National Toxicology Program Toxicity Report Series Number 82 NTP Technical Report on the 3-Month Toxicity Studies of Estragole (CAS No. 140-67-0) Administered by Gavage to F344/N ...
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Abstract for TOX-82 66KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox082
Abstract for TOX-82 Three-month Toxicity Studies of Estragole Administered by Gavage to F344/N Rats and B6C3F1 Mice CASRN: 140-67-0 Chemical Formula: C10H12O Molecular Weight: ...
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Minutes: BSC TRRS; Feb. 27, 2008 112KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2008/feb/trrs27feb2008mins_508.pdf
Estragole......ESTRAGOLE Dr. Douglas Bristol, NIEHS, introduced the toxicity studies of estragole by ...
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RoC Background Document: Methyleugenol; Dec. 13-14, 2000 1.2MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/me_no_appendices_508.pdf
... related allylbenzenes, safrole and estragole, induced liver tumors in mice after ... Methyleugenol, safrole, and estragole induced unscheduled DNA synthesis in rat ...
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Public Comment: Alkenylbenzenes; Timothy Adams; RoC; Jan. 19... 486KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/adams20120314.pdf
nomination of alkenylbenzenes (selected dietary: estragole, myristicin, isosafrole) to the Report on Carcinogens. Estragole was determined to be GRAS (Generally Recognized as ...
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RoC Profile: Methyleugenol; 15th RoC 2021 137KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/methyleugenol.pdf
related allylbenzenes, safrole and estragole, caused liver tumors in mice when ... Methyleugenol, safrole, and estragole caused unscheduled DNA synthesis in rat hepatocytes, ...
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Abstract for TR-491 81KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr491
Methyleugenol was nominated for testing because of its widespread use and because of its structural resemblance to safrole, a known carcinogen, and isosafrole and estragole. Male ...
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TR-551: Isoeugenol (CASRN 97-54-1) in F344/N Rats and B6C3F1... 6.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr551.pdf
... methyleugenol, estragole, and anethole, most of which are known rodent carcinogens. ... parison of the results of the NTP studies of estragole, methyleugenol, and isoeugenol. ...
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Public Comments for Ongoing & Considered Health Effects Evaluations 91KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/comments
Association of the United States (FEMA) Alkenylbenzenes (selected dietary: estragole, myristicin, isosafrole) Cancer Effects Jan 19, 2012 Federal Register notice Oct 16, ...
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TR-491: Methyleugenol (CASRN 93-15-2) in F344/N Rats and B6C3F1Mice... 22.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr491.pdf
... its structural resemblance to safrole, a known car- cinogen, and isosafrole and estragole. ... The 1N-hydroxy metabolites of safrole and estragole are converted by hepatic ...
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TOX-95: Toxicity Studies of Myristicin (CASRN 607-91-0) Administered... 3.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox095_508.pdf
... additives apiole, safrole, elemicin, estragole, and methyleugenol. 2 Production, Use, ... have been derived from myristicin or estragole, and 1-(3',4'- methylenedioxy-5'-hydroxy...
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Agenda: BSC TRRS; Feb. 27-28, 2008 36KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2008/feb/trrs27feb2008agendafnl_508.pdf
Christopher Bradfield Dr. Jon Mirsalis Dr. Tracie Bunton February 28, 2208 Estragole - NTP Toxicity Report (140-67-0) TOX 82 Gavage Male and female F-344/N rats and B6C3F1 mice Dr. ...
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Abstract for TR-551 73KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr551
because of its structural similarity to phenylpropenoids such as safrole, isosafrole, eugenol, methyleugenol, estragole, and anethole, most of which are known rodent carcinogens. ...
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Liver - Focus - Nonneoplastic Lesion Atlas 300KB
https://ntp.niehs.nih.gov/atlas/nnl/hepatobiliary-system/liver/Focus
... Abstract: https://www.ncbi.nlm.nih.gov/pubmed/2697942 National Toxicology Program. 2011. NTP TOX-82. 3-Month Toxicity Studies of Estragole (CAS No. 140-67-0) Administered by Gavage ...
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Short-Term Toxicity Reports 224KB
https://ntp.niehs.nih.gov/publications/reports/tox
... Mice 2017 Short-Term Toxicity TOX-82 PDF (3.26 MB) Toxicity Studies of Estragole (CASRN 140-67-0) Administered by Gavage to F344/N Rats and B6C3F1 Mice 2011 Short-Term ...
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Liver - Focus 1.0MB
https://ntp.niehs.nih.gov/sites/default/files/nnl/hepatobiliary/liver/foci/liver-foci_508.pdf
.../pubmed/2697942 National Toxicology Program. 2011. NTP TOX-82. 3-Month Toxicity Studies of Estragole (CAS No. 140-67-0) Administered by Gavage to F344/N Rats and B6C3F1 Mice. ...
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TR-223 Carcinogenesis Studies of Eugenol (CASRN 97-53-0) in F344... 6.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr223.pdf
... derivatives related to safrole and estragole, results on the carcinogenesis testing ... appear to be as carcinogenic in the mouse liver as safrole and estragole. ...
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Minutes: BSC RoC; Dec. 13-15, 2000 205KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/twelfth/draftbackgrounddocs/minutes20001213.pdf
... and the related estragole, a workshop was convened by FEMA and the Research Institute for Fragrance Materials (RIFM) to review the state of the science, including the NTP study. ...
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Minutes: BSC; June 12, 2008 280KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2008/june/minutes20080612.pdf
... findings and conclusions of a three-month study on estragole in conventional male rats. . ... in favor of the conclusions that estragole showed carcinogenic activity based on ...
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ICCVAM Test Method Evaluation Report on the Reduced LLNA 21.6MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-ld/tmer.pdf
... 461443-59-4 577.73 3.92 Solid Pharmaceutical chemicals GSK 4-Allylanisole Estragole 140-67-0 148.20 2.54 Liquid Ethers; Phenols Gerberick 4-Amino-3-nitrophenyl thiocyanate - ...
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Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB
https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf
... analog of a lactone) + + nonstd Unpublished Unilever data 4-Allylanisole// Estragole 140-67-0 aryl alkyl ether fragrance// flavoring in foods and liqueurs + + Unpublished ...
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Minutes: BSC; Nov. 2008 308KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2008/november/minutes_final.pdf
... some including methyleugenol, estragole, and safrole cause hepatic cancer in male rats. ... At the low dose, 45% to 65% of the samples suggested that estragole is carcinogenic, but ...
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TOX-83: Toxicity Studies of o-Chloropyridine (CASRN 109-09-1... 3.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox83_508.pdf
... in rats with multiple agent types [e.g., lead 50 ; cupric sulfate 51 ; estragole 52 ]. ... Program (NTP). Toxicity studies of estragole (CAS No. 140-67-0) administered by ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... Mice 2017 Short-Term Toxicity TOX-82 PDF (3.26 MB) Toxicity Studies of Estragole (CASRN 140-67-0) Administered by Gavage to F344/N Rats and B6C3F1 Mice 2011 Short-Term ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... Mice 2017 Short-Term Toxicity TOX-82 PDF (3.26 MB) Toxicity Studies of Estragole (CASRN 140-67-0) Administered by Gavage to F344/N Rats and B6C3F1 Mice 2011 Short-Term ...
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TR-427: Turmeric Oleoresin (CASRN 8024-37-1) (Major Component... 16.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr427.pdf
... Structure-activity studies o f the carcinogenicities in the mouse and rat o f some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole. ...
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TR-514: trans-Cinnamaldehyde (Microencapsulated) (CASRN 14371... 8.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr514.pdf
... Structure-activity studies of the hepatocarcino- genicities of alkenylbenzene derivatives related to estragole and safrole on administration to preweanling male C57BL/6J × C3H/HeJ ...
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TOX-52: Urethane 4.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox052.pdf
... The metabolic activation and nucleic acid adducts o f naturally-occurring carcinogens: Recent results with ethyl carbamate and the spice flavors safrole and estragole. Br. J. ...
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TR-510: Urethane + Ethanol (CASRNs. 51-79-6 & 64-17-5) in F344... 17.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr510.pdf
... The metabolic acti- vation and nucleic acid adducts of naturally-occurring carcinogens: Recent results with ethyl carbamate and the spice flavors safrole and estragole. Br. J. ...
