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CERHR Monograph: Potential Human Reproductive and Developmental... 4.3MB
https://ntp.niehs.nih.gov/ntp/ohat/egpg/ethylene/eg_monograph.pdf
NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Ethylene Glycol January 2004 NIH Publication No. 04-4481 Table of Contents Preface ...
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Stomach - Erosion - Nonneoplastic Lesion Atlas 291KB
https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/stomach-glandular-stomach/Erosion
Spontaneous occurrence of erosion of the glandular stomach is uncommon in NTP studies in mice and F344/N rats. Erosions are seen primarily in treated rats. An erosion (Figure 1 ...
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Stomach - Ulcer - Nonneoplastic Lesion Atlas 291KB
https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/stomach-glandular-stomach/Ulcer
Spontaneous occurrence of ulceration of the glandular stomach is uncommon in NTP studies in mice and F344/N rats. Ulceration is seen primarily in treated rats and has been ...
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Stomach, Glandular Stomach - Erosion 324KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/alimentary/glandular_stomach/erosion/glandular-stomach-erosion_508.pdf
Erosion Figure Legend: Figure 1 Stomach, Glandular stomach - Erosion in male B6C3F1 mouse from a subchronic study. The lesion does not extend through the entire mucosa. Figure 2 ...
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Stomach, Glandular Stomach - Ulcer 263KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/alimentary/glandular_stomach/ulcer/glandular-stomach-ulcer_508.pdf
Ulcer Figure Legend: Figure 1 Stomach, Glandular stomach - Ulcer in a male F344/N rat from a chronic study. The lesion extends through the entire mucosa. Figure 2 Stomach, ...
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Presentation: Conducting and Interpreting the BCOP Test Method 2.5MB
https://ntp.niehs.nih.gov/iccvam/meetings/implement-2011/ocular-present/7-raabe.pdf
Bovine Corneal Opacity and Permeability (BCOP) Assay ICCVAM Workshop on Best Practices for Assessing the Potential for Chemically Induced Eye Injuries Presented by Hans Raabe 20 ...
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Presentation: Mechanisms of Acute Toxicity 2.4MB
https://ntp.niehs.nih.gov/iccvam/meetings/at-wksp-2015/session4/1-wilson-508.pdf
Mechanisms of Acute Toxicity Dan Wilson, PhD, DABT Science Leader - Cheminformatics The Dow Chemical Company Acute Tox Workshop Sep 24, 2015 Acknowledgements . Barun Bhhatarai . Ed ...
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RoC Background Document: Saccharin; Oct. 30-31, 1997 8.9MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/saccharin1_3apps_508.pdf
BACKGROUND DOCUMENT for SACCHARIN FINAL MARCH 1999 Prepared for the October 30-31, 1997, Meeting of the Report on Carcinogens Subcommittee of the NTP Board of Scientific Counselors ...
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INVITTOX Protocol for the Cytosensor Microphysiometer Test Method 5.5MB
https://ntp.niehs.nih.gov/iccvam/docs/protocols/cm-invittoxno130-508.pdf
© ECVAM DB-ALM: INVI TTOX protoco l The Cytosens or Mi crophysio m eter (C M) Toxicity Test INVI TTOX no 130 Eye Ir ritation The effects of a test compound on intracellular ...
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TR-392: Chlorinated Water (CASRNs. 7782-50-5 and 7681-52-9) and... 75.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr392.pdf
NATIONAL TOXICOLOGY PROGRAM Technical Report Series No. 392 ~ Sl'gvlc~.¢. o S ~r~ ~ ~ - ~ . _ ~ %~o~ TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLORINATED WATER (CAS NOS. ...
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TR-420: Triamterene (CASRN 396-01-0) in F344/N Rats and B6C3F1Mice... 20.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr420.pdf
Program (NTP) is made up of four charter agencies o f the U.S. Department of Health and Human Services (DHHS): the National Cancer Institute (NCI), National Institutes o f Health; ...
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TR-427: Turmeric Oleoresin (CASRN 8024-37-1) (Major Component... 16.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr427.pdf
NATIONAL TOXICOLOGY PROGRAM Technical Report Series No. 427 TOXICOLOGY AND CARCINOGENESIS STUDIES OF TURMERIC OLEORESIN (CAS NO. 8024-37-1) (MAJOR COMPONENT 79%-85% CURCUMIN, CAS ...
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RoC Background Document: Nickel Compounds; Dec. 2-3, 1998 6.7MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/nickelcompds1_oneapp_508.pdf
NICKEL COMPOUNDS FINAL MARCH 1999 Prepared for the December 2-3, 1998, Meeting of the Report on Carcinogens Subcommittee of the NTP Board of Scientific Counselors Prepared by ...
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GMM-12: Genetically Modified Model Report on Phenolphthalein... 768KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm12_508.pdf
caRciNoGeNesis sTudy of PheNolPhThaleiN (casRN 77-09-8) iN GeNeTically Modified haPloiNsufficieNT P16 iNk4a /P19 aRf Mice (feed sTudy) NTP GMM 12 DECEMBER 2007 NTP REPORT ON THE ...
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TR-344: Tetracycline Hydrochloride (CASRN 64-75-5) in F344/N... 10.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr344.pdf
PROGRAM Technical Report Series No. 344 TOXICOLOGY AND CARCINOGENESIS STUDIES OF TETRACYCLINE HYDROCHLORIDE (CAS NO. 64-75-5) IN F344/N RATS AND B6C3Fi MICE (FEED STUDIES) U.S. ...
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Minutes: BSC; Nov. 2008 308KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2008/november/minutes_final.pdf
National Toxicology Program Board of Scientific Counselors November 20-21, 2008 National Institute of Environmental Health Sciences Research Triangle Park, NC Summary Minutes ...
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TR-356: Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1Mice... 11.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr356.pdf
6 TOXICOLOGY AND CARCINOGENESIS STUDIES OF FUROSEMIDE (CAS NO. 54-31-9) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES) U.S. DEPARTMENT O F HEALTH AND HUMAN SERVICES Public Health ...
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TR-517: Sodium Chlorate (CASRN 7775-09-9) in F344/N Rats and... 10.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr517.pdf
SODIUM CHLORATE (CAS NO. 7775-09-9) IN F344/N RATS AND B6C3F 1 MICE (DRINKING WATER STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle Park, NC 27709 December ...
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TOX-13: Trinitrofluorenone (CASRN 129-79-3) 2.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox013.pdf
National Toxicology Program Toxicity Report Series Number 13 NTP Technical Report on Toxicity Studies of Trinitrofluorenone (CAS No. 129-79-3) Administered by Dermal Application ...
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ICCVAM Evaluation of In Vitro Test Methods for Assessing Dermal... 3.1MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/cwgfinal02/cwgfinal.pdf
NIH Publication No: 02-4502 ICCVAM Evaluation of EPISKIN(tm), EpiDerm(tm) (EPI-200), and the Rat Skin Transcutaneous Electrical Resistance (TER) Assay: In Vitro Test Methods for ...
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CERHR Monograph: Amphetamines 4.1MB
https://ntp.niehs.nih.gov/ntp/ohat/stimulants/amphetamines/amphetaminemonograph.pdf
Amphetamines July 2005 NIH Publication No. 05 - 4474 iii Table of Contents Preface......
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TR-216: 11-Aminoundecanoic Acid (CASRN 2432-99-7) in F344 Rats... 7.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr216.pdf
6 CARCINOGENESIS BIOASSAY OF 11-AMINOUNDECANOIC ACID (CAS NO. 2432-99-7) IN F344 RATS AND B6C3F1 MICE (FEED STUDY) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health ...
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TR-465: Phenolphthalein (CASRN 77-09-8) in F344 Rats and B6C3F1Mice... 18.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr465.pdf
NATIONAL TOXICOLOGY PROGRAM Technical Report Series No. 465 TOXICOLOGY AND CARCINOGENESIS STUDIES OF PHENOLPHTHALEIN (CAS NO. 77-09-8) IN F344/N RATS AND B6C3Fl MICE (FEED STUDIES) ...
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Background Review Document: In Vitro Test Methods for Assessing... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/epis_brd0801.pdf
Episkin(tm), EpiDerm(tm), and Rat Skin Transcutaneous Electrical Resistance (TER) In Vitro Test Methods for Assessing the Dermal Corrosivity Potential of Chemicals Background ...
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Prospective and Retrospective Evaluation of the Eye Irritation... 344KB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/formulationreport_2021_fd-508.pdf
Prospective and Retrospective Evaluation of the Eye Irritation Potential of Agrochemical Formulations Prospective and Retrospective Evaluation of the Eye Irritation Potential of ...
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Performance Standards for In Vitro Test Methods for Skin Corrosion 6.3MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/ps/ps044510.pdf
... chloride 8001-54-5 quaternary ammonium 100 NC NC 7.6 Sodium acid carbonate 144-55-8 inorganic base 100 NC NC 8.3 Sodium undecylenate 3398-33-2 surfactant 33 NC NC 8.3 ...
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TR-389: Sodium Azide (CASRN 26628-22-8) in F344 Rats (Gavage... 8.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr389.pdf
89 TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM AZIDE (CAS NO. 26628-22-8) IN F344/N RATS (GAVAGE STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service ...
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ICCVAM Report: Corrositex: An In Vitro Method for Assessing Dermal... 5.1MB
https://ntp.niehs.nih.gov/iccvam/docs/dermal_docs/corprrep.pdf
... > 4 h RP-57 > 4 h RP-61 > 4 h RP-62 > 4 h RP-80B > 4 h RP-81B > 4 h sodium bicarbonate; sodium hydrogen carbonate 144-55-8 Source: ECVAM Validation Study (Fentem et al., 1998). ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 5.0MB
https://ntp.niehs.nih.gov/ntp/ohat/methanol/methanol_monograph.pdf
NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Methanol September 2003 NIH Publication No. 03-4478 Table of Contents Preface ...
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RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf
The chemical aNd Physical chaRacTeRizaTioN of Recycled TiRe cRumb RubbeR NTP RR 11 JULY 2019 NTP Research Report on the Chemical and Physical Characterization of Recycled Tire ...
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Peer Review Evaluation Report: Oral Up-and-down Procedure (NIH... 2.1MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/udpproc/udpfin01/vol_2.pdf
HTML NIH Publication No: 02-4501 The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals Results of an Independent Peer Review ...
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TR-296: Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) (CASRN... 16.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr296.pdf
6 TOXICOLOGY AND CARCINOGENESIS STUDIES OF TETRAKIS(HYDR0XYMETHYL)PHOSPHONIUM SULFATE (THPS) (CAS NO. 55566-30-8) AND TETRAKIS(HYDR0XYMETHYL)PHOSPHONIUM CHLORIDE (THPC) (CAS NO. ...
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RoC Background Document: Beryllium Compounds; Dec. 16-17, 1999 5.3MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/be_no_appendices_508.pdf
FINAL Report on Carcinogens Background Document for Beryllium and Beryllium Compounds December 16 - 17, 1999 Meeting of the NTP Board of Scientific Counselors Report on ...
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ICCVAM Test Method Evaluation Report: Ocular Hazard Testing Strategy... 4.3MB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/amcp/tmer-all.pdf
ICCVAM Test Method Evaluation Report: Current Validation Status of a Proposed In Vitro Testing Strategy for U.S. Environmental Protection Agency Ocular Hazard Classification and ...
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TR-472: Isobutyraldehyde (CASRN 78-84-2) in F344/N Rats and B6C3F1Mice... 11.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr472.pdf
OF ISOBUTYRALDEHYDE (CAS NO. 78-84-2) IN F344/N RATS AND B6C3F MICE 1 (INHALATION STUDIES) February 1999 NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle Park, NC 27709 ...
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TR-477: 1-Chloro-2-Propanol (Technical Grade) (CASRN 127-00-4... 9.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr477.pdf
OF 1-CHLORO-2-PROPANOL (TECHNICAL GRADE) (CAS NO. 127-00-4) IN F344/N RATS AND B6C3F MICE 1 (DRINKING WATER STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle ...
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TOX-103: Select Ionic Liquids (1-Ethyl-3-Methylimidazolium Chloride... 4.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox103_508.pdf
SelecT ioNic liquidS (1-eThyl-3-MeThyliMidazoliuM chloRide, 1-BuTyl-3-MeThyliMidazoliuM chloRide, 1-BuTyl-1-MeThylPyRRolidiNiuM chloRide, aNd N-BuTylPyRidiNiuM chloRide) ...
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Nomination Background: Dichloroacetic acid (CASRN: 79-43-6) 6.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dcaa_508.pdf
NATIONAL TOXICOLOGY PROGRAM EXECUTIVE SUMMARY OF SAFETY AND TOXICITY INFORMATION DICHLOROACETIC ACED CAS Number 79-43-6 TRICHLOROACETIC ACID CAS Number 76-03-9 September 30, 1991 ...
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TR-044 In Vitro Carcinogenesis: Guide to the Literature, Recent... 18.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr044.pdf
Institute CARCIIMOGENESIS Technical Report Series No. 44 1978 IN VITRO CARCINOGENESIS GUIDE TO THE LITERATURE, RECENT ADVANCES AND LABORATORY PROCEDURES NCI-CG-TR-44 U.S. ...
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TOX-106: Sodium Metavanadate (CASRN 13718-26-8) and Vanadyl Sulfate... 2.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox106_508.pdf
Sodium meTavaNadaTe (caSRN 13718-26-8) aNd vaNadyl SulfaTe (caSRN 27774-13-6) admiNiSTeRed iN dRiNkiNg WaTeR To SPRague daWley (hSd:SPRague daWley ® Sd ® ) RaTS aNd B6c3f1/N mice ...
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GMM-06: Genetically Modified Model Report on Sodium Bromate ... 1.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm06_508.pdf
SodiuM BRoMaTe (caSRN 7789-38-0) iN GeNeTically Modified (fVB TG.ac heMizyGouS) Mice (deRMal aNd dRiNkiNG WaTeR STudieS) aNd caRciNoGeNiciTy STudieS of SodiuM BRoMaTe iN ...
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TR-250: Benzyl Acetate (CASRN 140-11-4) in F344/N Rats and B6C3F1Mice... 8.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr250.pdf
NATIONAL TOXICOLOGY PROGRAM Technical Report Series No. 250 +~~,.,. su"'"t.r (~ TOXICOLOGY AND CARCINOGENESIS STUDIES OF BENZYL ACETATE (CAS N 0 . 140-11 -4) IN F344/N RATS AND ...
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ICCVAM Test Method Evaluation Report: In Vitro Test Methods for... 42.0MB
https://ntp.niehs.nih.gov/iccvam/docs/ocutox_docs/invitro-2010/tmer-vol1.pdf
ICCVAM Test Method Evaluation Report: Current Validation Status of In Vitro Test Methods Proposed for Identifying Eye Injury Hazard Potential of Chemicals and Products Interagency ...
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Japanese Minimum Requirements for Biological Products 2.0MB
https://ntp.niehs.nih.gov/iccvam/methods/biologics/vaccine/japan-minreqs.pdf
MINIMUM REQUIREMENTS FOR BIOLOGICAL PRODUCTS National Institute of Infectious Diseases Japan, 2006 - 1 - MINIMUM REQUIREMENTS FOR BIOLOGICAL PRODUCTS Notice: This English version ...
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TR-349: Two Pentachlorophenol Technical-Grade Mixtures (CASRN... 30.4MB
https://ntp.niehs.nih.gov/go/tr349
NATIONAL TOXICOLOGY PROGRAM Technical Report Series No. :349 TOXICOLOGY AND CARCINOGENESIS STUDIES OF TWO PENTACHLOROPHENOL TECHNICAL-GRADE MIXTURES (CAS NO. 87-86-5) IN B6C3FI ...
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ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf
Methods for Estimating Acute Oral Systemic Toxicity Background Review Document Volume 2 of 2 Prepared by The National Toxicology Program (NTP) Interagency Center for the Evaluation ...
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TR-414: Pentachloroanisole (CASRN 1825-21-4) in F344 Rats and... 15.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr414.pdf
The National Toxicology Program (NTP)is made up o f four charter agencies o f the U.S. Department o f Health and Human Services (DHHS): the National Cancer Institute (NCI), ...
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TR-561: Tetralin (CASRN 119-64-2) in F344/N Rats and B6C3F1 Mice... 13.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr561.pdf
AND CARCINOGENESIS STUDIES OF TETRALIN (CAS NO. 119-64-2) IN F344/N RATS AND B6C3F1 MICE AND A TOXICOLOGY STUDY OF TETRALIN IN MALE NBR RATS (INHALATION STUDIES) NATIONAL ...
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TR-495: Sodium Nitrite (CASRN 7632-00-0) IN F344/N Rats and B6C3F1Mice... 16.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr495.pdf
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM NITRITE (CAS NO. 7632-00-0) IN F344/N RATS AND B6C3F 1 MICE (DRINKING WATER STUDIES) NATIONAL ...
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Final RoC Background Document for Formaldehyde 5.8MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/formaldehyde_bd_final.pdf
Formaldehyde January 22, 2010 U.S. Department of Health and Human Services Public Health Service National Toxicology Program Research Triangle Park, NC 27709 This Page ...