-
RoC Profile: Cisplatin; 15th RoC 2021 131KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cisplatin.pdf
Cisplatin CAS No. 15663-27-1 Reasonably anticipated to be a human carcinogen First listed in the Fifth Annual Report on Carcinogens (1989) Also known as cis-dichlorodiammineplatinu...
-
Appendices for NTP Monograph on Developmental Effects and Pregnancy... 11.1MB
https://ntp.niehs.nih.gov/ntp/ohat/cancer_chemo_preg/cancerchemo_appendfinal_508.pdf
2A NA D Chlorambucil 1 Known D Cisplatin 2A Reasonably anticipated D ... OR Cerubidine OR chlorambucil OR cisplatin OR cis- platinum OR cyclophosphamide OR ...
-
NTP Monograph: Developmental Effects and Pregnancy Outcomes Associated... 23.8MB
https://ntp.niehs.nih.gov/ntp/ohat/cancer_chemo_preg/chemopregnancy_monofinal_508.pdf
......... 68 5.10 Cisplatin ......Table 34: Pharmacology of cisplatin in adult humans ......
-
Kidney - Fibrosis 522KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/urinary/kidney/fibrosis/kidney-fibrosis-pdf_508.pdf
Sato K, Machida Y, Ide M, Sato S, Nakatsuji S, Kuwamura M, Kotani T, Sakuma S. 2000. Cisplatin-induced rat renal interstitial fibrosis: A possible pathogenesis based on the data. ...
-
Kidney - Fibrosis - Nonneoplastic Lesion Atlas 290KB
https://ntp.niehs.nih.gov/atlas/nnl/urinary-system/kidney/Fibrosis
Yamate J, Sato K, Machida Y, Ide M, Sato S, Nakatsuji S, Kuwamura M, Kotani T, Sakuma S. 2000. Cisplatin-induced rat renal interstitial fibrosis: A possible pathogenesis based on ...
-
Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf
... and Its Hydrochloride Chlorozotocin (see Nitrosourea Chemotherapeutic Agents) Cisplatin Cobalt and Cobalt Compounds That Release Cobalt Ions In Vivo (see Cobalt-Related ...
-
15th RoC: Appendix F 174KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf
... cis-dichlorodiamine platinum (II) see Cisplatin cis-1,3-dichloropropene see ... diamminedichloro-, (SP-4-2)- see Cisplatin polychlorinated camphenes see Toxaphene ...
-
NCTR SOT Presentations; SOT; March 19-23, 2023 289KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/pressctr/ntp_news/2023/sot_nctr_508.pdf
... Cognitive Impairment in Cisplatin and Methotrexate Treated Sprague Dawley ... Poster Title: Behavioral Effects of Cisplatin and Methotrexate Treatment in Juvenile ...
-
Appendix G; 15th RoC 2021 73KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
... (lead acetate) see Lead and Lead Compounds 15468-32-3 (tridymite) see Silica 15663-27-1 see Cisplatin 16071-86-6 (C.I. direct brown 95) see Benzidine and Dyes Metabolized to ...
-
Appendices A-G; 15th RoC 2021 448KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf
... cis-dichlorodiammine platinum (II) see Cisplatin cis-1,3-dichloropropene see ... see Estrogens, Steroidal platinum see Cisplatin polychlorinated camphenes see Toxaphene ...
-
OHAT Evaluation: Protocol for a Systematic Review to Evaluate... 1018KB
https://ntp.niehs.nih.gov/ntp/ohat/aheaoecca/protocol201510_508.pdf
... OR chlorambucil[tiab] OR cisplatin[tiab] OR cis-platinum[tiab] OR ... pemetrexed[tiab] OR pentostatin[tiab] OR platinol[tiab] OR prednisone[tiab] OR ...
-
OHAT Evaluation: Protocol for a Systematic Review to Evaluate... 1.1MB
https://ntp.niehs.nih.gov/ntp/ohat/aheaoecca/protocol201812_508.pdf
... OR chlorambucil[tiab] OR cisplatin[tiab] OR cis- platinum[tiab] OR ... pemetrexed[tiab] OR pentostatin[tiab] OR platinol[tiab] OR prednisone[tiab] OR ...
-
RoC Profile: Tamoxifen; 15th RoC 2021 149KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tamoxifen.pdf
... Paddenberg R, Schubert S, Mannherz HG. 1996. Cell-cycle arrest, micronucleus formation, and cell death in growth inhibition of MCF-7 breast cancer cells by tamoxifen and cisplatin. ...
-
Minutes: MPRP; Oct. 1-2, 2012 559KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2012/october/minutes20121002_508.pdf
... Smith said that she would prefer that carboplatin and cisplatin be grouped with the ... DNA Intercalcating/Cross-linking Agents: Cisplatin Dr. Van Calsteren was first reviewer. ...
-
NTP Monograph: Systematic Review of Occupational Exposure to... 6.2MB
https://ntp.niehs.nih.gov/ntp/ohat/oeccaaho/mgraph/occchemo_final20190300_508.pdf
... platinum-containing agents, including cisplatin, carboplatin, and oxaliplatin; n = 18). ... a marker of platinum-containing agents: cisplatin, carboplatin, Systematic Review of ...
-
TOX-88: Toxicity Studies of p-Toluenesulfonamide (CASRN 70-55... 3.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox88_508.pdf
... did not appear to potentiate toxicity of gemcitabine plus cisplatin chemotherapy 7 . ... Zhong B, Wang D et al. Gemcitabine plus cisplatin chemotherapy with concurrent ...
-
TR-601: Di(2-ethylhexyl) Phthalate Administered in Feed to Sprague... 4.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr601_508.pdf
... bis(2-ethylhexyl) ester Trade names: Platinol DOP; Octoil; Silicol 150; Bisoflex 81; ... Trade names: Platinol DOP; Octoil; Silicol 150; Bisoflex 81; Eviplast 80. Chemical and ...
-
Draft TR-601: Di(2-ethylhexyl) Phthalate (CASRN 117-81-7) Administered... 3.6MB
https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/april/tr601_508.pdf
... 30 ester 31 Trade names: Platinol DOP; Octoil; Silicol 150; Bisoflex 81; ... ester. 6 7 Trade names: Platinol DOP; Octoil; Silicol 150; Bisoflex 81; ...
-
CERHR Monograph: Hydroxyurea 3.6MB
https://ntp.niehs.nih.gov/ntp/ohat/hydroxyurea/humonograph20090401.pdf
... S. (2007).J.Long-term.follow-up.of.a.random- ized. trial. comparing. concurrent. single. agent. cisplatin,. cisplatin-based. combina- tion. chemotherapy,. or. hydroxyurea. dur- ...
-
TOX-39: Cadmium Oxide (CASRN 1306-19-0) 2.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox039.pdf
... The frequencies o f chromosomal aberrations induced by known clastogens (mitomycin C, cisplatin, and methy l methanesulfonate) were enhanced by posttreatment of cells with cadmium. ...
-
RoC Background Document: Tamoxifen; Oct. 30-31, 1997 2.3MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/tamoxifen2_2apps_508.pdf
... H. G. Mannherz. 1996. Cell-cycle arrest, micronucleus formation, and cell death in growth inhibition of MCF-7 breast cancer cells by tamoxifen and cisplatin. J. Cancer Res. Clin. ...
-
TR 577: Nondecolorized Whole Leaf Extract of Aloe Barbadensis... 11.3MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr577_508.pdf
... In cell-based ELISA and Western blot analysis, aloe-emodin was shown to abolish cisplatin-triggered activation of extracellular signal-regulated kinase (ERK) in rat glioma and ...
-
TOX-102: Trans-resveratrol Administered by Gavage for Two Weeks... 2.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox102_508.pdf
... effect of resveratrol in preventing cisplatin-induced ovarian damage in rats: An ... chemoprotective role of resveratrol against cisplatin induced testicular damage in mice. ...
-
Report: International Workshop on In Vitro Methods for Assessing... 25.4MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf
... 0.8 127.0 1.27 100 0.8 150 Cis-platinum 15663-27-1 0.84 0.0028 25.8 0.086 33.0 0.11 300.07 ... 0.089 214.07 0.093 150 Cis-platinum 15663-27-1 0.84 0.0028 25.8 0.086 33.0 0.11 300.07 ...
-
MFDS NAMs Report: Regulatory Acceptance and Research Outcomes 20.5MB
https://ntp.niehs.nih.gov/sites/default/files/2024-01/MFDS_NAMs_Report-2023-508.pdf
... This focuses on the cardiac mitochondrial toxicity of commonly used anticancer drugs, i.e., doxorubicin, m trone, cisplatin, arsenic trioxide, and cyclophosphamide, and their ...
