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TR-521: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CASRN 1746... 15.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr521.pdf
REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN (TCDD) (CAS NO. 1746-01-6) IN FEMALE HARLAN SPRAGUE-DAWLEY RATS (GAVAGE STUDIES) NATIONAL ...
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RoC Background Document: 2,3,7,8-Tetrachlorodibenzo-p-dioxin... 7.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/tetrachl_tcdd_4apps_508.pdf
BACKGROUND DOCUMENT for 2,3, 7,8-TETRACHLORODIBENZO-p-DIOXIN (TCDD) FINAL MARCH 1999 ... for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) TABLE OF CONTENTS NTP Report on ...
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TR-526: a Mixture of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD... 9.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr526.pdf
THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF A MIXTURE OF 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN (TCDD) (CAS NO. 1746-01-6), 2,3,4,7,8-PENTACHLORODIBENZOFURAN (PeCDF) (CAS NO. ...
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TR-209: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6... 8.5MB
https://ntp.niehs.nih.gov/go/tr209
...,8-TETRACHLORODIBENZO-p-DIOXIN (CAS NO. 1746-01-6) IN OSBORNE-MENDEL RATS AND B6C3F1 MICE ...,8-TETRACHLORODIBENZO-p-DIOXIN (CAS No. 1746-01-6) in OSBORNE-MENDEL RATS and BGCSFj MICE ...
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TR-201: Carcinogenesis 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN... 5.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr201.pdf
...,8-TETRACHLORODIBENZO-p-DIOXIN (CAS NO. 1746-01-6) IN SWISS-WEBSTER MICE (DERMAL STUDY) ...,8-TETSACHLORODIBENZO-p-DIOXIN (CAS No. 1746-01-6) in SWISS-WEBSTER MICE (DERMAL STUDY) IE ...
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RoC Profile: 2,3,7,8-Tetrachlorodibenzo-p-dioxin; 15th RoC 2021 154KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tetrachlorodibenzodioxin.pdf
CAS No. 1746-01-6 Known to be a human carcinogen First listed in the Second Annual Report on Carcinogens (1981) Also known as dioxin, TCDD, or 2,3,7,8-TCDD O O Cl Cl Cl Cl ...
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Abstract for TR-521 77KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr521
Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) in Female Harlan Sprague-Dawley Rats (Gavage Studies) CASRN: 1746-01-6 Chemical Formula: ...
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Abstract for TR-201 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr201
CASRN: 1746-01-6 Chemical Formula: C12H4Cl4O2 Molecular Weight: 322 Synonyms/Common Names: 2,3,7,8-TCDD; TCDD Report Date: February 1982 Full Report PDF Abstract ...
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Abstract for TR-526 77KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr526
of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD), 2,3,4,7,8-Pentachlorodibenzofuran ... Substances: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CASRN 1746-01-6) ...
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Abstract for TR-209 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/200s/tr209
and B6C3F1 Mice (Gavage Study) CASRN: 1746-01-6 Chemical Formula: C12H4Cl4O2 Molecular Weight: 322 Synonyms/Common Names: 2,3,7,8-TCDD; TCDD Report Date: February 1982 Full ...
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2,3,7,8-Tetrachlorodibenzo-p-dioxin: Target Organs and Levels... 57KB
https://ntp.niehs.nih.gov/data/tr/200s/tr201levels
1746-01-6) in Swiss-Webster Mice (Dermal Study) Chemical (Study Title) CASRN Peer Review Date Route/Exposure Levels Study Laboratory 2,3,7,8-Tetrachlorodibenzo-p-dioxin 1746-01-6 ...
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2,3,7,8-Tetrachlorodibenzo-p-dioxin: Target Organs and Levels... 58KB
https://ntp.niehs.nih.gov/data/tr/200s/tr209levels
Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in ... 2,3,7,8-Tetrachlorodibenzo-p-dioxin 1746-01-6 06/27/1980 Gavage R&MM: 0,.01,.05,.5 UG/...
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Abstract for TR-529 71KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr529
Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) ... actions similar to TCDD are commonly referred to as "dioxin-like compounds" (DLCs). ...
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Abstract for TR-520 76KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr520
Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) ... actions similar to TCDD are commonly referred to as "dioxin-like compounds" (DLCs). ...
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Minutes: BSC TRRS; Feb. 17, 2004 661KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2004/feb/trrs17feb2004mins_508.pdf
2 2,3,7,8-Tetrachlorobenzo-p-dioxin (TCDD)............ 4 Dioxin Mixture (TCDD, PeCDF, PCB 126)......
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Abstract for TR-530 82KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr530
Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) ... actions similar to TCDD are commonly referred to as "dioxin-like compounds" (DLCs). ...
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Abstract for TR-531 82KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr531
Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) ... actions similar to TCDD are commonly referred to as "dioxin-like compounds" (DLCs). ...
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Abstract for TR-525 75KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr525
Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) ... actions similar to TCDD are commonly referred to as "dioxin-like compounds" (DLCs). ...
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Abstract for TR-559 71KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr559
Polyhalogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) ... actions similar to TCDD are commonly referred to as "dioxin-like compounds" (DLCs). ...
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Target Organs and Levels of Evidence for TR-521 58KB
https://ntp.niehs.nih.gov/data/tr/500s/tr521levels
Target Organs and Levels of Evidence for TR-521 Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CASRN 1746-01-6) in Female Harlan ...
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Abstract for ORST800001 59KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/orst80001
and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) toxicity in C57BL/6 mice: Reproduction ...7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproduction and fertility of treated male mice. ...
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Abstract for TOX-77 69KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox077
Its structural resemblance to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), ability to activate the aryl hydrocarbon (Ah) receptor, TCDD-like toxicities, and bioaccumulative nature ...
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TR-520: 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465... 16.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr520.pdf
... as 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate ... actions similar to TCDD are com- monly referred to as "dioxin-like compounds" (DLCs). ...
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TR-525: 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117... 7.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr525.pdf
... as 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate ... actions similar to TCDD are commonly referred to as "dioxin-like compounds" (DLCs). ...
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TR-531: a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl ... 12.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr531.pdf
... as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate ... actions similar to TCDD are com- monly referred to as "dioxin-like compounds" (DLCs). ...
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TR-559: 2,3',4,4',5-Pentachlorobiphenyl (PCB 118)(CASRN 31508... 6.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr559.pdf
... Polyhalogenated aromatic hydrocarbons such as 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) ... actions similar to TCDD are commonly referred to as "dioxin-like compounds" (DLCs). ...
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TR-530: a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl ... 13.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr530.pdf
... as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate ... actions similar to TCDD are com- monly referred to as "dioxin-like compounds" (DLCs). ...
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TR-529: 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065... 7.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr529.pdf
... as 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) have the ability to bind to and activate ... actions similar to TCDD are commonly referred to as "dioxin-like compounds" (DLCs). ...
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Target Organs and Levels of Evidence for TR-526 59KB
https://ntp.niehs.nih.gov/data/tr/500s/tr526levels
Toxicology and Carcinogenesis Studies of a Mixture of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) (CASRN 1746-01-6), 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117-31-4), ...
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TOX-77: Hexachlorobenzene (CASRN 118-74-1) Administered by Gavage... 2.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox077_508.pdf
... Its structural resemblance to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), ability to activate the aryl hydrocarbon (Ah) receptor, TCDD-like toxicities, and bioaccumulative nature ...
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TR-558: 3,3',4,4'-Tetrachloroazobenzene (TCAB) (CASRN 14047-09... 22.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr558.pdf
... TCAB is structurally similar to TCDD, one of a large family of hydrocarbons containing ... Daily doses of TCDD were 10, 30, or 100 milligrams (mg) per kilogram of body weight. ...
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TOX-65: 3,3',4,4'-Tetrachloroazobenzene 2.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox065.pdf
... a Effect Concentration Inducing Effect TCDD TCAB Relative Potency for TCAB Reference ... gavage study in female B6C3F mice 1 with TCDD and TCAB 0.000003-0.00001 Hébert et al., ...
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TOX-66: 3,3',4,4'-Tetrachloroazoxybenzene 3.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox066.pdf
... a Effect Concentration Inducing Effect TCDD TCAOB Relative Potency for TCAOB Reference ... gavage study in female B6C3F mice with TCDD 1 and TCAOB 0.000003-0.00001 Hébert et ...
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RoC Profile: Pentachlorophenol and By-products of Its Synthesis... 220KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/pentachlorophenol.pdf
Dioxin (spe- cifically 2,3,7,8-tetrachlorodibenzo-p-dioxin [2,3,7,8-TCDD]) (Cogli- ano et ... phenol (and its by-product 2,3,7,8-TCDD) in the U.S. pentachlorophenol-production ...
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Session 1 Presentation Abstracts: Collaborative Workshop on Aquatic... 302KB
https://ntp.niehs.nih.gov/iccvam/meetings/aquatictox-2014/speakers-session-1-508.pdf
TCDD and AHR in the Zebrafish Heart Warren Heideman, PhD School of Pharmacy, University of Wisconsin-Madison The organisms most sensitive to dioxin (TCDD) toxicity are developing ...
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Agenda: BSC TRRS; Feb. 17-18, 2004 82KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2004/feb/trrs17feb2004agenda_508.pdf
Mary Anna Thrall, Board Chair, Colorado State University Chemical/CAS # Report Number Primary Use, Route & Species 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) /1746-01-6 TR 521 ...
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RoC Monograph: Pentachlorophenol and By-products of Its Synthesis... 2.9MB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/pentachlorophenol_508.pdf
...ctachlorodibenzo-p-dioxin, but not 2,3,7,8-TCDD, which is not a by-product of the ... pentachlorophenol also results in formation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). ...
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TR-202: a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and... 4.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr202.pdf
... 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD), the literature on HCDD is very limited ... qualitatively, the biological effects of TCDD. Toxicity appears to be partly correlated ...
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Oviduct - Necrosis - Nonneoplastic Lesion Atlas 287KB
https://ntp.niehs.nih.gov/atlas/nnl/reproductive-system-female/oviduct/Necrosis
National Toxicology Program. 2006. NTP TR-521. Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6) in Female Harlan ...
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NTP at the SOT; 2007 433KB
https://ntp.niehs.nih.gov/ntp/meetings/2007/ntpsot20070329_508.pdf
D. R. Bell U. of Nottingham, UK ssion Developmental Toxicity and Teratology: TCDD is a ... 1337 Immunotoxicology: Apoptosis and TCDD (Co-Chair) Morning Session 9:00- 12:30 ...
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TR-198: a Mixture of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin and... 7.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr198.pdf
... dioxins in the early 1970's after TCDD, a contaminant in 2,4,5-T, was found to be ... control for the room in which studies on TCDD were being carried out. (d) Vehicle ...
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Abstract for TOX-66 65KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox066
6abs Abstract for TOX-66 Toxicity Studies of 3,3',4,4'-Tetrachloroazoxybenzene Administered by Gavage to F344/N Rats and B6C3F1 Mice CASRN: 21232-47-3 Chemical Formula: C12H6Cl4N2O ...
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Abstract for TOX-65 65KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox065
65abs Abstract for TOX-65 Toxicity Studies of 3,3',4,4'-Tetrachloroazobenzene Administered by Gavage to F344/N Rats and B6C3F1 Mice CASRN: 14047-09-7 Chemical Formula: C12H6Cl4N2 ...
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Oviduct - Necrosis 311KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/female_reproductive/oviduct/necrosis/oviduct-necrosis-pdf-508.pdf
References: National Toxicology Program. 2006. NTP TR-521. Toxicology and Carcinogenesis Studies of 2,3,7,8- Tetrachlorodibenzo-p-dioxin (TCDD) (CAS No. 1746-01-6) in Female Harlan ...
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Protocol: Evaluation of Human Cancer Studies on Exposure to Pentachlor... 363KB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/protocols/pcphumanstudies20130815_508.pdf
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD has rarely been detected in commercial ... for the carcinogenicity of TCDD from studies in humans is from all cancers combined. ...
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Protocol: Evaluation of Cancer Studies in Experimental Animals... 294KB
https://ntp.niehs.nih.gov/ntp/roc/thirteenth/protocols/pcpanimalcancer20130815_508.pdf
... determine biological potencies relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). ... A number of potential chemicals with dioxin-like (2,3,7,8-TCDD) activity have been ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... Factor Evaluation of a Mixture of PCB 126, TCDD, and PeCDF TEFDIOXINMIX NT Chemical Not ... of 2,3,7,8- Tetrachlorodibenzo-p-dioxin (TCDD) 1746-01-6 NT Chemical Not Tested in ...
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Presentation: Adverse Outcome Pathway (AOP) for Sustained Aryl... 822KB
https://ntp.niehs.nih.gov/iccvam/meetings/aop-wksp-2014/presentations/simon-508.pdf
... Poorly metabolized or persistent chemicals (e.g., TCDD) produce tumors . How to quantify ... was similar at 14, 31 and 53 weeks in three NTP bioassays for TCDD, 4-PeCDF and PCB126. . ...
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Peer Review Report: RoC Peer Review; Dec. 12-13, 2013 287KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2013/december/peerreviewrpt20131213_508.pdf
... Golden commented that although 2,3,7,8-tetrachlorodibenzodioxin (TCDD) is not considered a ... He stated that even in studies where it was assumed that there was no TCDD exposure, there ...
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Abstract for TR-558 90KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr558
to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and the potential for human exposure from the consumption of crops contaminated with 3,4-;dichloroaniline-derived herbicides. ...
