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Monograph: Perfluorooctanoic Acid or Perfluorooctane Sulfonate... 7.8MB
https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/pfoa_pfosmonograph_508.pdf
ACID (PFOA) OR PERFLUOROOCTANE SULFONATE (PFOS) September, 2016 Office of Health ... Associated with Exposure to PFOA or PFOS II TABLE OF CONTENTS Table of Contents ...
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Literature Search Results for the Systematic Review of Immunotoxicity... 419KB
https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/literaturesearch_201605_508.pdf
ACID (PFOA) OR PERFLUOROOCTANE SULFONATE (PFOS) May 2016 (updated for results of ... Associated with Exposure to PFOA or PFOS 2 LITERATURE SEARCH RESULTS Literature ...
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OHAT Protocol to Evaluate the Evidence for an Association Between... 1.7MB
https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/protocol_201506_508.pdf
PFOS Exposure and Immunotoxicity Page 1 of 70 PROTOCOL TO EVALUATE THE EVIDENCE FOR AN ASSOCIATION BETWEEN PERFLUOROOCTANOIC ACID (PFOA) OR PERFLUOROOCTANE SULFONATE (PFOS) ...
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Appendix 2: Guidance for Assessing Risk Of Bias in the Protocol... 500KB
https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/appendix_2_pfoa_pfos_riskofbias.pdf
Draft (April 9, 2013) Risk of Bias Tool for Evaluation of PFOA or PFOS Exposure and ... for an Association Between PFOA and PFOS Exposure and Immunotoxicity OHAT Risk of ...
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Protocol for Systematic Review to Evaluate the Evidence for an... 1.6MB
https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/pfos_pfoa_immuneprotocoldraft.pdf
ACID (PFOA) OR PERFLUROOCTANE SULFONATE (PFOS) EXPOSURE AND IMMUNOTOXICITY April 9 2013 ... Draft (April 9, 2013) Evaluation of PFOA or PFOS Exposure and Immunotoxicity ii TABLE OF ...
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Peer Review Report: Draft NTP Monograph on Immunotoxicity Associated... 206KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2016/july/peerreviewdraftmonographpfoa_pfos20160719.pdf
Sulfonate (PFOS) July 19, 2016 Peer Review Report - July 19, 2016 Peer Review of Draft NTP Monograph on Immunotoxicity Associated with Exposure to PFOA or PFOS Table of ...
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Integrating Bayesian Approaches with PBPK Modeling in a Human... 2.1MB
https://ntp.niehs.nih.gov/iccvam/meetings/popvar-2022/ppt/05_chou_508.pdf
Case Study with Perfluorooctane Sulfonate (PFOS) Wei-Chun Chou Center for Environmental ... PFOA and PFOS are two of most widespread PFAS PFAS: Per- and polyfluoroalkyl substances ...
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Public Comment: Draft OHAT Approach; Dr. Nancy Beck and Dr. Kimberly... 553KB
https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/beck20130611_508be.pdf
and BPA and PFOA/PFOS Protocols for Systematic Review and Evidence Integration Dear Dr. ... Acid (PFOA) or Perfluorooctane Sulfonate (PFOS) Exposure and Immunotoxicity (the draft ...
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TOX-96: Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane... 6.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox096_508.pdf
... Perfluorooctane Sulfonic Acid (PFOS) ......and perfluorooctane sulfonic acid [PFOS], and four carboxylates) via gavage in ...
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Public Comment: Draft OHAT Approach; Dr. Jennifer McPartland... 344KB
https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/mcpartland20130611_508.pdf
between Perfluorooctanoic acid (PFOA) Or Perfluorooctane Sulfonate (PFOS) Exposure and Immunotoxicity (PFOA/PFOS case study), 2 and Draft Protocol for Systematic Review to Evaluate ...
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Immunotoxicity Associated with Exposure to Perfluorooctanoic... 69KB
https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/completed/pfoa
Acid (PFOA) or Perfluorooctane Sulfonate (PFOS) commercial and industrial applications of PFOA Topic Overview CASRN: 335-67-1; 1763-23-1 Status: Evaluation completed Background ...
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Per- and Polyfluoroalkyl Substances (PFAS) 80KB
https://ntp.niehs.nih.gov/whatwestudy/topics/pfas
(8:2 FTOH) Perfluorooctane sulfonic acid (PFOS) Perfluorobutane sulfonic acid (PFBS) ... In human cell lines, exposure to PFOA and PFOS suppressed the release of a certain type ...
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Abstract for TOX-96 85KB
https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox096
Perfluorooctane sulfonic acid (CASRN 1763-23-1) WY-14643 (CASRN 50892-23-4) Report ... and perfluorooctane sulfonic acid [PFOS], and four carboxylates) via gavage in ...
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Draft Handbook for Conducting a Literature-Based Health Assessment... 4.4MB
https://ntp.niehs.nih.gov/ntp/ohat/pubs/handbookdraftmarch2019.pdf
... 3: Example of an Evidence Profile Table: PFOS/PFOA and Functional Antibody Response ... Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) PECO Human Participants Humans without ...
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Handbook for Conducting a Literature-Based Health Assessment... 4.3MB
https://ntp.niehs.nih.gov/ntp/ohat/pubs/handbookmarch2019_508.pdf
... 3: Example of an Evidence Profile Table: PFOS/PFOA and Functional Antibody Response ... Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) PECO Human Participants Humans without ...
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Handbook for Conducting a Literature-Based Health Assessment... 4.3MB
https://ntp.niehs.nih.gov/ntp/ohat/pubs/handbookjan2015_508.pdf
... 3: Example of an Evidence Profile Table: PFOS/PFOA and Functional Antibody Response ... Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) PECO Human Participants Humans without ...
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Public Comments on Draft OHAT Approach-February 2013 for Systematic... 62KB
https://ntp.niehs.nih.gov/events/webinars-workshops/2013/draft/comments
Approach - February 2013. Two protocols are being released to illustrate the application of this framework: BPA exposure and obesity and PFOA or PFOS exposure and immunotoxicity. ...
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Public Comment: Draft OHAT Approach; Dr. Tracey Woodruff; Feb... 775KB
https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/woodruff20130611_508.pdf
protocols (bisphenol A exposure and obesity, and PFOA & PFOS exposure and immunotoxicity). ... See (www.camarades.info); (5) We note that the BPA and PFOS/PFOA protocols include a step ...
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NTP Studies of Per-and Poly-fluoroalkyl Substances: Understanding... 504KB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2020/february/presentations/06blystone_bsc_508.pdf
Manufacturers agreed to discontinue use of PFOA and PFOS due to widespread exposure and ... NHANES PFAS (Geometric Mean) Years Serum [nM] PFOS (1) PFOA (2) PFHxS (3) PFNA PFDA PFuDA ...
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Monograph Peer Review Actions; July 19, 2016 78KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2016/july/actions20160719_508.pdf
with Exposure to Perfluorooctanoic Acid (PFOA) or Perfluorooctane Sulfonate (PFOS). ... associated with exposure to PFOA or PFOS. The Panel's recommendations do not ...
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Minutes: BSC; December 14-15, 2016 348KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2016/december/minutes20161214_508.pdf
... Associated with Exposure to PFOA or PFOS ...... 14 A. Presentation ... on Carcinogens PFOA perfluorooctanoic acid PFOS perfluorooctane sulfonate REACH ...
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Minutes: BSC; Dec. 9-10, 2014 270KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2014/dec/bsc_dec2014_minutes_508.pdf
... chemicals PFOA perfluorooctanoic acid PFOS perfluorooctane sulfonate RoC Report on ... with Exposure to Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) Dr. ...
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Public Health Impact 1.5MB
https://ntp.niehs.nih.gov/media/impact
... perfluorooctanesulfonic acid (PFOS), perfluorobutanesulfonic acid ... Park, NC. https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/pfoa_pfosmonograph_508.pdf NTP (National ...
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ICCVAM PFAS WG (SACATM Meeting 2023) 2.3MB
https://ntp.niehs.nih.gov/sites/default/files/2023-11/11_Vinas_SACATM2023_508.pdf
(PFOA) and perfluorooctane sulfonic acid (PFOS), which are currently under regulation ... PFOA PFOS 2 Blake and Fenton, 2020 Toxicology . The Report to Congress provides a high- ...
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Agenda: Webinar on Lessons Learned in Application of the OHAT... 78KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/evaluationprocess/agendawebinar20140731_508.pdf
for two case studies, BPA and obesity and PFOA/PFOS and immunotoxicity, which the Office of Health Assessment and Translation (OHAT) planned to undertake using the OHAT approach. ...
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ChemMaps.com V2 - Exploring the Environmental Chemical UniverseNICEATM... 5.6MB
https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-borrel-poster.pdf
Perfluorooctanoic acid Perfluorooctanesulfonic acid (PFOS) DTXSID40896601 Molecular ... Perfluorooctanoic acid (PFOA) PFAS DTXSID40896601 PFOS (user uploaded chemical) Molecular ...
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Safe and Sustainable Alternatives Program; Stephen Ferguson;... 3.2MB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2021/august/presentations/ssa_bsc_presentation_508.pdf
PBB flame retardants PBDE flame retardants OP flame retardants PFOS/PFOA GenX PFAS ... PFAS per- and polyfluoroalkyl substances PFOA perfluorooctanoic acid PFOS ...
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REACT Program; Michael DeVito; BSC; Dec. 7-8, 2017 88KB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2017/december/meetingmaterials/devito_react_508.pdf
acid (PFOA) and perfluorooctane sulfonate (PFOS). Due to their toxicity, persistence and bioaccumulation, PFOA and PFOS have been replaced by other PFAS. It is estimated ...
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Public Comment: Draft OHAT Approach; Dr. Jennifer Sass, Dr. Adam... 154KB
https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/sassetal20130611_508.pdf
- February 2013. The NTP included two protocols illustrate the application of this framework: (1) BPA exposure and obesity and (2) PFOA or PFOS exposure and immunotoxicity. ...
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NTP Studies of Per- and Poly-fluoroalkyl Substances: Understanding... 151KB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2020/february/meeting_materials/4blystone_bsc_508.pdf
based systematic review of PFOA and perfluorooctane sulfonate (PFOS) and immunotoxicity. ... associated with exposure to PFOA and PFOS. Based upon the available scientific ...
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NTP 2014: Current Directions & Evolving Strategies 3.3MB
https://ntp.niehs.nih.gov/ntp/pubs/currentdirections2014_508.pdf
Ethers PFOA Perfluorooctanoic Acid PFOS Perfluorooctane Sulfonate RoC Report on ... Perfluorinated compounds Perfluorinated compounds such as perfluorooctane sulfonate (PFOS) ...
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Research Concept for Perfluorinated Compounds Class ; July 8... 78KB
https://ntp.niehs.nih.gov/ntp/noms/final_resconcept/pfoaconcept_508.pdf
Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA), the most widely studied ... Because the developing organism is the primary target of PFOA and PFOS and because ...
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Minutes: BSC; February 21, 2020 163KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2020/february/minutesbsc20200221_508.pdf
... substances PFOA perfluorooctanoic acid PFOS perfluorooctanesulfonic acid RFR radio ... and perfluorooctanesulfonic acid (PFOS) due to widespread exposure and health concerns. ...
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Agenda: Peer Review of Draft Monograph; July 2016 262KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2016/july/agendapfoa_pfos_508.pdf
Acid (PFOA) or Perfluorooctane Sulfonate (PFOS) Agenda Rodbell Auditorium, Rall Building ... Chiu Discussion of Overall Conclusion Dr. Chiu Action Panel Draft NTP Monograph: PFOS ...
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Presentation: Draft OHAT Approach Part 1 Preparing the Topic... 2.5MB
https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/presentations/april2013/parti_boyles20130423_508.pdf
and Secondary Outcomes Example - PFOA/PFOS Exposure and Immunotoxicity Humans ... and Secondary Outcomes Example - PFOA/PFOS Exposure and Immunotoxicity Humans ...
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Presentation: Draft OHAT Approach Part 2 Confidence in the Body... 2.4MB
https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/presentations/april2013/partii_rooney20130423_508.pdf
... by Other Relevant Studies: PFOA/PFOS and Immunotoxicity Assessment of Biological Plausibility Provided by Other Relevant Studies: PFOA/PFOS and Immunotoxicity Factors ...
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Informational Meeting on the Draft OHAT Approach for Systematic... 62KB
https://ntp.niehs.nih.gov/events/webinars-workshops/2013/draft
Acid (PFOA) or Perflurooctane Sulfonate (PFOS) Exposure and Immunotoxicity Appendix 2: Risk of Bias Guidance for PFOA or PFOS Exposure and Immunotoxicity Protocol Register ...
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TOX-97: Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexa... 8.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox097_508.pdf
... Sulfonate Potassium Salt 3871-99-6 PFHSK 96 Perfluorooctane Sulfonic Acid 1763-23-1 PFOS 96 Perfluorohexanoic Acid 307-24-4 PFHxA 97 Perfluorooctanoic Acid 335-67-1 PFOA 97 ...
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Minutes: BSC; Oct. 9, 2018 718KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2018/october/minutes20181009_508.pdf
... alkyl substances PFCs perfluorinated compounds PFOA perfluorooctanoic acid PFOS perfluorooctane sulfonate PoD point of departure QSARs quantitative structure-activity ...
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Minutes: BSC; June 29, 2017 285KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2017/june/minutes20170629_508.pdf
... alkylated substances PFC perfluorinated chemicals PFOA perfluorooctanoic acid PFOS perfluorooctane sulfonate QSARs quantitative structure-activity relationship models ...
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Minutes: BSC; June 20, 2018 348KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2018/june/minutes20180620_508.pdf
... alkyl substances PFCs perfluorinated compounds PFOA perfluorooctanoic acid PFOS perfluorooctane sulfonate PoD point of departure QSARs quantitative structure-activity ...
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Presentation: Setting the Stage: Purpose, Definitions, Scope... 2.1MB
https://ntp.niehs.nih.gov/iccvam/meetings/ivive-wksp-2016/webinar-slides/1-wetmore-07oct2015-fd-508.pdf
... 0.36 2.00 0.44 Parathion 0.17 2.48 2.56 PFOS 19,990 f 153.23 f 171.51 f PFOA 20,120 f ... 0.36 2.00 0.44 Parathion 0.17 2.48 2.56 PFOS 19,990 f 153.23 f 171.51 f PFOA 20,120 f ...
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Minutes: BSC; Nov. 30-Dec. 1, 2010 984KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2010/novdec/minutes20101201.pdf
... the Ethical Treatment of Animals PFAA perfluoroalkyl acids PFOA perfluorooctanoic acid PFOS perfluorooctanesulfonic acid ppm parts per million QC quality control qHTS quantitative ...
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Summary Minutes December 7-8, 2017 NTP Board of Scientific Counselors 352KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2017/december/minutes20171208_508.pdf
... alkylated substances PFC perfluorinated chemicals PFOA perfluorooctanoic acid PFOS perfluorooctane sulfonate PoD point of departure QSARs quantitative structure-activity ...
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Webinar on the OHAT Approach for Systematic Review; Andrew Rooney... 814KB
https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/webinar_slides20130926_508.pdf
... Case studies to evaluate OHAT Approach or "Framework" - PFOA / PFOS exposure and ... Screening studies nearing completion Case-study Progress : PFOA/PFOS and Immunotoxicity ...
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Acronyms & Abbreviations 80KB
https://ntp.niehs.nih.gov/support/acronyms
... exposure limit PFOA Perfluorooctanoic acid PFOS Perfluorooctane sulfonate PHS Public Health Service Phy-Ab Physically Abnormal PISC PETA International Science Consortium, Ltd. ...
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Building Confidence in Larval Zebrafish Behavior Assays: From... 3.3MB
https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2023/20230130-iccvam-cop-tal-508.pdf
... Sebastian Gutsfeld Ifeoluwa Omoyeni Novel AOP for developmental neurotoxicity 42 www.ufz.de PFOS PFHxS ppara ppard pparg KE x Visual Startle Response (VSR) hyperactivity Ke x+1 ...
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Public Comment: Draft OHAT Approach; Dr. Martin Stephens; Feb... 178KB
https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/stephens20130611_508.pdf
... Is the other evidence ( with lower levels of confidence) d isregarded? This would be contrary to the spirit of EBM/HC. 6. Peer review (see, for e xample, PFOS/PFOA draft p rotocol, ...
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Safe and Sustainable Alternatives Program; BSC; Aug. 4, 2021 240KB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2021/august/meeting_materials/ssa_bsc_508.pdf
(e.g., perfluorooctanesulfonic acid (PFOS) has been associated with thyroid ... acid] PFOS dose-range finding (DRF) and MOG Rat and Mouse study report in 2022 . ...
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Comment: Fluoride; Paul Connett; Fluoride Action Network; BSC... 2.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/publiccomm/connett20230428_bsc_508.pdf
... 2 50 2 00 150 E 100 ::, z 5 0 0 humans flu orid e PFO A B D E--47 a ir po llutio n Chemical American Environmental Health Studies Project ';:?) fl~~~}~~t~~.~ T.ORG ~lowriskofbias . ...