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58 results found for "1763-23-1".
  1. Monograph: Perfluorooctanoic Acid or Perfluorooctane Sulfonate... 7.8MB

    https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/pfoa_pfosmonograph_508.pdf

    ACID (PFOA) OR PERFLUOROOCTANE SULFONATE (PFOS) September, 2016 Office of Health ... Associated with Exposure to PFOA or PFOS II TABLE OF CONTENTS Table of Contents ...

  2. Literature Search Results for the Systematic Review of Immunotoxicity... 419KB

    https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/literaturesearch_201605_508.pdf

    ACID (PFOA) OR PERFLUOROOCTANE SULFONATE (PFOS) May 2016 (updated for results of ... Associated with Exposure to PFOA or PFOS 2 LITERATURE SEARCH RESULTS Literature ...

  3. OHAT Protocol to Evaluate the Evidence for an Association Between... 1.7MB

    https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/protocol_201506_508.pdf

    PFOS Exposure and Immunotoxicity Page 1 of 70 PROTOCOL TO EVALUATE THE EVIDENCE FOR AN ASSOCIATION BETWEEN PERFLUOROOCTANOIC ACID (PFOA) OR PERFLUOROOCTANE SULFONATE (PFOS) ...

  4. Appendix 2: Guidance for Assessing Risk Of Bias in the Protocol... 500KB

    https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/appendix_2_pfoa_pfos_riskofbias.pdf

    Draft (April 9, 2013) Risk of Bias Tool for Evaluation of PFOA or PFOS Exposure and ... for an Association Between PFOA and PFOS Exposure and Immunotoxicity OHAT Risk of ...

  5. Protocol for Systematic Review to Evaluate the Evidence for an... 1.6MB

    https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/pfos_pfoa_immuneprotocoldraft.pdf

    ACID (PFOA) OR PERFLUROOCTANE SULFONATE (PFOS) EXPOSURE AND IMMUNOTOXICITY April 9 2013 ... Draft (April 9, 2013) Evaluation of PFOA or PFOS Exposure and Immunotoxicity ii TABLE OF ...

  6. Peer Review Report: Draft NTP Monograph on Immunotoxicity Associated... 206KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2016/july/peerreviewdraftmonographpfoa_pfos20160719.pdf

    Sulfonate (PFOS) July 19, 2016 Peer Review Report - July 19, 2016 Peer Review of Draft NTP Monograph on Immunotoxicity Associated with Exposure to PFOA or PFOS Table of ...

  7. Integrating Bayesian Approaches with PBPK Modeling in a Human... 2.1MB

    https://ntp.niehs.nih.gov/iccvam/meetings/popvar-2022/ppt/05_chou_508.pdf

    Case Study with Perfluorooctane Sulfonate (PFOS) Wei-Chun Chou Center for Environmental ... PFOA and PFOS are two of most widespread PFAS PFAS: Per- and polyfluoroalkyl substances ...

  8. Public Comment: Draft OHAT Approach; Dr. Nancy Beck and Dr. Kimberly... 553KB

    https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/beck20130611_508be.pdf

    and BPA and PFOA/PFOS Protocols for Systematic Review and Evidence Integration Dear Dr. ... Acid (PFOA) or Perfluorooctane Sulfonate (PFOS) Exposure and Immunotoxicity (the draft ...

  9. TOX-96: Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane... 6.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox096_508.pdf

    ... Perfluorooctane Sulfonic Acid (PFOS) ......and perfluorooctane sulfonic acid [PFOS], and four carboxylates) via gavage in ...

  10. Public Comment: Draft OHAT Approach; Dr. Jennifer McPartland... 344KB

    https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/mcpartland20130611_508.pdf

    between Perfluorooctanoic acid (PFOA) Or Perfluorooctane Sulfonate (PFOS) Exposure and Immunotoxicity (PFOA/PFOS case study), 2 and Draft Protocol for Systematic Review to Evaluate ...

  11. Immunotoxicity Associated with Exposure to Perfluorooctanoic... 69KB

    https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/completed/pfoa

    Acid (PFOA) or Perfluorooctane Sulfonate (PFOS) commercial and industrial applications of PFOA Topic Overview CASRN: 335-67-1; 1763-23-1 Status: Evaluation completed Background ...

  12. Per- and Polyfluoroalkyl Substances (PFAS) 80KB

    https://ntp.niehs.nih.gov/whatwestudy/topics/pfas

    (8:2 FTOH) Perfluorooctane sulfonic acid (PFOS) Perfluorobutane sulfonic acid (PFBS) ... In human cell lines, exposure to PFOA and PFOS suppressed the release of a certain type ...

  13. Abstract for TOX-96 85KB

    https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox096

    Perfluorooctane sulfonic acid (CASRN 1763-23-1) WY-14643 (CASRN 50892-23-4) Report ... and perfluorooctane sulfonic acid [PFOS], and four carboxylates) via gavage in ...

  14. Draft Handbook for Conducting a Literature-Based Health Assessment... 4.4MB

    https://ntp.niehs.nih.gov/ntp/ohat/pubs/handbookdraftmarch2019.pdf

    ... 3: Example of an Evidence Profile Table: PFOS/PFOA and Functional Antibody Response ... Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) PECO Human Participants Humans without ...

  15. Handbook for Conducting a Literature-Based Health Assessment... 4.3MB

    https://ntp.niehs.nih.gov/ntp/ohat/pubs/handbookmarch2019_508.pdf

    ... 3: Example of an Evidence Profile Table: PFOS/PFOA and Functional Antibody Response ... Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) PECO Human Participants Humans without ...

  16. Handbook for Conducting a Literature-Based Health Assessment... 4.3MB

    https://ntp.niehs.nih.gov/ntp/ohat/pubs/handbookjan2015_508.pdf

    ... 3: Example of an Evidence Profile Table: PFOS/PFOA and Functional Antibody Response ... Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) PECO Human Participants Humans without ...

  17. Public Comments on Draft OHAT Approach-February 2013 for Systematic... 62KB

    https://ntp.niehs.nih.gov/events/webinars-workshops/2013/draft/comments

    Approach - February 2013. Two protocols are being released to illustrate the application of this framework: BPA exposure and obesity and PFOA or PFOS exposure and immunotoxicity. ...

  18. Public Comment: Draft OHAT Approach; Dr. Tracey Woodruff; Feb... 775KB

    https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/woodruff20130611_508.pdf

    protocols (bisphenol A exposure and obesity, and PFOA & PFOS exposure and immunotoxicity). ... See (www.camarades.info); (5) We note that the BPA and PFOS/PFOA protocols include a step ...

  19. NTP Studies of Per-and Poly-fluoroalkyl Substances: Understanding... 504KB

    https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2020/february/presentations/06blystone_bsc_508.pdf

    Manufacturers agreed to discontinue use of PFOA and PFOS due to widespread exposure and ... NHANES PFAS (Geometric Mean) Years Serum [nM] PFOS (1) PFOA (2) PFHxS (3) PFNA PFDA PFuDA ...

  20. Monograph Peer Review Actions; July 19, 2016 78KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2016/july/actions20160719_508.pdf

    with Exposure to Perfluorooctanoic Acid (PFOA) or Perfluorooctane Sulfonate (PFOS). ... associated with exposure to PFOA or PFOS. The Panel's recommendations do not ...

  21. Minutes: BSC; December 14-15, 2016 348KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2016/december/minutes20161214_508.pdf

    ... Associated with Exposure to PFOA or PFOS ...... 14 A. Presentation ... on Carcinogens PFOA perfluorooctanoic acid PFOS perfluorooctane sulfonate REACH ...

  22. Minutes: BSC; Dec. 9-10, 2014 270KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2014/dec/bsc_dec2014_minutes_508.pdf

    ... chemicals PFOA perfluorooctanoic acid PFOS perfluorooctane sulfonate RoC Report on ... with Exposure to Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) Dr. ...

  23. Public Health Impact 1.5MB

    https://ntp.niehs.nih.gov/media/impact

    ... perfluorooctanesulfonic acid (PFOS), perfluorobutanesulfonic acid ... Park, NC. https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/pfoa_pfosmonograph_508.pdf NTP (National ...

  24. ICCVAM PFAS WG (SACATM Meeting 2023) 2.3MB

    https://ntp.niehs.nih.gov/sites/default/files/2023-11/11_Vinas_SACATM2023_508.pdf

    (PFOA) and perfluorooctane sulfonic acid (PFOS), which are currently under regulation ... PFOA PFOS 2 Blake and Fenton, 2020 Toxicology . The Report to Congress provides a high- ...

  25. Agenda: Webinar on Lessons Learned in Application of the OHAT... 78KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/evaluationprocess/agendawebinar20140731_508.pdf

    for two case studies, BPA and obesity and PFOA/PFOS and immunotoxicity, which the Office of Health Assessment and Translation (OHAT) planned to undertake using the OHAT approach. ...

  26. ChemMaps.com V2 - Exploring the Environmental Chemical UniverseNICEATM... 5.6MB

    https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-borrel-poster.pdf

    Perfluorooctanoic acid Perfluorooctanesulfonic acid (PFOS) DTXSID40896601 Molecular ... Perfluorooctanoic acid (PFOA) PFAS DTXSID40896601 PFOS (user uploaded chemical) Molecular ...

  27. Safe and Sustainable Alternatives Program; Stephen Ferguson;... 3.2MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2021/august/presentations/ssa_bsc_presentation_508.pdf

    PBB flame retardants PBDE flame retardants OP flame retardants PFOS/PFOA GenX PFAS ... PFAS per- and polyfluoroalkyl substances PFOA perfluorooctanoic acid PFOS ...

  28. REACT Program; Michael DeVito; BSC; Dec. 7-8, 2017 88KB

    https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2017/december/meetingmaterials/devito_react_508.pdf

    acid (PFOA) and perfluorooctane sulfonate (PFOS). Due to their toxicity, persistence and bioaccumulation, PFOA and PFOS have been replaced by other PFAS. It is estimated ...

  29. Public Comment: Draft OHAT Approach; Dr. Jennifer Sass, Dr. Adam... 154KB

    https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/sassetal20130611_508.pdf

    - February 2013. The NTP included two protocols illustrate the application of this framework: (1) BPA exposure and obesity and (2) PFOA or PFOS exposure and immunotoxicity. ...

  30. NTP Studies of Per- and Poly-fluoroalkyl Substances: Understanding... 151KB

    https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2020/february/meeting_materials/4blystone_bsc_508.pdf

    based systematic review of PFOA and perfluorooctane sulfonate (PFOS) and immunotoxicity. ... associated with exposure to PFOA and PFOS. Based upon the available scientific ...

  31. NTP 2014: Current Directions & Evolving Strategies 3.3MB

    https://ntp.niehs.nih.gov/ntp/pubs/currentdirections2014_508.pdf

    Ethers PFOA Perfluorooctanoic Acid PFOS Perfluorooctane Sulfonate RoC Report on ... Perfluorinated compounds Perfluorinated compounds such as perfluorooctane sulfonate (PFOS) ...

  32. Research Concept for Perfluorinated Compounds Class ; July 8... 78KB

    https://ntp.niehs.nih.gov/ntp/noms/final_resconcept/pfoaconcept_508.pdf

    Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA), the most widely studied ... Because the developing organism is the primary target of PFOA and PFOS and because ...

  33. Minutes: BSC; February 21, 2020 163KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2020/february/minutesbsc20200221_508.pdf

    ... substances PFOA perfluorooctanoic acid PFOS perfluorooctanesulfonic acid RFR radio ... and perfluorooctanesulfonic acid (PFOS) due to widespread exposure and health concerns. ...

  34. Agenda: Peer Review of Draft Monograph; July 2016 262KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2016/july/agendapfoa_pfos_508.pdf

    Acid (PFOA) or Perfluorooctane Sulfonate (PFOS) Agenda Rodbell Auditorium, Rall Building ... Chiu Discussion of Overall Conclusion Dr. Chiu Action Panel Draft NTP Monograph: PFOS ...

  35. Presentation: Draft OHAT Approach Part 1 Preparing the Topic... 2.5MB

    https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/presentations/april2013/parti_boyles20130423_508.pdf

    and Secondary Outcomes Example - PFOA/PFOS Exposure and Immunotoxicity Humans ... and Secondary Outcomes Example - PFOA/PFOS Exposure and Immunotoxicity Humans ...

  36. Presentation: Draft OHAT Approach Part 2 Confidence in the Body... 2.4MB

    https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/presentations/april2013/partii_rooney20130423_508.pdf

    ... by Other Relevant Studies: PFOA/PFOS and Immunotoxicity Assessment of Biological Plausibility Provided by Other Relevant Studies: PFOA/PFOS and Immunotoxicity Factors ...

  37. Informational Meeting on the Draft OHAT Approach for Systematic... 62KB

    https://ntp.niehs.nih.gov/events/webinars-workshops/2013/draft

    Acid (PFOA) or Perflurooctane Sulfonate (PFOS) Exposure and Immunotoxicity Appendix 2: Risk of Bias Guidance for PFOA or PFOS Exposure and Immunotoxicity Protocol Register ...

  38. TOX-97: Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexa... 8.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox097_508.pdf

    ... Sulfonate Potassium Salt 3871-99-6 PFHSK 96 Perfluorooctane Sulfonic Acid 1763-23-1 PFOS 96 Perfluorohexanoic Acid 307-24-4 PFHxA 97 Perfluorooctanoic Acid 335-67-1 PFOA 97 ...

  39. Minutes: BSC; Oct. 9, 2018 718KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2018/october/minutes20181009_508.pdf

    ... alkyl substances PFCs perfluorinated compounds PFOA perfluorooctanoic acid PFOS perfluorooctane sulfonate PoD point of departure QSARs quantitative structure-activity ...

  40. Minutes: BSC; June 29, 2017 285KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2017/june/minutes20170629_508.pdf

    ... alkylated substances PFC perfluorinated chemicals PFOA perfluorooctanoic acid PFOS perfluorooctane sulfonate QSARs quantitative structure-activity relationship models ...

  41. Minutes: BSC; June 20, 2018 348KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2018/june/minutes20180620_508.pdf

    ... alkyl substances PFCs perfluorinated compounds PFOA perfluorooctanoic acid PFOS perfluorooctane sulfonate PoD point of departure QSARs quantitative structure-activity ...

  42. Presentation: Setting the Stage: Purpose, Definitions, Scope... 2.1MB

    https://ntp.niehs.nih.gov/iccvam/meetings/ivive-wksp-2016/webinar-slides/1-wetmore-07oct2015-fd-508.pdf

    ... 0.36 2.00 0.44 Parathion 0.17 2.48 2.56 PFOS 19,990 f 153.23 f 171.51 f PFOA 20,120 f ... 0.36 2.00 0.44 Parathion 0.17 2.48 2.56 PFOS 19,990 f 153.23 f 171.51 f PFOA 20,120 f ...

  43. Minutes: BSC; Nov. 30-Dec. 1, 2010 984KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2010/novdec/minutes20101201.pdf

    ... the Ethical Treatment of Animals PFAA perfluoroalkyl acids PFOA perfluorooctanoic acid PFOS perfluorooctanesulfonic acid ppm parts per million QC quality control qHTS quantitative ...

  44. Summary Minutes December 7-8, 2017 NTP Board of Scientific Counselors 352KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2017/december/minutes20171208_508.pdf

    ... alkylated substances PFC perfluorinated chemicals PFOA perfluorooctanoic acid PFOS perfluorooctane sulfonate PoD point of departure QSARs quantitative structure-activity ...

  45. Webinar on the OHAT Approach for Systematic Review; Andrew Rooney... 814KB

    https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/webinar_slides20130926_508.pdf

    ... Case studies to evaluate OHAT Approach or "Framework" - PFOA / PFOS exposure and ... Screening studies nearing completion Case-study Progress : PFOA/PFOS and Immunotoxicity ...

  46. Acronyms & Abbreviations 80KB

    https://ntp.niehs.nih.gov/support/acronyms

    ... exposure limit PFOA Perfluorooctanoic acid PFOS Perfluorooctane sulfonate PHS Public Health Service Phy-Ab Physically Abnormal PISC PETA International Science Consortium, Ltd. ...

  47. Building Confidence in Larval Zebrafish Behavior Assays: From... 3.3MB

    https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2023/20230130-iccvam-cop-tal-508.pdf

    ... Sebastian Gutsfeld Ifeoluwa Omoyeni Novel AOP for developmental neurotoxicity 42 www.ufz.de PFOS PFHxS ppara ppard pparg KE x Visual Startle Response (VSR) hyperactivity Ke x+1 ...

  48. Public Comment: Draft OHAT Approach; Dr. Martin Stephens; Feb... 178KB

    https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/stephens20130611_508.pdf

    ... Is the other evidence ( with lower levels of confidence) d isregarded? This would be contrary to the spirit of EBM/HC. 6. Peer review (see, for e xample, PFOS/PFOA draft p rotocol, ...

  49. Safe and Sustainable Alternatives Program; BSC; Aug. 4, 2021 240KB

    https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2021/august/meeting_materials/ssa_bsc_508.pdf

    (e.g., perfluorooctanesulfonic acid (PFOS) has been associated with thyroid ... acid] PFOS dose-range finding (DRF) and MOG Rat and Mouse study report in 2022 . ...

  50. Comment: Fluoride; Paul Connett; Fluoride Action Network; BSC... 2.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/publiccomm/connett20230428_bsc_508.pdf

    ... 2 50 2 00 150 E 100 ::, z 5 0 0 humans flu orid e PFO A B D E--47 a ir po llutio n Chemical American Environmental Health Studies Project ';:?) fl~~~}~~t~~.~ T.ORG ~lowriskofbias . ...

 
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