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48 results found for "1972-08-3".
  1. Abstract for TR-446 69KB

    https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr446

    CASRN: 1972-08-3 Chemical Formula: C21H30O2 Molecular Weight: 314.5 Synonyms/Common Names: ... delta9-tetrahydrocannabinon; THC; delta1-THC; delta9-THC Report Date: ...

  2. TR-446: 1-Trans-Delta9-Tetrahydrocannabinol (CASRN 1972-08-3... 16.4MB

    https://ntp.niehs.nih.gov/go/tr446

    STUDIES OF 1-TRANS-DELTA'=TETRAHYDROCANNABINOL (CAS NO. 1972-08-3) IN F344/N RATS AND ...NS-DELTA9-TETRAHYDROCANNABINOL (CAS NO. 1972-08-3) IN F344/N RATS AND B6C3Fl MICE (GAVAGE ...

  3. Target Organs and Levels of Evidence for TR-446 60KB

    https://ntp.niehs.nih.gov/data/tr/400s/tr446levels

    1972-08-3) in F344 Rats and B6C3F1 Mice (Gavage Studies) Chemical (Study Title) CASRN Peer Review Date Route/Exposure Levels Study Laboratory 1-trans-delta-9-Tetrahydrocannabinol ...

  4. Minutes: BSC TRRS; June 21, 1994 1.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1994/june/trrs21june1994mins_508.pdf

    1-Trans-Delta-9-Tetrahydroc8~abinol 1972-08-3 Gavage......studies of 1-tram-deltas-tetrahyhaanabinol(THC) by discussing the uses and rationale for ...

  5. Federal Agency Response to ICCVAM Recommendations on the LLNA 2.0MB

    https://ntp.niehs.nih.gov/iccvam/methods/immunotox/transmitjuly11/niosh-response.pdf

    ... The ICCV AM TMER also states that thc test method protocol can reduce the number of required animals per group fTom five to four, thus reducing the number of animals used in a ...

  6. TR-503: Chloral Hydrate (Ad Libitum and Dietary Controlled) ... 5.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr503.pdf

    ... Toxi- cology and Carcinogenesis Studies of 1-trans-delta 9 - Tetrahydrocannabinol (CAS No. 1972-08-3) in F344/N Rats and B6C3F 1 Mice (Gavage Studies). Technical Report Series No. ...

  7. TR-393: Sodium Fluoride (CASRN 7681-49-4)in F344/N Rats and B6C3F1Mice... 21.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr393.pdf

    ... Negacive r e s u l ~ , in which thc sludy animalsdo not have a greater incidence of neoplasia t h a n control animab, d o not neccrsarily mean that a cbcmical is not a a r c b o p ...

  8. NTP Technical Reports Index 1.5MB

    https://ntp.niehs.nih.gov/data/tr

    ... NE No Evidence NE No Evidence TR-446 06/21/94 1-Trans-Delta9-Tetrahydrocannabinol 1972-08-3 NE No Evidence NE No Evidence EE Equivocal Evidence EE Equivocal Evidence TR-445 06/...

  9. Public Health Impact 1.5MB

    https://ntp.niehs.nih.gov/media/impact

    ... and Delta-9-Tetrahydrocannabinol (Delta-9-THC) Exposure On August 4, 2022, the Office of ... The new sections address exposures to listed cannabis (marijuana) smoke and Delta-9-THC. ...

  10. TR-360: N,N-Dimethylaniline (CASRN 121-69-7) in F344/N Rats and... 10.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr360.pdf

    ... During the 2-year studies, thc dose mixtures were stored at 4" C for up to 2 weeks for ... Pharmacol. 48:A97. 27 Haseman, J.K. (1984) Statistical issues in thc design, analysis and ...

  11. MFDS NAMs Report: Regulatory Acceptance and Research Outcomes 20.5MB

    https://ntp.niehs.nih.gov/sites/default/files/2024-01/MFDS_NAMs_Report-2023-508.pdf

    ... splu:roiils .improvcd\'i.abil:i.t:y and thc lmr phtl'lolypt [ 4,5]. lmpom:rii:lr, ... Rewlts lnoubntionwitb Mctb THC, I...Yl 183240 and AB-CHFUPYCA foc2 min incre=:d the number ...

  12. TR-433: Tricresyl Phosphate (CASRN 1330-78-5) in F344/N Rats... 24.1MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr433.pdf

    ... to <)00. l.700. 3.300. or 6.1J()0 ppm and thc adrenal gland. gallbladdcr. kidney. ovary. ... lation and cyclization reactions involvcd in thc metabolism of tri-o-cresyl phosphate. ...

  13. Minutes: BSC; March 14, 1989 53.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1989/march/19890314bsc_minutes_508.pdf

    ... Currently maintained in the archive are approxiamtely 1900 unique chemicals. Thc chemical repository provides industrial hygiene support for the NTP laboratories. This support ...

  14. TR-243: Trichloroethylene (Without Epichlorohydrin) (CASRN 79... 7.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr243.pdf

    ... Not surprisingly, thc archival rccords wcrc found to bc incomplete and somctimcs ... support the data, results, and statemcnts of fact presentcd in thc Technical Report. ...

  15. TR-359: 8-Methoxypsoralen (CASRN 298-81-7) in F344/N Rats (Gavage... 7.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr359.pdf

    ... The cells were then harvested by mitotic shake-off, fixed, and stained with Giemsa. For thc chromosomal aberration test with S9,cells were treated with the study chemical and S9 ...

  16. TR-391: Tris(2-chloroethyl) Phosphate (CASRN 115-96-8) in F344... 11.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr391.pdf

    ... FIGURE 4a. Focal renal tubule hyperplasia (arrow) in thc kidney o f a given 88 mghg tris(Zch1oroethyl) phosphate. (HSrE, x60) FIGURE 4c. Renal tubule carcinoma (C) in the kidncy o ...

  17. TR-353: 2,4-Dichlorophenol (CASRN 120-83-2) in F344/N Rats and... 10.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr353.pdf

    ... Statistical an:ilyses wcre conducted or1 both thc slopes of the dose-response curves and the indi- vidual dose points. An SCE frequcncy 20% above the concurrent solvent control ...

  18. TR-453: Nickel Subsulfide (CASRN 12035-72-2) in F344 Rats and... 17.9MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr453.pdf

    ... Reports on analyses performed in support of the nickel subsulfide studies are on file at the National Institute of Environmental Health Sciences (NIEHS). Thc chemical, a gray or ...

  19. TR-458: Butyl Benzyl Phthalate (CASRN 85-68-7) in F344 Rats ... 12.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr458.pdf

    ... Averige severity grade of lesions i n affected animals: 1 = , ' m i n i m a l ; . I . Thc absoluteright cauda, right epididymis, and right testis weights of the 25,000ppm'males ...

  20. TR-471: Cobalt Sulfate Heptahydrate (CASRN 10026-24-1) in F344... 9.0MB

    https://ntp.niehs.nih.gov/sites/default/files/2023-08/tr471_508.pdf

    ... studies or from an unaffected study, 1-trans-delta 9 -tetrahydrocannabinol (NTP, 1996). ... from the unaffected 1-trans-delta 9 -tetrahydrocannabinol study (Table J7; NTP, ...

  21. TR-322: Phenylephrine Hydrochloride (CASRN 61-76-7) in F344/N... 10.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr322.pdf

    ... Pheochromocytoma + + + + + + + + + + + + + + + + + + + + + + + + + X X X X X X X X 13 Pheochromocytoma, mahrnant X 1 50 Thc?'C:tadenoma + + + + + + + + + + + + + + + + + + + + + + ...

  22. TR-464: Technical Grade Sodium Xylene Sulfonate (CASRN 1300-72... 9.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr464.pdf

    ... studies or from an unaffected study, 1-trans-delta 9 -tetrahydrocannabinol (NTP, 1996). ... from the unaffected 1-trans-delta 9 - tetrahydrocannabinol study (Table L7; NTP, ...

  23. TR-491: Methyleugenol (CASRN 93-15-2) in F344/N Rats and B6C3F1Mice... 22.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr491.pdf

    ... studies or from an unaffected study, 1-trans-delta 9 -tetrahydrocannabinol (NTP, 1996). ... from the unaffected 1-trans- delta 9 -tetrahydrocannabinol study (Table S7; NTP, ...

  24. Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB

    https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf

    ... including significant animal wclfare advantages. Since the initial publicallon on thc LLNA In 1986 by Kimber and his associates. there have been numerous publications ...

  25. TR-284: Diallylphthalate (CASRN 131-17-9) in F344/N Rats (Gavage... 8.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr284.pdf

    ... Six to seven pcrmnt a n d 1'14-,~'% of thc dosc: WZL. found in tissues of rats and mice, respectively, 24 hours after oral or intravenous administration of diallylphthalate. TABLE ...

  26. TR-454: Nickel Sulfate Hexahydrate (CASRN 10101-97-0) in F344... 19.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr454.pdf

    ... In areas where epidemiology studies were available, Doll et a l . (1990) estimated exposures to individual nickel compounds at various refineries or nickel Thc incidences of ...

  27. TR-386: Tetranitromethane (CASRN 509-14-8) in F344/N Rats and... 12.9MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr386.pdf

    ... not yet completed i t s evaluation of the data collected during thc studies with T Y h l . ... During thc terminal sacrifice. lung tumors and normal lung tissue were col- lected for ...

  28. TR-419: HC Yellow 4 (CASRN 59820-43-8) in F344 Rats and B6C3F1Mice... 10.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr419.pdf

    ... Revertants are presented as mean f standard error from three plates. ' Precipitate on plate slight toxicity e 2-aminoanthracene was used on all strains in thc presence o f S9. In ...

  29. TR-518: Triethanolamine (CASRN 102-71-6) in B6C3F1Mice (Dermal... 5.0MB

    https://ntp.niehs.nih.gov/go/tr518

    ... 311 Tetracycline Hydrochloride 344 Tetrafluoroethylene 450 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Tetrahydrofuran 475 Tetrakis(Hydroxymethyl)Phosphonium Sulfate 296 ...

  30. TR-257: Diglycidyl Resorcinol Ether (Technical Grade) (CASRN... 10.0MB

    https://ntp.niehs.nih.gov/go/tr257

    ... The lik table analysis regards tumor5 in animals dying prior to terminal kill :I$ being (directl! or indirectly) the cause of death. Thc incidental tumor test rcgards these lesions ...

  31. TR-502: Chloral Hydrate (CASRN 302-17-0) in B6C3F1Mice (Gavage... 8.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr502.pdf

    ... 311 Tetracycline Hydrochloride 344 Tetrafluoroethylene 450 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Tetrahydrofuran 475 Tetrakis(Hydroxymethyl)Phosphonium Sulfate 296 ...

  32. TR-388: Ethylene Thiourea (CASRN 96-45-7) in F344 Rats and B6C3F1Mice... 13.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr388.pdf

    ... A d e t a i w protocd ol thc tranrkrrtioa assay ia prcunted by Zimmering et d.(1985). Ekpcd m u l a were mated to three X,Y,y;bs,st femaks for 3 days and dLcarded, The females were ...

  33. TR-437: Hexachlorocyclopentadiene (CASRN 77-47-4) in F344/N Rats... 15.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr437.pdf

    ... CHINESE HAMSTER OVARY PROTOCOLS CELL CYTOGENETICS Testing was performed as reported by Galloway e f aI. (1987). Hexachlorocyclopentadiene was sent to thc laboratory as a coded ...

  34. TR-479: Coconut Oil Acid Diethanolamine Condensate (CASRN 68603... 7.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr479.pdf

    ... 311 Tetracycline Hydrochloride 344 Tetrafluoroethylene 450 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Tetrahydrofuran 475 Tetrakis(Hydroxymethyl)Phosphonium Sulfate 296 ...

  35. TR-498: p-Nitrotoluene (CASRN 99-99-0) in F344/N Rats and B6C3F1Mice... 10.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr498.pdf

    ... 311 Tetracycline Hydrochloride 344 Tetrafluoroethylene 450 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Tetrahydrofuran 475 Tetrakis(Hydroxymethyl)Phosphonium Sulfate 296 ...

  36. TR-511: Dipropylene Glycol (CASRN 25265-71-8) in F344/N Rats... 10.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr511.pdf

    ... 311 Tetracycline Hydrochloride 344 Tetrafluoroethylene 450 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Tetrahydrofuran 475 Tetrakis(Hydroxymethyl)Phosphonium Sulfate 296 ...

  37. TR-508: Riddelliine (CASRN 23246-96-0) in F344/N Rats and B6C3F1Mice... 9.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr508.pdf

    ... 311 Tetracycline Hydrochloride 344 Tetrafluoroethylene 450 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Tetrahydrofuran 475 Tetrakis(Hydroxymethyl)Phosphonium Sulfate 296 ...

  38. TR-509: 2,4-Hexadienal (89% trans,trans Isomer, CASRN 142-83... 10.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr509.pdf

    ... 311 Tetracycline Hydrochloride 344 Tetrafluoroethylene 450 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Tetrahydrofuran 475 Tetrakis(Hydroxymethyl)Phosphonium Sulfate 296 ...

  39. TR-512: Elmiron (CASRN 37319-17-8) in F344/N Rats and B6C3F1Mice... 12.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr512.pdf

    ... Tetrachloroethylene 311 Tetracycline Hydrochloride 344 Tetrafluoroethylene 450 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Tetrahydrofuran 475 Tetrakis(Hydroxymethyl)Phosphonium ...

  40. TR-514: trans-Cinnamaldehyde (Microencapsulated) (CASRN 14371... 8.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr514.pdf

    ... 311 Tetracycline Hydrochloride 344 Tetrafluoroethylene 450 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Tetrahydrofuran 475 Tetrakis(Hydroxymethyl)Phosphonium Sulfate 296 ...

  41. TR-515: Propylene Glycol Mono-t-Butyl Ether (CASRN 57018-52-7... 9.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr515.pdf

    ... 344 Mirex 313 Tetrafluoroethylene 450 Molybdenum Trioxide 462 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Monochloroacetic Acid 396 Tetrahydrofuran 475 Monuron 266 ...

  42. TR-516: 2-Methylimidazole (CASRN 693-98-1) in F344/N Rats and... 9.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr516.pdf

    ... 311 Tetracycline Hydrochloride 344 Tetrafluoroethylene 450 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Tetrahydrofuran 475 Tetrakis(Hydroxymethyl)Phosphonium Sulfate 296 ...

  43. TR-519: Stoddard Solvent IIC (CASRN 64742-88-7) in F344/N Rats... 8.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr519.pdf

    ... 311 Tetracycline Hydrochloride 344 Tetrafluoroethylene 450 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Tetrahydrofuran 475 Tetrakis(Hydroxymethyl)Phosphonium Sulfate 296 ...

  44. TR-527: Malachite Green Chloride and Leucomalachite Green (CASRNs... 7.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr527.pdf

    ... 311 Tetracycline Hydrochloride 344 Tetrafluoroethylene 450 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Tetrahydrofuran 475 Tetrakis(Hydroxymethyl)Phosphonium Sulfate 296 ...

  45. TR-504: o-Nitrotoluene (CASRN 88-72-2) in F344/N Rats and B6C3F1... 14.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr504.pdf

    ... 311 Tetracycline Hydrochloride 344 Tetrafluoroethylene 450 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Tetrahydrofuran 475 Tetrakis(Hydroxymethyl)Phosphonium Sulfate 296 ...

  46. TR-513: Decalin (CASRN 91-17-8) in F344/N Rats and B6C3F1Mice... 11.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr513.pdf

    ... Tetrachloroethylene 311 Tetracycline Hydrochloride 344 Tetrafluoroethylene 450 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Tetrahydrofuran 475 Tetrakis(Hydroxymethyl)Phosphonium ...

  47. TR-507: Vanadium Pentoxide (CASRN 1314-62-1) in F344/N Rats and... 6.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr507.pdf

    ... 311 Tetracycline Hydrochloride 344 Tetrafluoroethylene 450 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Tetrahydrofuran 475 Tetrakis(Hydroxymethyl)Phosphonium Sulfate 296 ...

  48. TR-510: Urethane + Ethanol (CASRNs. 51-79-6 & 64-17-5) in F344... 17.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr510.pdf

    ... 311 Tetracycline Hydrochloride 344 Tetrafluoroethylene 450 1-Trans-Delta 9 -Tetrahydrocannabinol 446 Tetrahydrofuran 475 Tetrakis(Hydroxymethyl)Phosphonium Sulfate 296 ...

 
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