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GMM-01: Genetically Modified Model Report on Aspartame (Feed... 1.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm01_508.pdf
The ToxicoloGy STudieS of aSPaRTaMe (caSRN 22839-47-0) iN GeNeTically Modified (fVB TG.ac heMizyGouS) aNd B6.129-cdkN2a TM1RdP (N2) deficieNT Mice aNd caRciNoGeNiciTy STudieS of ...
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Transgenic model evaluation II (Aspartame): Target Organs and... 61KB
https://ntp.niehs.nih.gov/data/gmm/gmm01levels
4 Transgenic model evaluation II (Aspartame): Target Organs and Levels of Evidence for GMM-01 Toxicology Studies of Aspartame (CASRN 22839-47-0) in Genetically Modified (FVB Tg.AC ...
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Abstract for GMM-1 71KB
https://ntp.niehs.nih.gov/publications/reports/gmm/gmm01
Toxicology Studies of Aspartame in Genetically Modified (FVB Tg.AC Hemizygous) and B6.129-Cdkn2atm1Rdp (N2) Deficient Mice and Carcinogenicity Studies of Aspartame in Genetically ...
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GMM-01: PATHOLOGY TABLES AND CURVES 63KB
https://ntp.niehs.nih.gov/data/tables/gmm/gmm01
GMM-01: PATHOLOGY TABLES AND CURVES GMM-01 - Transgenic Model Evaluation II (Aspartame) See Aspartame Questions & Answers Study Protocol Pathology Tables - 01 Mice (TGAC (FVB/N) ...
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Minutes: BSC TRRS; May 22, 2003 842KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2003/may/trrs22may2003mins_508.pdf
Aspartame ......The motion was approved unanimously with eight votes. Aspartame Dr. Bucher introduced a ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 5.0MB
https://ntp.niehs.nih.gov/ntp/ohat/methanol/methanol_monograph.pdf
... People also are exposed to methanol through two direct food additives, aspartame and ... apABGlu p-acetamidobenzoylglutamate Asp aspartame AUC area under curve BEI biological ...
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Agenda: BSC TRRS; May 22, 2003 89KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2003/may/trrs22may2003agenda_508.pdf
John French transgenic mouse models for short-term cancer bioassays Aspartame 22839-47-0 GMM 1 artificial sweetener feed p53 mice Acesulfame K GMM 2 artificial sweetener 55589-62-3 ...
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Historical Controls: Pathology Tables by All Routes/Vehicles... 224KB
https://ntp.niehs.nih.gov/ntp/historical_controls/historicalratesgmm_508.pdf
2/135 (1.5%) Tg.AC Females, 9 months Aspartame Acesulfame potassium ... 1/2 1/28 (3.6%) Tg.AC Males, 9 months Aspartame Acesulfame potassium ...
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Minutes: BSC; Sept. 10-11, 2003 500KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2003/mins2003sept10_508.pdf
... The NTP now has 3 report series - NTP Technical Reports, NTP Toxicity Reports and NTP GMM Reports. To date, draft reports for two chemicals, aspartame and acesulfame potassium, ...
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RoC Background Document: Saccharin; Oct. 30-31, 1997 8.9MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/saccharin1_3apps_508.pdf
... The approval and introduction of other artificial sweeteners such as aspartame and ... equivalent tons (2,333 Mg) whereas aspartame's consumption was I,500 sugar sweetness ...
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GMM-02: Genetically Modified Model Report on Acesulfame Potassium... 2.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm02_508.pdf
... aspartame (3.5, 35, and 350 mg/kg); doses were chosen based on proposed limits of the two sweeteners together in soft drinks (150 ppm acesulfame potassium and 350 ppm aspartame); ...
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GMM-08: Genetically Modified Model Report on Benzene (Gavage... 1.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm08_508.pdf
... stud- ies and 40-week aspartame and glycidol studies (Tables 7, A1, and E1). ... In 46-week-old mice in the aspartame and glycidol 9-month GMM studies, alveolar/...
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RR-03: Absence of Formaldehyde-Induced Neoplasia in TRP53 Haploinsuffi... 1.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr03_508.pdf
... Nature. 1991; 351(6326):453-456. Nature. http://dx.doi.org/10.1038/351453a0 23. NTP NTP report on the toxicology studies of aspartame (CAS No. 22839-47-0) in genetically modified ...
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GMM-13: Genetically Modified Model Report on Glycidol (Gavage... 905KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm13_508.pdf
... Lymphoma 0/15 (0%) 1/15 (7%) 1/30 (3%) Aspartame Glycidol Total 40 Weeks Lung Alveolar/... p16 Ink4a /p19 Arf Mice Aspartame Glycidol Total 40 Weeks Kidney Casts ...
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CERHR Monograph: Methylphenidate 11.6MB
https://ntp.niehs.nih.gov/ntp/ohat/stimulants/methylphenidate/methylphenidatemonograph.pdf
... NF,.and.talc.USP. Mallinckrodt. (6) Methylin. chewable. tablets 50/50.d,l- 2.5,.5,.or.10 Aspartame. NF,. maltose,. microcrystalline. cellulose. NF,. guar. gum. NF,. grape. ...
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GMM-12: Genetically Modified Model Report on Phenolphthalein... 768KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm12_508.pdf
... Lymphoma 0/15 (0%) 1/15 (7%) 1/30 (3%) Aspartame Glycidol Total 40 Weeks Lung Alveolar/... p16 Ink4a /p19 Arf Mice Aspartame Glycidol Total 40 Weeks Kidney Casts ...
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Minutes: BSC; Sept. 17, 2002 762KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2002/september/20020917bscsummmins_508.pdf
... OF SCIENTIFIC COUNSELORS Summary Minutes - September17-18, 2002 (mice only), as well as two artificial sweeteners, aspartame and acesulfame potassium, studied in transgenic mice. ...
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Minutes: SACATM; Mar. 10-11, 2004 961KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/sacatm/archives/2004/minutes20040311_508be.pdf
... The Board was presented with a review of Tg.AC, p 53+/- and p16/19+/- studies of aspartame ... male or female Tg.AC mice administered aspartame/acesulfame K in feed at concentrations ...
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GMM-06: Genetically Modified Model Report on Sodium Bromate ... 1.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm06_508.pdf
... Other chemicals, including diisopropylcarbodiimide (NTP, 2006b) and aspartame (NTP, ... (NTP) (2005b). Toxicology Studies of Aspartame (CAS No. 22839-47-0) in Genetically ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... 2005 Genetically Modified Models GMM-01 PDF (1.23 MB) Toxicology Studies of Aspartame (CASRN 22839-47-0) in Genetically Modified (FVB Tg.AC Hemizygous) and B6.129-Cdkn2atm1Rdp (N2) ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... 2005 Genetically Modified Models GMM-01 PDF (1.23 MB) Toxicology Studies of Aspartame (CASRN 22839-47-0) in Genetically Modified (FVB Tg.AC Hemizygous) and B6.129-Cdkn2atm1Rdp (N2) ...
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Final RoC Background Document for Formaldehyde 5.8MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/formaldehyde_bd_final.pdf
... Human Exposure The artificial sweetener aspartame consists of 10% methanol, which ... has shown that formaldehyde adducts accumulate in the tissues after aspartame ingestion. ...
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GMM-15: Genetically Modified Model Report on Senna (Feed Studies... 4.0MB
https://ntp.niehs.nih.gov/ntp/htdocs/gmm_rpts/gmm15_508.pdf
... Park, NC. National Toxicology Program (NTP) (2005a). Toxicology Studies of Aspartame (CAS No. 22839-
47-0) in Genetically Modified (FVB Tg.AC Hemizygous) and B6.129-Cdkn2a tm1Rdp ...
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GMM-14: Genetically Modified Model Report on 3'-Azido-3'-Deoxythymidin... 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm14_508.pdf
... Toxicology Studies of Aspartame (CAS No. 22839-
47-0) in Genetically Modified (FVB Tg.AC Hemizygous) and B6.129-Cdkn2a tm1Rdp (N2) Deficient Mice and Carcinogenicity Studies of ...
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GMM-16: Genetically Modified Model Report on Study of Mixtures... 5.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/gmm_rpts/gmm16_508.pdf
... Park, NC. National Toxicology Program (NTP) (2005b). Toxicology Studies of Aspartame (CAS No. 22839-47-0) in Genetically Modified (FVB Tg.AC Hemizygous) and B6.129-Cdkn2a tm1Rdp ...
