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RoC Profile: Hydrazine and Hydrazine Sulfate; 15th RoC 2021 215KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/hydrazine.pdf
Hydrazine and Hydrazine Sulfate CAS Nos. 302-01-2 and 10034-93-2 Reasonably anticipated to be human carcinogens First listed in the Third Annual Report on Carcinogens (1983) H 2 N ...
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Abstract for TR-92 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr092
Hydrazobenzene is a hydrazine derivative selected for bioassay by the National Cancer Institute because of the documented carcinogenicity of the parent compound hydrazine and of ...
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RoC Profile: 1,1-Dimethylhydrazine; 15th RoC 2021 131KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dimethylhydrazine.pdf
Following administration of 1,1-dimethyl- hydrazine in drinking water, high incidences of ... Admin- istration of 1,1-dimethyl hydrazine by stomach tube increased the incidence of lung ...
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RoC Profile: 4-Chloro-o-phenylenediamine; 15th RoC 2021 112KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chlorophenylenediamine.pdf
4-Chloro-o-phenylene- diamine is stable at normal temperatures and pressures. Physical and chemical properties of 4-chloro-o-phenylene diamine are listed in the following table. ...
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Minutes: BSC; June 12, 2008 280KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2008/june/minutes20080612.pdf
... 26 4,7,10,-Trioxatridecane-1,13-diamine ......and 4,7,10-trioxatridecane-1,13-diamine, an industrial chemical that is ...
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TR-143: 1,5-Naphthalenediamine (CASRN 2243-62-1) 4.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr143.pdf
... rats and B6C3F1 mice. 1,5-Naphthalene- diamine was administered in the feed, at either ... SURVIVAL COMPARISONS OF 1,5-NAPHTHALENE- DIAMINE CHRONIC STUDY RATS 22 GROWTH CURVES FOR ...
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Abstract for TR-85 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr085
CASRN: 5131-60-2 Chemical Formula: C6H7ClN2 Molecular Weight: 142.588 Synonyms/Common Names: 4-chloro-1,3-benzenediamine; 4-chlorophene-1,3-diamine; 4-chloro-1,3-phenylenediamine; ...
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Abstract for TR-337 68KB
https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr337
CASRN: 59-87-0 Chemical Formula: C6H6N4O4 Molecular Weight: 198.1 Synonyms/Common Names: 5-Nitro-2-furaldehyde semicarbazone; 2-[(5-nitro-2-furanyl)methylene]hydrazine carboximide ...
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Abstract for TR-372 66KB
https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr372
CASRN: 20325-40-0 Chemical Formula: C14H16N2O2 . 2HCl Molecular Weight: 317.2 Synonyms/Common Names: omicron-Dianisidine dihydrochloride; 3,3'-dimethoxy-1,1-biphenyl)-4,4'-diamine ...
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Abstract for TR-390 68KB
https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr390
CASRN: 612-82-8 Chemical Formula: C14H16N2 . 2HCl Molecular Weight: 285.2 Synonyms/Common Names: o-Tolidine dihydrochloride; 3,3'-dimethylbiphenyl-4,4'-diamine dihydrochloride; ...
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Abstract for TR-397 67KB
https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr397
leather pure blue; C.I. 24400; cresotine pure blue; diacotton sky blue 5B; diamine blue 6B; diamine sky blue; diaphtamine pure blue; diazol pure blue 4B; 3,3'-[(3,3'-dimethoxy[1,...
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Target Organs and Levels of Evidence for TR-246 58KB
https://ntp.niehs.nih.gov/data/tr/200s/tr246levels
Chemical (Study Title) CASRN Peer Review Date Route/Exposure Levels Study Laboratory Asbestos, chrysotile(IR) + Dimethyl hydrazine 12001-29-5 06/23/1981 Dosed-Feed 0,1 %/60 PER ...
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Target Organs and Levels of Evidence for TR-279 57KB
https://ntp.niehs.nih.gov/data/tr/200s/tr279levels
Chemical (Study Title) CASRN Peer Review Date Route/Exposure Levels Study Laboratory Asbestos, amosite + Dimethyl hydrazine 12172-73-5 09/22/1982 Dosed-Feed 0,1% /250 PER GROUP ...
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TR-168: N-(1-Naphthyl)ethylenediamine Dihydrochloride (CASRN... 5.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr168.pdf
... The high and low dietary concentrations of N-(l-naphthyl)ethylene- diamine dihydrochloride ... RATS TREATED WITH N-(1-NAPTHYL)ETHYLENE- DIAMINE DIHYDROCHLORIDE A-l APPENDIX B SUMMARY OF ...
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Target Organs and Levels of Evidence for TR-295 60KB
https://ntp.niehs.nih.gov/data/tr/200s/tr295levels
Chemical (Study Title) CASRN Peer Review Date Route/Exposure Levels Study Laboratory Asbestos, chrysotile(IR) + Dimethyl hydrazine 12001-29-5 07/27/1984 Dosed-Feed 0,1 %/175 PER ...
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TR-113: 2-Chloro-p-phenylenediamine Sulfate (CASRN 61702-44-1... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr113.pdf
... DIAMINE SULFATE GROWTH CURVES FOR 2-CHLORO-p-PHENYLENEDIAMINE SULFATE CHRONIC STUDY RATS 20 SURVIVAL COMPARISONS OF 2-CHLORO-p-PHENYLENE- DIAMINE SULFATE CHRONIC ...
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TR-372: 3,3'-Dimethoxybenzidine Dihydrochloride (CASRN 20325... 12.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr372.pdf
... 3,3 '-dime thoxy-( 1,l-biphenyl)-4,4'-diamine dihydrochloride; 3,3'-dimethoxy-4,4'-diam... 3,3'-dimethoxy-(l ,l-biphenyl)-4,4'-diamine dihydrochloride; 3,3'-dimethoxy-4,4'-diam...
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TR-412: 4,4'-Diamino-2,2'-Stilbenedisulfonic Acid Disodium Salt... 11.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr412.pdf
... chloride, 4% impurities, and 76% 4,4'-diamine-2,2'-stilbenedisulfonic acid) in feed to ... Mean Body Weights and Survival of Male Mice in the 2-YearFeed Study > , ' of 4,4' -Diamine...
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TR-085: 4-Chloro-m-phenylenediamine (CASRN 5131-60-2) 3.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr085.pdf
... 4-CHLORO-m-PHENYLENE- DIAMINE 4 GROWTH CURVES FOR CHRONIC STUDY RATS 4-CHLORO-m-PHENYLENEDIAMINE 20 SURVIVAL COMPARISONS OF 4-CHLORO-m-PHENYLENE- DIAMINE CHRONIC STUDY RATS 21 ...
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TR-174: p-Phenylenediamine Dihydrochloride (CASRN 624-18-0) 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr174.pdf
... DIAMINE DIHYDROCHLORIDE C-l IX D-l TABLE OF CONTENTS (Concluded) APPENDIX D SUMMARY OF THE INCIDENCE OF NONNEOPLASTIC LESIONS IN MICE TREATED WITH p-PHENYLENE- DIAMINE ...
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TR-295: Chrysotile Asbestos (CASRN 12001-29-5) in F344/N Rats... 25.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr295.pdf
... CHRYSOTILE ASBESTOS WITH 14-DIMETHYL- HYDRAZINE DIHYDROCHLORIDE ......CHRYSOTILE ASBESTOS WITH ta-DIMETHYL- HYDRAZINE DIHYDROCHLORIDE ......
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RoC Background Document: Tobacco Smoking; Dec. 2-3, 1998 3.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/environmentalts_noapps_508.pdf
... CIB (1991) Hoffmann and Hecht (1989) Hydrazine 90 ng 30 ng CIB (1991) Hoffmann and ... O 2A a: Ayer and Yeager (1982) b: NRC (1986) Hydrazine H 4 N 2 94.2 ng/cig 31.5 ng/cig ...
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Appendix G; 15th RoC 2021 73KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
... 15 Listings 298-81-7 (methoxsalen) see Methoxsalen with Ultraviolet A Therapy 302-01-2 (hydrazine) see Hydrazine and Hydrazine Sulfate 303-47-9 see Ochratoxin A 305-03-3 see ...
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RoC Profile: 4,4'-Oxydianiline; 15th RoC 2021 184KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/oxydianiline.pdf
Properties 4,4'-Oxydianiline is an aromatic diamine ether that is a colorless crys- tal at room temperature (IARC 1982). It is insoluble in water, ben- zene, carbon tetrachloride, ...
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TR-126: 2,5-Toluenediamine Sulfate (CASRN 6369-59-1) 3.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr126.pdf
... TREATED WITH 2,5-TOLUENE- DIAMINE SULFATE C-l APPENDIX D SUMMARY OF THE INCIDENCE OF NONNEOPLASTIC LESIONS IN MICE TREATED WITH 2,5-TOLUENE- DIAMINE SULFATE D-l ix LIST OF ...
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TR-180: 4-Nitro-o-phenylenediamine (CASRN 99-56-9) 2.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr180.pdf
... DIAMINE CHRONIC STUDY RATS GROWTH CURVES FOR 4-NITRO-o-PHENYLENEDIAMINE CHRONIC STUDY MICE SURVIVAL COMPARISONS OF 4-NITRO-o-PHENYLENE- DIAMINE CHRONIC STUDY MICE ...
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RoC Profile: 4,4'-Thiodianiline; 15th RoC 2021 129KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/thiodianiline.pdf
In rats, 4,4'-thiodiani- line binds to hemoglobin as both the diamine and the N-acetylamine. Among several bicyclic diamines studied (including 4,4'-thiodian- iline), the extent of ...
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TR-169: 2-Nitro-p-phenylenediamine (CASRN 5307-14-2) 3.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr169.pdf
... DIAMINE CHRONIC STUDY RATS 24 GROWTH CURVES FOR 2-NITRO-p-PHENYLENEDIAMINE CHRONIC STUDY MICE 33 SURVIVAL COMPARISONS OF 2-NITRO-p-PHENYLENE- DIAMINE CHRONIC STUDY ...
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RoC Background Document: Dyes Metabolized to 3,3'-Dimethoxybenzidine... 2.6MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/dmob_no_appendices_508.pdf
... A: IARC. 1974. Some Aromatic Amines, Hydrazine and Related Substances, N- Nitroso ... 6 3,3'-dimethoxy-1,1'-biphenyl-4,4'-diamine 4,4'-diamino-3,3'-dimethoxybiphenyl ...
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RoC Profile: Hydrazobenzene; 15th RoC 2021 129KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/hydrazobenzene.pdf
Properties Hydrazobenzene is a hydrazine derivative that is a colorless crystal or tablet at room temperature. It is very soluble in ethanol, slightly soluble in benzene and ...
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TR-092: Hydrazobenzene (CASRN 122-66-7) 4.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr092.pdf
... C01854) is a hydrazine derivative selected for bioassay by the National Cancer Institute because of the documented carcinogenicity of the parent compound hydrazine and of certain ...
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TOX-24: 1,6-Hexanediamine Dihydrochloride (CASRN 6055-52-3) 1.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox024.pdf
... 1,6-Hexanediamine (HDA) is an aliphatic diamine that is widely used as an intermediate in ... Bacterial diamine oxidases were shown to be incapable of metabolizing HDA (Tanzil and ...
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RoC Background Document: Dyes Metabolized to Benzidine (Benzidine... 8.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/dyesmetabenzidine_508.pdf
... Name: (1 ,1'-Biphenyl)-4,4'-diamine /UPAC Systematic Name: Benzidine Synonyms: Benzidine; benzidine base; 4,4'-bianiline; p,p'-bianiline; 4,4'-biphenyl- . diamine; ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 1.4MB
https://ntp.niehs.nih.gov/ntp/ohat/egpg/propylene/pg_monograph.pdf
... 2-methylpiperazine, 1,2-propylene diamine, hydroxylated poly- ester, polyester-type ... 2-methylpiperazine, 1,2-propylene diamine, hydroxylated polyester, polyester-type ...
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RoC Background Document: Dyes Metabolized to 3,3'-Dimethylbenzidine... 1.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/dmb_no_appendices_508.pdf
... 113 fast dark blue base R 3,3'-dimethyl-1,1'-biphenyl-4,4'-diamine 3,3'-dimethylbiphenyl-4,4'-diamine tolidine dimethyl benzidine 3,3'-tolidine 4,4'-bi-o-toluidine ...
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TR-082: N-Phenyl-p-phenylenediamine (CASRN 101-54-2) 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr082.pdf
... N-phenyl-p- phenylene- Sex and Initial diamine Time on Study Test No. of in Diet Dosed ... Animals 3 20 50 50 20 50 50 N-phenyl-p- phenylene- diamine in Diet (ppm)b 0 2,500 1,250 0 ...
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TR-219: 2,6-Dichloro-p-Phenylenediamine (CASRN 609-20-1) in F344... 4.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr219.pdf
... Survival, and Mean Body Weights of Rats Fed Diets Containing 2,6-Dichloro-p- phenylem>diamine for 13 Weeks Doses, Survival, and Mean Body Weights of Mice Fed Diets Containing ...
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TR-390: 3,3'-Dimethylbenzidine Dihydrochloride (CASRN 612-82... 12.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr390.pdf
0 TOXICOLOGYANDCARCINOGENESIS STUDIES OF 3,3'-DIMETHYLBENZIDINEDIHYDROCHLORIDE (CAS NO. 612-82-8) IN F344/N RATS (DRINKING WATER STUDIES) U.S.DEPARTMENT OF HEALTHANDHUMANSERVICES ...
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Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf
... Certain Glycidol Hexachlorobenzene Hexachloroethane Hexamethylphosphoramide Hydrazine and Hydrazine Sulfate Hydrazobenzene Indeno[1,2,3-cd]pyrene (see Polycyclic Aromatic ...
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TR-397: C.I. Direct Blue 15 (CASRN 2429-74-5) in F344 Rats (Drinking... 13.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr397.pdf
... Leather Pure Blue, C.I. 24400, Creytine !ure Blue, Diacptton Sky Blue,SB, Diamine Blue 6B, Diamine Sky Blue, Diaphtamine Pure Blue, Diazo1 Pure Blue 4B, 3 5 -[(3,3 dimethoxy[l,l ...
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RoC Profile: Chromium Hexavalent Compounds; 15th RoC 2021 174KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chromiumhexavalentcompounds.pdf
... It reacts explosively with hydrazine, acetic anhydride, boron, silicon, and other ... It is not flammable but reacts explo- sively with hydrazine (HSDB 2009). Zinc chromate ...
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RoC Profile: Methyl Methanesulfonate; 15th RoC 2021 113KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/methylmethanesulfonate.pdf
... In Re-evaluation of Some Organic Chemicals, Hydrazine, and Hydrogen Peroxide. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, vol. 71. Lyon, France: ...
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RoC Profile: Tobacco-Related Exposures; 15th RoC 2021 124KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/tobaccorelatedexposures.pdf
... These include carbon oxides, nitrogen oxides, ammonia, hydrogen cyanide, volatile aldehydes and ketones, non- volatile alkanes and alkenes, benzene, hydrazine, vinyl chloride, iso- ...
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RoC Background Document: Vinyl Bromide; Jan. 20-21, 2000 220KB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/vb_no_appendices_508.pdf
... Re-evaluation of Some Organic Chemicals, Hydrazine, and Hydrogen Peroxide. Monographs on ... Re-evaluation of Some Organic Chemicals, hydrazine, and Hydrogen Peroxide. IARC Monographs ...
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RoC Background Document for 4,4'-Thiodianiline; March 27, 2002 1.1MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/tdapub_no_appendices_508.pdf
... However, no information was found regarding quantitation or documentation of such exposures. 2.8 Biological indices of exposure TDA, as either the diamine or the monoacetyl-diamine ...
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RoC Profile: 1,4-Butanediol Dimethanesulfonate; 15th RoC 2021 114KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/butanedioldimethanesulfonate.pdf
... Last accessed: 12/2/09. IARC. 1974. 1,4-Butanediol dimethanesulphonate. In Some Aromatic Amines, Hydrazine and Related Substances, N-Nitroso Compounds and Miscellaneous Alkylating ...
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RoC Profile: Diglycidyl Resorcinol Ether; 15th RoC 2021 116KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/diglycidylresorcinolether.pdf
... In Re-evaluation of Some Organic Chemicals, Hydrazine, and Hydrogen Peroxide. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, vol. 71. Lyon, France: ...
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TR-083: Daminozide (CASRN 1596-84-5) 3.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr083.pdf
... (CAS 1596-84-5; NCI C03827) is a hydrazine compound that has been used as a plant ... Daminozide was selected for testing for carcinogenic activity because other hydrazine ...
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RoC Profile: Dimethylcarbamoyl Chloride; 15th RoC 2021 123KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dimethylcarbamoylchloride.pdf
... In Re-evaluation of Some Organic Chemicals, Hydrazine, and Hydrogen Peroxide. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, vol. 71. Lyon, France: ...
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RoC Profile: Diethyl Sulfate; 15th RoC 2021 129KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/diethylsulfate.pdf
... Last accessed: 3/22/09. IARC. 1974. Diethyl sulfate. In Some Aromatic Amines, Hydrazine ... In Re-evaluation of Some Organic Chemicals, Hydrazine, and Hydrogen Peroxide. IARC ...