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TR-568: Photocarcinogenesis Studies of Retinoic Acid and Retinyl... 18.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr568_508.pdf
PHOTOCOCARCINOGENESIS STUDY OF RETINOIC ACID AND RETINYL PALMITATE [CAS Nos. 302-79-4 ... ACID AND RETINYL PALMITATE [CAS Nos. 302-79-4 (All-trans-retinoic acid) and 79-81-2 ...
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Abstract for TR-568 80KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr568
Solar Light and Topical Application Study) Substances: All-trans-retinoic acid (CASRN 302-79-4) All-trans-retinyl palmitate (CASRN 79-81-2) Report Date: August 2012 Full Report PDF ...
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NTP Monograph: Developmental Effects and Pregnancy Outcomes Associated... 23.8MB
https://ntp.niehs.nih.gov/ntp/ohat/cancer_chemo_preg/chemopregnancy_monofinal_508.pdf
U.S. Department of Health and Human Services National Toxicology Program NTP NTP Monograph Developmental Effects and Pregnancy Outcomes Associated With Cancer Chemotherapy Use ...
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Introduction 1.9MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/egnashposter-2015.pdf
Introduction We previously developed an in vitro, biomarker-based, human induced pluripotent stem (iPS) cell-based assay to screen compounds for developmental toxicity. The assay ...
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Appendices for NTP Monograph on Developmental Effects and Pregnancy... 11.1MB
https://ntp.niehs.nih.gov/ntp/ohat/cancer_chemo_preg/cancerchemo_appendfinal_508.pdf
APPENDICES FOR NTP MONOGRAPH ON DEVELOPMENTAL EFFECTS AND PREGNANCY OUTCOMES ASSOCIATED WITH CANCER CHEMOTHERAPY USE DURING PREGNANCY June 2013 Office of Health Assessment and ...
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Minutes: TRPRP; Jan. 26, 2011 168KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2011/january/minutes20110126.pdf
National Toxicology Program Technical Reports Peer Review Panel Meeting January 26, 2011 National Institute of Environmental Health Sciences Research Triangle Park, NC Summary ...
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Comparison of devTOX quickPredict Assay With Other Methods 1.0MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/comparisonspreadsheet-508.pdf
www.stemina.com Author: JA Palmer jpalmer@stemina.com Header Description/Notes Compound Common Compound Name Therapeutic C max (μM) Published human therapeutic Cmax Negative ...
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A BIOMARKER BASED DEVELOPMENTAL ... 919KB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/egnashposter-2014-sot.pdf
A BIOMARKER BASED DEVELOPMENTAL TOXICITY SCREEN USING HUMAN INDUCED PLURIPOTENT STEM CELLS FOR COMPOUND PRIORITIZATION Egnash LA, Palmer JA, Smith AM, Conard KR, West PR, Burrier ...
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Presentation: The Many Faces of Pertussis Toxin: Workshop on... 1.0MB
https://ntp.niehs.nih.gov/iccvam/meetings/histwksp-2012/present/carbonetti-508.pdf
The Many Faces of Pertussis Toxin Nicholas Carbonetti, PhD University of Maryland Medical School NICEATM-ICCVAM HIST Workshop, November 2012 Historical names . Histamine ...
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Panel Actions: TRPRP; Jan. 26, 2011 65KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2011/january/actions20110126.pdf
Actions on Draft NTP Technical Reports Peer Reviewed at the NTP Technical Reports Peer Review Panel Meeting on January 26, 2011 The NTP convened the NTP Technical Reports Peer ...
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Comparison of the Stemina devTOX quickPredict system with other... 2.1MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2018-09961/palmer-stemina-spreadsheet.pdf
Stemina BIOMARKER DISCOVERY Page 1 of 11 www.stemina.com Author: JA Palmer jpalmer@stemina.com Column Header Definitions Header Description/Notes Compound Common Compound Name. ...
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Minutes: BSC; April 13, 2011 257KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2011/april/minutesbsc20110413.pdf
National Toxicology Program Board of Scientific Counselors April 13, 2011 National Institute of Environmental Health Sciences Research Triangle Park, NC Contents I. Frequently ...
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Response to 81 FR 42718: Miguel Sogorb 100KB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/sogorb-81fr42718.pdf
Original response is reproduced below; NICEATM has made minor edits to correct errors introduced in the webform submission. Attention NTP Interagency Center for the Evaluation of ...
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TOWARD VALIDATION OF A HUMAN IN... 1.1MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/egnashposter-2014-wc.pdf
TOWARD VALIDATION OF A HUMAN IN VITRO ASSAY FOR DEVELOPMENTAL TOXICITY ASSESSMENT Egnash LA, Conard KR, Palmer JA, Smith AM, West PR, Burrier RE, Donley ELR, Kirchner FR Stemina ...
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ILS Response: NICEATM Request for Data and Information in Technologies... 61KB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2018-09961/hobbs-ils.pdf
[1] Response to NICEATM Request for Data and Information in Technologies Used for Identifying Potential Developmental Toxicants Federal Register Notice: 83 FR 20082 Name: Cheryl A. ...
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National Institute of Environmental Health Sciences: Pei-Li Yao... 157KB
https://www.niehs.nih.gov/research/atniehs/dtt/assoc/opo/staff/yao
Skip Navigation Pei-Li Yao, Ph.D. National Institute of Environmental Health Sciences (NIEHS) Office of Program Operations Pei-Li Yao, Ph.D. Pei-Li Yao, Ph.D. Staff Scientist; ...
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DEVELOPMENT OF A TARGETED BIOMARKER... 3.4MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/palmerposter.pdf
DEVELOPMENT OF A TARGETED BIOMARKER ASSAY TO PREDICT DEVELOPMENTAL TOXICITY USING INDUCED PLURIPOTENT STEM CELLS Palmer JA, Egnash LA, Smith AM, Conard KR, West PR, Burrier RE, ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... No Evidence EE Equivocal Evidence TR-568 01/26/11 Retinoic Acid and Retinyl Palmitate 302-79-4 and 79-81-2 TR-567 11/19/09 Ginseng 50647-08-0 NE No Evidence NE No Evidence NE No ...
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Session 6 Presentation Abstracts: Collaborative Workshop on Aquatic... 312KB
https://ntp.niehs.nih.gov/iccvam/meetings/aquatictox-2014/speakers-session-6-508.pdf
Session 6: Emerging Issues In Vivo Behavioral and Morphological Screening of a 1078-Chemical Library Using Zebrafish Robert Tanguay, PhD Department of Environmental and Molecular ...
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PowerPoint Presentation 925KB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/knudsenposter.pdf
U.S. Environmental Protection Agency Office of Research and Development EPA www.epa.gov EVALUATION OF 1066 TOXCAST CHEMICALS IN A HUMAN STEM CELL ASSAY FOR DEVELOPMENTAL TOXICITY ...
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TR-505: Citral (Microencapsulated) (CASRN 5392-40-5) in F344... 10.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr505.pdf
THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CITRAL (MICROENCAPSULATED) (CAS NO. 5392-40-5) IN F344/N RATS AND B6C3F 1 MICE (FEED STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box ...
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Tox21 Cross-partner Projects 101KB
https://ntp.niehs.nih.gov/iccvamreport/2021/technology/tox21
Tox21 Cross-partner Projects Tox21 is a collaboration among groups within four U.S. federal organizations aimed at developing more efficient approaches to predict how chemicals may ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... Study of Retinoic Acid and Retinyl Palmitate (All-trans-retinoic acid (CASRN 302-79-4) and All-trans-retinyl palmitate (CASRN 79-81-2)) in SKH-1 Mice (Simulated Solar ...
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Minutes: BSC; Dec. 9-10, 2009 394KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2009/december/minutes20091210.pdf
National Toxicology Program Board of Scientific Counselors December 9-10, 2009 National Institute of Environmental Health Sciences Research Triangle Park, NC Table of Contents I. ...
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CERHR Update on the Reproductive and Developmental Toxicity of... 4.5MB
https://ntp.niehs.nih.gov/ntp/ohat/phthalates/dehp/dehp-monograph.pdf
Monograph on the Potential Human Reproductive and Developmental Effects of Di(2-Ethylhexyl) Phthalate (DEHP) November 2006 NIH Publication No. 06 - 4476 iii Table of ConTenTs ...
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RoC Background Document for Hepatitis B Virus; June 11, 2003 2.8MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/hbv_rg2public_508.pdf
FINAL Report on Carcinogens Background Document for Hepatitis B Virus June 11, 2003 Prepared for the: U.S. Department of Health and Human Services Public Health Service National ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... Study of Retinoic Acid and Retinyl Palmitate (All-trans-retinoic acid (CASRN 302-79-4) and All-trans-retinyl palmitate (CASRN 79-81-2)) in SKH-1 Mice (Simulated Solar ...
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IVIVE to Facilitate Animal-free Risk Assessment of Potential... 3.5MB
https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Chang-poster.pdf
Models for In Vitro and In Vivo Kinetics IVIVE to Facilitate Animal-free Risk Assessment of Potential Developmental Toxicants X. Chang 1 , J. Palmer 2 , E. Donley 2 , E. Reinke 1 , ...
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Minutes: BSC; May 20, 1999 365KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1999/may/19990520bscmins_508.pdf
NATIONAL TOXICOLOGY PROGRAM BOARD OF SCIENTIFIC COUNSELORS May 20, 1999 Summary Minutes NATIONAL TOXICOLOGY PROGRAM BOARD OF SCIENTIFIC COUNSELORS May 20, 1999 Summary Minutes ...
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Minutes: BSC; Aug. 18, 2005 1.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/2005/august/bscmins2005aug18_508.pdf
National Toxicology Program Board of Scientific Counselors August 18, 2005 NIEHS, Research Triangle Park, NC Summary Minutes I. Attendees ......
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Minutes: MPRP; Oct. 1-2, 2012 559KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2012/october/minutes20121002_508.pdf
National Toxicology Program Draft NTP Monograph on Developmental Effects and Pregnancy Outcomes Associated with Cancer Chemotherapy Use during P regnancy Peer Review Panel Meeting ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... Study of Retinoic Acid and Retinyl Palmitate (All-trans-retinoic acid (CASRN 302-79-4) and All-trans-retinyl palmitate (CASRN 79-81-2)) in SKH-1 Mice (Simulated Solar ...
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Predicting human developmental toxicity of pharmaceuticals using... 510KB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/westtap2016.pdf
Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics Paul R. West a, ⁎ , April M. Weir a , Alan M. Smith a , Elizabeth ...
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CERHR Monograph: Potential Human Reproductive and Developmental... 6.3MB
https://ntp.niehs.nih.gov/ntp/ohat/bisphenol/bisphenol.pdf
MoNogRaPH oN THE PoTENTial HuMaN REPRoduCTivE aNd dEvEloPMENTal EffECTs of BisPHENol a September 2008 NIH Publication No. 08 - 5994 Center for The Evaluation of Risks To Human ...
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Minutes: BSC TRRS; May 3, 2001 62KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/2001/may/trrs3may2001mins_508.pdf
PROGRAM BOARD OF SCIENTIFIC COUNSELORS TECHNICAL REPORTS REVIEW SUBCOMMITTEE Peer Review of Draft Technical Reports of Toxicology and Carcinogenesis Studies by the Technical ...
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Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf
Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity Based on Recommendations from an International Workshop Organized by the Interagency ...
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Background Review Document: Frog Embryo Teratogenesis Assay ... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/fetax2000/brd/fetax-brd-all.pdf
... No No Hydroxyurea 127-07-1 Yes No Methotrexate 59-05-2 Yes No all-trans-Retinoic acid 302-79-4 Yes No 6-Aminonicotinamide 329-89-5 Yes No Moderate Embryotoxicity Boric acid ...
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Monograph: Night Shift Work and Light at Night; August 24, 2018 6.2MB
https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/landraftmonograph20180824.pdf
Draft Report on Carcinogens Monograph on Night Shift Work and Light at Night Peer Review Draft Running title: Draft RoC Monograph on Night Shift Work and Light at Night August 24, ...
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Articles by Topic and Agency 548KB
https://ntp.niehs.nih.gov/iccvamreport/2021/tags
Articles by Topic and Agency Article Topic Agency About this Report The ICCVAM Biennial Report is prepared by the NTP Interagency Center for the Evaluation of Alternative ...
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Report: International Workshop on In Vitro Methods for Assessing... 25.4MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf
... 157.24 11.1 52 all-trans-Retinoic acid 302-79-4 33.05 0.11 2001.2 6.66 NA NA 300.48 6.66 ... 14 286.5 6.98 52 all-trans-Retinoic acid 302-79-4 33.05 0.11 2001.2 6.66 NA NA 300.48 6.66 ...
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Minutes: BSC; April 6, 1994 2.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1994/april/19940406bscmins_508.pdf
SUABLARY MINUTES 0 NATIONAL TOXICOLOGY PROGRA M BOARD OF SCIENTIFIC COUNSELORS'MEETIN G April 6, 1994 14 The National Toxicology Program (NTP) Board of Scientific Counselors (the ...
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RR-04: Biological Activity of Bisphenol A (BPA) Structural Analogues... 7.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr04_508.pdf
Biological acTiviTy of BisPheNol a (BPa) sTRucTuRal aNalogues aNd fuNcTioNal alTeRNaTives NTP RR 4 OCTOBER 2017 NTP Research Report on Biological Activity of Bisphenol A (BPA) ...
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OHAT Evaluation: Protocol for a Systematic Review to Evaluate... 1018KB
https://ntp.niehs.nih.gov/ntp/ohat/aheaoecca/protocol201510_508.pdf
OHAT Evaluation of Occupational Exposure to Chemotherapy and Health Page 1 of 54 PROTOCOL FOR A SYSTEMATIC REVIEW TO EVALUATE THE EVIDENCE FOR AN ASSOCIATION BETWEEN OCCUPATONAL ...
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OHAT Evaluation: Protocol for a Systematic Review to Evaluate... 1.1MB
https://ntp.niehs.nih.gov/ntp/ohat/aheaoecca/protocol201812_508.pdf
PROTOCOL FOR A SYSTEMATIC REVIEW TO EVALUATE THE EVIDENCE FOR AN ASSOCIATION BETWEEN OCCUPATONAL EXPOSURE TO CANCER CHEMOTHERAPY AGENTS AND ADVERSE HEALTH OUTCOMES Project Leader: ...
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All Past Events 1004KB
https://ntp.niehs.nih.gov/events/past
https://ntp.niehs.nih.gov/go/meeting All Past Events The sidebars on this page are hidden to provide an optimal data view. may prevent you from viewing the data in an optimal ...
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TOX-62: WY-14,643 (CASRN 50892-23-4) 2.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox062.pdf
NATIONAL TOXICOLOGY PROGRAM Toxicity Report Series Number 62 NTP Technical Report on the Toxicity Studies of Wy-14,643 (CAS No. 50892-23-4) Administered in Feed to Sprague-Dawley ...
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NTP Cancer Hazard Report: Night Shift Work and Light at Night... 10.1MB
https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal20210400_508.pdf
NTP Cancer Hazard Assessment Report on Night Shift Work and Light at Night April 2021 Night Shift Work and Light at Night and Cancer i National Toxicology Program Cancer Hazard ...
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TR-597: 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered... 3.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr597_508.pdf
NTP TechNical RePoRT oN The Toxicology aNd caRciNogeNesis sTudies of 2-hydRoxy- 4-meThoxybeNzoPheNoNe (casRN 131-57-7) admiNisTeRed iN feed To sPRague dawley (hsd:sPRague dawley ® ...
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ICCVAM Biennial Progress Report 2020-2021 940KB
https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/annrpt/iccvam-rpt-2020-2021.pdf
ICCVAM Biennial Report 2020-2021 August 2022 1 Biennial Progress Report 2020-2021 Interagency Coordinating Committee on the Validation of Alternative Methods August 2022 ICCVAM ...
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DART-05: Modified One-Generation Study of 2-Hydroxy-4-methoxybenzophen... 6.0MB
https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart05_508.pdf
hyDRoxy-4-meTho xybeNzoPheNoNe (caSRN 131-57-7) aDmiNiSTeReD iN feeD To SPRaGue Dawley (hSD:SPRaGue Dawley ® SD ® ) RaTS wiTh PReNaTal aND RePRoDucTive PeRfoRmaNce aSSeSSmeNTS iN ...