TR-021: Aldrin and Dieldrin (CASRN 309-00-2) (CASRN 60-57-1) 5.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr021.pdf

Technical Report Series No. 21 BIOASSAYS OF ALDRIN and DIELDRIN FOR POSSIBLE CARCINOGEN ICITY CAS No's. 309-00-2 and 60-57-1 NCI-CG-TR-21 U.S. DEPARTMENT OF HEALTH, ...

Aldrin: Target Organs and Levels of Evidence for TR-021 59KB

https://ntp.niehs.nih.gov/data/tr/000s/tr021levels

2370 Aldrin: Target Organs and Levels of Evidence for TR-021 Bioassays of Aldrin and Dieldrin for Possible Carcinogenicity (CASRN 309-00-2) (CASRN 60-57-1) Chemical (Study Title) ...

Abstract for TR-21 69KB

https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr021

1abs Abstract for TR-21 Bioassays of Aldrin and Dieldrin for Possible Carcinogenicity Substances: Aldrin (CASRN 309-00-2) Dieldrin (CASRN 60-57-1) Report Date: 1978 Full Report PDF ...

Abstract for TR-22 60KB

https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr022

It is also a metabolic conversion product of aldrin, another pesticide, and can be ... was found to be more effective than aldrin, and later, was used as an insecticide ...

Abstract for TR-8 64KB

https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr008

Chlordane is a member of the cyclodiene group of chlorinated insecticides, which includes aldrin, dieldrin, endrin, heptachlor, and endosulfan. It was introduced in 1945 and was ...

Abstract for TR-12 63KB

https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr012

Endrin is an organochlorine pesticide having a structural characteristic of the cyclodiene group, which includes aldrin (CAS No. 309-00-2), dieldrin (CAS No. 60-57-1), chlordane ...

TR-022: Dieldrin (CASRN 60-57-1) 1.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr022.pdf

... It is also a metabolic conversion product of aldrin, another pesticide, and can be ... was found to be more effective than aldrin, and later, was used as an insecticide ...

TR-304: Chlorendic Acid (CASRN 115-28-6) in F344/N Rats and B6C3F1Mice... 14.6MB

https://ntp.niehs.nih.gov/go/tr304

... Organ Site Male Female Male Female Aldrin NCITR21 (1978a) (b) Liver No effect No effect 3/... Institute (NCI) (1978a) Bio- assay of Aldrin and Dieldrin for Possible Car- cinogenicity. ...

TR-017: Photodieldrin (CASRN 13366-73-9) 3.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr017.pdf

... The photochemical rearrangement and oxidation of aldrin and photoaldrin also will yield ... Mice receiving photodieldrin were maintained in a room housing mice administered aldrin ...

RoC Profile: Chlorendic Acid; 15th RoC 2021 124KB

https://ntp.niehs.nih.gov/ntp/roc/content/profiles/chlorendicacid.pdf

... of polyesters, and it is an oxidation product of numerous pesticides, including endosulfan, chlordane, heptachlor, aldrin, dieldrin, isodrin, and endrin and their metabolites. ...

PowerPoint Presentation 925KB

https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/knudsenposter.pdf

... Chemical TC-CytoBurst MTC Activity * LEC-o/c REP1, REP2 oc-var sq / total LEC-cv REP1, REP2 cv-var sq / total comment Dieldrin 17.44 10 negative NA 0.14 NA 0.24 Aldrin 23.18 10 ...

TR-012: Endrin (CASRN 72-20-8) 3.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr012.pdf

... C I of the cyclodiene group, which includes aldrin (CAS 309-00-2), dieldrin (CAS 60-57-1), chlordane (CAS 57-74-9), heptachlor (CAS 76-44-8), and endosulfan (CAS 115-29-7). ...

TR-437: Hexachlorocyclopentadiene (CASRN 77-47-4) in F344/N Rats... 15.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr437.pdf

... such as heptachlor,chlordane,aldrin,dieldrin,endrin,and mirex (Bell et al., 1 9 7 9 ) . ... hepato- carcinogens such as heptachlor, aldrin, and dieldrin (NCI, 1977a,1978); and ...

TR-008: Chlordane (CASRN 57-74-9) 3.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr008.pdf

... insecticides, which includes aldrin, dieldrin, endrin, heptachlor, and endosulfan. ... male and 10 female controls from tests on aldrin and heptachlor, and 10 male and 10 female ...

Application of In Vitro to In Vivo Extrapolation (IVIVE) to Inform... 2.9MB

https://ntp.niehs.nih.gov/iccvam/meetings/sot22/poster/mumtaz-sot2022.pdf

... Chemical MRL In Vivo PoD EAD Range PBDEs 0.00006 0.06 1.4 - 180.2 2,4-D 0.009 0.9 0.008 - 5.8 PBDEs decabrominated 0.01 1 68.9 aldrin 0.002 2 0.7 - 106.0 pentachlorophenol 0.005 5 ...

Protocol: Evidence Map of Inflammation-Based Atherosclerosis... 643KB

https://ntp.niehs.nih.gov/sites/default/files/2023-07/protocol_atherosclerosis_supplementaljuly2023_508.pdf

... OR air- quality[tiab] OR aldrin[tiab] OR allergen*[tiab] OR Allergens[mh] ... OR air-pollution OR air-quality OR aldrin OR allergen* OR Amitraz OR ...

TR-010: Dichlorvos (CASRN 62-73-7) 3.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr010.pdf

... for the studies of aldrin, dieldrin, chlordane, dichlorvos, dimethoate, and heptachlor. ... dieldrin (20 males, 20 females), aldrin (20 males, 10 females), heptachlor (20 ...

TR-035: Methoxychlor (CASRN 72-43-5) 2.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr035.pdf

... It may also substitute in some cases for aldrin, dieldrin, chlordane and hepta- chlor, all of which have had their registrations cancelled (Ouellette and King, 1976). According to ...

TR-004: Dimethoate (CASRN 60-51-5) 2.3MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr004.pdf

... plus the matched controls for the studies of aldrin, chlordane, dichlorvos, dieldrin, and heptachlor; these studies overlapped the dimethoate feeding study for at least a year. ...

TR-015: Captan (CASRN 133-06-2) 3.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr015.pdf

... Mice receiving captan were maintained in a room housing mice administered aldrin (CAS 309-00-2) or photodieldrin (CAS 13366-73-9), together with their respective matched controls. ...

In Vitro to In Vivo Extrapolation for Developmental Neurotoxicity... 1.7MB

https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Kreutz-poster.pdf

... Esfe nvaler ate Te fluthrin Methoxy chlor D ie thy ls tilbes trol Tetr acy cline Aldrin o,p'-DD T Pipe rony l butox ide A ur am ine hydrochlor ide p,p'-D DD P erm ethrin Per ...

TR-009: Heptachlor (CASRN 76-44-8) 3.5MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr009.pdf

... group of chlorinated insecticides (aldrin, dieldrin, endrin, chlordane, heptachlor, ... controls taken from tests performed on aldrin, dieldrin, chlordane, heptachlor, ...

TOX-6: Pentachlorobenzene (CASRN 608-93-5) 3.9MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox006.pdf

... after administration of penta- chlorobenzene by intraperitoneal injection in male Wistar rats were 4-dimethylaminoanti- pyrine and aldrin epoxidase (Denomme et al., 1983). ...

TOX-7: 1,2,4,5-Tetrachlorobenzene (CASRN 95-94-3) 4.1MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox007.pdf

... deethylase, and aldrin epoxidase (Ariyoshi et al., 1975a,b; Chu et al., 1983, 1984b; Denomme et al., 1983; Kitchin and Ebron, 1983a,b; Kacew et al., 1984; Ikegami et al., 1987). ...

NTP Technical Reports Index 1.5MB

https://ntp.niehs.nih.gov/data/tr

... N No Evidence N No Evidence E Equivocal Evidence N No Evidence TR-021 09/26/77 Aldrin 309-00-2 E Equivocal Evidence E Equivocal Evidence P Clear Evidence N No Evidence TR-020 ...

Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB

https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf

... 187 4-Hexylresorcinol 0.064 2.83 549.9 43 Aldrin 0.067 0.11 40.1 44 Hydroxyzine * HCl ... 0.071 36.0 25 Thio-TEPA 0.011 0.2 37.8 43 Aldrin 0.067 0.11 40.1 185 Heptachlor 0.059 0.11 ...

Report: International Workshop on In Vitro Methods for Assessing... 25.4MB

https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf

... 15.2 187 4- Hexylresorcinol 136-77-6 12.44 0.064 549.9 2.83 NA NA 194.3 2.83 43 Aldrin 309-00-2 24.45 0.067 40.1 0.11 43.8 0.12 364.9 0.11 44 Hydroxyzine * HCl 1244-76-4 27.56 ...

RoC Background Document: p-Chloro-o-toluidine and its Hydrochloride... 2.6MB

https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/chloro-o-toluidine_508.pdf

... and Parke (1983; cited by Leslie et al., 1988), who found that concurrent decrease in aldrin epoxidation and elevation of EROD activity are characteristic of many carcinogens. ...

TOX-77: Hexachlorobenzene (CASRN 118-74-1) Administered by Gavage... 2.2MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox077_508.pdf

... persistent organic pollutants: DDT-aldrin-dieldrin-endrin-chlordane, ... δ-BHC a <0.01 - 1 Heptachlor a <0.01 - 1 Aldrin a <0.01 - 1 Heptachlor Epoxide a <0.01 - ...

TOX-103: Select Ionic Liquids (1-Ethyl-3-Methylimidazolium Chloride... 4.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox103_508.pdf

... 1 δ-BHC a <0.01 1 Heptachlor a <0.01 1 Aldrin a <0.01 1 Heptachlor Epoxide a <0.01 1 ... δ-BHC a <0.01 - 4 Heptachlor a <0.01 - 4 Aldrin a <0.01 - 4 Heptachlor Epoxide a <0.01 - ...

Technical Reports 903KB

https://ntp.niehs.nih.gov/publications/reports/tr

... 1978 Technical Report TR-021 PDF (5.18 MB) Bioassays of Aldrin and Dieldrin for Possible Carcinogenicity (CASRN 309-00-2) (CASRN 60-57-1) 1978 Technical Report TR-020 PDF (2.99 ...

DART-07: Prenatal Development Studies of 2-((1-(4-Phenoxyphenoxy... 1.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/dart/dart07_508.pdf

... 1 δ-BHC b <0.01 1 Heptachlor b <0.01 1 Aldrin b <0.01 1 Heptachlor Epoxide b <0.01 1 ... 1 δ-BHC a <0.01 1 Heptachlor a <0.01 1 Aldrin a <0.01 1 Heptachlor Epoxide a <0.01 1 ...

NTP Monograph on Health Effects of Low-Level Lead Appendices... 6.8MB

https://ntp.niehs.nih.gov/ntp/ohat/lead/final/appendicesathrue_final_508.pdf

... Observed effect functions examined with 10 motor tasks Also measured PCB congeners, aldrin, β- HCH, DDE, DDT, Mirex, Hexachlorobenzene, Chlordane, Cis- Nonachlor, Trans- ...

NTP Monograph on Health Effects of Low-Level Lead Appendix A... 2.5MB

https://ntp.niehs.nih.gov/ntp/ohat/lead/final/leadappendixa_final_508.pdf

... Observed effect functions examined with 10 motor tasks Also measured PCB congeners, aldrin, β- HCH, DDE, DDT, Mirex, Hexachlorobenzene, Chlordane, Cis- Nonachlor, Trans- ...

Study Reports 1.1MB

https://ntp.niehs.nih.gov/publications/reports

... 1978 Technical Report TR-021 PDF (5.18 MB) Bioassays of Aldrin and Dieldrin for Possible Carcinogenicity (CASRN 309-00-2) (CASRN 60-57-1) 1978 Technical Report TR-020 PDF (2.99 ...

Toxicology/Carcinogenicity 1.1MB

https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox

... Carcinogenicity TR-021 PDF (5.18 MB) Bioassays of Aldrin and Dieldrin for Possible Carcinogenicity (CASRN 309-00-2) (CASRN 60-57-1) 1978 Long-Term Carcinogenicity TR-020 ...

IMM-01: Dermal Hypersensitivity and Irritancy Studies of 4-Methylcyclo... 969KB

https://ntp.niehs.nih.gov/ntp/htdocs/imm/imm001_508.pdf

... <0.01 - 3 β-BHC <0.02 - 3 γ-BHC <0.01 - 3 δ-BHC <0.01 - 3 Heptachlor <0.01 - 3 Aldrin <0.01 - 3 Heptachlor Epoxide <0.01 - 3 DDE <0.01 - 3 DDD <0.01 - 3 DDT <0.01 - 3 HCB ...

TR-002: Trichloroethylene (CASRN 79-01-6) 19.9MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr002.pdf

... No lindane, heptachlor, aldrin, heptachlor epoxide, endrin, DDD, chlordane, methoxy- chlor, toxaphene, or organophosphate was found. Two of the samples contained 0.00392 and ...

DART-01: Prenatal Development Studies of Tris(chloropropyl) Phosphate... 937KB

https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart01_508.pdf

... <0.01 - 1 β-BHC <0.02 - 1 γ-BHC <0.01 - 1 δ-BHC <0.01 - 1 Heptachlor <0.01 - 1 Aldrin <0.01 - 1 Heptachlor Epoxide <0.01 - 1 DDE <0.01 - 1 DDD <0.01 - 1 DDT <0.01 - 1 HCB ...

DART-02: Prenatal Development Studies of 4-Methylcyclohexanemethanol... 1.1MB

https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart02_508.pdf

... (ppm) α-BHC <0.01 1 β-BHC <0.02 1 γ-BHC <0.01 1 δ-BHC <0.01 1 Heptachlor <0.01 1 Aldrin <0.01 1 Heptachlor Epoxide <0.01 1 DDE <0.01 1 DDD <0.01 1 DDT <0.01 1 HCB <0.01 1 ...

DART-04: Prenatal Development Studies of Dimethylaminoethanol... 1006KB

https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart04_508.pdf

... <0.01 - 2 β-BHC <0.02 - 2 γ-BHC <0.01 - 2 δ-BHC <0.01 - 2 Heptachlor <0.01 - 2 Aldrin <0.01 - 2 Heptachlor Epoxide <0.01 - 2 DDE <0.01 - 2 DDD <0.01 - 2 DDT <0.01 - 2 HCB ...

TOX-101: Trimethylsilyldiazomethane (CASRN 18107-18-1) Administered... 6.7MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox101_508.pdf

... - 2 β-BHC a <0.02 - 2 γ-BHC a <0.01 - 2 δ-BHC a <0.01 - 2 Heptachlor a <0.01 - 2 Aldrin a <0.01 - 2 Heptachlor Epoxide a <0.01 - 2 DDE a <0.01 - 2 DDD a <0.01 - 2 DDT a <0.01 ...

TOX-102: Trans-resveratrol Administered by Gavage for Two Weeks... 2.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox102_508.pdf

... 1 δ-BHC a <0.01 1 Heptachlor a <0.01 1 Aldrin a <0.01 1 Heptachlor Epoxide a <0.01 1 ... δ-BHC a <0.01 - 5 Heptachlor a <0.01 - 5 Aldrin a <0.01 - 5 Heptachlor Epoxide a <0.01 - ...

Public Comment on 81 FR 42718: C. Elegans Models for Developmental... 2.0MB

https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/hunt-81fr42718.pdf

... EPN Phenylmercuric acetate Captafol DDE Oxyfluorfen Henicosafluoroundecanoic acid Aldrin Kepone Nitrofen Pharma4736 Endosulfan Indoxacarb Heptachlor Perfluorodecanoic acid ...

DART-03: Prenatal Development Studies of Vinpocetine (CASRN 42971... 1.2MB

https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart03_508.pdf

... (ppm) α-BHC <0.01 1 β-BHC <0.02 1 γ-BHC <0.01 1 δ-BHC <0.01 1 Heptachlor <0.01 1 Aldrin <0.01 1 Heptachlor epoxide <0.01 1 DDE <0.01 1 DDD <0.01 1 DDT <0.01 1 HCB <0.01 1 ...

TR-600: Di-n-butyl Phthalate Administered in Feed to Sprague... 3.4MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr600_508.pdf

... δ-BHC a <0.01 - 2 Heptachlor a <0.01 - 2 Aldrin a <0.01 - 2 Heptachlor Epoxide a <0.01 - ... a <0.01 - 25 Heptachlor a <0.01 - 25 Aldrin a <0.01 - 25 Heptachlor Epoxide a <0.01 - ...

TOX-98: Acetoin (CASRN 513-86-0) and 2,3-Pentanedione (CASRN... 3.0MB

https://ntp.niehs.nih.gov/go/tox098

... δ-BHC a <0.01 - 8 Heptachlor a <0.01 - 8 Aldrin a <0.01 - 8 Heptachlor Epoxide a <0.01 - ... δ-BHC a <0.01 - 4 Heptachlor a <0.01 - 4 Aldrin a <0.01 - 4 Heptachlor Epoxide a <0.01 - ...

TOX-99: A Gum Guggul Extract Formulation Administered by Gavage... 1.1MB

https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox99_508.pdf

... <0.01 - 5 β-BHC <0.02 - 5 γ-BHC <0.01 - 5 δ-BHC <0.01 - 5 Heptachlor <0.01 - 5 Aldrin <0.01 - 5 Heptachlor Epoxide <0.01 - 5 DDE <0.01 - 5 DDD <0.01 - 5 DDT <0.01 - 5 HCB ...

TR-603: Black Cohosh Root Extract (CASRN 84776-26-1) Administered... 3.1MB

https://ntp.niehs.nih.gov/sites/default/files/2023-12/tr603_508.pdf

... δ-BHC a <0.01 - 4 Heptachlor a <0.01 - 4 Aldrin a <0.01 - 4 Heptachlor Epoxide a <0.01 - ... a <0.01 - 32 Heptachlor a <0.01 - 32 Aldrin a <0.01 - 32 Heptachlor Epoxide a <0.01 - ...

TR-288: 1,3-Butadiene (CASRN 106-99-0) in B6C3F1Mice (Inhalation... 5.4MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr288.pdf

... N-Nitrosodimethylamine (ppb) N-Nitrosopyrrolidine ippb) Pesticides (ppm) Alpha BHC (1) Beta BHC Gamma BHC-Lindane Delta BHC Heptachlor Aldrin He@achlor eposide DDE DDD DDT HCB ...