OHAT Protocol to Evaluate the Evidence for an Association Between... 1.7MB

https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/protocol_201506_508.pdf

OHAT Evaluation of PFOA or PFOS Exposure and Immunotoxicity Page 1 of 70 PROTOCOL TO EVALUATE THE EVIDENCE FOR AN ASSOCIATION BETWEEN PERFLUOROOCTANOIC ACID (PFOA) OR ...

Monograph: Perfluorooctanoic Acid or Perfluorooctane Sulfonate... 7.8MB

https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/pfoa_pfosmonograph_508.pdf

WITH EXPOSURE TO PERFLUOROOCTANOIC ACID (PFOA) OR PERFLUOROOCTANE SULFONATE (PFOS) ... Immunotoxicity Associated with Exposure to PFOA or PFOS II TABLE OF CONTENTS Table of ...

Protocol for Systematic Review to Evaluate the Evidence for an... 1.6MB

https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/pfos_pfoa_immuneprotocoldraft.pdf

BETWEEN PERFLUOROOCTANOIC ACID (PFOA) OR PERFLUROOCTANE SULFONATE (PFOS) ... Draft (April 9, 2013) Evaluation of PFOA or PFOS Exposure and Immunotoxicity ii TABLE OF ...

Peer Review Report: Draft NTP Monograph on Immunotoxicity Associated... 206KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2016/july/peerreviewdraftmonographpfoa_pfos20160719.pdf

(PFOA) or Perfluorooctane Sulfonate (PFOS) July 19, 2016 Peer Review Report - July 19, 2016 Peer Review of Draft NTP Monograph on Immunotoxicity Associated with Exposure to PFOA ...

Immunotoxicity Associated with Exposure to Perfluorooctanoic... 69KB

https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/completed/pfoa

Immunotoxicity Associated with Exposure to Perfluorooctanoic Acid (PFOA) or Perfluorooctane Sulfonate (PFOS) commercial and industrial applications of PFOA Topic Overview CASRN: ...

Literature Search Results for the Systematic Review of Immunotoxicity... 419KB

https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/literaturesearch_201605_508.pdf

WITH EXPOSURE TO PERFLUOROOCTANOIC ACID (PFOA) OR PERFLUOROOCTANE SULFONATE (PFOS) May ... Immunotoxicity Associated with Exposure to PFOA or PFOS 2 LITERATURE SEARCH RESULTS ...

Appendix 2: Guidance for Assessing Risk Of Bias in the Protocol... 500KB

https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/appendix_2_pfoa_pfos_riskofbias.pdf

Draft (April 9, 2013) Risk of Bias Tool for Evaluation of PFOA or PFOS Exposure and ... the Evidence for an Association Between PFOA and PFOS Exposure and Immunotoxicity OHAT ...

NTP Studies of Per-and Poly-fluoroalkyl Substances: Understanding... 504KB

https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2020/february/presentations/06blystone_bsc_508.pdf

Manufacturers agreed to discontinue use of PFOA and PFOS due to widespread exposure and ... NHANES PFAS (Geometric Mean) Years Serum [nM] PFOS (1) PFOA (2) PFHxS (3) PFNA PFDA PFuDA ...

TR-598: Perfluorooctanoic Acid (CASRN 335-67-1) Administered... 5.5MB

https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr598_508.pdf

PeRfluoRoocTaNoic acid (casRN 335-67-1) admiNisTeRed iN feed To sPRague dawley ... Studies of Perfluorooctanoic Acid (CASRN 335-67-1) Administered in Feed to Sprague Dawley ...

Roster: TRPRP; Dec. 12, 2019 177KB

https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2019/december/rostertrprp20191212_508.pdf

Acrobat Accessibility Report HMB_PFOA_Roster.pdf.accreport.html Accessibility Report Filename: HMB_PFOA_Roster.pdf Report created by: Organization: [Enter personal and organization ...

Comment: Per- and Poly-fluoroalkyl Substances; Joseph Manuppello... 194KB

https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2020/february/publiccomm/manuppello20200214_bsc_508.pdf

that the data clearly demonstrate that PFOA induces liver toxicity and adenomas via a PPARα agonist mode of action in rats, noting that PFOA activates the PPARα and that the ...

TOX-97: Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexa... 8.6MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox097_508.pdf

... Perfluorooctanoic Acid (PFOA) ......Histopathologic Descriptions for PFHxA, PFOA, PFNA, PFDA, and WY ......

Agenda: TRPRP; Dec. 12, 2019 171KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2019/december/agendatrprp20191212_508.pdf

Cattley Closing Remarks on Draft Reports Panel Adjournment Dr. Cattley Acrobat Accessibility Report HMB_PFOA_Agenda.pdf.accreport.html Accessibility Report Filename: HMB_PFOA_Age...

Public Comment: Draft OHAT Approach; Dr. Nancy Beck and Dr. Kimberly... 553KB

https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/beck20130611_508be.pdf

and BPA and PFOA/PFOS Protocols for Systematic Review and Evidence Integration Dear Dr. ... Between Perfluorooctanoic Acid (PFOA) or Perfluorooctane Sulfonate (PFOS) ...

Public Comment: Draft OHAT Approach; Dr. Jennifer McPartland... 344KB

https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/mcpartland20130611_508.pdf

for an Association between Perfluorooctanoic acid (PFOA) Or Perfluorooctane Sulfonate (PFOS) Exposure and Immunotoxicity (PFOA/PFOS case study), 2 and Draft Protocol for ...

Actions: TRPRP; Dec. 12, 2019 223KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/trpanel/2019/december/actionstrprp20191212_508.pdf

... of Perfluorooctanoic Acid (CAS No. 335-67-1) Administered in Feed to Sprague Dawley ... Acrobat Accessibility Report HMB_PFOA_Actions_v2.pdf.accreport.html Accessibility Report ...

Per- and Polyfluoroalkyl Substances (PFAS) 80KB

https://ntp.niehs.nih.gov/whatwestudy/topics/pfas

(potassium PFBS) Perfluorooctanoic acid (PFOA) Perfluorodecanoic acid (PFDA) Nominated: ... outcomes in rats with lifetime exposure to PFOA, and those with only post-weaning exposure ...

Draft TR-598: Perfluorooctanoic Acid (CASRN 335-67-1) Administered... 5.1MB

https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2019/december/tr598draft.pdf

of Perfluorooctanoic Acid (CAS No. 335-67-1) Administered in Feed to Sprague Dawley ... 1. Perfluorooctanoic Acid (CAS No. 335-67-1; Chemical Formula C 8 HF 15 O 2 ; ...

Monograph Peer Review Actions; July 19, 2016 78KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2016/july/actions20160719_508.pdf

with Exposure to Perfluorooctanoic Acid (PFOA) or Perfluorooctane Sulfonate (PFOS). ... immunotoxicity associated with exposure to PFOA or PFOS. The Panel's recommendations do ...

Draft Handbook for Conducting a Literature-Based Health Assessment... 4.4MB

https://ntp.niehs.nih.gov/ntp/ohat/pubs/handbookdraftmarch2019.pdf

... Example of an Evidence Profile Table: PFOS/PFOA and Functional Antibody Response ... with Exposure to Perflurooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) PECO ...

Handbook for Conducting a Literature-Based Health Assessment... 4.3MB

https://ntp.niehs.nih.gov/ntp/ohat/pubs/handbookmarch2019_508.pdf

... Example of an Evidence Profile Table: PFOS/PFOA and Functional Antibody Response ... with Exposure to Perflurooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) PECO ...

Handbook for Conducting a Literature-Based Health Assessment... 4.3MB

https://ntp.niehs.nih.gov/ntp/ohat/pubs/handbookjan2015_508.pdf

... Example of an Evidence Profile Table: PFOS/PFOA and Functional Antibody Response ... with Exposure to Perflurooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) PECO ...

Abstract for TOX-97 125KB

https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox097

Perfluorohexanoic acid (CASRN 307-24-4) Perfluorooctanoic acid (CASRN 335-67-1) ... acid [PFHxA], perfluorooctanoic acid [PFOA], perfluorononanoic acid [PFNA], and ...

Public Health Impact 1.5MB

https://ntp.niehs.nih.gov/media/impact

... These nine PFAS are perfluorooctanoic acid (PFOA), perfluorooctanesulfonic ... Park, NC. https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/pfoa_pfosmonograph_508.pdf NTP (National ...

Public Comment: Draft OHAT Approach; Dr. Tracey Woodruff; Feb... 775KB

https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/woodruff20130611_508.pdf

protocols (bisphenol A exposure and obesity, and PFOA & PFOS exposure and immunotoxicity). ... Guide to our first case study on PFOA demonstrated that NTP's proposed approach ...

NTP Studies of Per- and Poly-fluoroalkyl Substances: Understanding... 151KB

https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2020/february/meeting_materials/4blystone_bsc_508.pdf

on perfluorooctanoic acid (PFOA), conducted rodent and cell-based immune toxicity studies, and carried out a literature- based systematic review of PFOA and perfluorooctane ...

Minutes: BSC; December 14-15, 2016 348KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2016/december/minutes20161214_508.pdf

... Immunotoxicity Associated with Exposure to PFOA or PFOS ...... 14 A. Presentation ... ORoC Office of the Report on Carcinogens PFOA perfluorooctanoic acid PFOS ...

Public Comments on Draft OHAT Approach-February 2013 for Systematic... 62KB

https://ntp.niehs.nih.gov/events/webinars-workshops/2013/draft/comments

Approach - February 2013. Two protocols are being released to illustrate the application of this framework: BPA exposure and obesity and PFOA or PFOS exposure and immunotoxicity. ...

ChemMaps.com V2 - Exploring the Environmental Chemical UniverseNICEATM... 5.6MB

https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-borrel-poster.pdf

ChemMaps.com uses Tox21/ToxCast assays to characterize biological activity. PFOA is active ... On the whole space PFOA is in a low-density area around other PFAS chemicals. Chemical ...

Minutes: BSC; Dec. 9-10, 2014 270KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2014/dec/bsc_dec2014_minutes_508.pdf

... disease PFC perfluorinated chemicals PFOA perfluorooctanoic acid PFOS ... with Exposure to Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) Dr. ...

Minutes: BSC; February 21, 2020 163KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2020/february/minutesbsc20200221_508.pdf

... PFAS per- and poly-fluoroalkyl substances PFOA perfluorooctanoic acid PFOS ... the use of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) ...

Research Concept for Perfluorinated Compounds Class ; July 8... 78KB

https://ntp.niehs.nih.gov/ntp/noms/final_resconcept/pfoaconcept_508.pdf

Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA), the most widely studied ... reproductive toxicity studies, and a 2-year bioassay of PFOA with in utero exposure. ...

Agenda: Peer Review of Draft Monograph; July 2016 262KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2016/july/agendapfoa_pfos_508.pdf

with Exposure to Perfluorooctanoic Acid (PFOA) or Perfluorooctane Sulfonate (PFOS) ... Panel Public Comments Draft NTP Monograph: PFOA Antibody Response . Presentation Dr. ...

Integrating Bayesian Approaches with PBPK Modeling in a Human... 2.1MB

https://ntp.niehs.nih.gov/iccvam/meetings/popvar-2022/ppt/05_chou_508.pdf

PFOA and PFOS are two of most widespread PFAS PFAS: Per- and polyfluoroalkyl substances PFC : Perfluorinated compound PFOA: Perfluorooctanoic acid PFAS were invented by 3M company ...

ICCVAM PFAS WG (SACATM Meeting 2023) 2.3MB

https://ntp.niehs.nih.gov/sites/default/files/2023-11/11_Vinas_SACATM2023_508.pdf

potential, such as perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS), ... PFOA PFOS 2 Blake and Fenton, 2020 Toxicology . The Report to Congress provides a high- ...

REACT Program; Michael DeVito; BSC; Dec. 7-8, 2017 88KB

https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2017/december/meetingmaterials/devito_react_508.pdf

PFAS are perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). Due to their toxicity, persistence and bioaccumulation, PFOA and PFOS have been replaced by other ...

National Institute of Environmental Health Sciences: Jason P... 158KB

https://www.niehs.nih.gov/research/atniehs/dtt/assoc/opo/staff/stanko

... exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay. Reprod. ... exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay. Reprod. ...

Agenda: Webinar on Lessons Learned in Application of the OHAT... 78KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/ohat/evaluationprocess/agendawebinar20140731_508.pdf

for two case studies, BPA and obesity and PFOA/PFOS and immunotoxicity, which the Office of Health Assessment and Translation (OHAT) planned to undertake using the OHAT approach. ...

NTP 2014: Current Directions & Evolving Strategies 3.3MB

https://ntp.niehs.nih.gov/ntp/pubs/currentdirections2014_508.pdf

PBDEs Polybrominated Diphenyl Ethers PFOA Perfluorooctanoic Acid PFOS ... (PFOS) and perfluorooctanoic acid (PFOA) have been used since the 1950s to make a ...

NTP Technical Reports Index 1.5MB

https://ntp.niehs.nih.gov/data/tr

Evidence EE Equivocal Evidence NE No Evidence TR-598 12/12/19 Perfluorooctanoic Acid 335-67-1 CE Clear Evidence SE Some Evidence TR-597 12/12/19 2-Hydroxy-4-methoxybenzophenone ...

Safe and Sustainable Alternatives Program; Stephen Ferguson;... 3.2MB

https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2021/august/presentations/ssa_bsc_presentation_508.pdf

PBB flame retardants PBDE flame retardants OP flame retardants PFOS/PFOA GenX PFAS ... PBDE polybrominated diphenyl ether PFAS per- and polyfluoroalkyl substances PFOA ...

Public Comment: Draft OHAT Approach; Dr. Jennifer Sass, Dr. Adam... 154KB

https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/sassetal20130611_508.pdf

- February 2013. The NTP included two protocols illustrate the application of this framework: (1) BPA exposure and obesity and (2) PFOA or PFOS exposure and immunotoxicity. ...

Informational Meeting on the Draft OHAT Approach for Systematic... 62KB

https://ntp.niehs.nih.gov/events/webinars-workshops/2013/draft

Between Perfluorooctanoic Acid (PFOA) or Perflurooctane Sulfonate (PFOS) Exposure and Immunotoxicity Appendix 2: Risk of Bias Guidance for PFOA or PFOS Exposure and ...

Validation of an In Vitro Gastrointestinal Digestion and Co-culture... 19.2MB

https://ntp.niehs.nih.gov/sites/default/files/2023-12/Wksp_06_Sayes_GutModels2023_508.pdf

... Control 1 µM PFOA 1000 µM PFOA 0 20 40 0 50 100 150 200 Exposure time (hrs) TEER (Ω *cm 2 ) 1000 µM 300 µM 1 µM 0 µM Above: Tight junction visualization via ZO-1 staining; ...

Environmental Factors Under Consideration 61KB

https://ntp.niehs.nih.gov/whatwestudy/assessments/cancer/nominated

First listed as Reasonably Anticipated to be a Human Carcinogen in the 12th RoC. January 19, 2012 (HTML) Provide Information E F G - O P Perfluorooctanoic acid (PFOA) 335-67-1 Used ...

Presentation: Draft OHAT Approach Part 1 Preparing the Topic... 2.5MB

https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/presentations/april2013/parti_boyles20130423_508.pdf

Primary and Secondary Outcomes Example - PFOA/PFOS Exposure and Immunotoxicity Humans ... Primary and Secondary Outcomes Example - PFOA/PFOS Exposure and Immunotoxicity Humans ...

TOX-96: Toxicity Studies of Perfluoroalkyl Sulfonates (Perfluorobutane... 6.0MB

https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox096_508.pdf

... exposure to perfluorooctanoic acid (PFOA) chronic toxicity and carcinogenicity in ... 307-24-4 PFHxA 97 Perfluorooctanoic Acid 335-67-1 PFOA 97 Perfluorononanoic Acid 375-95-1 ...

Presentation: Draft OHAT Approach Part 2 Confidence in the Body... 2.4MB

https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/presentations/april2013/partii_rooney20130423_508.pdf

... Provided by Other Relevant Studies: PFOA/PFOS and Immunotoxicity Assessment of Biological Plausibility Provided by Other Relevant Studies: PFOA/PFOS and Immunotoxicity Factors ...

Summary Minutes December 7-8, 2017 NTP Board of Scientific Counselors 352KB

https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2017/december/minutes20171208_508.pdf

... substances PFC perfluorinated chemicals PFOA perfluorooctanoic acid PFOS ... A systematic review of perfluorooctanoic acid (PFOA) immunotoxicity has been published. ...

Public Comment: Draft OHAT Approach; Ms. Patricia Kablach Casano... 4.3MB

https://ntp.niehs.nih.gov/ntp/ohat/evaluationprocess/publiccomm/casano20130611_508.pdf

... to be developed on a chemical-by-chemical basis. such as the Draft BPA and PFOA protocols. ... OHAT should combine the Draft BPA and PFOA protocols. substitute "Chemical of ...