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RoC Profile: Azathioprine; 15th RoC 2021 123KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/azathioprine.pdf
Azathioprine CAS No. 446-86-6 Known to be a human carcinogen First listed in the Fourth Annual Report on Carcinogens (1985) N N S N N CH 3 O 2 N N HN Carcinogenicity Azathioprine ...
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RoC Background Document: Cyclosporin A; Nov. 18-19, 1996 4.9MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/cyclosporin_a1_508.pdf
... CsA is used alone or in combination with azathioprine, prednisolone, prednisone, ... were detected in another 140 patients that received CsA followed by azathioprine. ...
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Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf
Phenacetin) Aristolochic Acids Arsenic and Inorganic Arsenic Compounds Asbestos Azathioprine Benzene Benzidine (see Benzidine and Dyes Metabolized to Benzidine) Beryllium and ...
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RoC Profile: Cyclosporin A; 15th RoC 2021 130KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cyclosporina.pdf
... Cyclosporin A is used alone or in combination with azathioprine, prednisolone, pred- nisone, antilymphocyte globulin, actinomycin, cyclophosphamide, methylprednisolone, or ...
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Appendix G; 15th RoC 2021 73KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
... and Nickel Compounds 434-07-1 see Oxymetholone 443-48-1 see Metronidazole 446-86-6 see Azathioprine 475-80-9 (aristolochic acid II) see Aristolochic Acids 505-60-2 see Mustard ...
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NTP Monograph: Developmental Effects and Pregnancy Outcomes Associated... 23.8MB
https://ntp.niehs.nih.gov/ntp/ohat/cancer_chemo_preg/chemopregnancy_monofinal_508.pdf
... The drug is a metabolite of the immunosuppressive drug azathioprine. 6-Mercaptopurine is ... (6-MMP)) following administration of azathioprine to pregnant mothers. ...
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Appendices A-G; 15th RoC 2021 448KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf
...o-1H-imidazol-5-yl)thio]-1H-purine see Azathioprine 1-methyl-3-nitro-1-nitrosoguanidine ... Oxymetholone 443-48-1 see Metronidazole 446-86-6 see Azathioprine 475-80-9 (aristolochic ...
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15th RoC: Appendix F 174KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf
... see Metronidazole 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine see Azathioprine 1-methyl-3-nitro-1-nitrosoguanidine see N-Nitrosamines: 15 Listings, ...
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NTP Monograph: Systematic Review of Occupational Exposure to... 6.2MB
https://ntp.niehs.nih.gov/ntp/ohat/oeccaaho/mgraph/occchemo_final20190300_508.pdf
... The remaining agents were evaluated in six or fewer studies: azathioprine, daunorubicin, ... to chloramphenicol and azathioprine among workers in a South African pharmaceutical plant. ...
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RoC Background Document for 4,4'-Thiodianiline; March 27, 2002 1.1MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/tdapub_no_appendices_508.pdf
... However, in re-examining the potential carcinogenicity of azathioprine, Gombar et al. ... B.W. Blake. 1993. Carcinogenicity of azathioprine: an S-AR investigation [published ...
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RoC Background Document on Human Papillomaviruses: Genital-Mucosal... 2.9MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/hpv_rg2_public_508.pdf
... All animals treated with azathioprine experienced a substantial drop in peripheral blood ... Benign bladder hemangiomas occurred in all animals treated with azathioprine. Malignant ...
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Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf
... Thallium I acetate 0.14 0.13 34.2 204 Azathioprine 0.14 1.93 535.2 58 Dihydralazine ... Oral Rat or Mouse LD50 (mg/kg) 204 Azathioprine 0.14 1.93 535.2 156 ...
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Report: International Workshop on In Vitro Methods for Assessing... 25.4MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf
... 7.5 57 L- Dopa 59-92-7 25.64 0.13 1780.8 9.03 2366.5 12 197.21 9.03 204 Azathioprine 446-86-6 38.82 0.14 535.2 1.93 1389.2 5.01 277.29 1.93 58 Dihydralazine sulfate 7327-87-9 ...
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TR-329: 1,2-Epoxybutane (CASRN 106-88-7) in F344/N Rats and B6C3F1Mice... 10.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr329.pdf
... Ind. Hyg. ASSOC. J. 23:95-107. 65. Speck, W.T.; Rosenkranz, H. (1976) Muta- genicity of azathioprine. Cancer Res. 36:108- 109. V. REFERENCES 66. Tarone, R. (1975) Tests for trend ...
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DART-03: Prenatal Development Studies of Vinpocetine (CASRN 42971... 1.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart03_508.pdf
... M. Review of the potential effects of three commonly used antineoplastic and immunosuppressive drugs (cyclophosphamide, azathioprine, doxorubicin on the embryo and placenta). ...
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ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf
.../kg) 2 Rat Oral LD 50 (mg/kg) 2 Triethyl citrate 276.32 14.7 4061.9 25.3 6990.9 Azathioprine 277.29 0.14 38.8 1.93 535.2 Amitriptyline 277.44 0.056 15.5 1.15 319.1 ...
