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Salivary Gland, Parotid - Basophilic Hypertrophic Focus - Nonneoplasti... 291KB
https://ntp.niehs.nih.gov/atlas/nnl/alimentary-system/salivary-gland/Parotid-BasophilicHypertrophicFocus
This change may be seen occasionally in untreated rats, but chemicals, including doxylamine, have produced this change in the parotid gland of F344 rats. This change is not thought ...
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A BIOMARKER BASED DEVELOPMENTAL ... 919KB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/egnashposter-2014-sot.pdf
... NON NON NON Diphenhydramine NON NON NON Doxylamine NON NON NON Folic Acid NON NON NON ... Warfarin (n=2) D-Penicillamine (n=3) Isoniazid (n=2) Doxylamine (n=4) Thalidomide (n=2) ...
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Salivary Gland, Parotid - Basophilic Hypertrophic Focus 447KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/alimentary/salivary_gland/bhfoc/salivary-gland-parotid-basophilic-hypertrophic-focus_508.pdf
This change may be seen occasionally in untreated rats, but chemicals, including doxylamine, have produced this change in the parotid gland of F344 rats. This change is not thought ...
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DEVELOPMENT OF A TARGETED BIOMARKER... 3.4MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/palmerposter.pdf
... NON >300 NON Caffeine NON >300 NON >300 NON Diphenhydramine NON 1.8 NON 1.1 NON Doxylamine ... acid, busulfan, carbamazepine and doxylamine is within 2- fold. ¨ Hydroxyurea is an ...
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Predicting human developmental toxicity of pharmaceuticals using... 510KB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/westtap2016.pdf
... (Blind 1) 0.286 (Gazala et al., 2002) Doxylamine (Blind 2) 0.103 (Friedman et al., 1989) ... Blind # Drug Actual Predicted B1 Retinol Non Non B2 Doxylamine Non Non B3 Amiodarone Ter ...
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TOWARD VALIDATION OF A HUMAN IN... 1.1MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/egnashposter-2014-wc.pdf
... TER 2 Diphenhydramine Pharmaceutical TER 2 Carbamazepine Pharmaceutical TER 3 Doxylamine Pharmaceutical TER 5 Cytosine Arabinoside Pharmaceutical TER 0.8 Folic Acid ...
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Minutes: BSC; March 27, 1984 3.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1984/march/bsc_minutes19840327_508.pdf
... ; and (c) the metabolic pathways for doxylamine succinate in the Rhesus monkey . VII . ... Catecholamine s Ethanol, Isoproterenol, Doxylamine 2.4 .5-T, Methiphenidate, Marijuana ...
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Comparison of devTOX quickPredict Assay With Other Methods 1.0MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/comparisonspreadsheet-508.pdf
... Diquat dibromide N/A N/A N/A n.d. DT n.d. DT (6) DT (6) DT (5), NON (14) n.d. n.d. DT DT Doxylamine 0.38 N/A N/A B NON NON (1) NON (4) NON (4) n.d. DT (Weak, 3) NON (4) NON NON ...
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US Strategic Roadmap Goal: Encourage the Use and Adoption of... 3.6MB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2018/september/presentations/02berridge_508.pdf
... fluoxetine (Prozac) Lithium Antihistamines Dip hen hyd ram ine ( Benad ryl) , doxylamine (Un isom) A nt imicrob ials Acydovir (Zovirax) A minog lycosides Amp hoterici n B ...
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Comparison of the Stemina devTOX quickPredict system with other... 2.1MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2018-09961/palmer-stemina-spreadsheet.pdf
... Diquat Dibromide DT n.d. n.d. DT (6) DT (6) DT (5) NON (14) n.d. n.d. n.d. DT DT N/A N/A N/A Threshold Rodent Doxylamine NON B NON (1) NON (4) NON (4) n.d. DT (3) NON (4) 0.14 NON ...
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TR-588: Glycidamide (CASRN 5694-00-8) in F344/N Nctr Rats and... 3.6MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr588_508.pdf
... 1/163 (0.6%) 0/163 (0.0%) 1/163 (0.6%) Doxylamine (April 1991) Diet 1/48 (2.1%) 0/48 ... (November 1988) Diet 6/180 (3.3%) Doxylamine (April 1991) Diet 2/48 (4.2%) ...
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TR-413: Ethylene Glycol (CASRN 107-21-1) in B6C3F1Mice (Feed... 11.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr413.pdf
... Dr. McDonald said that degeneration was observed in studies of doxylamine, pentachloroanisole, and polybrominated biphenyls, but that none of the three were structurally related to ...
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TR-575: Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1... 9.9MB
https://ntp.niehs.nih.gov/go/tr575
... Carcinoma Adenoma or Carcinoma Doxylamine (April 1991) Diet 0/48 (0.0%) 1/48 ... of Administration Incidence in Controls Doxylamine (April 1991) Diet 2/48 (4.2%) Fumonisin ...
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Minutes: BSC TRRS; July 9, 1991 979KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1991/july/trrs9july1991mins_508.pdf
... McDonald responded t h a t t h e l e s i o n s had been observed i n s t u d i e s w i t h a t l e a s t t h r e e o t h e r chemicals, doxylamine, pentachloroanisole, and ...
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TR-527: Malachite Green Chloride and Leucomalachite Green (CASRNs... 7.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr527.pdf
... Adenoma Carcinoma Adenoma or Carcinoma Doxylamine 1/48 0/48 1/48 Fumonisin B 1 0/48 0/48 ... F344 Rats a Study Incidence in Controls Doxylamine 36/48 Fumonisin B 1 33/48 Gentian ...
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TOX-16: Glyphosate (CASRN 1071-83-6) 1.9MB
https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox016.pdf
... studies with some chemicals, such as doxylamine (Jackson and Blackwell, 1988) and ... Blackwell, B. (1988) Subchronic studies of doxylamine in Fischer 344 rats. Fundam. Appl. ...
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TR-355: Diphenhydramine Hydrochloride (CASRN 147-24-0) in F344... 10.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr355.pdf
... Other antihistaminic drugs un- der study by the NTP for carcinogenicity include doxylamine, pyrilamine, tripelennamine, and triprolidine. G e n e t i c Toxicology Diphenhydramine ...
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Background: Dimethylethanolamine (DMAE) [108-01-0] and Selected... 1.3MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dmae_update_110002_508.pdf
... including the antihistamines paracarbinoxamine, diphenhydramine (Dow, 2001a), doxylamine, medrylamine, p-methyldiphenhydramine, moxastine, orphenadrine, 15 Toxicological ...
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TR-502: Chloral Hydrate (CASRN 302-17-0) in B6C3F1Mice (Gavage... 8.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr502.pdf
... Study Adenoma or Carcinoma Doxylamine 2/38 Fumonisin B 1 0/29 Pyrilamine 2/45 ... Study Incidence in Controls Doxylamine 13/48 Fumonisin B 1 20/47 Pyrilamine 10/48 ...
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TR-510: Urethane + Ethanol (CASRNs. 51-79-6 & 64-17-5) in F344... 17.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr510.pdf
... hydrate 2/48 Chloral hydrate 1/48 Doxylamine 0/48 Fumonisin B 1 0/48 Pyrilamine 0/47 ... 24/48 Chloral hydrate 12/48 4/48 16/48 Doxylamine 6/48 4/48 9/48 Fumonisin B 1 9/47 4/47 ...
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Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf
... 243 p-Anisidine 0.73 11.4 1404.1 244 Doxylamine succinate 0.75 1.21 470.1 88 Dibutyl ... 456.3 40 Chlordan 0.06 1.12 458.9 244 Doxylamine succinate 0.75 1.21 470.1 54 23 ...
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Background Review Document: Frog Embryo Teratogenesis Assay ... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/fetax2000/brd/fetax-brd-all.pdf
... Diphenylhydramine HCl Tested Not Tested Doxylamine succinate* Tested Tested EM12 Not ... - - Diphenhydramine hydrochloride + - - Doxylamine succinate + - - Furazolidone + - - ...
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TR-503: Chloral Hydrate (Ad Libitum and Dietary Controlled) ... 5.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr503.pdf
... Incidence in Controls Study Adenoma Carcinoma Adenoma or Carcinoma Doxylamine 6/48 4/48 9/... Approximately 150 mice from each of the doxylamine, pyrilamine, and triprolidine bioassays ...
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TR-317: Chlorpheniramine Maleate (CASRN 113-92-8) in F344/N Rats... 10.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr317.pdf
... Other antihistaminic drugs being studied by the National Toxicology Program for toxicity and carcinogenicity include diphenhy- dramine, doxylamine, pyrilamine, tripelenna- mine, ...
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TOX-20: Diethanolamine (CASRN 111-42-2) 2.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox020.pdf
... other chemicals which have induced enlargement of salivary gland acinar cells and which also have structural similarities to catecholamines, such as doxylamine and methapyrilene. ...
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Report: International Workshop on In Vitro Methods for Assessing... 25.4MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf
... 0.73 1404.1 11.4 NA NA 123.17 11.4 244 Doxylamine succinate 562-10-7 291.38 0.75 NA NA ... 0.00033 NA NA 696.0 1.2 580.03 1.2 244 Doxylamine succinate 562-10-7 291.38 0.75 NA NA ...
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TR-569: Mixtures of 3'-Azido-3'-Deoxythymidine (AZT), Lamivudine... 7.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr569_508.pdf
.../185 (10.8%) 0/183 (0.0%) 3/187 (1.6%) Doxylamine - b 4/48 (8.3%) 1/47 (2.1%) 0/48 (0.0%) ... 5/180 (2.8%) 0/181 (0.0%) 5/182 (2.7%) Doxylamine 0/44 (0.0%) 0/44 (0.0%) 1/48 (2.1%) 3/...
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TR 577: Nondecolorized Whole Leaf Extract of Aloe Barbadensis... 11.3MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr577_508.pdf
... Colon/Rectum Adenoma or Carcinoma Doxylamine (April 1991) Diet 0/48 0/48 Fumonisin B ... Colon/Rectum Adenoma or Carcinoma Doxylamine (April 1991) Diet 0/48 0/48 Fumonisin B ...
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Public Health Impact 1.5MB
https://ntp.niehs.nih.gov/media/impact
... Dec. 9, 1992. Amendment of final rule to include doxylamine succinate. NTP Information ... Type: Final Rule January 28, 1994 59 FR 4216 469-21-6 91-84-9 1994 FDA Indirect Food ...
