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41 results found for "50-02-2".

  1. Thymus - Necosis, Lymphocyte 306KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/immune/thymus/necrosis/thymus-necrosis-lymphocyte-pdf_508.pdf

    Necrosis, Lymphocyte Figure Legend: Figure 1 Thymus - Necrosis, Lymphocyte in a male Harlan Sprague-Dawley rat from a subchronic study. Treatment with dexamethasone resulted in ...

  2. Submission of the CertiChem Cell Proliferation Test Method for... 3.1MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/submdoc.pdf

    ... The four false negatives are 4-hydroxytamoxifen, dexamethasone, 2,4,5-trichloro-phenoxyace... For example, ICCVAM (2003a) reported only one study as EA positive for dexamethasone and ...

  3. Lymph node - Apoptosis, Lymphocyte - Nonneoplastic Lesion Atlas 289KB

    https://ntp.niehs.nih.gov/atlas/nnl/immune-system/lymph-node/ApoptosisLymphocyte

    Examples of such stimuli include heat, irradiation, hypoxia, and cytotoxic cancer drugs (e.g., cyclophosphamide). Dexamethasone can also incite lymphocyte apoptosis; however, the ...

  4. Lymph Node - Apoptosis, Lymphocyte 642KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/immune/lymph_node/apop/lymph-node-apoptosis-lymphocyte-pdf_508.pdf

    Examples of such stimuli include heat, irradiation, hypoxia, and cytotoxic cancer drugs (e.g., cyclophosphamide). Dexamethasone can also incite lymphocyte apoptosis; however, the ...

  5. Thymus - Necrosis, Lymphocyte - Nonneoplastic Lesion Atlas 289KB

    https://ntp.niehs.nih.gov/atlas/nnl/immune-system/thymus/NecrosisLymphocyte

    ... Treatment with dexamethasone resulted in severe lymphocyte apoptosis with focal areas of ... Treatment with dexamethasone resulted in severe lymphocyte apoptosis with focal areas of ...

  6. Immunotoxicity Study Pathology Specifications; Oct. 7, 2016 678KB

    https://ntp.niehs.nih.gov/ntp/htdocs/levels/finalntpitoxspecs_508.pdf

    Generally 5 treatment groups plus a vehicle control group iii. Positive control(s): either cyclophosphamide or dexamethasone iv. Each group generally consists of 8 mice or 12 rats, ...

  7. Eye, Cornea - Neovascularization - Nonneoplastic Lesion Atlas 290KB

    https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/eye/Cornea-Neovascularization

    GS, Chavane F. 2010. Inhibition of corneal neovascularization after alkali burn: Comparison of different doses of bevacizumab in monotherapy or associated with dexamethasone. ...

  8. Eye, Cornea - Neovascularization 300KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/eye/crneov/eye-cornea-neovascularization_508.pdf

    GS, Chavane F. 2010. Inhibition of corneal neovascularization after alkali burn: Comparison of different doses of bevacizumab in monotherapy or associated with dexamethasone. ...

  9. National Institute of Environmental Health Sciences: NIEHS-06 152KB

    https://www.niehs.nih.gov/research/atniehs/dtt/assoc/reports/niehs-reports/niehs-06

    ... The most sensitive gene sets for which a reliable estimate of the BMD could be made were cellular response to dexamethasone stimulus and cellular response to glucocorticoid ...

  10. ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf

    ... metabolite o,p'-DDT 789-02-6 Organochlorine; Diphenylalkene Pesticide Dexamethasone 50-02-2 Steroid, nonphenolic Pharmaceutical Dibenzo[a,h]anthracene 53-70-3 Polycyclic ...

  11. Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf

    ... ER agonist and antagonist; weak AR antagonist; being tested in vivo by OECD Dexamethasone 50-02-2 Steroid Pharmaceutical, Veterinary Agent † ER AR ER-/AR- ER±/AR+ Y weak ER and ...

  12. Nomination of MAT Test for Pyrogen Detection (April 2011) 1.4MB

    https://ntp.niehs.nih.gov/iccvam/methods/pyrogen/mat-2011/iccvamnom-pyrodetecthk290311f-508.pdf

    ... Curr Pharm Des. 12 , 4163-4172 (2006 ) 8 Kern J. A. , R.J . Lamb , J.C. Reed , R.P . Daniele , and P.C . Nowell: Dexamethasone Inhibition of lnterleukin 1 Beta Production by Human ...

  13. Predicting human developmental toxicity of pharmaceuticals using... 510KB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/westtap2016.pdf

    ... 0.0353 (Brocks, 1999) Teratogens Dexamethasone 5.0 (Toth et al., 1999) ... M.F., 1999. Pharmacokinetics of high-dose oral and intravenous dexamethasone (1999). Ther. ...

  14. NICEATM Validation Study Report on the MCF-7 Cell Proliferation... 1.8MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/mcf7/mcf7-valstudyreport-19jun12-wcv2-draft.pdf

    ... 3 Daidzein POS (1/1) POS (2/2) POS 3 Dexamethasone NEG (1/1) NEG (1/1) NEG 3 Di-n-butyl .../1) POS (1/1) NT NEG (1/1) NEG NEG 3 Dexamethasone NEG (1/1) POS (1/1) NT POS (1/1) NEG ...

  15. Public Comment: 2-Butoxyethanol (Attachment); Seth Barna; RoC... 758KB

    https://ntp.niehs.nih.gov/ntp/roc/nominations/2013/publiccomm/barna_attachmentacc_508be.pdf

    ... following multiple dermal exposure to dexamethasone, ethanol or 2- butoxyethanol (2-BE). ... Treatment with a general inducing agent such as dexamethasone enhanced ethanol and 2-BE ...

  16. ICCVAM Test Method Evaluation Report on the BG1Luc ER TA Test... 17.5MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/bg1lucer-ta-tmer-combined.pdf

    ... Dihydrotestosterone (AR ligand) and dexamethasone (glucocorticoid receptor ligand) induced ... Product ≥97.5 Alfa Aesar GmbH Dexamethasone 50-02-2 Steroid Pharmaceutical, ...

  17. Expert Panel Evaluation of the Validation Status of In Vitro... 1.1MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/expertpanfinalrpt/panelrpt1102.pdf

    ... The response was 3-9 fold for DHT and 1-19.5 fold for dexamethasone. Hydroxyflutamide was ... The response was 24 fold with 0.1 nM DHT and 248 fold with 1 µM dexamethasone (Hartig et ...

  18. XDS Submission of the LUMI-CELL ER Test Method 3.2MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/iccvamsubmission28jan05.pdf

    ... - 1.95E+03 1.00E+01 - 4.88E-03 3.93E-05 - 1.92E-08 > 98% Sigma Powder Dexamethasone 50-02-2 Steroid, nonphenolic Pharmaceutical 4.00E+07 - 3.91E+04 1.00E+02 - 9.77E-02 ...

  19. Submission of XDS's LUMI-CELL ER High-Throughput System for Screening... 2.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexa/xds-sub.pdf

    ... - 1.95E+03 1.00E+01 - 4.88E-03 3.93E-05 - 1.92E-08 > 98% Sigma Powder Dexamethasone 50-02-2 Steroid, nonphenolic Pharmaceutical 4.00E+07 - 3.91E+04 1.00E+02 - 9.77E-02 ...

  20. TR-597: 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered... 3.2MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr597_508.pdf

    ... Findings for 2H4MBP are suggestive of effects on glucocorticoid (dexamethasone) and ... Chemical drug 0.0411 2.173 Activated Dexamethasone Chemical drug 0.000916 2.096 Activated ...

  21. TOX-104: (+)-Usnic Acid (CASRN 7562-61-0) Administered in Feed... 4.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox104_508.pdf

    ... K.2.2. Method 2 This method utilized dexamethasone as an internal standard and a Waters ... Internal standard (30 pmol of dexamethasone-21- acetate (Sigma-Aldrich) in 30 µL of ...

  22. TOX-105: Usnea Lichens Containing (+/-)-Usnic Acid (CASRN 125... 4.2MB

    https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox105_508.pdf

    ... K.2.2. Method 2 This method utilized dexamethasone as an internal standard and a Waters ... Internal standard (30 pmol of dexamethasone-21- acetate (Sigma-Aldrich) in 30 µL of ...

  23. Peer Review Panel Report on Evaluation of the LUMI-CELL ER Test... 287KB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edprprept2011.pdf

    ... that there was discordance among the laboratories for six substances: dicofol, fluoranthene, butylphenol, androstenedione, clomiphene citrat, resveratrol. What about dexamethasone? ...

  24. ICCVAM Test Method Evaluation Report: Five In Vitro Pyrogenicity... 7.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/pyrogen/tmer/pyrotmer2008.pdf

    ... Martinez V, Mitjans M, Vinardell MP. 2004. TNFα measurement in rat and human whole blood as an in vitro method to assay pyrogens and its inhibition by dexamethasone and ...

  25. RoC Background Document on Human Papillomaviruses: Genital-Mucosal... 2.9MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/hpv_rg2_public_508.pdf

    ... Dexamethasone treatment of SW 756 cervical squamous carcinoma cells induced repression of ... E6-E7 expression and neoplastic growth were restored upon withdrawal of dexamethasone or ...

  26. RoC Background Document: Silica, Crystalline (Respirable Size... 1.7MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/silica_no_app_508.pdf

    ... Fundam.Appl.Toxicol 17:614-626. 104. VanDyke, K., J.M. Antonini, L. Wu, Z. Ye, and M.J. Reasor. 1994. The inhibition of silica- induced lung inflammation by dexamethasone as ...

  27. NTP Cancer Hazard Report: Night Shift Work and Light at Night... 10.1MB

    https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal20210400_508.pdf

    ... A study using the glucocorticoid analog dexamethasone demonstrated that glucocorticoids efficiently synchronized the phase of circadian gene expression in cultured rat fibroblasts ...

  28. Documents Provided to the NTP Board of Scientific Counselors... 55.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/fluoride/documents_provided_bsc_wg_031523.pdf

    ... fluoride- and dexamethasone-induced oxidative damage in osteoblast and hippocampal cells. ... fluoride- and dexamethasone-induced oxidative damage in osteoblast and hippocampal cells. ...

  29. Literature Search Results: Systematic Review of Fluoride Exposure... 768KB

    https://ntp.niehs.nih.gov/ntp/ohat/fluoride/literature_results20200916_508.pdf

    ... Fluoride 47: 161-169. Inkielewicz-Stepniak I, Radomski MW, Wozniak M. 2012. Fisetin prevents fluoride- and dexamethasone- induced oxidative damage in osteoblast and hippocampal ...

  30. Background Review Document: Frog Embryo Teratogenesis Assay ... 2.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/fetax2000/brd/fetax-brd-all.pdf

    ... Tested Not Tested Cyclophosphamide** Tested Tested Cytochalasin D* Tested Tested Dexamethasone Not Tested Not Tested Diazapam* Tested Not Tested Diethylstilbestrol* Not Tested ...

  31. Template Copyright 2014 © Clean Production Action 1.9MB

    https://ntp.niehs.nih.gov/ntp/ohat/publiccomms/2016/attachment-1.pdf

    ... Positive controls received cyclophosphamide or dexamethasone for five days, negative controls received carboxymethyl cellulose for 28 days. Animals were weighed daily. Seven days ...

  32. TR-432: Barium Chloride Dihydrate (CASRN 10326-27-9) in F344... 15.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr432.pdf

    ... Res. 257, 229-306. Ayre, and J. ( 1 9 6 7 ) . Some J.E., LeGuerrier, (regressive) effects o f DMSO dexamethasone upon cervical cells in cervical dysplasia and carcinoma in situ. ...

  33. TR-536: bis(2-Chloroethoxy)methane (CASRN 111-91-1) in Male F344... 9.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr536.pdf

    ... Pathol. 20, 1079-1083. Brüggemann, S.K., Pfäffle, S., Peters, S.O., and Wagner, T. (2007). Influence of short-term use of dexamethasone on the pharmacokinetics of ifosfamide in ...

  34. TR-503: Chloral Hydrate (Ad Libitum and Dietary Controlled) ... 5.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr503.pdf

    ... Toxicol. 15, 878-884. Steineger, H.H., Sørensen, H.N., Tugwood, J.D., Skrede, S., Spydevold, Ø., and Gautvik, K.M. (1994). Dexamethasone and insulin demonstrate marked and ...

  35. CERHR Monograph: Soy Infant Formula 122.6MB

    https://ntp.niehs.nih.gov/ntp/ohat/genistein-soy/soyformula/soymonograph2010_508.pdf

    ... On PND 65, males from each diet group received either dexamethasone or corn oil vehicle by ... In rats not receiving dexamethasone, corticosterone 6β-hydroxylase was increased 9% by ...

  36. RoC Background Document for Lead and Lead Compounds - May 8,... 3.5MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/lead-public_508.pdf

    ... Carcinogenesis 13:379-383. 191. Ledda-Columbano, G.M., A. Columbano, A. Cannas, G. Simbula, K. Okita, K. Kayano, Y. Kubo, S.L. Katyal, and H. Shinozuka. 1994. Dexamethasone ...

  37. Monograph on Potential Human Reproductive and Developmental Effects... 2.4MB

    https://ntp.niehs.nih.gov/ntp/ohat/fluoxetine/fluoxetine_monograph.pdf

    ... Eur J Endocrinol 2001; 144: 535-41. 131. Thakore, J. H. and Dinan, T. G. Effect of fluoxetine on dexamethasone-induced growth hormone re- lease in depression: a double-blind, ...

  38. TR-582: Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and... 5.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr582_508.pdf

    ... sarcoma viral related oncogene homolog Lyn (v-yes) 5.02 5.44 RAS-Mapk Pathway RAS, dexamethasone-induced 1 Rasd1 38.52 14.18 Rho family GTPase 1 Rnd1 -13.26 -8.60 Rho family GTPase ...

  39. NTP Working Group Report: Draft State of the Science Monograph... 20.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may/wgrptbsc20230400.pdf

    ... Fluoride 47: 161-169. Inkielewicz-Stepniak I, Radomski MW, Wozniak M. 2012. Fisetin prevents fluoride- and dexamethasone-induced oxidative damage in osteoblast and hippocampal ...

  40. NTP Board of Scientific Counselors Working Group Report on the... 9.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may16/bsc_wg_report_final_version_bsc_approved051623_508.pdf

    ... Fluoride 47: 161-169. Inkielewicz-Stepniak I, Radomski MW, Wozniak M. 2012. Fisetin prevents fluoride- and dexamethasone-induced oxidative damage in osteoblast and hippocampal ...

  41. NTP Working Group Report: Draft State of the Science Monograph... 9.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2023/may16/meeting_materials/wgrptbsc20230400_interimver_508.pdf

    ... Fluoride 47: 161-169. Inkielewicz-Stepniak I, Radomski MW, Wozniak M. 2012. Fisetin prevents fluoride- and dexamethasone-induced oxidative damage in osteoblast and hippocampal ...

 
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