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Search suggestions for "50-06-6".

  1. CEBS Data Related to Phenobarbital (50-06-6) https://cebs.niehs.nih.gov/cebs/test_article/50-06-6


168 results found for "50-06-6".

  1. TR-476: Primidone (CASRN 125-33-7) in F344/N Rats and B6C3F1Mice... 13.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr476.pdf

    ... H Determinations of Primidone and Phenobarbital in Plasma . . . . . . . . . . . . . . ... responses to a primary metabolite, phenobarbital, and that some discussion should be ...

  2. Abstract for RACB20103, RACB20104, RACB20105, RACB20106, and... 69KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro/racb20104

    Pubertal Toxicity Study of Vinclozolin, Flutamide and Phenobarbital in Male Sprague Dawley Rats and Methoxychlor, Ethinyl Estradiol and Phenobarbital in Female Sprague Dawley Rats ...

  3. Reproductive Abstracts 202KB

    https://ntp.niehs.nih.gov/publications/abstracts/repro

    ... of Vinclozolin (CASRN: 50471-44-8), Flutamide (CASRN: 13311-84-7) and Phenobarbital (CASRN: 50-06-6) in Male Sprague Dawley Rats and Methoxychlor (CASRN: 72-43-5), Ethinyl ...

  4. Public Comment: Ethylbenzene; Jack Snyder; RoC; Jan. 19, 2012 288KB

    https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/snyder20120228.pdf

    ... liver tumors in female mice via a Phenobarbital type mode of action of induction of ... liver tumors in female mice via a Phenobarbital type mode of action of induction of ...

  5. Study Abstracts 375KB

    https://ntp.niehs.nih.gov/publications/abstracts

    ... of Vinclozolin (CASRN: 50471-44-8), Flutamide (CASRN: 13311-84-7) and Phenobarbital (CASRN: 50-06-6) in Male Sprague Dawley Rats and Methoxychlor (CASRN: 72-43-5), Ethinyl ...

  6. Abstract for TR-404 70KB

    https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr404

    psychomotor seizures, often in combination with other anticonvulsants, including phenobarbital. 5,5-Diphenylhydantoin is a suspected human carcinogen and was one of three ...

  7. RoC Profile: Phenytoin and Phenytoin Sodium; 15th RoC 2021 139KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/phenytoin.pdf

    ... treated with phenobarbital and phenytoin (White et al. 1979) and in two cohort incidence studies of patients treated with phenytoin (with or without phenobarbital) (Olsen et al. ...

  8. Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf

    ... included five substances (oxazepam, phenobarbital, L-thyroxine, ammonium perchlorate, ... being tested in vivo by EPA Phenobarbital 57-30-7 Heterocyclic Compound, ...

  9. TR-404: 5,5-Diphenylhydantoin (CASRN 57-41-0) (Phenytoin) in... 16.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr404.pdf

    ... with other anticonvulsants, including phenobarbital. 5,5Diphenylhydantoin is a suspected ... with other anticonvulsants, such as phenobarbital, it might be o f interest to see if ...

  10. TR-443: Oxazepam (CASRN 604-75-1) in Swiss-Webster and B6C3F1Mice... 15.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr443.pdf

    ... diazepam or oxazepam at 0.05% or 0.15%, or given phenobarbital inwater at 500 ppm. .../15)or 0.05% oxazepam (2/16), and none were observed in mice receiving only phenobarbital. ...

  11. TOX-61: Benzophenone 2.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox061.pdf

    ... was a relatively potent inducer of the phenobarbital-type (2B) cytochrome P 450 enzymes. ... There was induction of a form of cytochrome P 450 characteristic of a phenobarbital-type ...

  12. Validation of In Vitro Cytotoxicity Test Methods: Test Chemicals 188KB

    https://ntp.niehs.nih.gov/iccvam/methods/acutetox/invitrocyto/ivcytodocs/valstdchm.pdf

    ... 1910-42-5 257.20 SIGMA M2254 100 Parathion 56-38-2 291.28 SUPELCO PS-95 98 Phenobarbital 50-06-6 232.23 SPECTRUM PH118 100 Phenol 108-95-2 94.11 SIGMA P4161 > 99.0 Phenylthiourea ...

  13. Presentation: Using Adverse Outcome Pathway Analysis to Identify... 2.2MB

    https://ntp.niehs.nih.gov/iccvam/meetings/aop-wksp-2014/presentations/paul-508.pdf

    ... Rodent thyroid tumors may be a biomarker for potential Δ[TH]. Phenobarbital example: ... and weight ↑ Vehicle 50 mg/kg phenobarbital, b.i.d., 5 wks. h h Reproduced from ...

  14. Final Report on the Cumene (CASRN 98-82-8) Genetoxicity Studies 924KB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/genotoxstudies/cumenegtox_508.pdf

    ... and without metabolic activation (10% phenobarbital/benzoflavone-induced rat liver S9). ... and cofactors from phenobarbital/benzoflavone-induced male Sprague Dawley rat liver S9). ...

  15. ICCVAM Test Method Evaluation Report on the BG1Luc ER TA Test... 17.5MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/bg1lucer-ta-tmer-combined.pdf

    ... NEG (1/1) p,p'- Methoxychlor 72-43-5 POS POS POS (1/1) POS (1/1) POS (2/2) Phenobarbital 50-06-6 NEG NEG NEG (1/1) NEG (1/1) NT Procymidone 32809-16-8 NEG I I (1/1) NT NT ...

  16. Abstract for TOX-61 63KB

    https://ntp.niehs.nih.gov/publications/reports/tox/000s/tox061

    ... Biochemical data indicated that benzophenone was a relatively potent inducer of the phenobarbital-type (2B) cytochrome P450 enzymes. Overall, induction was greater in rats than in ...

  17. Poster: Assessment of Genotoxic Potential of Elk River Chemical... 623KB

    https://ntp.niehs.nih.gov/ntp/research/areas/wvspill/auerbach_sot_201603_508.pdf

    ... and negative controls, in triplicate, with and without S9 mix containing 10% phenobarbital/benzoflavone-induced rat liver S9. The test substance was pre-incubated with the ...

  18. TR-508: Riddelliine (CASRN 23246-96-0) in F344/N Rats and B6C3F1Mice... 9.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr508.pdf

    ... microsomes of rats pretreated with phenobarbital than with those from untreated rats ... Pretreatment of the animal with phenobarbital increases the rate of metabolic conversion, ...

  19. Public Comment: Pulegone Christie Harman; RoC; Sept. 20, 2013 126KB

    https://ntp.niehs.nih.gov/ntp/roc/nominations/2013/publiccomm/harman20131018_508.pdf

    ... Other non-genotoxic compounds that induce liver enzyme expression, such as phenobarbital, ... enzyme-inducing drugs: experimental and clinical perspectives with phenobarbital. ...

  20. Poster: Comparison of the Genotoxicity of Glyphosate, (Aminomethyl... 667KB

    https://ntp.niehs.nih.gov/ntp/results/pubs/posters/swartz_emgs20190919.pdf

    ... or to positive and negative controls, in triplicate, with and without 10% phenobarbital/benzoflavone-induced rat liver S9 mix using pre- incubation at 37°C for 20 minutes. ...

  21. Draft RoC Monograph Epstein-Barr virus (EBV): RoC Peer Review... 3.0MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/haadraftmonograph_appendices.pdf

    ... groups and a positive control of phenobarbital at 500 mg/l (positive controls are not ... groups and a positive control of phenobarbital at 500 mg/l (positive controls are not ...

  22. Public Comment: Methyl isobutyl ketone; Steven Risotto; RoC;... 379KB

    https://ntp.niehs.nih.gov/ntp/roc/nominations/2013/publiccomm/risotto20131018_508.pdf

    ... Previous investigations of rodents exposed to MIBK suggest a phenobarbital (PB)-like ... Subchronic effects of dieldrin and phenobarbital on hepatic DNA synthesis in mice and ...

  23. RoC Background Document: Vinyl Bromide; Jan. 20-21, 2000 220KB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/vb_no_appendices_508.pdf

    ... from Aroclor- induced rats or phenobarbital-induced mice) (Bartsch 1976; Bartsch ... Pretreatment of rats with phenobarbital accelerated the release of bromide from inhaled ...

  24. Applying In vitro Approaches to Understand Complex Mixtures in... 5.3MB

    https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2021/20210126-iccvam-cop-rider-508.pdf

    ... Log 10 Concentration (% v/v) Log 10 Relative Fold mRNA Content phenobarbital = 1.3 -4 -3 -2 -1 0 -2 -1 0 1 2 3 CYP1A2 (AhR) Log 10 Concentration (% v/v) Log 10 Relative Fold mRNA ...

  25. TR-589: Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade... 7.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr589_508.pdf

    ... and BDE-153 upregulated expression of CYP2B and CYP3B in a phenobarbital-like manner. ... Incubation of PBDEs with phenobarbital treated liver microsomes (mostly P450 2B enriched) ...

  26. RoC Monograph: 1-Bromopropane; September 2013 1.9MB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/monographs_final/1bromopropane_508.pdf

    ... metabolism of 1-bromopropane by phenobarbital-induced rat liver microsomes; when ... from the incubation mixture with phenobarbital-induced rat liver microsomes, ...

  27. TR-398: Polybrominated Biphenyls (CASRN 67774-32-7)(Firemaster... 14.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr398.pdf

    ... of liver microsomes from animals pretreated with phenobarbital or methylcholanthrene. ... induce enzymes typical of both phenobarbital and 3-methylcholanthrene (Dent et al., 1976). ...

  28. TOX-77: Hexachlorobenzene (CASRN 118-74-1) Administered by Gavage... 2.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox077_508.pdf

    ... with or without pretreatment with phenobarbital. 94 Role of the Aryl Hydrocarbon ... fact, in rodents, the CAR-activator phenobarbital increased replicative DNA synthesis in ...

  29. Evaluation of Glyphosate, (Aminomethyl)phosphonic Acid, and Glyphosate... 1.3MB

    https://ntp.niehs.nih.gov/sites/default/files/whatwestudy/topics/glyphosate/smith-roe_emgs20190919_508.pdf

    ... Pre-incubation protocol 5 to 7 Doses + vehicle control and appropriate positive controls for each tester strain +/- Phenobarbital/benzoflavone-induced SD male rat liver S9 mix Top ...

  30. Minutes: BSC TRRS; Dec. 11, 1996 1.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1996/dec/trrs11dec1996mins_508.pdf

    ... responses to a primary metabolite, phenobarbital, and some discussion should be given ... She liked the section looking at plasma concentrations of primidone and phenobarbital and ...

  31. Peer Review Report: RoC Peer Review; Mar. 21-22, 2013 352KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2013/march/peerreviewrpt20130322_508.pdf

    ... Mouse lung tumors are mediated through mouse lung-specific metabolism by CYP2F2. o Mouse liver tumors are plausibly mediated through a phenobarbital-like liver enzyme induction. . ...

  32. NICEATM Validation Study Report on the MCF-7 Cell Proliferation... 1.8MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/mcf7/mcf7-valstudyreport-19jun12-wcv2-draft.pdf

    ... methyl testosterone, testosterone, and phenobarbital) were distributed only to CCi. ... Comprehensive Confirmation Overall 4 Phenobarbital NEG (1/1) NT NEG 4 Pimozide NEG (1/1) ...

  33. TR-470: Pyridine (CASRN 110-86-1) in F344/N Rats, Wistar Rats... 16.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr470.pdf

    ... et al., 1993). Pyridine is similar to phenobarbital (Lubet et al., 1989) and oxazepam ... The patient was also taking other medications (including phenobarbital), and it was not ...

  34. Draft monograph HAA appendices 3.1MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2017/july/haa_appendices20171030.pdf

    ... groups and a positive control of phenobarbital at 500 mg/l (positive controls are not ... groups and a positive control of phenobarbital at 500 mg/l (positive controls are not ...

  35. RoC Concept: Pentachlorophenol 299KB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/concepts/pcp_concdocroc8-30-12_508.pdf

    ... PCP has also been tested in the diet for tumor initiation and promoting activity in mice. Phenobarbital was administered as the promoter when the initiating activity of PCP was ...

  36. ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf

    ... The in vivo list included fve substances (oxazepam, phenobarbital, L-thyroxine, ammonium ... Phenol Chemical intermediate Oxazepam 604-75-1 Benzodiazepine Pharmaceutical Phenobarbital ...

  37. Background: Dimethylethanolamine (DMAE) [108-01-0] and Selected... 1.3MB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dmae_update_110002_508.pdf

    ... of cardiazol, strychnine, morphine, chlorpromazine, evipan, and phenobarbital in rats. ... of cardiazol, strychnine, morphine, chlorpromazine, evipan, and phenobarbital in rats. ...

  38. RoC Profile: Lindane, Hexachlorocyclohexane (Technical Grade... 155KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/lindane.pdf

    ... Schulte-Hermann R, Parzefall W. 1981. Failure to discriminate initiation from promotion of liver tumors in a long-term study with the phenobarbital-type inducer ...

  39. Cumene: Preliminary Literature Search Strategy and List of References 698KB

    https://ntp.niehs.nih.gov/ntp/roc/thirteenth/litsearchstrategy/cumene-litsearch&references5oct2012_508.pdf

    ... Accessed on 5/22/12. 11. Aydinlik H, Nguyen TD, Moennikes O, Buchmann A, Schwarz M. 2001. Selective pressure during tumor promotion by phenobarbital leads to clonal outgrowth of ...

  40. Presentation: Fundamentals of QSAR Modeling: Basic Concepts and... 7.7MB

    https://ntp.niehs.nih.gov/iccvam/meetings/commprac-2016/tropsha-508.pdf

    ... Pemoline Non-toxic 0.766 Chloramphenicol Toxic 0.776 Phenylbutazone Non-toxic 0.737 Disulfiram Toxic 0.770 Phenobarbital Non-toxic 0.721 Phenylanthranilic acid Non-toxic 0.767 O O ...

  41. Minutes: BSC TRRS; June 23, 1992 1.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1992/june/trrs23june1992mins_508.pdf

    ... He noted that since DPH is commonly used clinically in combination with other anticonvulsants, such as phenobarbital, it might be of interest to see if such drug combinations ...

  42. TOX-6: Pentachlorobenzene (CASRN 608-93-5) 3.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox006.pdf

    ... These findings have led to general agreement that pentachlorobenzene is a "phenobarbital- type" inducer, resembling phenobarbital more than 3-methyl-cholanthrene in the types of ...

  43. Minutes: BSC; April 30, 1985 1.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1985/april/19850430bscmins_508.pdf

    ... Thompson showed slides of transverse whole body sections of rats from an initiation/promotion study using diethylnitrosamine as the initiator and phenobarbital . as the promoter, ...

  44. TR-044 In Vitro Carcinogenesis: Guide to the Literature, Recent... 18.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr044.pdf

    ... "Comparative Enchancing Effects of Phenobarbital, Aminobarbital, 35 Diphenylhydantoin ... S-epoxide Transferase and its Enhancement by Phenobarbital in Rat Liver in vivo." Biochem. ...

  45. Nomination Background: Dichloroacetic acid (CASRN: 79-43-6) 6.5MB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dcaa_508.pdf

    ... Thirty-eight animals serving as positive controls were given 0.5 g/L sodium phenobarbital ... of the animals were given 500.0 pprn phenobarbital (PB) daily in their drinking water for ...

  46. TR-242: Diallyl Phthalate (CASRN 131-17-9) in B6C3F1Mice (Gavage... 4.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr242.pdf

    ... Patel et al. (1980) demonstrated the ability of liver tissue from phenobarbital-pretreated rats to metabolize allyl alcohol to acrolein and allylic acid (2-propenoic acid). The ...

  47. RoC Background Document: 6-Nitrochrysene; Nov. 18-19, 1996 2.9MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/nitrochrysene-6_508.pdf

    ... or from SD male rats pretreated with phenobarbital, 3- methylcholanthrene (3-MCA), or ... were detected in hepatocytes from untreated and phenobarbital-pretreated rats. ...

  48. Minutes: BSC; March 10, 1982 1.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1982/march/bsc_mins19820310_508.pdf

    ... Single treatment with carcinogen during liver regeneration, followed by phenobarbital ... He said a dose-response study had been done with phenobarbital so this didn't I I .1 I i I ...

  49. TOX-7: 1,2,4,5-Tetrachlorobenzene (CASRN 95-94-3) 4.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox007.pdf

    ... inducer, thus resembling phenobarbital more than 3-methylcholanthrene in its activity. ... A.; Val- li, V.E. (1986) Effect of phenobarbital and poly- chlorinated biphenyls on the ...

  50. TOX-27: Riddelliine (CASRN 23246-96-0) 3.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox027.pdf

    ... It has been shown that pretreatment of the animal with phenobarbital increases the rate of metabolic conversion and enhances toxicity (White et al., 1983; Bruner et al., 1986). ...

 
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