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Search suggestions for "50-18-0".

  1. Report on Carcinogens Cyclophosphamide https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/profiles/cyclophosphamide.pdf
  2. CEBS Data Related to Cyclophosphamide (50-18-0) https://cebs.niehs.nih.gov/cebs/test_article/50-18-0


328 results found for "50-18-0".

  1. RoC Profile: Cyclophosphamide; 15th RoC 2021 126KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cyclophosphamide.pdf

    Cyclophosphamide CAS No. 50-18-0 Known to be a human carcinogen First listed in the First Annual Report on Carcinogens (1980) Cl C H 2 H 2 C N H 2 C C H 2 Cl P O NH O ...

  2. Appendices for NTP Monograph on Developmental Effects and Pregnancy... 11.1MB

    https://ntp.niehs.nih.gov/ntp/ohat/cancer_chemo_preg/cancerchemo_appendfinal_508.pdf

    2A Reasonably anticipated D Cyclophosphamide 1 Known D Cytarabine NA NA D ... OR cisplatin OR cis- platinum OR cyclophosphamide OR cytarabine OR cytosar OR ...

  3. NTP Monograph: Developmental Effects and Pregnancy Outcomes Associated... 23.8MB

    https://ntp.niehs.nih.gov/ntp/ohat/cancer_chemo_preg/chemopregnancy_monofinal_508.pdf

    ......... 71 5.11 Cyclophosphamide ......Table 36: Pharmacology of cyclophosphamide in adult humans ......

  4. NTP Monograph: Systematic Review of Occupational Exposure to... 6.2MB

    https://ntp.niehs.nih.gov/ntp/ohat/oeccaaho/mgraph/occchemo_final20190300_508.pdf

    ... Agents v Figure 9. Maximum Levels of Cyclophosphamide Contamination Reported for the ... Figure 10. Percent of Workers with Cyclophosphamide Detected Above the Level of ...

  5. Thymus - Necrosis, Lymphocyte - Nonneoplastic Lesion Atlas 289KB

    https://ntp.niehs.nih.gov/atlas/nnl/immune-system/thymus/NecrosisLymphocyte

    Necrosis of thymic lymphocytes can occur in rats and/or mice as a direct effect of toxicants such as corticosteroids, estrogen, and cyclophosphamide, and usually in conjunction ...

  6. Appendix G; 15th RoC 2021 73KB

    https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf

    or metals that are highlighted in the profile. 50-00-0 see Formaldehyde 50-18-0 see Cyclophosphamide 50-28-2 (estradiol-17β) see Estrogens, Steroidal 50-29-3 see ...

  7. Thymus - Necosis, Lymphocyte 306KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/immune/thymus/necrosis/thymus-necrosis-lymphocyte-pdf_508.pdf

    Comment: Necrosis of thymic lymphocytes can occur in rats and/or mice as a direct effect of toxicants such as corticosteroids, estrogen, and cyclophosphamide, and usually in ...

  8. Listed Substances; 15th RoC 2021 76KB

    https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf

    Chromium Hexavalent Compounds Coal Tars and Coal-Tar Pitches Coke-Oven Emissions Cyclophosphamide Cyclosporin A Diethylstilbestrol Dyes Metabolized to Benzidine (Benzidine Dye ...

  9. Human Stem Cells & Genomics for Precision Medicine 104.0MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2020/september/present/3-4-wu-508.pdf

    ... 2000 mg/m 2 epirubicin + cyclophosphamide then trastuzumab + docetaxel 80 71-77 27.2 DOX2 60 F 66 4 cycles 240 mg/mL doxorubicin + cyclophosphamide then trastuzumab + docetaxel ...

  10. Immunotoxicity Study Pathology Specifications; Oct. 7, 2016 678KB

    https://ntp.niehs.nih.gov/ntp/htdocs/levels/finalntpitoxspecs_508.pdf

    Generally 5 treatment groups plus a vehicle control group iii. Positive control(s): either cyclophosphamide or dexamethasone iv. Each group generally consists of 8 mice or 12 rats, ...

  11. RoC Profile: 1,4-Butanediol Dimethanesulfonate; 15th RoC 2021 114KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/butanedioldimethanesulfonate.pdf

    ... It also may be used in combina- tion with cyclophosphamide as a conditioning regimen prior to bone marrow transplants for chronic myelogenous leukemia. It is given in tablets or by ...

  12. Minutes: MPRP; Oct. 1-2, 2012 559KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/monopeerrvw/2012/october/minutes20121002_508.pdf

    ... cyclophosphamide, both of which have had patterns of malformations associated with their use in the first trimester. She cited Vaux et al. 2003, who described a cyclophosphamide-...

  13. Predicting human developmental toxicity of pharmaceuticals using... 510KB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/westtap2016.pdf

    ... (Blind 6) 0.412 (Khoo et al., 1982) Cyclophosphamide (Blind 7) 154 (Chen et al., 1997) 3 ... teratogens such as carbamazepine, cyclophosphamide, cytosine arabinoside, 5-fluoro- ...

  14. RoC Background Document: Cyclosporin A; Nov. 18-19, 1996 4.9MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/cyclosporin_a1_508.pdf

    ... globulin, actinomycin, cyclophosphamide, methylprednisolone and/or ... actinomycin, cyclophosphamide, methylprednisolone and/or phototherapy (e.g., PUVA, UVB). ...

  15. RoC Profile: Thiotepa; 15th RoC 2021 127KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/thiotepa.pdf

    ... By the late 1980s, thiotepa was also used at high doses in combination che- motherapy with cyclophosphamide in patients with refractory ma- lignancies treated with autologous bone ...

  16. Poster: Building a Comprehensive Search of Epigenetic Studies... 1.3MB

    https://ntp.niehs.nih.gov/ntp/results/pubs/posters/garner_sot20220327.pdf

    ... Ethylene oxide 2-Naphthlamine Cyclophosphamide Results; 1. For each epigenetic ... with epigenetic changes (except cyclophosphamide), as expected, found few new ...

  17. TOX-48: Allyl Acetate (CASRN 591-87-7), Allyl Alcohol (CASRN... 18.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox048.pdf

    ... also a metabolite of the antineoplastic agent cyclophosphamide and is thought to be responsible for the hemorrhagic cystitis that occurs in patients treated with cyclophosphamide. ...

  18. TOX-43: o-,m-, and p-Chloroanilines (CASRNs 95-51-2; 108-42-9... 5.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox043.pdf

    ... oil only; the positive control animals received injections of 25 mg/kg cyclophosphamide. ... 50 1,027 457 0.44 9.1 25.5 Cyclophosphamide 0.3 2.0 50 5 1,034 102 631 135 0.61 ...

  19. RoC Background Document: Thiotepa; Nov. 18-19, 1996 2.3MB

    https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/thiotepa1_508.pdf

    ... in combination chemotherapy with cyclophosphamide in patients with refractory ... Melphalan, chlorambucil, cyclophosphamide, and treosulphan (alkylating agents known to be ...

  20. RoC Profile: Cyclosporin A; 15th RoC 2021 130KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cyclosporina.pdf

    ... Cyclosporin A is used alone or in combination with azathioprine, prednisolone, pred- nisone, antilymphocyte globulin, actinomycin, cyclophosphamide, methylprednisolone, or ...

  21. RoC Profile: Melphalan; 15th RoC 2021 124KB

    https://ntp.niehs.nih.gov/ntp/roc/content/profiles/melphalan.pdf

    ... S, Castegnaro M, Sportouch MH, De Meo M, Milhavet JC, Laget M, Dumenil G. 1997. Chemical degradation of wastes of antineoplastic agents: cyclophosphamide, ifosfamide and melphalan. ...

  22. TR-032: Isophosphamide (CASRN 3778-73-2) 3.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr032.pdf

    ... NSC 109724, NCI C016380) is a cyclophosphamide analog differing from the parent chemical by transposition of a chloroethyl group from the side chain to the ring nitrogen. ...

  23. TOX-67: 2-Methylimidazole and 4-Methylimidazole 5.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox067.pdf

    ... The positive control rats and mice received injections of cyclophosphamide. The animals ... saline c 5 1.7 ± 0.3 Cyclophosphamide d 7.5 5 22.3 ± 1.6 ...

  24. TOX-76: 2,4-Decadienal (CASRN 25152-84-5) 3.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox076.pdf

    ... The positive control animals received injections of cyclophosphamide. In the single ... P=0.294 e Cyclophosphamide f 25 5 7.50 ± 2.77 0.0000 a Study was performed at ILS, Inc. ...

  25. TOX-47: Methacrylonitrile 3.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox047.pdf

    ... The positive control animals received injections of cyclophosphamide. The animals were ... c Trial 1 Corn oil d 4 0.25 ± 0.14 Cyclophosphamide e 25 4 6.00 ± 0.98 0.0000 ...

  26. TOX-53: t-Butyl Alcohol 3.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox053.pdf

    ... The positive control animals received cyclophosphamide. The rats were killed 24 hours ... Medium 50 1,035 474 0.45 9.5 26.0 Cyclophosphamide 0.3 2.0 50 10 1,041 210 606 322 0.58 ...

  27. TOX-89: Toxicity Studies of 5-Amino-o-cresol (CASRN 2835-95-2... 2.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox089_508.pdf

    ... The positive control was cyclophosphamide. Twenty-four hours after the final treatment, ... P = 0.696 e P = 0.562 P = 0.009 Cyclophosphamide f 50 5 28.0 ± 1.09 0.0000 1.91 ± ...

  28. TOX-59: Chloral Hydrate (CASRN 302-17-0) 10.8MB

    https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox059.pdf

    ... The positive control mice received injections of cyclophosphamide. The mice were killed 24 ... 50 1,036 464 0.44 9.3 26.0 Cyclophosphamide 0.4 50 1,042 651 0.62 13.0 26.0 ...

  29. Background Review Document: Frog Embryo Teratogenesis Assay ... 2.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/fetax2000/brd/fetax-brd-all.pdf

    ... Federal Regulations cm centimeter CP cyclophosphamide CRM comparative research material ... with metabolic activation is cyclophosphamide (CP) at a concentration of 4 mg/mL. ...

  30. TOX-23: o-,m-, and p- Nitrotoluenes (CASRNs 88-72-2, 99-08-1... 15.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox023.pdf

    ... 50 1,050 380 0.36 7.6 25.5 Cyclophosphamide 1.50 50 1,049 1,651 1.57 33.0 25.5 ... 50 1,003 343 0.34 6.9 25.5 Cyclophosphamide 1.5 25 505 522 1.03 20.9 25.5 202.27 ...

  31. TOX-50: Cyclohexanone Oxime 2.0MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox050.pdf

    ... The positive control mice received injections of cyclophosphamide. Twenty-four hours after ... 0.5 Mitomycin-C 0.4 25 10 0.40 36.0 Cyclophosphamide 20 25 14 0.56 44.0 Cyclohexanone ...

  32. TOX-70: p-tert-Butylcatechol (CASRN 98-29-3) 4.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox070.pdf

    ... The positive control rats received injections of 10 mg/kg cyclophosphamide. The rats were ... Cyclophosphamide g 10 5 17.80 ± 2.41 0.0000 Trial 2 Corn oil 5 1.80 ± 0.34 ...

  33. TR-585: Green Tea Extract in F344/NTac Rats and B6C3F1/N Mice... 3.6MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr585_508.pdf

    ... Some studies have examined the effects of green tea extracts on cyclophosphamide ... et al. Green tea extract increases cyclophosphamide-induced teratogenesis by modulating ...

  34. TR-253: Allyl Isovalerate (CASRN 2835-39-4) in F344/N Rats and... 11.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr253.pdf

    ... Cyclophosphamide-a "prodrug" used thera- peutically as an antitumor and immunosuppres- ... observed urotoxic effects of cyclophosphamide are largely due to the acrolein ...

  35. TR-323: Dimethyl Methylphosphonate (CASRN 756-79-6) in F344/N... 9.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr323.pdf

    ... 26.5 26.5 97.4 102.6 107.8 103.9 Cyclophosphamide 1.5 50 1,052 1,123 1.07 22.5 26.5 ... 26.0 26.0 26.0 102.3 94.3 90.8 100.0 Cyclophosphamide 1.5 50 1,042 1,430 1.37 28.6 26.0 ...

  36. TR-584: Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and... 4.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr584_508.pdf

    ... with known genotoxicants such as cyclophosphamide, benzo[a] pyrene, ... The positive control was 25 mg/kg cyclophosphamide and the vehicle control was corn oil. ...

  37. TR-585: Green Tea Extract in F344/NTac Rats and B6C3F1/N Mice... 3.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr585_508.pdf

    ... Some studies have examined the effects of green tea extracts on cyclophosphamide ... et al. Green tea extract increases cyclophosphamide-induced teratogenesis by modulating ...

  38. TOX-12: Castor Oil (CASRN 8001-79-4) 367KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox012.pdf

    ... Cyclophosphamide (e) 0.10 50 1049 531 0.50 10.6 26.0 31.44 0.60 10 210 228 1.08 22.8 26.0 ... Summary: Negative Summary: Negative Mitomycin-C (d) Cyclophosphamide (d) 0.0625 200 48 ...

  39. TOX-61: Benzophenone 2.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox061.pdf

    ... The positive control mice received injections of 25 mg cyclophosphamide/kg. The mice were ... P Value c Corn Oil d 5 1.2 ± 0.4 Cyclophosphamide e 25 5 22.4 ± 1.9 0.000 ...

  40. OHAT Evaluation: Protocol for a Systematic Review to Evaluate... 1018KB

    https://ntp.niehs.nih.gov/ntp/ohat/aheaoecca/protocol201510_508.pdf

    ... OR cis-platinum[tiab] OR cyclophosphamide[tiab] OR cytarabine[tiab] OR ... OR cisplatin OR cis-platinum OR cyclophosphamide OR cytarabine OR cytosar OR ...

  41. TR-361: Hexachloroethane (CASRN 67-72-1) in F344/N Rats (Gavage... 7.2MB

    https://ntp.niehs.nih.gov/go/tr361

    ... (e)33.2 (e)33.2 97.9 129.2 141.7 Cyclophosphamide 1.5 25 522 801 1.53 32.0 25.7 333.3 ... 50 1,048 638 0.61 12.8 (e)35.8 147.1 Cyclophosphamide 1.5 25 520 889 1.71 35.6 25.3 409.2 ...

  42. Appendices A-G; 15th RoC 2021 448KB

    https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf

    ... amine, 2-oxide monohydrate see Cyclophosphamide N,N-dibutylnitrosoamine see ... in the profile. 50-00-0 see Formaldehyde 50-18-0 see Cyclophosphamide 50-28-2 ...

  43. TR-364: Rhodamine 6G (C.I. Basic Red 1) (CASRN 989-38-8) in F344... 11.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr364.pdf

    ... 0.55 11.6 26.0 119.6 39.6 0 td) 30.0 Cyclophosphamide 0.4 50 1,048 583 0.56 11.7 26.0 ... 722 0.70 14.4 (d)30.0 26.0 148.5 Cyclophosphamide 0.5 2.5 50 10 1,043 210 618 308 0.59 ...

  44. TR-415: Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1Mice... 12.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr415.pdf

    ... Weekly injection of polysorbate 80 and the chemotherapeutic agent cyclophosphamide into ... Evaluation of combinations of CuDIPS, 'been $0 and cyclophosphamide as therapy for ...

  45. TR-419: HC Yellow 4 (CASRN 59820-43-8) in F344 Rats and B6C3F1Mice... 10.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr419.pdf

    ... Cyclophosphamide 0 . 4 50 1,035 601 0 . 5 8 1 2 . 0 2 6 . 0 3 6 . 3 3 2 . 0 5 1 0 4 135 1 ... W 0.0525 1 0 25 24 15 0.24 0.60 1 6 . 0 36.0 Cyclophosphamide 7.5 37.5 1 0 25 9 20 H C ...

  46. TR-535: 4-Methylimidazole (CASRN 822-36-6) in F344/N Rats and... 10.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr535.pdf

    ... The positive control animals received injections of cyclophosphamide. The animals were ... 40.5 ± 3.6 30.8 ± 2.5 P = 0.939 e Cyclophosphamide f 7.5 5 22.30 ± 1.62 0.0000 33.0 ± ...

  47. MonoMac6 In Vitro Pyrogen Test Method: ICCVAM Recommended Protocol 711KB

    https://ntp.niehs.nih.gov/iccvam/docs/protocols/pyro-mm6il6.pdf

    ... Potency [PP])/λ As an example, for Cyclophosphamide Injection, the ELC is 0.17 EU/mg, PP ... human dose As an example, for Cyclophosphamide Injection, the PP is 20 mg/mL, M is ...

  48. PBMC In Vitro Pyrogen Test Method: ICCVAM Recommended Protocol 666KB

    https://ntp.niehs.nih.gov/iccvam/docs/protocols/pyro-pbmcil6.pdf

    ... Potency [PP])/λ As an example, for Cyclophosphamide Injection, the ELC is 0.17 EU/mg, PP ... human dose As an example, for Cyclophosphamide Injection, the PP is 20 mg/mL, M is ...

  49. Whole Blood IL-1 In Vitro Pyrogen Test Method: ICCVAM Recommended... 638KB

    https://ntp.niehs.nih.gov/iccvam/docs/protocols/pyro-wbil1b.pdf

    ... Potency [PP])/λ As an example, for Cyclophosphamide Injection, the ELC is 0.17 EU/mg, PP ... human dose As an example, for Cyclophosphamide Injection, the PP is 20 mg/mL, M is ...

  50. Cryo Whole Blood IL-1 In Vitro Pyrogen Test Method: ICCVAM Recommended... 577KB

    https://ntp.niehs.nih.gov/iccvam/docs/protocols/pyro-wbil1bcryo.pdf

    ... Potency [PP])/λ As an example, for Cyclophosphamide Injection, the ELC is 0.17 EU/mg, PP ... human dose As an example, for Cyclophosphamide Injection, the PP is 20 mg/mL, M is ...

 
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