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89 results found for "50-22-6".

  1. BG1Luc ER TA Protocol Standardization Study Report (Annex C of... 2.9MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexc/c0-prot-stand.pdf

    ... C-65 10.2.4 N0004 - Corticosterone ......C-159 15.2.2 N0004 - Corticosterone ......

  2. Appendix D: Overview of experimental animal studies: Non-cancer... 157KB

    https://ntp.niehs.nih.gov/ntp/roc/meetings/2016/alan/appendix_d_508.pdf

    body temperature, melatonin and corticosterone levels, and expression of ... Measures of circadian disruption Activity; body temperature; melatonin; corticosterone; ...

  3. Adrenal Gland, Cortex - Vacuolization, Cytoplasmic - Nonneoplastic... 294KB

    https://ntp.niehs.nih.gov/atlas/nnl/endocrine-system/adrenal-gland/Cortex-VacuolizationCytoplasmic

    can also result from experimental administration of excess ACTH or corticosterone. ... and biochemical features of C57BL/6NCrl mice maintained on chronic oral corticosterone. ...

  4. Adrenal Gland, Cortex - Vacuolization, Cytoplasmic 452KB

    https://ntp.niehs.nih.gov/sites/default/files/nnl/endocrine/adrenal/cxvacuol/adrenal-gland-cortex-vacuolization-cytoplasmic-pdf_508.pdf

    can also result from experimental administration of excess ACTH or corticosterone. ... and biochemical features of C57BL/6NCrl mice maintained on chronic oral corticosterone. ...

  5. TR-446: 1-Trans-Delta9-Tetrahydrocannabinol (CASRN 1972-08-3... 16.4MB

    https://ntp.niehs.nih.gov/go/tr446

    ... than those o f the controls, as was the serum corticosterone level o f 25 mg/kg females. ... In rats, THC induced a dose-dependent increase in serum corticosterone levels (Zuardi et ...

  6. ICCVAM Test Method Evaluation Report on the BG1Luc ER TA Test... 17.5MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/bg1lucer-ta-tmer-combined.pdf

    ... POS (2/2) NT NT Clomiphene citrate 50-41-9 POS I I (1/1) NEG (1/1) POS (1/1) Corticosterone 50-22-6 NEG NEG NEG (3/3) POS (3/3) NEG (4/4) Coumestrol 479-13-0 POS POS POS (1/1) POS ...

  7. Appendix B: Overview of experimental animal studies: Carcinogenicity 208KB

    https://ntp.niehs.nih.gov/ntp/roc/meetings/2016/alan/appendix_b_508.pdf

    ... serum corticosterone) or tumor development (gene expression) were also reported. ... FA uptake, LA uptake, 13-HODE, serum corticosterone, serum estradiol, GSK3β ...

  8. Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf

    ... Y Binds to ER; being tested in vitro by EPA; recommended by the Expert Panel Corticosterone 50-22-6 Steroid Pharmaceutical † ER AR ER-/AR+ ER-/AR- Y binds weakly to AR; being ...

  9. ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf

    ... 50-41-9 Chlorinated triphenylethylene; Benzylidene; Stilbene Pharmaceutical Corticosterone 50-22-6 Steroid, nonphenolic Pharmaceutical Coumestrol 479-13-0 Coumestan; Ketone ...

  10. NICEATM Validation Study Report on the MCF-7 Cell Proliferation... 1.8MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/mcf7/mcf7-valstudyreport-19jun12-wcv2-draft.pdf

    ... (3/3) POS (1/2) POS (1/1) POS POS 2 Corticosterone POS (3/3) NEG (3/3) NEG (1/1) NT NEG ... phthalate POS (4/4) POS (1/1) POS 2 Corticosterone NEG (3/3) NT NEG 2 Diethylstilbestrol ...

  11. Abstract for TR-446 69KB

    https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr446

    ... Levels of follicle stimulating and luteinizing hormones in all dosed groups of males were significantly greater than those of the controls, as was the serum corticosterone level of ...

  12. Presentation: Contaminants in the Food Supply: How the AOP Concept... 720KB

    https://ntp.niehs.nih.gov/iccvam/meetings/aop-wksp-2014/presentations/powers-508.pdf

    ... Learning deficits in C57BL/6 mice following perinatal arsenic exposure: Consequence of lower corticosterone receptor levels? Pharmacol Biochem Behav. 2009 December ; 94(2): ...

  13. TR-567: Ginseng (CASRN 50647-08-0) in F344/N Rats and B6C3F1... 6.7MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr567.pdf

    ... divided into two portions, one for corticosterone analyses and one for clinical chemistry. ... All clinical chemistry analyses, except for corticosterone concentrations, were performed ...

  14. Literature Search Results for the Systematic Review of Immunotoxicity... 419KB

    https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/literaturesearch_201605_508.pdf

    ... 644-650. DeWitt JC, Copeland CB, Luebke RW. 2009. Suppression of humoral immunity by perfluorooctanoic acid is independent of elevated serum corticosterone concentration in mice. ...

  15. CERHR Monograph: Amphetamines 4.1MB

    https://ntp.niehs.nih.gov/ntp/ohat/stimulants/amphetamines/amphetaminemonograph.pdf

    ....20.minutes.later.for.measurement.of.plasma. corticosterone.levels..Amphetamine.treatment.significantly.increased.plasma.corticosterone.levels.in. male.and.female.periadolescents.b...

  16. Session Abstract 265KB

    https://ntp.niehs.nih.gov/ntp/roc/meetings/2016/alan/session_abstract20160311_508.pdf

    ... Biomarkers of circadian disruption were not as consistently measured across the various exposure scenarios; activity and corticosterone levels were the most commonly measured ...

  17. TR-313: Mirex (1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachlorooctahydro... 13.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr313.pdf

    ... Corticosterone and adrenalectomy affect the mirex distribution in rats. Forty-eight hours ... animals given supple- mentary doses of corticosterone (Erwin and Yar- brough, 1983). ...

  18. TR-377: CS2 (94 o-Chlorobenzalmalononitrile, CASRN 2698-41-1... 12.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr377.pdf

    ... Additionally, blood corticosterone levels were increased only in mice receiving the highest dose of CS and were more than twice those in controls. CS was found to inhibit ...

  19. Submission of the CertiChem Cell Proliferation Test Method for... 3.1MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/submdoc.pdf

    ... triphenylethylene; Benzylidene; Stilbene 5E-6 - 5E-13 99% MP Biomidical Corticosterone 50-22-6 Steroid, nonphenolic 5E-5 - 5E-12 >99% TCI Coumestrol 479-13-0 Coumestan; ...

  20. Minutes: BSC; June 21-22, 2012 280KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2012/june/bscminutes20120622_508.pdf

    ... He expressed full support for environmental enrichment and noted that determining fecal corticosterone concentrations would be a good, non-invasive biomonitor for changes in the ...

  21. TR-597: 2-Hydroxy-4-methoxybenzophenone (CASRN 131-57-7) Administered... 3.2MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr597_508.pdf

    ... chemicals: 17β-estradiol, 17α-estradiol, 17α-methyltestosterone, and corticosterone. ... 0.1% (v/v). 17¡-methyltestosterone, 17¡-estradiol, corticosterone, and 17¢-estradiol. ...

  22. NTP Cancer Hazard Report: Night Shift Work and Light at Night... 10.1MB

    https://ntp.niehs.nih.gov/ntp/results/pubs/cancer_assessment/lanfinal20210400_508.pdf

    ... (cortisol in humans and corticosterone in rodents) (Sollars and Pickard 2015). ... acid, acid-gas levels, glucose, corticosterone, and leptin were lower in rats ...

  23. XDS Submission of the LUMI-CELL ER Test Method 3.2MB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/iccvamsubmission28jan05.pdf

    ... - 4.00E+02 1.00E+02 - 1.00E-03 6.66E-04 - 6.66E-09 > 98% Sigma Powder Corticosterone 50-22-6 Steroid, nonphenolic Steroid, nonphenolic 4.00E+07 - 3.91E+04 1.00E+02 - ...

  24. TR-433: Tricresyl Phosphate (CASRN 1330-78-5) in F344/N Rats... 24.1MB

    https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr433.pdf

    ... corticosterone was increased 4-fold, and luteinizing hormone (LH) was increased %fold over control values. Moreover, the concentrations o f ACTH and corticosterone ...

  25. Submission of XDS's LUMI-CELL ER High-Throughput System for Screening... 2.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexa/xds-sub.pdf

    ... - 4.00E+02 1.00E+02 - 1.00E-03 6.66E-04 - 6.66E-09 > 98% Sigma Powder Corticosterone 50-22-6 Steroid, nonphenolic Steroid, nonphenolic 4.00E+07 - 3.91E+04 1.00E+02 - ...

  26. NICEATM Pre-Screen Evaluation of the LUMI-CELL ER Test Method... 595KB

    https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/xdseval2.pdf

    ... (ICCVAM reported as presumed negative for ER agonist 634 activity) 635 . Corticosterone (ICCVAM reported as negative in one ER agonist study and as 636 binding weakly to ...

  27. Monograph on Potential Human Reproductive and Developmental Effects... 2.4MB

    https://ntp.niehs.nih.gov/ntp/ohat/fluoxetine/fluoxetine_monograph.pdf

    ... blood levels of adrenocorticotropin, corticosterone, and renin) No effect 58% ↓ in ... Blood was collected for an analysis of plasma oxytocin, ACTH, and corticosterone, as ...

  28. Draft DART-05: Modified One-Generation Study of 2-Hydroxy-4-methoxyben... 3.3MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/trpanel/2021/october/dart05_508.pdf

    ... body weight, has been reported for corticosterone 4 administered in drinking water. 105 ... Chronic 13 stress would be expected to increase corticosterone levels and result in lower ...

  29. DART-05: Modified One-Generation Study of 2-Hydroxy-4-methoxybenzophen... 6.0MB

    https://ntp.niehs.nih.gov/ntp/htdocs/dart/dart05_508.pdf

    ... body weight, has been reported for corticosterone administered in drinking water. 109 ... Chronic stress would be expected to increase corticosterone levels and result in lower ...

  30. Monograph: Perfluorooctanoic Acid or Perfluorooctane Sulfonate... 7.8MB

    https://ntp.niehs.nih.gov/ntp/ohat/pfoa_pfos/pfoa_pfosmonograph_508.pdf

    ... PFOA) in C57BL6 mice were not stress or corticosterone mediated (DeWitt et al. 2009a). ... acid is independent of elevated serum corticosterone concentration in mice. ...

  31. TOX-99: A Gum Guggul Extract Formulation Administered by Gavage... 1.1MB

    https://ntp.niehs.nih.gov/ntp/htdocs/st_rpts/tox99_508.pdf

    ... This particular change is most consistent with stress (i.e., corticosterone induced). All other significant hematological changes were mild and inconsistent and not considered ...

  32. TR-375: Vinyl Toluene (Mixed Isomers) (65%meta-isomer and 32... 20.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr375.pdf

    PROGRAM Technical Report Series No. 375 (1- <~ TOXICOLOGY AND CARCINOGENESIS STUDIES OF VINYL TOLUENE (MIXED ISOMERS) (65%-71% META-ISOMER AND 32%-35% PARA-ISOMER) (CAS NO. ...

  33. TOX-99: A Gum Guggul Extract Formulation Administered by Gavage... 1.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox99_508.pdf

    ... This particular change is most consistent with stress (i.e., corticosterone induced). All other significant hematological changes were mild and inconsistent and not considered ...

  34. TR-387: dl-Amphetamine Sulfate (CASRN 60-13-9) in F344/N Rats... 10.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr387.pdf

    TOXICOLOGY AND CARCINOGENESIS STUDIES OF dl-AMPHETAMINE SULFATE (CAS NO. 60-13-9) IN F344/N RATS AND B6C3F 1 MICE (FEED STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public ...

  35. Peer Review Panel Report on Evaluation of the LUMI-CELL ER Test... 287KB

    https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edprprept2011.pdf

    ... But in some cases more than three replicates are available, e.g. Independent Peer Review Panel Report 29 Corticosterone at Hiyoshi (Table 4-13). This means that for different ...

  36. Response to Request for Data and Information on Zebrafish Embryo... 1.6MB

    https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-26605/kanungo-508.pdf

    ... Prolactin, luteinizing hormone, follicle- stimulating hormone, testosterone and corticosterone levels in males and effects of two anesthetics. Biol. Reprod. 28: 122-127. De Nicola ...

  37. TR-309: Decabromodiphenyl Oxide (CASRN 1163-19-5) In F344/N Rats... 17.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr309.pdf

    9 TOXICOLOGY AND CARCINOGENESIS STUDIES OF DECABROMODIPHENYL OXIDE (CAS NO. 1163-19-5) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES ...

  38. TR-404: 5,5-Diphenylhydantoin (CASRN 57-41-0) (Phenytoin) in... 16.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr404.pdf

    4 TOXICOLOGY AND CARCINOGENESIS STUDIES OF 5,5=DIPHENYLHYDANTOIN (PHENYTOIN) (CAS NO. 57-41-0) IN F344/N RATS AND B6C3Fl MICE (FEEDSTUDIES) U . S . DEPARTMENT OF HEALTH AND ...

  39. TR-480: Lauric Acid Diethanolamine Condensate (CASRN 120-40-1... 8.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr480.pdf

    LAURIC ACID DIETHANOLAMINE CONDENSATE (CAS NO. 120-40-1) IN F344/N RATS AND B6C3F MICE 1 (DERMAL STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle Park, NC ...

  40. TR-364: Rhodamine 6G (C.I. Basic Red 1) (CASRN 989-38-8) in F344... 11.2MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr364.pdf

    NO. 364 TOXICOLOGY AND CARCINOGENESIS STUDIES OF RHODAMINE 6G (C.I. BASIC RED 1) (CAS NO. 989-38-8) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES) U.S. DEPARTMENT OF HEALTH AND ...

  41. TR-379: 2-Chloroacetophenone (CASRN 532-27-4) in F344/N Rats... 24.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr379.pdf

    9 (l ,..,..~ TOXICOLOGY AND CARCINOGENESIS STUDIES OF 2-CHLOROACETOPHENONE (CAS NO. 532.27-4) IN F344/N RATS AND B6C3Ft MICE (INHALATION STUDIES) U.S. DEPARTMENT OF HEALTH AND ...

  42. TR-419: HC Yellow 4 (CASRN 59820-43-8) in F344 Rats and B6C3F1Mice... 10.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr419.pdf

    Program (NTP) is made up of four charter agencies of the U.S. Department of HealthandHuman Services (DHHS): the National Cancer Institute (NCI), National Institutes of Health, the ...

  43. Monograph: Night Shift Work and Light at Night; August 24, 2018 6.2MB

    https://ntp.niehs.nih.gov/ntp/about_ntp/monopeerrvw/2018/october/landraftmonograph20180824.pdf

    ... acid, acid-gas levels, glucose, corticosterone, and leptin were lower in rats ... temporal profiles of melatonin and corticosterone levels, although their overall levels ...

  44. TR-495: Sodium Nitrite (CASRN 7632-00-0) IN F344/N Rats and B6C3F1Mice... 16.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr495.pdf

    NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM NITRITE (CAS NO. 7632-00-0) IN F344/N RATS AND B6C3F 1 MICE (DRINKING WATER STUDIES) NATIONAL ...

  45. TR-570: Alpha,Beta-Thujone (CASRN 76231-76-0) in F344/N Rats... 15.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr570.pdf

    α,β-THUJONE (CAS NO. 76231-76-0) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle Park, NC 27709 November 2011 NTP TR ...

  46. TR-511: Dipropylene Glycol (CASRN 25265-71-8) in F344/N Rats... 10.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr511.pdf

    ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF DIPROPYLENE GLYCOL (CAS NO. 25265-71-8) IN F344/N RATS AND B6C3F 1 MICE (DRINKING WATER STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. ...

  47. TR-303: 4-Vinylcyclohexene (CASRN 100-40-3) in F344/N Rats and... 11.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr303.pdf

    3 TOXICOLOGY AND CARCINOGENESIS STUDIES OF 4-VINYLCYCLOHEXENE (CAS NO. 100-40-3) IN F344/N RATS AND B6C3Ft MICE (GAVAGE STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public ...

  48. TR-318: Ampicillin Trihydrate (CASRN 7177-48-2) in F344/N Rats... 10.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr318.pdf

    ... (b) Accidentally killed Animals missing Killed a t termination 50 17 1 0 32 50 22 6 1 21 50 23 6 1 20 Survival P values (c) 0.189 0.374 0.238 FEMALE (a) Animals initially ...

  49. TR-333: N-Phenyl-2-naphthylamine (CASRN 135-88-6) in F344/N Rats... 9.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr333.pdf

    3 TOXICOLOGY AND CARCINOGENESIS STUDIES O F N-PHENY L-2-NAPHTHYLAMINE (CAS NO. 135-88-6) IN F344/N RATS AND B6C3F1 MICE (FEED STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES ...

  50. TR-347: d-Limonene (CASRN 5989-27-5) in F344/N Rats and B6C3F1Mice... 9.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr347.pdf

    7 4 "^,oC C Z» TOXICOLOGY ANDCARCINOGENESIS STUDIES OF d-LIMONENE (CAS NO. 5989-27-5) IN F344/N RATS AND B6C3Fi MICE (GAVAGE STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES ...

 
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