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TR-131: Bioassays of DDT, TDE, and p,p'-DDE (CASRN 50-29-3, CASRN... 7.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr131.pdf
FOR POSSIBLE CARCINOGENICITY CAS No. 50-29-3 72-54-8 72-55-9 NCI-CG-TR-131 U.S. ... of * The CAS registry numbers are: DDT-50-29-3 TDE-72-54-8 DDE-72-55-9 5 DDT applied as ...
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Abstract for TR-131 66KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr131
Bioassays of DDT, TDE, and p,p'-DDE for Possible Carcinogenicity (CAS No. 50-29-3, CAS No. 72-54-8, CAS No. 72-55-9) Substances: DDT (CASRN 50-29-3) TDE (CASRN 72-54-8) p,p'-DDE ...
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RoC Profile: Dichlorodiphenyltrichloroethane; 15th RoC 2021 155KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/dichlorodiphenyltrichloroethane.pdf
Dichlorodiphenyltrichloroethane CAS No. 50-29-3 Reasonably anticipated to be a human carcinogen First listed in the Fourth Annual Report on Carcinogens (1985) Also known as DDT or ...
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Abstract for TR-35 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr035
5abs Abstract for TR-35 Bioassay of Methoxychlor for Possible Carcinogenicity CASRN: 72-43-5 Chemical Formula: C16H15Cl3O2 Molecular Weight: 345.651 Synonyms/Common Names: ...
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p,p'-Dichlorodiphenyl dichloroethylene: Target Organs and Levels... 60KB
https://ntp.niehs.nih.gov/data/tr/100s/tr131levels
Bioassays of DDT, TDE, and p,p'-DDE for Possible Carcinogenicity (CASRN 50-29-3, CASRN ... Dichlorodiphenyltrichloroethane (DDT) 50-29-3 06/29/1978 Dosed-Feed MR: 0,321,642 ...
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BG1Luc ER TA Protocol Standardization Study Report (Annex C of... 2.9MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexc/c0-prot-stand.pdf
Appendix C - Background Review Document C-1 REPORT THE XDS BG1LUC ER TA PROTOCOL STANDARDIZATION STUDY AGONIST AND ANTAGONIST PROTOCOLS National Toxicology Program (NTP) ...
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Abstract for TR-156 62KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr156
6abs Abstract for TR-156 Bioassay of p,p'-Ethyl-DDD for Possible Carcinogenicity CASRN: 72-56-0 Chemical Formula: C18H20Cl2 Molecular Weight: 307.262 Synonyms/Common Names: ...
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Abstract for TR-192 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr192
2abs Abstract for TR-192 Bioassay of Malathion for Possible Carcinogenicity CASRN: 121-75-5 Chemical Formula: C10H19O6PS2 Molecular Weight: 330.3601 Synonyms/Common Names: ...
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Abstract for TR-90 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr090
0abs Abstract for TR-90 Bioassay of Dicofol for Possible Carcinogenicity CASRN: 115-32-2 Chemical Formula: C14H9Cl5O Molecular Weight: 370.489 Synonyms/Common Names: ...
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Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf
... - - AR- negative for ER and AR binding and no in vivo testing planned p,p'-DDT* 50-29-3 Hydrocarbon (Halogenated) Pesticide - - ER+/AR+ ER+/AR- AR## weak ER agonist; AR ...
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Abstract for TR-12 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr012
2abs Abstract for TR-12 Bioassay of Endrin for Possible Carcinogenicity CASRN: 72-20-8 Chemical Formula: C12H8Cl6O Molecular Weight: 380.91 Report Date: 1979 Full Report PDF ...
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ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf
NIH Publication No: 03-4503 ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and ...
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Safe and Sustainable Alternatives Program; Stephen Ferguson;... 3.2MB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2021/august/presentations/ssa_bsc_presentation_508.pdf
Safe and Sustainable Alternatives Program Stephen Ferguson, PhD Suril Mehta, DrPH Division of the NTP National Institute of Environmental Health Sciences NTP Board of Scientific ...
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Integrating KMD/TK Data with MoA and Other Information in a Weight... 686KB
https://ntp.niehs.nih.gov/iccvam/meetings/kmd-symp-2020/ppt/12-clewell-508.pdf
Integrating KMD/TK Data with MoA and Other Information in a Weight of Evidence Approach Harvey Clewell Ramboll 1 Development of the KMD Concept . HESI Working Group on Dose ...
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Appendix G; 15th RoC 2021 73KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
50-18-0 see Cyclophosphamide 50-28-2 (estradiol-17β) see Estrogens, Steroidal 50-29-3 see Dichlorodiphenyltrichloroethane 50-32-8 (benzo[a]pyrene) see Polycyclic Aromatic ...
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Public Comment from Jayanta Das, Florida International University... 675KB
https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2015/tsaioun-safermedicines-508.pdf
Humanizing Drug Safety Testing - pragmatic validation ICCVAM Public Forum May 27, 2015 Katya Tsaioun - Science Director (US) Safer Medicines Trust Background . Current approach to ...
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Endocrine Disruptors Low-Dose Peer Review, October 10-12, 2000 17.3MB
https://ntp.niehs.nih.gov/ntp/pressctr/mtgs_wkshps/2000/lowdosepeerfinalrpt.pdf
National Toxicology Program's Report of the Organized by the National Institute of Environmental Health Sciences, NIH National Toxicology Program Sponsored by the U.S. ...
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TR-090: Dicofol (CASRN 115-32-2) 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr090.pdf
... sulfallate (95-06-7); p,p'-DDT (50-29-3); amitrole (61- 82-5); pentachloronitrobenzene (82-68-8); nitrofen (1836-75-5); endo- sulfan (115-29-7); and mexacarbate (315-18-4). ...
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TR-501: p,p'-Dichlorodiphenyl Sulfone (CASRN 80-07-9) in F344... 13.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr501.pdf
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF p,pN N N N-DICHLORODIPHENYL SULFONE (CAS NO. 80-07-9) IN F344/N RATS AND B6C3F 1 MICE (FEED STUDIES) NATIONAL ...
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TR-035: Methoxychlor (CASRN 72-43-5) 2.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr035.pdf
... with trifluralin (1582-09-8), dioxathion (78-34-2), sulfallate (95-06-7), p,p'-DDT (50-29-3), chlorobenzilate (510-15-6), p,p'-DDE (72-55-9), p,p'-TDE (72-54-8), dicofol ...
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15th RoC: Acronyms 58KB
https://ntp.niehs.nih.gov/ntp/roc/content/acronyms_508.pdf
--%multipart-mixed-boundary-6616.1.1711999470.215.1804289383% X-Anytotx-Content-Type: application/pdf X-Anytotx-Identified-By: command-line Content-Type: text/plain; charset=UTF-8 ...
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15th RoC: Appendix F 174KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf
71.1.1711999472.152.1804289383% X-Anytotx-Content-Type: application/pdf X-Anytotx-Identified-By: command-line Content-Type: text/plain; charset=UTF-8 Content-Transfer-Encoding: ...
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National Institute of Environmental Health Sciences: Safe and... 149KB
https://www.niehs.nih.gov/research/atniehs/dtt/strategic-plan/responsive/sustainable
Safe and Sustainable Alternatives Program National Institute of Environmental Health Sciences (NIEHS) NTP Logo Much of the work carried out by DTT is in support of the National ...
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Acronyms & Abbreviations 80KB
https://ntp.niehs.nih.gov/support/acronyms
acronyms Acronyms & Abbreviations List of acronyms and abbreviations commonly used by NTP Acronym/Abbreviation Definition 2,4-D 2,4-dichlorophenoxyacetic acid 3Rs Principles of ...
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TR-156: p,p'-Ethyl-DDD (CASRN 72-56-0) 3.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr156.pdf
National Cancer Institute CARCINOGENESIS Technical Report Series No. 156 1979 BIOASSAY OF p, p'-ETHYL-DDD FOR POSSIBLE CARCINOGENICITY CAS No. 72-56-0 NCI-CG-TR-156 U.S. ...
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Developmental Neurotoxicity Health Effects Innovation Program... 3.4MB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2020/december/presentations/13behl_bsc_508.pdf
Developmental Neurotoxicity Health Effects Innovation Program Mamta Behl, PhD, DABT Division of the NTP National Institute of Environmental Health Sciences NTP Board of Scientific ...
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Safe and Sustainable Alternatives Program; BSC; Aug. 4, 2021 240KB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2021/august/meeting_materials/ssa_bsc_508.pdf
Safe and Sustainable Alternatives Program Presenters: Dr. Stephen Ferguson, Mechanistic Toxicology Branch, and Dr. Suril Mehta, Integrative Health Assessments Branch, NIEHS/DNTP ...
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ICCVAM Test Method Evaluation Report on the BG1Luc ER TA Test... 17.5MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/bg1lucer-ta-tmer-combined.pdf
ICCVAM Test Method Evaluation Report The LUMI-CELL ® ER (BG1Luc ER TA) Test Method: An In Vitro Assay for Identifying Human Estrogen Receptor Agonist and Antagonist Activity of ...
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TOWARD VALIDATION OF A HUMAN IN... 1.1MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/egnashposter-2014-wc.pdf
TOWARD VALIDATION OF A HUMAN IN VITRO ASSAY FOR DEVELOPMENTAL TOXICITY ASSESSMENT Egnash LA, Conard KR, Palmer JA, Smith AM, West PR, Burrier RE, Donley ELR, Kirchner FR Stemina ...
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E04: Mean Body Weights and Survival Table for Male & Female Mice... 20KB
https://ntp.niehs.nih.gov/ntp-db/ntp_reports/ntp_pathology_tbls/20523_tables/04_f1_m3_e04.pdf
Control List: Male: 001 Female: 002 Study Gender: Both TDMSE Version: 3.0.2.2_002 PWG Approval Date: NONE Experiment Number: 20523 - 04 E04: MEAN BODY WEIGHTS AND SURVIVAL TABLE ...
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Minutes: BSC; July 7, 2009 399KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2009/july/minutes20090724.pdf
National Toxicology Program Board of Scientific Counselors July 23-24, 2009 National Institute of Environmental Health Sciences Research Triangle Park, NC Summary Minutes Table of ...
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TR-192: Malathion (CASRN 121-75-5) 2.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr192.pdf
National Cancer Institute CARCINOGENESIS Technical Report Series No. 192 1979 BIOASSAY OF MALATHION FOR POSSIBLE CARCINOGENICITY CAS No. 121-75-5 NCI-CG-TR-192 U.S. DEPARTMENT OF ...
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Background Document: RoC: Captafol; 2010 1.1MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2010/finalbds/captafol_final_508.pdf
Captafol June 20, 2008 U.S. Department of Health and Human Services Public Health Service National Toxicology Program Research Triangle Park, NC 27709 This Page Intentionally Left ...
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NICEATM Validation Study Report on the MCF-7 Cell Proliferation... 1.8MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/mcf7/mcf7-valstudyreport-19jun12-wcv2-draft.pdf
NICEATM DRAFT VALIDATION STUDY REPORT: MCF-7 CP TM June 18, 2012 1 Draft ¶ Validation Study Report¶ MCF-7 Cell Proliferation Test Method¶ National Toxicology Program (NTP) ...
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TR-012: Endrin (CASRN 72-20-8) 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr012.pdf
National Cancer Institute CARCINOGENESIS Technical Report Series No. 12 1979 BIOASSAY OF ENDRIN FOR POSSIBLE CARCINOGENICITY CAS No. 72-20-8 NCI-CG-TR-12 U.S. DEPARTMENT OF ...
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TR-157: Methyl Parathion (CASRN 298-00-0) 3.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr157.pdf
1979 National Cancer Institute CARCINOGENESIS Technical Report Series NO. 157 BIOASSAY OF METHYL PARATHION FOR POSSIBLE CARCINOGEN ICITY CAS No. 298-00-0 NCI-CG-TR-157 U.S. ...
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Presentation: Suspected Modes of Action Affected by Pesticides... 599KB
https://ntp.niehs.nih.gov/iccvam/meetings/aop-wksp-2014/presentations/alavanja-508.pdf
Suspected Modes of Action Affected by Pesticides Exposure: Informing an Adverse Outcomes Pathway (AOP) for Cancer Michael Alavanja, Dr.P.H. Senior Investigator, Occupational & ...
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Appendices A-G; 15th RoC 2021 448KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf
... 50-18-0 see Cyclophosphamide 50-28-2 (estradiol-17β) see Estrogens, Steroidal 50-29-3 see Dichlorodiphenyltrichloroethane 50-32-8 (benzo[a]pyrene) see Polycyclic Aromatic ...
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TR-075: Chlorobenzilate (CASRN 510-15-6) 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr075.pdf
... containing sulfallate (95-06-7); DDT (50-29-3); and TDE (72-54-8), * CAS registry ... (78-34-2); sulfallate (95-06-7); DDT (50-29-3); methoxychlor (72-43-5); DDE (72-55-9); ...
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TR-115: Sulfallate (CASRN 95-06-7) 3.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr115.pdf
... receiving diets containing chlorobenzilate (510-15-6); DDT (50-29-3); and TDE (72- 54-8). ... (53-96-3); clonitralid (1420-04-8); DDT (50-29-3); pentachloronitrobenzene (82-68-8); ...
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Minutes: BSC; Aug. 4, 2021 1.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/2021/august/minutesbsc20210804_508.pdf
National Toxicology Program Board of Scientific Counselors August 4, 2021 National Institute of Environmental Health Sciences Research Triangle Park, NC Summary Minutes Summary ...
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Comparison of devTOX quickPredict Assay With Other Methods 1.0MB
https://ntp.niehs.nih.gov/iccvam/pubcomment/fr-2016-15444/stemina/comparisonspreadsheet-508.pdf
www.stemina.com Author: JA Palmer jpalmer@stemina.com Header Description/Notes Compound Common Compound Name Therapeutic C max (μM) Published human therapeutic Cmax Negative ...
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TR-026: Nitrofen (CASRN 1836-75-5) 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr026.pdf
... with trifluralin (1582- 09-8), dioxathion (78-34-2), sulfallate (95-06-7), p,p'-DDT (50-29-3), methoxychlor (72-43-5), p,p'-DDE (72-55-9), p,p'-TDE (72-54-8), dico- fol ...
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TR-062: Endosulfan (CASRN 115-29-7) 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr062.pdf
... trifluralin (1582-09-8); dioxathion (78-34-2); sulfallate (95- 06-7); p,p f -DDT (50-29-3); methoxychlor (72-43-5); ρ,ρ'-DDE (72-55-9); ρ,ρ'-TDE (72-54-8); dicofol ...
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TR-147: Mexacarbate (CASRN 315-18-4) 3.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr147.pdf
... All mice, including controls, were housed in the same room as other mice receiving diets containing chlorobenzilate (510-15-6); dioxathion (78-34-2); DDT (50-29-3); methoxychlor ...
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In Vitro to In Vivo Extrapolation for Developmental Neurotoxicity... 1.7MB
https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Kreutz-poster.pdf
In Vitro to In Vivo Extrapolation for Developmental Neurotoxicity: A Comparison of Physiologically Based Pharmacokinetic Models A. Kreutz 1 , X. Chang 1 , M. Lawless 2 , T.J. ...
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TR-061: Pentachloronitrobenzene (CASRN 82-68-8) 2.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr061.pdf
... with trifluralin (1582-09-8); dioxathion (78-34-2); sulfallate (95-06-7); p,p'-DDT (50-29-3); methoxychlor (72-43-5); p,p'-DDE (72-55-9); p,p'-TDE (72-54-8); dicofol (115-32-2); ...
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TR-125: Dioxathion (CASRN 78-34-2) 1.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr125.pdf
... trifluralin (1582-09- 8); chlorobenzilate (510-15-6); sulfallate (95-06-7); p,p'-DDT (50-
29-3); methoxychlor (72-43-5); p,p'-DDE (72-55-9); p,p'-TDE (72-54-8); dicofol (115-32-2); ...
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TR-034: Trifluralin (CASRN 1582-09-8) 3.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr034.pdf
... chlorobenzilate (510-15-6), dioxathion (78-34-2), sulfallate (95-06-7), p,p'-DDT (50-29-3), methoxychlor (72-43-5), p,p'-DDE (72-55-9), p,p'-TDE (72-54-8), dicofol (115-32-2), ...
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TR-091: Clonitralid (CASRN 1420-04-8) 2.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr091.pdf
... chlorobenzilate (510-15-6); dioxathion (78-34- 2); sulfallate (95-06-7); p,p'-DDT (50-29-3); methoxychlor (72-43-5); p,p'-DDE (72-55-9); p,p'-TDE (72-54-8); dicofol (115-32-2); ...
