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Comment: Meat-related exposures (ORoC3); Shalene McNeill, The... 69KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/mcneill_3oroc20161007.pdf
PAHs, in particular benzo[a]pyrene (BaP), and HCA content in foods, is confounded ... meats are not significant sources of BaP compared to other sources of animal protein. ...
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Comment: Meat-related exposures (OHAT4); Shalene McNeill, The... 70KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/mcneill_4ohat20161007.pdf
PAHs, in particular benzo[a]pyrene (BaP), and HCA content in foods, is confounded ... meats are not significant sources of BaP compared to other sources of animal protein. ...
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Polycyclic Aromatic Compounds 83KB
https://ntp.niehs.nih.gov/whatwestudy/topics/pacs
Status: Ongoing Substances: Acenaphthenequinone Benzo(a)pyrene Pyrene ... PAC CASRN Testing Status Benzo[a]pyrene 50-32-8 Ongoing Phenanthrene 85-01-8 Ongoing ...
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Poster: Building a Comprehensive Search of Epigenetic Studies... 1.3MB
https://ntp.niehs.nih.gov/ntp/results/pubs/posters/garner_sot20220327.pdf
Widely associated with epigenetic changes As Inorganic arsenic Benzo(a)pyrene Aflatoxin B1 Background . Key characteristics of carcinogens (KCCs) are used for Report on Carcinogens ...
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Poster: Use of Survey Sampling to Develop an Evidence Map of... 1.7MB
https://ntp.niehs.nih.gov/ntp/results/pubs/posters/wang_gems_20221101.pdf
For example, epigenetic changes were studied in roughly 250 benzo(a)pyrene references , ... NIEHS is updating the benzo(a)pyrene evaluation and is assessing the potential ...
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Appendix G; 15th RoC 2021 73KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
(estradiol-17β) see Estrogens, Steroidal 50-29-3 see Dichlorodiphenyltrichloroethane 50-32-8 (benzo[a]pyrene) see Polycyclic Aromatic Hydrocarbons: 15 Listings 50-55-5 see ...
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TR-044 In Vitro Carcinogenesis: Guide to the Literature, Recent... 18.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr044.pdf
... in Hamsters by Different Dose Levels of Benzo(a)pyrene and Ferric Oxide." £._ Natl. ... Induced by Different Numbers of Administrations of Benzo(a)pyrene and Ferric Oxide." ...
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Comment: Meat-related exposures; Jane Pouzou, Solenne Costard... 945KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/pouzou_costard_zagmutt20161011.pdf
HCAs and BaP were not necessarily the same foodstuffs. Fish contributed somewhat more of MeIQx than other sources (up to 5.66 ng/g of MeIQx), 3 whereas PhIP and BaP were more ...
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E04: Mean Body Weights and Survival Table for Male & Female Mice... 20KB
https://ntp.niehs.nih.gov/ntp-db/ntp_reports/ntp_pathology_tbls/20523_tables/04_f1_m3_e04.pdf
Control List: Male: 001 Female: 002 Study Gender: Both TDMSE Version: 3.0.2.2_002 PWG Approval Date: NONE Experiment Number: 20523 - 04 E04: MEAN BODY WEIGHTS AND SURVIVAL TABLE ...
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Comment: Meat-related exposures; Jerrad Legako, TTU; OHAT/ORoC... 355KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/legako20161007.pdf
... data, with only a very limited amount of BaP data contributed to reflect PAH. Granted, ... The same is apparent in the PAH/BaP literature. For example, in some countries "grilling" ...
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RoC Profile: Polycyclic Aromatic Hydrocarbons: 15 Listings; 15th... 373KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/polycyclicaromatichydrocarbons.pdf
Also known as B[j]F Benzo[k]fluoranthene CAS No. 207-08-9 Also known as B[k]F Benzo[a]pyrene CAS No. 50-32-8 Also known as B[a]P Dibenz[a,h]acridine CAS No. 226-36-8 Also known as ...
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Comment: Meat-related exposures, Shalene McNeill, The Beef Checkoff... 74KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/mcneill20180911-2.pdf
(PhIP) and 2-amino-3,8- dimethylimidazo[4,5-f]quinoxaline (MeIQx), and 8 PAH [BaP, Chrysene (Chy), Benzo[a]Anthracene (BaA), Benzo[k]Fluoranthene (BkF), ...
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RoC Background Document: Diesel Exhaust Particulates; Dec. 2... 5.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/dieselexhaust_508.pdf
... 252 207-08-9 91-289 Benzo[a]pyrene 252 50-32-8 208-558 Benzo[e]pyrene 252 192-97-2 ... elimination rate and induction of benzo(a)pyrene hydroxylase and ethoxycoumarin de- ...
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National Institute of Environmental Health Sciences: Carcinogenicity... 151KB
https://www.niehs.nih.gov/research/atniehs/dtt/strategic-plan/health/carcinogenicity
... Use of read across to classify carcinogenic hazard of PAHs with limited animal cancer data. Evaluation of benzo(a)pyrene, which was listed as a reasonably anticipated human ...
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Protocol: Systematic Review of Inflammation-based Atherosclerosis... 1001KB
https://ntp.niehs.nih.gov/sites/default/files/2023-07/protocol_atherosclerosisjuly2023_508.pdf
.../exp OR "3,4-benzopyrene":ti,ab OR "benzo(a)pyrene":ti,ab OR "benzo-a-pyrene":ti,ab OR ... OR "3,4- Benz(a)pyrene":ti,ab OR "3,4-Benzo(a)pyrene":ti,ab OR "3,4-Benzofluoranthene":ti,...
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Protocol: Evidence Map of Inflammation-Based Atherosclerosis... 643KB
https://ntp.niehs.nih.gov/sites/default/files/2023-07/protocol_atherosclerosis_supplementaljuly2023_508.pdf
.../exp OR "3,4-benzopyrene":ti,ab OR "benzo(a)pyrene":ti,ab OR "benzo-a-pyrene":ti,ab OR ... OR "3,4-benzopyrene"[tiab] OR "benzo(a)pyrene"[mh] OR "benzo(a)pyrene"[tiab] OR ...
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TR-404: 5,5-Diphenylhydantoin (CASRN 57-41-0) (Phenytoin) in... 16.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr404.pdf
... obtained with benzo(a)pyrene, 3-methyl- cholanthrene, and urethane (Pietra et al., 1961). ... safrole, 4-amino- biphenyl, and benzo(a)pyrene bind to the DNA o f the maternal ...
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Mechanistic Insights from Profiling Chemical-Mediated Transcription... 6.9MB
https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-medvedev-poster.pdf
... Benz(a)anthracene 200uM 0.90 Cupferron 66.7uM 0.90 Benz(a)anthracene 7.4uM 0.90 Benzo(a)pyrene 60uM 0.90 Cyclohexylphenylketone 66.7uM 0.90 Benz(a)anthracene 22.2uM 0.90 Day 1 Day ...
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TR-398: Polybrominated Biphenyls (CASRN 67774-32-7)(Firemaster... 14.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr398.pdf
... obtained with benzo(a)pyrene, 3-methylchotanthrene, and urethane (Pietra et al., 1961). ... safrole, 4-aminobiphenyl, and benzo(a)pyrene bind to the DNA of the maternal ...
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RoC Background Document: Tobacco Smoking; Dec. 2-3, 1998 3.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/environmentalts_noapps_508.pdf
... C 20 H 12 199 ng/cig 44 ng/cig 50-32-8 252.31 2A Grimmer et al. (1977) 4 RoC ... ST + V79 + Benzene 71-43-2 CCC + CYI + MNT + SCE - TRM + Benzo[a]pyrene 50-32-8 CCC + CT + ...
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Literature Search Results: Systematic Review of Traffic-Related... 275KB
https://ntp.niehs.nih.gov/ntp/ohat/airpollchildhealth/literature_results_508.pdf
... diesel[tiab] OR petrol*[tiab] OR Polycyclic hydrocarbons, aromatic[mh:noexp] OR "benzo(a)pyrene"[mh] OR benzene[mh] OR "polycyclic aromatic hydrocarbons"[tiab] OR ...
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TR-203: Phenol for Possible Carcinogenicity (CASRN108-95-2) 4.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr203.pdf
... Duuren et al. (1968) have shown that phenol in acetone or benzene promotes skin cancer in mice pretreated with 7,12-dimethylbenz(a)anthracene (DMBA) or 3,4-benzo(a)pyrene (BaP). ...
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Nomination Background: Wireless Communication Devices (CASRN... 153KB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/wireless051999_508.pdf
... Of particular interest is, for example, the study conducted by Szmigielski et al (1983), who observed faster development of benzo(a)pyrene-induced skin tumors in mice that were ...
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Protocol for a Systematic Review of Traffic-Related Air Pollution... 1.3MB
https://ntp.niehs.nih.gov/ntp/ohat/airpollchildhealth/protocol_20160616_508.pdf
... dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene. ... hydrocarbons, aromatic[mh:noexp] OR "benzo(a)pyrene"[mh] OR benzene[mh] OR "polycyclic ...
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Combined Exposures and Mixtures Program; BSC; Feb. 2, 2021 277KB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2021/february/meeting_materials/cem_bsc_508.pdf
... biloba extract) or constituents with established toxicological activity (e.g., benzo(a)pyrene in cookstove emissions). 20 Nontargeted chemical analysis methods can be used to ...
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Minutes: BSC; March 27, 1984 3.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1984/march/bsc_minutes19840327_508.pdf
... and diol formation at sites 6 0 such as the 7, 8, 9, 10-position of benzo(a)pyrene . ... activity of 1-, 3- and 6-nitrobenzo(a)pyrenes in Chinese hamster ovary (CHO) cells . ...
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TOX-13: Trinitrofluorenone (CASRN 129-79-3) 2.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox013.pdf
... It was not specified, however, if these were concurrent controls. Under similar protocols, 8/9 (89%) rats given an oral dose of 100 mg of benzo(a)pyrene developed mammary tumors; ...
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TR-209: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6... 8.5MB
https://ntp.niehs.nih.gov/go/tr209
... 72 hours prior to skin painting with benzo(a)pyrene ( B ( a ) P , 100 nmol) or with 7,12- ...3,7,8-tetrachlorodibenzo-p- dioxin on benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene ...
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Minutes: BSC; Sept. 27, 1983 638KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1983/september/bsc_mins19830927_508.pdf
... Employees, tumor initi- benzo(a)pyrene dinitropyrenes ation & promo- -Teratoloay study in mixture a s tion studies (inh .) that utilized AFL-CIO by EPA of dinitro- (H) pyrene ...
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TR-201: Carcinogenesis 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN... 5.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr201.pdf
... 72 hours prior to skin painting with benzo(a)pyrene (B(a)P, 100 nmol) or with 7,12-di- ...3,7,8-tetrachlorodibenzo-p- dioxin on benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene ...
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Comment: Meat-related exposures; Robert Turesky, University of... 4.6MB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/turesky20161005.pdf
... ARC formed in tobacco smoke are ∼25- to 100-fold higher than those of 4-ABP 4 or benzo(a)pyrene, 143 and comparable to the levels of the tobacco-specific nitrosamine ...
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TR-565: Milk Thistle Extract (CASRN 84604-20-6) in F344/N Rats... 7.6MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr565.pdf
... hemolysates from benzo(a)pyrene-induced oxidative damage (Kiruthiga et al., 2007). ... Protective effect of silymarin on erythrocyte haemolysate against benzo(a)pyrene and ...
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TR-574: Pyrogallol (CASRN 87-66-1) in F344/N Rats and B6C3F1... 13.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr574_508.pdf
... When 5 mg (0.04 mmol) pyrogallol and 0.005 mg benzo(a)pyrene were simultaneously applied ... The incidence of benzo(a)pyrene-induced micronuclei in mouse bone marrow was decreased ...
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RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf
... Analytical Conc. (μg/mL) Acenaphthene - 83-32-9 2001 Acenaphthylene - 208-96-8 2001 Anthracene - 120-12-7 2001 Benz(a)anthracene - 56-55-3 1995 Benzo(a)pyrene - 50-32-8 2002 ...
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TR-327: Xylenes (Mixed) (60%m-Xylene, 14%p-Xylene, 9%o-Xylene... 8.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr327.pdf
... P-450-mediated metabolism of bi- phenyl and benzo(a)pyrene in male Sprague- Dawley rats. ... organic solvents on cytochrome P-450-media- ted metabolism of biphenyl and benzo(a)pyrene. ...
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TR-388: Ethylene Thiourea (CASRN 96-45-7) in F344 Rats and B6C3F1Mice... 13.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr388.pdf
... were obtained with benzo(a)pyrene, 3-methylcholanthrene, and urethane (Pietra et al.,1%1). ... induced by the environmental carcinogens safrole, 4-aminobiphenyl, and benzo(a)pyrene. ...
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Minutes: BSC; March 10, 1982 1.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1982/march/bsc_mins19820310_508.pdf
... Maronpot replied that the female was more sensitive and that both diethy1nitrosamine and benzo(a)pyrene had been used and found effective as initiators . Dr . Swenberg expressed ...
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TR-022: Dieldrin (CASRN 60-57-1) 1.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr022.pdf
... Sellakumar, A. R., Cefis, F., and Kaufman, D. G., Respiratory tract carcinogenesis in hamsters induced by different numbers of administrations of benzo(a)pyrene and ferric oxide. ...
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TR-529: 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065... 7.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr529.pdf
... In addition to the persistent DLCs, there are a wide variety of other com- pounds that can also bind to the AhR, including poly- cyclic aromatic hydrocarbons, (e.g., benzo(a)pyrene ...
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TR-559: 2,3',4,4',5-Pentachlorobiphenyl (PCB 118)(CASRN 31508... 6.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr559.pdf
... In addition to the persistent DLCs, there are a wide variety of other com- pounds that can also bind to the AhR, including poly- cyclic aromatic hydrocarbons (e.g., benzo(a)pyrene ...
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Public Health Impact 1.5MB
https://ntp.niehs.nih.gov/media/impact
... Type: Notice June 13, 2018 Proposition 65 7440-48-4 TRIMVX 50-32-8 2018 EPA Asbestos; ... of the Final Public Health Goals for Benzo(A)Pyrene, Methoxychlor, and TCDD (Dioxin) In ...
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TR-520: 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465... 16.2MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr520.pdf
... In addition to the persistent DLCs, there are a wide variety of other compounds that can also bind to the AhR, including polycyclic aromatic hydrocarbons, (e.g., benzo(a)pyrene ...
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TR-521: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CASRN 1746... 15.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr521.pdf
... In addition to the persistent DLCs, there is a wide variety of other compounds that can also bind to the AhR, including polycyclic aromatic hydrocarbons, (e.g., benzo(a)pyrene ...
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TR-525: 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117... 7.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr525.pdf
... In addition to the persistent DLCs, there are a wide variety of other com- pounds that can also bind to the AhR, including poly- cyclic aromatic hydrocarbons, (e.g., benzo(a)pyrene ...
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TR-526: a Mixture of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD... 9.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr526.pdf
... In addition to the persistent DLCs, there is a wide variety of other com- pounds that can also bind to the AhR, including poly- cyclic aromatic hydrocarbons, (e.g., benzo(a)pyrene ...
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XDS Submission of the LUMI-CELL ER Test Method 3.2MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/iccvamsubmission28jan05.pdf
... Benzo(a)anthracene 56-55-3 Natural Product carcinogenic 8.00E+06 - 3.91E+03 2.00E+01 - 9.77E-03 8.76E-05 - 4.28E-08 99% Sigma Powder Benzo(a)pyrene 50-32-8 Natural Product ...
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TR-017: Photodieldrin (CASRN 13366-73-9) 3.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr017.pdf
... , Sellakumar, A. R., Cefis, F., and Kaufman, D. G., Respiratory tract carcinogenesis in hamsters induced by different numbers of administrations of benzo(a)pyrene and ferric oxide. ...
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TR-050: Acetohexamide (CASRN 968-81-0) 2.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr050.pdf
... Sellakumar, A. R., Cefis, F., and Kaufman, D. G. , Respiratory tract carcinogenesis in hamsters induced by different numbers of administrations of benzo(a)pyrene and ferric oxide. ...
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TR-415: Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1Mice... 12.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr415.pdf
... Intratracheal instillation of a mixture o f benzo(a)pyrene and polysorbate $0 into hamsters resulted in respiratory tract neoplasms in 12 o f 50 treated animals, while neoplasms ...
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TR-530: a Binary Mixture of 3,3',4,4',5-Pentachlorobiphenyl ... 13.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr530.pdf
... In addition to the persistent DLCs, there are a wide variety of other com- pounds that can also bind to the AhR, including poly- cyclic aromatic hydrocarbons, (e.g., benzo(a)pyrene ...