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29 results found for "50-53-3".

  1. Abstract for TER82055 61KB

    https://ntp.niehs.nih.gov/publications/abstracts/dev/ter82055

    5abs Abstract for TER82055 Chlorpromazine Hydrochloride Administered to Fischer/344 Rats ... Chlorpromazine HCl, a widely used tranquilizer and antipsychotic agent, was evaluated for ...

  2. Abstract for TER82056 62KB

    https://ntp.niehs.nih.gov/publications/abstracts/dev/ter82056

    56abs Abstract for TER82056 Chlorpromazine Hydrochloride Administered to CD-1 Mice on ... Chlorpromazine HCl, a widely used major tranquilizer (antipsychotic), was evaluated for ...

  3. Cover Letter for Nomination of IVSA to ICCVAM (2012) 531KB

    https://ntp.niehs.nih.gov/iccvam/methods/immunotox/ivsa/ivsa-iccvamsubmissionletter-092712-508.pdf

    ... CASRN Source Vehicle Conc. tested SI Result Viability Date Solubility Formula (g/mol) Phase Class 1 Chlorpromazine CPZ 69-09-0 Sigma H 2 O 0.003% no SSL 2.89 + 46.6% 03/23/12 H2O C ...

  4. Computational Tools Applications 81KB

    https://ntp.niehs.nih.gov/iccvamreport/2021/confidence/comp-tools-app

    ... identified drugs with known cardiotoxic effects in a variety of use classes including estrogenic modulators, anti-arrhythmic drugs, and antipsychotic drugs like chlorpromazine. ...

  5. Background: Dimethylethanolamine (DMAE) [108-01-0] and Selected... 1.3MB

    https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dmae_update_110002_508.pdf

    ... strychnine, morphine, chlorpromazine, evipan, and phenobarbital in rats. Treatment with DMAE for seven to fourteen days increased levels of chlorpromazine in the brains of rat, ...

  6. Advancing Flexibility for Defined Approach Guidelines: Developing... 1.2MB

    https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Sullivan-poster.pdf

    ... 1154-59-2 Y 1A 1A 1 1A/1B Aniline* 62-53-3 Y 1B 1B NC 1B Chlorpromazine 50-53-3 N 1B 1 NC 1B Cinnamic alcohol 104-54-1 Y 1B 1B 1 1B Dibenzoyl peroxide 94-36-0 N ...

  7. TR-425: Promethazine Hydrochloride (CASRN 58-33-3) in F344/N... 22.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr425.pdf

    ... Chlorpromazine (a structur- ally related drug) was not carcinogenic to mice given 5 mg/kg ... for up to However, promethazine and chlorpromazine (a structur- 16 days, 13 weeks, or 2 ...

  8. CERHR Monograph: Amphetamines 4.1MB

    https://ntp.niehs.nih.gov/ntp/ohat/stimulants/amphetamines/amphetaminemonograph.pdf

    ... and.inhibited.by.chlorpromazine,.haloperidol,.and.lithium.carbonate......an.8-week.trial.of.placebo.(n.=.10),.chlorpromazine,. (n.=.17),.hydroxyzine.(n.=.17),.or....

  9. Guidance Document on Using In Vitro Data to Estimate In Vivo... 6.5MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/guidance0801/iv_guide.pdf

    ... Silver I nitrate 0.013 0.29 49.3 27 Chlorpromazine 0.014 0.44 140.3 29 28 Mercury II ... Cupric chloride 0.11 1.04 139.8 27 Chlorpromazine 0.014 0.44 140.3 96 Cygon 1.24 0.66 ...

  10. National Toxicology Program Toxicity Report Series 590KB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox037.pdf

    ... Toxicol. 5, S150-S159. PETTERSEN, J. C., AND COHEN, S. D. (1985). Antagonism of cyanide poisoning by chlorpromazine and sodium thiosulfate. Toxicol. Appl. Pharmacol. 81, 265-273. ...

  11. Report: International Workshop on In Vitro Methods for Assessing... 25.4MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/finalrpt/finalall0801.pdf

    ... 161 Silver I nitrate 7761-88-8 2.21 0.013 NA NA 49.3 0.29 169.88 0.29 27 Chlorpromazine 50-53-3 4.46 0.014 140.3 0.44 261.5 0.82 318.89 0.44 28 Aldosterone 52-39-1 5.05 0.014 ...

  12. Independent Peer Review Evaluation of the Murine Local Lymph... 13.1MB

    https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna/llnarep.pdf

    ... halide + Basketter et al. (1993) Chlorpromazine 69-09-0 phenothiazine// tertiary ... + 1-Chlorotetradecane 2425-54-9 + Chlorpromazine 69-09-0 + +* + Cinnamic aldehyde ...

  13. Usefulness and Limitations of the LLNA for Potency Categorization... 25.3MB

    https://ntp.niehs.nih.gov/iccvam/docs/immunotox_docs/llna-pot/tmer.pdf

    ... b 895 41 Mercury bichloride b 924 98 Chlorpromazine 1150 b 463 Benzylidene Acetone 1200 c ... Oxon, UK (Warbrick et al. 1999a) Chlorpromazine DMF 0.25 2.5 25 1.02 1.75 3.53 18.3 ...

  14. TR-549: Bromochloroacetic Acid (CAS 5589-96-8) in F344/N Rats... 20.0MB

    https://ntp.niehs.nih.gov/go/tr549

    ... 58.3 2.5 59.0 11 2.4 57.7 21 2.3 54.6 42 49 2.8 58.5 2.7 58.4 12 2.5 57.7 22 2.7 54.1 50 53 3.1 59.4 2.8 59.2 12 2.7 58.5 23 2.5 55.9 45 57 2.6 59.3 2.8 59.2 12 2.6 59.3 22 2.3 ...

  15. TR-387: dl-Amphetamine Sulfate (CASRN 60-13-9) in F344/N Rats... 10.4MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr387.pdf

    ... Lu, T.-C., Claghorn, J.L., and Schoolar, J.C. (1973). Chronic administration of d-amphetamine and chlorpromazine in rats. Eur. J. Pharmacol. 21, 61- 65. Magour, S., Coper, H., and ...

  16. TR-506: Acrylonitrile (CASRN 107-13-1) in B6C3F1Mice (Gavage... 7.1MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr506.pdf

    NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ACRYLONITRILE (CAS NO. 107-13-1) IN B6C3F 1 MICE (GAVAGE STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 ...

  17. TR-574: Pyrogallol (CASRN 87-66-1) in F344/N Rats and B6C3F1... 13.3MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr574_508.pdf

    PYROGALLOL (CAS NO. 87-66-1) IN F344/N RATS AND B6C3F1/N MICE (DERMAL STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle Park, NC 27709 February 2013 NTP TR 574 ...

  18. TR-580: β-Picoline (CASRN 108-99-6) in F344/N Rats and B6C3F1... 2.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr580_508.pdf

    The Toxicology aNd caRciNogeNesis sTudies of β-PicoliNe (casRN 108-99-6) iN f344/N RaTs aNd B6c3f1/N Mice (dRiNkiNg WaTeR sTudies) NTP TR 580 AUGUST 2014 NTP Technical Report on ...

  19. TOX-56: Carisoprodol (CASRN 78-44-4) 3.8MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox056.pdf

    ... Sci. 86, 226-230. Kamada, N., Brecher, G., and Tjio, J.H. (1971). In vitro effects of chlorpromazine and meprobamate on blast transformation and chromosomes. Proc. Soc. Exp. Biol. ...

  20. Articles by Topic and Agency 548KB

    https://ntp.niehs.nih.gov/iccvamreport/2021/tags

    ... identified drugs with known cardiotoxic effects in a variety of use classes including estrogenic modulators, anti-arrhythmic drugs, and antipsychotic drugs like chlorpromazine. ...

  21. TR-509: 2,4-Hexadienal (89% trans,trans Isomer, CASRN 142-83... 10.5MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr509.pdf

    2,4-HEXADIENAL (89% trans,trans isomer, CAS No. 142-83-6; 11% cis,trans isomer) IN F344/N RATS AND B6C3F 1 MICE (GAVAGE STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research ...

  22. TR-572: Methyl trans-styryl ketone (CASRN 1896-62-4) in F344... 8.6MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr572_508.pdf

    METHYL trans-STYRYL KETONE (CAS NO. 1896-62-4) IN F344/N RATS AND B6C3F1 MICE (FEED AND DERMAL STUDIES) National Toxicology Program P.O. Box 12233 Research Triangle Park, NC 27709 ...

  23. ICCVAM Biennial Progress Report 2020-2021 940KB

    https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/annrpt/iccvam-rpt-2020-2021.pdf

    ... identified drugs with known cardiotoxic effects in a variety of use classes including estrogenic modulators, anti- arrhythmic drugs, and antipsychotic drugs like chlorpromazine. ...

  24. TR-594: p-Chloro-α,α,α-trifluorotoluene (CASRN 98-56-6) in... 4.3MB

    https://ntp.niehs.nih.gov/go/tr594

    of P-chloRo-α,α,α- TRifluoRoTolueNe (casRN 98-56-6) iN sPRague dawley (hsd:sPRague dawley ® sd ® ) RaTs aNd B6c3f1/N Mice (iNhalaTioN sTudies) NTP TR 594 JUNE 2018 NTP ...

  25. TR-495: Sodium Nitrite (CASRN 7632-00-0) IN F344/N Rats and B6C3F1Mice... 16.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr495.pdf

    NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM NITRITE (CAS NO. 7632-00-0) IN F344/N RATS AND B6C3F 1 MICE (DRINKING WATER STUDIES) NATIONAL ...

  26. TR-515: Propylene Glycol Mono-t-Butyl Ether (CASRN 57018-52-7... 9.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr515.pdf

    THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF PROPYLENE GLYCOL MONO-t-BUTYL ETHER (CAS NO. 57018-52-7) IN F344/N RATS AND B6C3F 1 MICE AND A TOXICOLOGY STUDY OF PROPYLENE GLYCOL ...

  27. TR-561: Tetralin (CASRN 119-64-2) in F344/N Rats and B6C3F1 Mice... 13.7MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr561.pdf

    ... 39 29.8 50 29.6 99 50 29.4 99 50 28.7 96 50 46 30.8 50 30.4 99 50 30.1 98 50 29.6 96 50 53 31.8 50 31.0 97 50 30.8 97 50 30.3 95 50 60 32.7 50 31.9 97 50 31.6 97 50 31.0 95 50 67 ...

  28. TR-581: Cobalt Metal (CASRN 7440-48-4) in F344/N Rats and B6C3F1... 9.9MB

    https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr581_508.pdf

    The Toxicology STudieS of cobalT MeTal (caSRN 7440-48-4) iN f344/N RaTS aNd b6c3f1/N Mice aNd Toxicology aNd caRciNogeNeSiS STudieS of cobalT MeTal iN f344/NTac RaTS aNd b6c3f1/N ...

  29. ICCVAM Background Review Document (Vol 2): In Vitro Cytotoxicity... 61.6MB

    https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/brd_tmer/brdvol2_nov2006.pdf

    ... p,p'-DDE 318.02 0.1 31.8 2.77 880.9 Chlorpromazine 318.89 0.014 4.5 0.44 140.3 p,p'-DDD ... 0.021 Antipsychotic, anxiolytic 27 Chlorpromazine -0.176 44 Hydroxyzine HCl 0.248 63 ...

 
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