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TR-193: Reserpine (CASRN 50-55-5) 3.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr193.pdf
3 NTP No. 80-16 BIOASSAY OF RESERPINE FOR POSSIBLE CARCINOGENICITY CAS No. 50-55-5 NCI-CG-TR-193 NTP-80-16 U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service ...
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RoC Profile: Reserpine; 15th RoC 2021 131KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/reserpine.pdf
Reserpine CAS No. 50-55-5 Reasonably anticipated to be a human carcinogen First listed in the Second Annual Report on Carcinogens (1981) Also known as methyl 18β-hydroxy-11,17α-d...
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Reserpine: Target Organs and Levels of Evidence for TR-193 57KB
https://ntp.niehs.nih.gov/data/tr/100s/tr193levels
7 Reserpine: Target Organs and Levels of Evidence for TR-193 Bioassay of Reserpine for Possible Carcinogenicity (CASRN 50-55-5) Chemical (Study Title) CASRN Peer Review Date Route/...
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Abstract for TR-193 61KB
https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr193
3abs Abstract for TR-193 Bioassay of Reserpine for Possible Carcinogenicity (CAS No. 50-55-5) CASRN: 50-55-5 Chemical Formula: C33H40N2O9 Molecular Weight: 608.684 Report Date: ...
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Appendix G; 15th RoC 2021 73KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_g.pdf
50-32-8 (benzo[a]pyrene) see Polycyclic Aromatic Hydrocarbons: 15 Listings 50-55-5 see Reserpine 51-52-5 see Propylthiouracil 51-79-6 see Urethane 52-24-4 see Thiotepa 53-16-7 ...
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Ear - Inflammation - Nonneoplastic Lesion Atlas 297KB
https://ntp.niehs.nih.gov/atlas/nnl/special-senses-system/ear/Inflammation
... National Toxicology Program. 1982. NTP TR-193. Bioassay of Reserpine for Possible Carcinogenicity (CAS No. 50-55-5). NTP, Research Triangle Park, NC. Abstract: https://...
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Ear - Inflammation 436KB
https://ntp.niehs.nih.gov/sites/default/files/nnl/special_senses/ear/inflamm/ear-inflammation_508.pdf
.../doi/10.1097/01.mlg.0000147930.29261.51/full National Toxicology Program. 1982. NTP TR-193. Bioassay of Reserpine for Possible Carcinogenicity (CAS No. 50-55-5). ...
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Minutes: BSC; Feb. 5, 1998 713KB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1998/february/19980205bscmins_508.pdf
... chloroprene, N-methyl-o -acrylamide, reserpine, and methylphenidate, as was the ... of the transgenic systems -- glycidol, chloroprene, N-methylolacrylamide, and reserpine. ...
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Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting... 2.9MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edaddendfinal.pdf
... M-PA; **; 2G inhibits T3/T4 synthesis; being tested in vivo by EPA and by OECD Reserpine 50-55-5 Heterocyclic Compound, Indole Pharmaceutical, Veterinary Agent † - - Y IM ...
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Listed Substances; 15th RoC 2021 76KB
https://ntp.niehs.nih.gov/ntp/roc/content/listed_substances_508.pdf
... Progesterone 1,3-Propane Sultone β-Propiolactone Propylene Oxide Propylthiouracil Reserpine Riddelliine Safrole Selenium Sulfide Streptozotocin (see Nitrosourea Chemotherapeutic ...
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TR-051: Tolazamide (CASRN 1156-19-0) 2.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr051.pdf
... 139-65-1) ethionamide (CAS 536-33-4) reserpine (CAS 50-55-66) MICE Feed Studies ... 139-65-1) ethionamide (CAS 536-33-4) reserpine (CAS 50-55-6) Gavage Studies cholesterol ...
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NICEATM Update 5.1MB
https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2020/ppt/04-niceatm-kleinstreuer-508.pdf
... Tamoxifen Diethylstilbestrol Gentian Violet Fluorouracil Bisphenol A Reserpine Leveraging human cell-based in vitro systems COVID-19 Therapeutic Work . HEK293 and MVECs . ...
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Update on NICEATM Computational Resources 6.6MB
https://ntp.niehs.nih.gov/ntp/about_ntp/sacatm/2021/ppt/2021_sacatm_s4-1_kleinstreuer_v2_508.pdf
... Cyfluthrin Spironolactone Linuron Cycloheximide Estrone 17alpha-Estradiol Reserpine Se&rdl, 2, 2' ,4,4' -Tetrahydroxybenzophenone Hydroxyflutamide Search Results: Table ...
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TR-296: Tetrakis(hydroxymethyl)phosphonium sulfate (THPS) (CASRN... 16.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr296.pdf
... BODY WEIGHTS AND CLINICAL SIGNS ...... SURVIVAL ...... 50 50
55
5 THPS and THPC. NTP TR 296 ...
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ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential... 10.6MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/edfinalrpt0503/edfinrpt.pdf
... Pharmaceutical Propylthiouracil 51-52-5 Pyrimidine; Uracil Pharmaceutical Reserpine 50-55-5 Heterocycle; Yohimban Pharmaceutical Sodium azide 26628-22-8 Organic salt; Azide ...
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Appendices A-G; 15th RoC 2021 448KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendices_508.pdf
... 3,4,5-trimethoxybenzoate (ester) see Reserpine 2-methylbenzenamine see o-Toluidine ... ester, (3β,16β,17α,18β,20α)- see Reserpine Z (Z)-1,3-dichloropropene see ...
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TR-060: Phenesterin (CASRN 3546-10-9) 4.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr060.pdf
... (CAS 80-08-0) 4,4'-thiodianiline (CAS 139-65-1) ethionamide (CAS 536-33-4) reserpine (CAS 50-55-5) Gavage Studies estradiol bis((p-(bis(2-chloroethyl)amino)phenyl)acetate) ...
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TR-049: Acronycine (CASRN 7008-42-6) 5.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr049.pdf
... (CAS 80-08-0) 4,4'-thiodianiline (CAS 139-65-1) ethionamide (CAS 536-33-4) reserpine (CAS 50-55-5) Gavage Studies cholesterol (p-(bis(2-chloroethyl)amino)phenyl)acetate ...
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TR-299: C.I. Disperse Blue 1 (A commercial dye containing approximatel... 15.0MB
https://ntp.niehs.nih.gov/go/tr299
... at Southern Research Institute Reserpine C ytembena Eugenol Stannous chloride ... at Southern Research Institute Reserpine Cytembena Eugenol Stannous chloride ...
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15th RoC: Appendix F 174KB
https://ntp.niehs.nih.gov/ntp/roc/content/appendix_f.pdf
... 3,4,5-trimethoxybenzoate (ester) see Reserpine 2-methylbenzenamine see o-Toluidine ... ester, (3β,16β,17α,18β,20α)- see Reserpine Z (Z)-1,3-dichloropropene see ...
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TR-307: Ephedrine Sulfate (CASRN 134-72-5) in F344/N Rats and... 11.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr307.pdf
... that pretreatment of cats with reserpine markedly reduces the pe- ripheral ... de la Sierra, B. (1962) Modification by reserpine of the action of sympathomimetic amines ...
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NICEATM Validation Study Report on the MCF-7 Cell Proliferation... 1.8MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/mcf7/mcf7-valstudyreport-19jun12-wcv2-draft.pdf
... 4 Procymidone NEG (1/1) NEG (1/1) NEG 4 Reserpine NEG (1/1) NT NEG 4 Spironolactone NEG ... 4 Procymidone POS (1/1) NEG (1/1) NEG 4 Reserpine POS (1/1) NEG (1/1) NEG NICEATM DRAFT ...
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NTP Technical Reports Index 1.5MB
https://ntp.niehs.nih.gov/data/tr
... Clear Evidence P Clear Evidence N No Evidence P Clear Evidence TR-193 05/01/79 Reserpine 50-55-5 P Clear Evidence N No Evidence P Clear Evidence P Clear Evidence TR-192 05/01/79 ...
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TR-271: HC Blue No. 1 (CASRN 2784-94-3) in F344/N Rats and B6C3F1Mice... 10.0MB
https://ntp.niehs.nih.gov/go/tr271
... at Southern Research Institute Reserpine Cytembena Eugenol Stannous chloride ... Historical Incidence a t Southern Research Institute Reserpine Cytembena Eugenol Stannous ...
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TR-567: Ginseng (CASRN 50647-08-0) in F344/N Rats and B6C3F1... 6.7MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr567.pdf
... Some products sold as ginseng contain Man- dragora officinarum, with hyoscine; Rauwolfia ser- pentina, with reserpine; and Cola, with caffeine. Some products were adulterated with ...
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TR-439: Methylphenidate Hydrochloride (CASRN 298-59-9) in F344... 15.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr439.pdf
... Another differ- ence between amphetamine and methylphenidate is that reserpine antagonizes methylphenidate effects but not thoseof amphetamine (Patrick et al., 1987). A s ...
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XDS Submission of the LUMI-CELL ER Test Method 3.2MB
https://ntp.niehs.nih.gov/iccvam/methods/endocrine/endodocs/iccvamsubmission28jan05.pdf
... 99% 99% Sigma Sigma Sigma Sigma Sigma Powder Powder Powder Powder Powder Reserpine Spironolactone 50-55-5 52-01-7 Heterocycle; Yohimban Steroid, nonphenolic; Pregnene lactone ...
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TR-293: HC Blue No. 2 [2,2'-((4-((2-Hydroxyethyl)amino)-3-nitrophenyl... 8.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr293.pdf
... at Southern Research Institute Reserpine 0/49 0/49 0/49 Cytembena 0/50 1150 1/50 ... at Southern Research Institute Reserpine 3/48 1148 Cytembena 11/48 0/48 Eugenol ...
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Submission of XDS's LUMI-CELL ER High-Throughput System for Screening... 2.4MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/appxc/annexa/xds-sub.pdf
... 99% 99% Sigma Sigma Sigma Sigma Sigma Powder Powder Powder Powder Powder Reserpine Spironolactone 50-55-5 52-01-7 Heterocycle; Yohimban Steroid, nonphenolic; Pregnene lactone ...
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Minutes: BSC TRRS; Dec. 9, 1997 1.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/trrs/1997/dec/trrs9dec1997mins_508.pdf
... The non-mutagenic carcinogens, N- methyl-o-acrylamide, reserpine, and methylphenidate, were negative in these studies. Thus, Dr. French said that it was no surprise that for six of ...
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Technical Reports 903KB
https://ntp.niehs.nih.gov/publications/reports/tr
... 1980 Technical Report TR-193 PDF (3.49 MB) Bioassay of Reserpine for Possible Carcinogenicity (CASRN 50-55-5) 1982 Technical Report TR-192 PDF (2.22 MB) Bioassay of ...
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Nomination Background: p-Synephrine (CASRN: 94-07-5) 1.3MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/bitterorange_508.pdf
... The actions were antagonized by propranolol but not by pretreatment with reserpine, cocaine, butoxamine, or phenoxybenzamine, which indicated that the selective actions were ...
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Minutes: BSC; March 27, 1984 3.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/about_ntp/bsc/archives/1984/march/bsc_minutes19840327_508.pdf
... Zearalenone, Cyclophosphamide, Retinoic Acid, Reserpine, Propranolol Agent GB, Agent GD, Ultrasound, Silicone, d-Amphetamine . Methylmercury, Vitamin A, Aflatoxin METHODS ...
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Toxicology/Carcinogenicity 1.1MB
https://ntp.niehs.nih.gov/whatwestudy/testpgm/cartox
... Long-Term Carcinogenicity TR-193 PDF (3.49 MB) Bioassay of Reserpine for Possible Carcinogenicity (CASRN 50-55-5) 1982 Long-Term Carcinogenicity TR-192 PDF (2.22 MB) Bioassay of ...
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ICCVAM Test Method Evaluation Report on the BG1Luc ER TA Test... 17.5MB
https://ntp.niehs.nih.gov/iccvam/docs/endo_docs/erta-tmer/bg1lucer-ta-tmer-combined.pdf
... 82640-04-8 Hydrocarbon (Cyclic) Pharmaceutical 100.0 Sigma-Aldrich Corporation Reserpine 50-55-5 Heterocyclic Compound, Indole Pharmaceutical, Veterinary Agent 98.0 Sigma-Aldrich ...
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Study Reports 1.1MB
https://ntp.niehs.nih.gov/publications/reports
... 1980 Technical Report TR-193 PDF (3.49 MB) Bioassay of Reserpine for Possible Carcinogenicity (CASRN 50-55-5) 1982 Technical Report TR-192 PDF (2.22 MB) Bioassay of ...
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TR-356: Furosemide (CASRN 54-31-9) in F344/N Rats and B6C3F1Mice... 11.6MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr356.pdf
... Institute studie!; include benzene (NTP, 1986), reserpine (NCI, 1982), 1,2-dibromoethane ... Cancer Institute (NCI) (1982) Bio- assay of Reserpine for Possible Carcinogenicity. ...
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CERHR Monograph: Amphetamines 4.1MB
https://ntp.niehs.nih.gov/ntp/ohat/stimulants/amphetamines/amphetaminemonograph.pdf
... Additional.drug.interactions.are.discussed.in.labels.for.d,l-.and.d-amphetamine..Gastrointestinal. acidifying.agents.(e.g.,.guanethidine,.reserpine,.glutamic.acid.HCl,.ascorbic.aci...
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TR-223 Carcinogenesis Studies of Eugenol (CASRN 97-53-0) in F344... 6.8MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr223.pdf
... MALE B6C3Fi MICE Chemical Eugenol Reserpine Cytembena Mannitol Ziram Propyl Gallate ... Chemical l Eugeno Eugenol l Reserpin Reserpine e Cytemben Cytembena a Mannito Mannitol ...
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TR-558: 3,3',4,4'-Tetrachloroazobenzene (TCAB) (CASRN 14047-09... 22.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr558.pdf
REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF 3,3N,4,4N-TETRACHLOROAZOBENZENE (TCAB) [CAS NO. 14047-09-7] IN HARLAN SPRAGUE-DAWLEY RATS AND B6C3F1 MICE (GAVAGE STUDIES) ...
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TR-453: Nickel Subsulfide (CASRN 12035-72-2) in F344 Rats and... 17.9MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr453.pdf
... (NTP, 1990) andorallyto2-mercaptobenzothiazole (NTP, 1988) and reserpine (NCI, 1982). ... Bioassay of Reserpine for Carcinogenicity Possible (CAS No. 50-55-5). Technical Report ...
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TR-555: 1,2-Dibromo-2,4-dicyanobutane (CASRN 35691-65-7) in F344... 6.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr555.pdf
1,2-DIbROmO-2,4-DICYANObUTANE (CAS NO. 35691-65-7) IN F344/N RATS AND b6C3F1 mICE (DERmAL STUDIES) NATIONAL TOXICOLOGY PROGRAm P.O. box 12233 Research Triangle Park, NC 27709 June ...
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TR-537: Dibromoacetic Acid (CASRN 631-64-1) in F344/N Rats and... 9.3MB
https://ntp.niehs.nih.gov/go/tr537
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF DIBROMOACETIC ACID (CAS NO. 631-64-1) IN F344/N RATS AND B6C3F 1 MICE (DRINKING WATER STUDIES) NATIONAL ...
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TR-425: Promethazine Hydrochloride (CASRN 58-33-3) in F344/N... 22.5MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr425.pdf
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF PROMETHAZINE HYDROCHLORIDE (CAS NO. 58-33-3) IN F344/N RATS AND B6C3F MICE 1 (GAVAGE STUDIES) NTP TR 425 NIH ...
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TR-455: Codeine (CASRN 76-57-3) in F344 Rats and B6C3F1Mice ... 15.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr455.pdf
... Neurogenic signals regulate chromaffin cell proliferation mediate and the mitogenic effect of reserpine in the adult rat adrenal medulla. Lab. Invest. 65, 374-376. Tucker, M. J. ...
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TR-542: Cumene (CASRN 98-82-8) in F344/N Rats and B6C3F1 Mice... 9.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr542.pdf
ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF CUMENE (CAS NO. 98-82-8) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research ...
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TR-451: Nickel Oxide (CASRN 1313-99-1) in F344 Rats and B6C3F1... 27.7MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr451.pdf
... Public Health Service, National Institutes of Health, Bethesda, MD. National Cancer Institute (NCI) (1982). Bioassay of Reserpine for Possible Carcinogenicity (CAS No. 50-55-5). ...
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TR-393: Sodium Fluoride (CASRN 7681-49-4)in F344/N Rats and B6C3F1Mice... 21.9MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr393.pdf
NATIONAL TOXICOLOGY PROGRAM Technical Report Series No. 393 TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING ...
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Peer Review Evaluation Report: Oral Up-and-down Procedure (NIH... 2.1MB
https://ntp.niehs.nih.gov/iccvam/docs/acutetox_docs/udpproc/udpfin01/vol_2.pdf
... oil fatty acids, reaction prod- ucts with polyamines, alkyl substituted. 721.9470 Reserpine. 721.9480 Resorcinol, formaldehyde sub- stituted carbomonocycle resin. 721.9488 ...