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RoC Profile: Mustard Gas; 15th RoC 2021 121KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/mustardgas.pdf
Mustard Gas CAS No. 505-60-2 Known to be a human carcinogen First listed in the First Annual Report on Carcinogens (1980) Also known as bis(2-chloroethyl) sulfide Cl H 2 C C H 2 S ...
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Abstract for TER87038 60KB
https://ntp.niehs.nih.gov/publications/abstracts/dev/ter87038
8abs Abstract for TER87038 Arsine: Absence of Developmental Toxicity in Rats and Mice CASRN: 7784-42-1 Chemical Formula: AsH3 Molecular Weight: 77.9457 Abstract The following ...
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RR-11: The Chemical and Physical Characterization of Recycled... 3.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/results/pubs/rr/reports/rr11_508.pdf
The chemical aNd Physical chaRacTeRizaTioN of Recycled TiRe cRumb RubbeR NTP RR 11 JULY 2019 NTP Research Report on the Chemical and Physical Characterization of Recycled Tire ...
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Abstract for TR-544 74KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr544
4abs Abstract for TR-544 Toxicology and Carcinogenesis Studies of Dibromoacetonitrile in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) CASRN: 3252-43-5 Chemical Formula: ...
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Abstract for TR-65 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/000s/tr065
5abs Abstract for TR-65 Bioassay of Chloropicrin for Possible Carcinogenicity CASRN: 76-06-2 Chemical Formula: CCl3NO2 Molecular Weight: 164.375 Synonyms/Common Names: ...
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Abstract for TR-379 64KB
https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr379
9abs Abstract for TR-379 Toxicology and Carcinogenesis Studies of 2-Chloroacetophenone in F344/N Rats and B6C3F1 Mice (Inhalation Studies) CASRN: 532-27-4 Chemical Formula: C8H7ClO ...
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Abstract for TR-389 63KB
https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr389
9abs Abstract for TR-389 Toxicology and Carcinogeneis Studies of Sodium Azide in F344 Rats (Gavage Studies) CASRN: 26628-22-8 Chemical Formula: Na N3 Molecular Weight: 65.02 ...
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Abstract for TR-506 71KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr506
6abs Abstract for TR-506 Toxicology and Carcinogenesis Studies of Acrylonitrile in B6C3F1 Mice (Gavage Studies) CASRN: 107-13-1 Chemical Formula: C3H3N Molecular Weight: 53.06 ...
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TR-379: 2-Chloroacetophenone (CASRN 532-27-4) in F344/N Rats... 24.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr379.pdf
9 (l ,..,..~ TOXICOLOGY AND CARCINOGENESIS STUDIES OF 2-CHLOROACETOPHENONE (CAS NO. 532.27-4) IN F344/N RATS AND B6C3Ft MICE (INHALATION STUDIES) U.S. DEPARTMENT OF HEALTH AND ...
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Japanese Minimum Requirements for Biological Products 2.0MB
https://ntp.niehs.nih.gov/iccvam/methods/biologics/vaccine/japan-minreqs.pdf
MINIMUM REQUIREMENTS FOR BIOLOGICAL PRODUCTS National Institute of Infectious Diseases Japan, 2006 - 1 - MINIMUM REQUIREMENTS FOR BIOLOGICAL PRODUCTS Notice: This English version ...
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DOT PHMSA Update: ICCVAM Public Forum 2017 243KB
https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2017/03p-hwang-dot-508.pdf
Pipeline and Hazardous Material Administration (PHMSA) Department of Transportation AN ICCVAM UPDATE Presented at the Public Forum, NIH Natcher Center, MD May 23, 2017 Steve Hwang, ...
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Sulfolane 65KB
https://ntp.niehs.nih.gov/whatwestudy/topics/sulfolane
sulfolane Sulfolane Smoke stacks of petroleum factory Research Overview Status: Ongoing Substances: Sulfolane Nominated: September 2011 Background Information Sulfolane is a highly ...
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TR-310: Marine Diesel Fuel (NO CAS) and JP-5 Navy Fuel (CASRN... 10.1MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr310.pdf
10 TOXICOLOGY AND CARCINOGENESIS STUDIES OF MARINE DIESEL FUEL AND JP-5 NAVY FUEL (CAS NO. 8008-20-6) IN B6C3F1 MICE (DERMAL STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES ...
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DOT Update: ICCVAM Public Forum 2015 265KB
https://ntp.niehs.nih.gov/iccvam/meetings/iccvam-forum-2015/dot-iccvampubforum-2015-508.pdf
Pipeline and Hazardous Material Administration (PHMSA) Department of Transportation AN ICCVAM UPDATE Presented at the Public Forum, NIH Natcher Center, MD May 27, 2015 Steve Hwang, ...
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Nomination Background: Dichloroacetic acid (CASRN: 79-43-6) 6.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dcaa_508.pdf
NATIONAL TOXICOLOGY PROGRAM EXECUTIVE SUMMARY OF SAFETY AND TOXICITY INFORMATION DICHLOROACETIC ACED CAS Number 79-43-6 TRICHLOROACETIC ACID CAS Number 76-03-9 September 30, 1991 ...
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TR-314: Methyl Methacrylate (CASRN 80-62-6) in F344/N Rats and... 11.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr314.pdf
4 /~ t.,~f_ TOXICOLOGY AND CARCINOGENESIS STUDIES OF METHYL METHACRYLATE (CAS NO. 80-62-6) IN F344/N RATS AND B6C3Ft MICE (INHALATION STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN ...
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TR-487: Isobutene (CASRN 115-11-7) in F344/N Rats and B6C3F1Mice... 11.0MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr487.pdf
ISOBUTENE (CAS NO. 115-11-7) IN F344/N RATS AND B6C3F MICE 1 (INHALATION STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle Park, NC 27709 December 1998 NTP TR ...
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NTP Research Concept: Sulfolane Project Leader Chad Blystone... 102KB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2011/december/sulfolanedraftconcept201112.pdf
NTP Research Concept: Sulfolane Project Leader Chad Blystone, PhD, DABT NIEHS/DNTP/Toxicology Branch Background and Rationale Sulfolane (CAS# 126-33-0) was nominated by the State ...
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RoC Background Document: Diesel Exhaust Particulates; Dec. 2... 5.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/dieselexhaust_508.pdf
FINAL Report on Carcinogens Background Document for Diesel Exhaust Particulates December 2 - 3, 1998 Meeting of the NTP Board of Scientific Counselors Report on Carcinogens ...
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Final RoC Background Document for Formaldehyde 5.8MB
https://ntp.niehs.nih.gov/ntp/roc/twelfth/2009/november/formaldehyde_bd_final.pdf
Formaldehyde January 22, 2010 U.S. Department of Health and Human Services Public Health Service National Toxicology Program Research Triangle Park, NC 27709 This Page ...
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ICE Tools to Facilitate PBPK Modeling and IVIVE for Various Exposure... 1016KB
https://ntp.niehs.nih.gov/iccvam/meetings/ascct-2022/unnikrishnan_ascct-2022-poster_fd.pdf
. The Integrated Chemical Environment (ICE) is an open-source resource containing curated chemical property and bioactivity data, and tools for summarizing, analyzing, and ...
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RoC Background Document: 1,3-Butadiene; Oct. 30-31, 1997 9.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/butadiene_508.pdf
1,3-BUTADIENE FINAL MARCH 1999 Prepared for the October 30-31, 1997, Meeting of the Report on Carcinogens Subcommittee of the NTP Board of Scientific Counselors Prepared by ...
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Curation and Characterization of a Rat Acute Inhalation Toxicity... 2.5MB
https://ntp.niehs.nih.gov/sites/default/files/2024-03/SOT2024-Allen-poster.pdf
. Hazard classification is essential for regulatory decision-making. Evaluation of alternative models can often involve reviewing how these models align with hazard classifications ...
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TR-272: Propylene (CASRN 115-07-1) in F344/N Rats and B6C3F1Mice... 8.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr272.pdf
Technical Report Series No. 272 3 c TOXICOLOGY AND CARCINOGENESIS STUDIES OF PROPYLENE (CAS NO. 115-07-1) IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES) U.S. DEPARTMENT OF ...
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TR-288: 1,3-Butadiene (CASRN 106-99-0) in B6C3F1Mice (Inhalation... 5.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr288.pdf
88 TOXICOLOGY AND CARCINOGENESIS STUDIES OF 1,S-BUTADIENE (CAS NO. 106-99-0) IN B6C3F1 MICE (INHALATION STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service ...
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TR-506: Acrylonitrile (CASRN 107-13-1) in B6C3F1Mice (Gavage... 7.1MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr506.pdf
NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ACRYLONITRILE (CAS NO. 107-13-1) IN B6C3F 1 MICE (GAVAGE STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 ...
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Combining NAM Data and IVIVE for Evaluating Potential Inhalation... 595KB
https://ntp.niehs.nih.gov/iccvam/meetings/sot23/sot2023-chang-poster.pdf
Combining NAM Data and IVIVE for Evaluating Potential Inhalation Toxicity X. Chang 1 , E. Reinke 1 , A. Daniel 1 , D.G. Allen 1 , M. Mumtaz 2 , N. Kleinstreuer 3 1 Inotiv, RTP, NC; ...
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Abstract for TR-561 77KB
https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr561
1abs Abstract for TR-561 Toxicology and Carcinogenesis Studies of Tetralin in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Tetralin in Male NBR Rats (Inhalation studies) ...
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RoC Background Document: Tetrafluoroethylene; March 1999 4.5MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/tetrafluoroethylene1.pdf
for TETRAFLUOROETHYLENE FINAL MARCH 1999 Prepared for the October 30-31, 1997, Meeting of the Report on Carcinogens Subcommittee of the NTP Board of Scientific Counselors Prepared ...
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15th RoC: Glossary 200KB
https://ntp.niehs.nih.gov/ntp/roc/content/glossary_508.pdf
--%multipart-mixed-boundary-6689.1.1711999472.839.1804289383% X-Anytotx-Content-Type: application/pdf X-Anytotx-Identified-By: command-line Content-Type: text/plain; charset=UTF-8 ...
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Nomination Background: 1,3-Dichloro-2-propanol (CASRN: 96-23... 1.5MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/dichloropropanol_508.pdf
1,3-Dichloro-2-propanol [CAS No. 96-23-1] Review of Toxicological Literature January 2005 1,3-Dichloro-2-propanol [CAS No. 96-23-1] Review of Toxicological Literature Prepared for ...
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RoC Profile: Nitroarenes (Selected); 15th RoC 2021 233KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/nitroarenes.pdf
Nitroarenes (Selected) Introduction The nitroarenes are a large class of structurally related chemicals nor- mally found in particulate emissions from many combustion sources, most ...
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TR-494: Anthraquinone (CASRN 84-65-1) in F344/N Rats and B6C3F1Mice... 10.7MB
https://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr494.pdf
REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF ANTHRAQUINONE (CAS NO. 84-65-1) IN F344/N RATS AND B6C3F 1 MICE (FEED STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 ...
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TR-478: Diethanolamine (CASRN 111-42-2) in F344/N Rats and B6C3F1Mice... 10.2MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr478.pdf
OF DIETHANOLAMINE (CAS NO. 111-42-2) IN F344/N RATS AND B6C3F MICE 1 (DERMAL STUDIES) NATIONAL TOXICOLOGY PROGRAM P.O. Box 12233 Research Triangle Park, NC 27709 July 1999 NTP TR ...
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TR-561: Tetralin (CASRN 119-64-2) in F344/N Rats and B6C3F1 Mice... 13.7MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr561.pdf
AND CARCINOGENESIS STUDIES OF TETRALIN (CAS NO. 119-64-2) IN F344/N RATS AND B6C3F1 MICE AND A TOXICOLOGY STUDY OF TETRALIN IN MALE NBR RATS (INHALATION STUDIES) NATIONAL ...
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Public Comment: Carbon black; Patrick Beatty; RoC; Jan. 19, 2012 118KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2012/publiccomm/beatty20120227.pdf
Patrick W. Beatty, Ph.D., DABT Scientific Advisor Research and Scientific Affairs Department 1220 L Street, NW Washington, DC 20005-4070 USA Telephone 202-682-8473 Fax 202-682-8270 ...
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TR-282: Chlorodibromomethane (CASRN 124-48-1) in F344/N Rats... 9.0MB
https://ntp.niehs.nih.gov/go/tr282
NATIONAL TOXICOLOGY PROGRAM Technical Report Series No. 282 HUMAN 'e@* TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLORODIBROMOMETHANE (CAS NO. 124-48-1) IN F344/NRATS AND B6C3F1 ...
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TR-421: Talc (CASRN 14807-96-6)(Non-Asbestiform) in F344/N Rats... 16.3MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr421.pdf
AND FOREWORD The National Toxicology Program (NTP) is made up o f four charter agencies o f the U.S. Department o f Health and Human Services (DHHS): the National Cancer Institute ...
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Nomination Background: 2,3-Butanedione (CASRN: 431-03-8) 1.8MB
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/artificial_butter_flavoring_508be.pdf
Chemical Information Review Document for Artificial Butter Flavoring and Constituents Diacetyl [CAS No. 431-03-8] and Acetoin [CAS No. 513-86-0] Supporting Nomination for ...
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Comment: Meat-related exposures (ORoC7); Shalene McNeill, The... 80KB
https://ntp.niehs.nih.gov/ntp/roc/nominations/2016/publiccomm/mcneill_7oroc20161007.pdf
Received via email on October 11, 2016 From: Shalene McNeill, The Beef Checkoff Comments: Dear Dr. Lunn: The Beef Checkoff appreciates the opportunity to submit scientific evidence ...
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RoC Background Document: Ethylene Oxide; Dec. 2-3, 1998 4.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/ethyloxide_oneapp_508.pdf
ETHYLENE OXIDE FINAL MARCH 1999 Prepared for the December 2-3, 1998, Meeting of the Report on Carcinogens Subcommittee of the NTP Board of Scientific Counselors Prepared by ...
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RoC Background Document: Furan; Nov. 18-19, 1996 3.0MB
https://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/furan1_508.pdf
FURAN FINAL MARCH 1999 Prepared for the November 18-19, 1996, Meeting of the Report on Carcinogens Subcommittee of the Board of Scientific Counselors Prepared by Integrated ...
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RoC Profile: Coke-Oven Emissions; 15th RoC 2021 121KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/cokeovenemissions.pdf
Coke-Oven Emissions CAS No.: none assigned Known to be human carcinogens First listed in the Second Annual Report on Carcinogens (1981) Carcinogenicity Coke-oven emissions are ...
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Abstract for TR-478 72KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr478
78abs Abstract for TR-478 Toxicology and Carcinogenesis Studies of Diethanolamine in F344/N Rats and B6C3F1 Mice (Dermal Studies) CASRN: 111-42-2 Chemical Formula: C4H11NO2 ...
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Supporting Document: Sulfolane; Sept. 15, 2011 2.5MB
https://ntp.niehs.nih.gov/ntp/noms/support_docs/atsdr100711_sulfolane_508.pdf
~ StR\Itt.rs ( ' ~ DEPARTMENT OF HEALTH & HUMAN SERVICES Public Health Service ~~-~,~\[- Agency for Toxic Substances and Disease Registry Atlanta , GA 30333 October 7, 2011 Scott ...
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Abstract for TR-487 70KB
https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr487
7abs Abstract for TR-487 Toxicology and Carcinogenesis Studies of Isobutene in F344/N Rats and B6C3F1 Mice (Inhalation Studies) CASRN: 115-11-7 Chemical Formula: C4H8 Molecular ...
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RoC Profile: Acetaldehyde; 15th RoC 2021 176KB
https://ntp.niehs.nih.gov/ntp/roc/content/profiles/acetaldehyde.pdf
National Toxicology Program, Department of Health and Human Services Report on Carcinogens, Fifteenth Edition For Table of Contents, see home page: http://ntp.niehs.nih.gov/go/roc ...
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Sulfolane Chad Blystone, Ph.D., D.A.B.T. National Institute of... 576KB
https://ntp.niehs.nih.gov/ntp/about_ntp/bsc/2011/december/5_blystone_sulfolane.pdf
Sulfolane Chad Blystone, Ph.D., D.A.B.T. National Institute of Environmental Health Sciences NTP Board of Scientific Counselors Meeting December 15, 2011 National Institute of ...
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TR-278: 2,6-Xylidine (2,6-Dimethylaniline) (CASRN 87-62-7) in... 9.4MB
https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/lt_rpts/tr278.pdf
8 TOXICOLOGY AND CARCINOGENESIS STUDIES OF 2,6=XYLIDINE (2,6-DIMETHY LANILINE) (CAS NO. 87-62-7) IN CHARLES RIVER CD RATS (FEED STUDIES) U.S. DEPARTMENT OF HEALTH AND HUMAN ...
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RoC Background Document: Vinyl Fluoride; Jan. 20-21, 2000 468KB
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc10/vf_no_appendices_508.pdf
Vinyl Fluoride Meeting of the NTP Board of Scientific Counselors Report on Carcinogens Subcommittee Prepared for the: U.S. Department of Health and Human Services Public Health ...